메뉴 건너뛰기




Volumn 9, Issue 2, 2010, Pages 47-53

Effect of bioflavonoid Quercetin on endotoxin- induced hepatotoxicity and oxidative stress in rat liver

Author keywords

Flavonoids; Lipid peroxidation; Lipopolysaccharide; Septicemia

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GLUTATHIONE; INTERLEUKIN 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; OXYGEN RADICAL; PROTEIN; QUERCETIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR ALPHA;

EID: 78649895916     PISSN: 17352657     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (8)

References (38)
  • 1
    • 0021223241 scopus 로고
    • Kinetics of endotoxin release during antibiotic therapy for experimental gram-negative bacterial sepsis
    • Shenep JL, Mogan KA. Kinetics of endotoxin release during antibiotic therapy for experimental gram-negative bacterial sepsis. J Infect Dis 1984; 150:380-8.
    • (1984) J Infect Dis , vol.150 , pp. 380-388
    • Shenep, J.L.1    Mogan, K.A.2
  • 2
    • 0025303027 scopus 로고
    • Septic shock in humans, Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy
    • Parrillo JE, Parker MM, Natanson C. Septic shock in humans, Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann Intern Med 1990; 113:227-42.
    • (1990) Ann Intern Med , vol.113 , pp. 227-242
    • Parrillo, J.E.1    Parker, M.M.2    Natanson, C.3
  • 3
    • 0035087432 scopus 로고    scopus 로고
    • Melatonin prevents endotoxin-induced circulatory failure in rats
    • Wu CC, Chiao CW, Hsiao G, Chen A, Yen MH. Melatonin prevents endotoxin-induced circulatory failure in rats. J Pineal Res 2001; 30:147-56.
    • (2001) J Pineal Res , vol.30 , pp. 147-156
    • Wu, C.C.1    Chiao, C.W.2    Hsiao, G.3    Chen, A.4    Yen, M.H.5
  • 4
    • 0033932898 scopus 로고    scopus 로고
    • Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of grampositive shock
    • Zacharowski K, Olbrich A, Cuzzocrea S, Foster SJ, Thiemermann C. Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of grampositive shock. Crit Care Med 2000; 28:1953-61.
    • (2000) Crit Care Med , vol.28 , pp. 1953-1961
    • Zacharowski, K.1    Olbrich, A.2    Cuzzocrea, S.3    Foster, S.J.4    Thiemermann, C.5
  • 5
    • 0028054728 scopus 로고
    • Changes in tissue antioxidant enzyme activities and lipid peroxides in endotoxin-induced multiple organ failure
    • Yoshikawa T, Takano H, Takahashi S, Ichikawa H, Kondo M. Changes in tissue antioxidant enzyme activities and lipid peroxides in endotoxin-induced multiple organ failure. Circ Shock 1994; 42:53-8.
    • (1994) Circ Shock , vol.42 , pp. 53-58
    • Yoshikawa, T.1    Takano, H.2    Takahashi, S.3    Ichikawa, H.4    Kondo, M.5
  • 6
    • 0023180925 scopus 로고
    • The role of lipid peroxidation in endotoxin-induced hepatic damage and the protective effect of antioxidants
    • Sugino K, Dohi K, Yamada K, Kawasaki T. The role of lipid peroxidation in endotoxin-induced hepatic damage and the protective effect of antioxidants. Surgery 1987; 101:746-52.
    • (1987) Surgery , vol.101 , pp. 746-752
    • Sugino, K.1    Dohi, K.2    Yamada, K.3    Kawasaki, T.4
  • 7
    • 0027168520 scopus 로고
    • Complement activates Kupffer cells and neutrophils during reperfusion after hepatic ischemia
    • Jaeschke H, Farhood A, Bautista AP, Spolarics Z, Spitzer JJ. Complement activates Kupffer cells and neutrophils during reperfusion after hepatic ischemia. Am J Physiol 1993; 264: G801-9.
    • (1993) Am J Physiol , vol.264
    • Jaeschke, H.1    Farhood, A.2    Bautista, A.P.3    Spolarics, Z.4    Spitzer, J.J.5
  • 8
  • 9
    • 22044435401 scopus 로고    scopus 로고
    • The effect of quercetin, a bioflavonoid on ischemia/reperfusion induced renal injury in rats
    • Singh D, Chander V, Chopra K. The effect of quercetin, a bioflavonoid on ischemia/reperfusion induced renal injury in rats. Arch Med Res 2004; 35:484-94.
    • (2004) Arch Med Res , vol.35 , pp. 484-494
    • Singh, D.1    Chander, V.2    Chopra, K.3
  • 10
    • 1942473768 scopus 로고    scopus 로고
    • Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats
    • Anjaneyulu M, Chopra K. Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats. Clin Exp Pharm Phys 2004; 31:244-8.
    • (2004) Clin Exp Pharm Phys , vol.31 , pp. 244-248
    • Anjaneyulu, M.1    Chopra, K.2
  • 11
    • 26444581298 scopus 로고    scopus 로고
    • Quercetin decreases oxidative stress, activation of NF-kB Activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats
    • Dias AS, Porawski M, Alonso M, Marroni N, Collado PS, Gonzalez-Gallego J. Quercetin decreases oxidative stress, activation of NF-kB Activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats. J Nut 2005; 135:2299-304.
    • (2005) J Nut , vol.135 , pp. 2299-2304
    • Dias, A.S.1    Porawski, M.2    Alonso, M.3    Marroni, N.4    Collado, P.S.5    Gonzalez-Gallego, J.6
  • 13
    • 0035291848 scopus 로고    scopus 로고
    • Quercetin, coenzyme Q10, and lcanavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain
    • Al-Gawad HM, Khalifa AE. Quercetin, coenzyme Q10, and lcanavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain. Pharmacol Res 2001; 43:257-63.
    • (2001) Pharmacol Res , vol.43 , pp. 257-263
    • Al-Gawad, H.M.1    Khalifa, A.E.2
  • 14
    • 0035479909 scopus 로고    scopus 로고
    • Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharideinduced signaling pathways involved in the release of tumor necrosis factor-alpha
    • Wadsworth TL, McDonald TL, Koop DR. Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharideinduced signaling pathways involved in the release of tumor necrosis factor-alpha. Biochem Pharmacol 2001; 62:963-74.
    • (2001) Biochem Pharmacol , vol.62 , pp. 963-974
    • Wadsworth, T.L.1    McDonald, T.L.2    Koop, D.R.3
  • 15
    • 0032759115 scopus 로고    scopus 로고
    • Inhibition of NFkappaB activation with antioxidants is correlated with reduced cytokine transcription in PTC
    • Rangan GK, Wang Y, Tay YC, Harris DC. Inhibition of NFkappaB activation with antioxidants is correlated with reduced cytokine transcription in PTC. Am J Physiol 1999; 277: F779-89.
    • (1999) Am J Physiol , vol.277
    • Rangan, G.K.1    Wang, Y.2    Tay, Y.C.3    Harris, D.C.4
  • 16
    • 0031969571 scopus 로고    scopus 로고
    • Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells
    • Kawada N, Seki S, Inoue M, Kuroki T. Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells. Hepatology 1998; 27:1265-74.
    • (1998) Hepatology , vol.27 , pp. 1265-1274
    • Kawada, N.1    Seki, S.2    Inoue, M.3    Kuroki, T.4
  • 17
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000; 52:673-751.
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton, E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 18
    • 0034222395 scopus 로고    scopus 로고
    • Quantitative structure-activity relationship of flavonoid analogues. 3. Inhibition of p56lck protein tyrosine kinase
    • Oblak M, Randic M, Solmajer T. Quantitative structure-activity relationship of flavonoid analogues. 3. Inhibition of p56lck protein tyrosine kinase. J Chem Inf Comput Sci 2000; 40:994-1001.
    • (2000) J Chem Inf Comput Sci , vol.40 , pp. 994-1001
    • Oblak, M.1    Randic, M.2    Solmajer, T.3
  • 19
    • 33748660469 scopus 로고    scopus 로고
    • Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity
    • Kaur G, Tirkey N, Chopra K. Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity. Toxicology 2006; 226:152-60.
    • (2006) Toxicology , vol.226 , pp. 152-160
    • Kaur, G.1    Tirkey, N.2    Chopra, K.3
  • 20
    • 0016374492 scopus 로고
    • Detection and measurement of total bilirubin in serum, with use of surfactants as solubilizing agents
    • Pearlman FC, Lee RT. Detection and measurement of total bilirubin in serum, with use of surfactants as solubilizing agents. Clin Chem 1974; 20:447-53.
    • (1974) Clin Chem , vol.20 , pp. 447-453
    • Pearlman, F.C.1    Lee, R.T.2
  • 21
    • 0013914976 scopus 로고
    • Mechanisms of lipid peroxide formation in animal tissues
    • Wills ED. Mechanisms of lipid peroxide formation in animal tissues. Biochem J 1966; 99:667-76.
    • (1966) Biochem J , vol.99 , pp. 667-676
    • Wills, E.D.1
  • 22
    • 78649889480 scopus 로고
    • In: Varley H, editor. Practical Clinical Biochemistry, Delhi: CBS
    • Varley H. The plasma proteins. In: Varley H, editor. Practical Clinical Biochemistry, Delhi: CBS;1988. pp. 236-238.
    • (1988) The plasma proteins , pp. 236-238
    • Varley, H.1
  • 23
    • 0016151122 scopus 로고
    • Bromobenze induced liver necrosis: Protective role of glutathione and evidence for 3, 4-bromobenzenoxide as the hepatotoxic metabolite
    • Jollow D, Mitchell L, Zampaglione N, Gillete J. Bromobenze induced liver necrosis: protective role of glutathione and evidence for 3, 4-bromobenzenoxide as the hepatotoxic metabolite. Pharmacol 1974; 11:151-69.
    • (1974) Pharmacol , vol.11 , pp. 151-169
    • Jollow, D.1    Mitchell, L.2    Zampaglione, N.3    Gillete, J.4
  • 24
    • 0017804313 scopus 로고
    • Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase
    • Kono Y. Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys 1978; 186:189-95.
    • (1978) Arch Biochem Biophys , vol.186 , pp. 189-195
    • Kono, Y.1
  • 25
    • 13244267206 scopus 로고    scopus 로고
    • Protection of endotoxininduced oxidative renal tissue damage of rats by vitamin E or/and EGb 761 treatment
    • Coskun OAF, Kanter M, Kuzey GM. Protection of endotoxininduced oxidative renal tissue damage of rats by vitamin E or/and EGb 761 treatment. J Appl Toxicol 2005; 25:8-12.
    • (2005) J Appl Toxicol , vol.25 , pp. 8-12
    • Coskun, O.A.F.1    Kanter, M.2    Kuzey, G.M.3
  • 26
    • 0025730414 scopus 로고
    • Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide
    • Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. J Biol Chem 1991; 266:4244-50.
    • (1991) J Biol Chem , vol.266 , pp. 4244-4250
    • Radi, R.1    Beckman, J.S.2    Bush, K.M.3    Freeman, B.A.4
  • 27
    • 0027412607 scopus 로고
    • Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells
    • Stadler J, Harbrecht BG, Di Silvio M et. al. Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells. J Leukoc Biol 1993; 53:165-72.
    • (1993) J Leukoc Biol , vol.53 , pp. 165-172
    • Stadler, J.1    Harbrecht, B.G.2    di Silvio, M.3
  • 28
    • 0027104253 scopus 로고
    • Biochemistry of nitric oxide and its redox-activated forms
    • Stamler JS, Singel DJ, Loscalzo J. Biochemistry of nitric oxide and its redox-activated forms. Science 1992; 258:1898-902.
    • (1992) Science , vol.258 , pp. 1898-1902
    • Stamler, J.S.1    Singel, D.J.2    Loscalzo, J.3
  • 29
    • 0028988038 scopus 로고
    • Endogenous peroxynitrite is involved in the inhibition of mitochondrial respiration in immuno-stimulated J774.2 macrophages
    • Szabo C, Salzman AL. Endogenous peroxynitrite is involved in the inhibition of mitochondrial respiration in immuno-stimulated J774.2 macrophages. Biochem Biophys Res Commun 1995; 209:739-43.
    • (1995) Biochem Biophys Res Commun , vol.209 , pp. 739-743
    • Szabo, C.1    Salzman, A.L.2
  • 30
    • 0344327080 scopus 로고    scopus 로고
    • Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophages
    • Manjeet KR, Ghosh B. Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophages. Int J Immunopharmacol 1999; 21:435-43.
    • (1999) Int J Immunopharmacol , vol.21 , pp. 435-443
    • Manjeet, K.R.1    Ghosh, B.2
  • 31
    • 76849090223 scopus 로고    scopus 로고
    • Inhibition of nitric oxide production by quercetin in endotoxin/cytokinestimulated microglia
    • Kao TK, Raung SL, Lai CY, Liao SL, Chen CJ. Inhibition of nitric oxide production by quercetin in endotoxin/cytokinestimulated microglia. Life Sci 2010; 86: 315-21.
    • (2010) Life Sci , vol.86 , pp. 315-321
    • Kao, T.K.1    Raung, S.L.2    Lai, C.Y.3    Liao, S.L.4    Chen, C.J.5
  • 32
    • 0029906360 scopus 로고    scopus 로고
    • Inhibitory effect of quercetin on tumor necrosis factor and interleukin-1 beta proosteoclastic activities
    • Zhang JP, Wu TM, Hu ZL, Qian DH. Inhibitory effect of quercetin on tumor necrosis factor and interleukin-1 beta proosteoclastic activities. Zhongguo Yao Li Xue Bao 1996; 17:261-3.
    • (1996) Zhongguo Yao Li Xue Bao , vol.17 , pp. 261-263
    • Zhang, J.P.1    Wu, T.M.2    Hu, Z.L.3    Qian, D.H.4
  • 33
    • 0020319120 scopus 로고
    • Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions
    • Fantone JC, Ward PA. Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am J Pathol 1982; 107:395-418.
    • (1982) Am J Pathol , vol.107 , pp. 395-418
    • Fantone, J.C.1    Ward, P.A.2
  • 34
    • 0017834531 scopus 로고
    • Oxygen-dependent microbial killing by phagocytes (first of two parts)
    • Babior BM. Oxygen-dependent microbial killing by phagocytes (first of two parts). N Engl J Med 1978; 298:659-68.
    • (1978) N Engl J Med , vol.298 , pp. 659-668
    • Babior, B.M.1
  • 35
    • 0023280583 scopus 로고
    • Antibiotic therapy, endotoxin concentration in cerebrospinal fluid, and brain edema in experimental Escherichia coli meningitis in rabbits
    • Tauber MG, Shibl AM, Hackbarth CJ, Larrick JW, Sande MA. Antibiotic therapy, endotoxin concentration in cerebrospinal fluid, and brain edema in experimental Escherichia coli meningitis in rabbits. J Infect Dis 1987; 156:456-62.
    • (1987) J Infect Dis , vol.156 , pp. 456-462
    • Tauber, M.G.1    Shibl, A.M.2    Hackbarth, C.J.3    Larrick, J.W.4    Sande, M.A.5
  • 36
    • 29944432474 scopus 로고    scopus 로고
    • Quercetin inhibits LPS-induced delay in spontaneous apoptosis and activation of neutrophils
    • Liu JJ, Song CW, Yue Y, Duan CG, Yang J, He T, He YZ. Quercetin inhibits LPS-induced delay in spontaneous apoptosis and activation of neutrophils. Inflamm Res 2005; 54:500-7.
    • (2005) Inflamm Res , vol.54 , pp. 500-507
    • Liu, J.J.1    Song, C.W.2    Yue, Y.3    Duan, C.G.4    Yang, J.5    He, T.6    He, Y.Z.7
  • 37
    • 0023181223 scopus 로고
    • The bioflavonoid quercetin inhibits neutrophil degranulation, superoxide production, and the phosphorylation of specific neutrophil proteins
    • Blackburn WD, Jr., Heck LW, Wallace RW. The bioflavonoid quercetin inhibits neutrophil degranulation, superoxide production, and the phosphorylation of specific neutrophil proteins. Biochem Biophys Res Commun 1987; 144:1229-36.
    • (1987) Biochem Biophys Res Commun , vol.144 , pp. 1229-1236
    • Blackburn Jr., W.D.1    Heck, L.W.2    Wallace, R.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.