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Volumn 6, Issue 1, 2014, Pages 35-42

Pathophysiological processes in multiple sclerosis: Focus on nuclear factor erythroid-2-related factor 2 and emerging pathways

Author keywords

Fumaric acid ester; MS; ROS

Indexed keywords

FREE RADICAL; FUMARIC ACID DIMETHYL ESTER; KELCH LIKE ECH ASSOCIATED PROTEIN 1; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR MAF; TRANSCRIPTION FACTOR NRF2;

EID: 84895821027     PISSN: None     EISSN: 11791438     Source Type: Book Series    
DOI: 10.2147/CPAA.S35033     Document Type: Review
Times cited : (34)

References (85)
  • 1
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol. 2000;47(6):707-717.
    • (2000) Ann Neurol. , vol.47 , Issue.6 , pp. 707-717
    • Lucchinetti, C.1    Bruck, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 2
    • 0642345898 scopus 로고    scopus 로고
    • Axonal degeneration and progressive neurologic disability in multiple sclerosis
    • Bjartmar C, Trapp BD. Axonal degeneration and progressive neurologic disability in multiple sclerosis. Neurotox Res. 2003;5(1-2):157-164.
    • (2003) Neurotox Res. , vol.5 , Issue.1-2 , pp. 157-164
    • Bjartmar, C.1    Trapp, B.D.2
  • 3
    • 0036788406 scopus 로고    scopus 로고
    • Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time
    • Kuhlmann T, Lingfeld G, Bitsch A, Schuchardt J, Bruck W. Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain. 2002;125(Pt 10):2202-2212.
    • (2002) Brain. , vol.125 , Issue.PART 10 , pp. 2202-2212
    • Kuhlmann, T.1    Lingfeld, G.2    Bitsch, A.3    Schuchardt, J.4    Bruck, W.5
  • 4
    • 0031002545 scopus 로고    scopus 로고
    • Axonal damage in acute multiple sclerosis lesions
    • Ferguson B, Matyszak MK, Esiri MM, Perry VH. Axonal damage in acute multiple sclerosis lesions. Brain. 1997;120 (Pt 3):393-399.
    • (1997) Brain. , vol.120 , Issue.PART 3 , pp. 393-399
    • Ferguson, B.1    Matyszak, M.K.2    Esiri, M.M.3    Perry, V.H.4
  • 5
    • 0003062838 scopus 로고    scopus 로고
    • Magnetic resonance imaging in the diagnosis of multiple sclerosis, elucidation of disease, course, and determining prognosis
    • In: In: Burks JS, Johnson KP, editors. New York: Demos Medical Publishing
    • Simon J. Magnetic resonance imaging in the diagnosis of multiple sclerosis, elucidation of disease, course, and determining prognosis. In: In: Burks JS, Johnson KP, editors. Multiple Sclerosis: Diagnosis, Medical Management, and Rehabilitation. New York: Demos Medical Publishing; 2000:99-126.
    • (2000) Multiple Sclerosis: Diagnosis, Medical Management, and Rehabilitation , pp. 99-126
    • Simon, J.1
  • 6
    • 1642281535 scopus 로고    scopus 로고
    • Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion
    • Barnett MH, Prineas JW. Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion. Ann Neurol. 2004;55(4): 458-468.
    • (2004) Ann Neurol. , vol.55 , Issue.4 , pp. 458-468
    • Barnett, M.H.1    Prineas, J.W.2
  • 7
    • 53049093018 scopus 로고    scopus 로고
    • Neurodegeneration in multiple sclerosis: The role of oxidative stress and excitotoxicity
    • Gonsette RE. Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicity. J Neurol Sci. 2008;274(1-2):48-53.
    • (2008) J Neurol Sci. , vol.274 , Issue.1-2 , pp. 48-53
    • Gonsette, R.E.1
  • 9
    • 77049114949 scopus 로고    scopus 로고
    • Transcriptional responses to oxidative stress: Pathological and toxicological implications
    • Ma Q. Transcriptional responses to oxidative stress: pathological and toxicological implications. Pharmacol Ther. 2010;125(3):376-393.
    • (2010) Pharmacol Ther. , vol.125 , Issue.3 , pp. 376-393
    • Ma, Q.1
  • 10
    • 84856821006 scopus 로고    scopus 로고
    • Signal transduction by mitochondrial oxidants
    • Finkel T. Signal transduction by mitochondrial oxidants. J Biol Chem. 2012;287(7):4434-4440.
    • (2012) J Biol Chem. , vol.287 , Issue.7 , pp. 4434-4440
    • Finkel, T.1
  • 11
    • 0021288856 scopus 로고
    • Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria
    • Boveris A. Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria. Methods Enzymol. 1984;105: 429-435.
    • (1984) Methods Enzymol. , vol.105 , pp. 429-435
    • Boveris, A.1
  • 12
    • 0018776894 scopus 로고
    • Hydroperoxide metabolism in mammalian organs
    • Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev. 1979;59(3):527-605.
    • (1979) Physiol Rev. , vol.59 , Issue.3 , pp. 527-605
    • Chance, B.1    Sies, H.2    Boveris, A.3
  • 13
    • 0030615104 scopus 로고    scopus 로고
    • Dependence of H2O2 formation by rat heart mitochondria on substrate availability and donor age
    • Hansford RG, Hogue BA, Mildaziene V. Dependence of H2O2 formation by rat heart mitochondria on substrate availability and donor age. J Bioenerg Biomembr. 1997;29(1):89-95.
    • (1997) J Bioenerg Biomembr. , vol.29 , Issue.1 , pp. 89-95
    • Hansford, R.G.1    Hogue, B.A.2    Mildaziene, V.3
  • 14
    • 0019083215 scopus 로고
    • Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria
    • Turrens JF, Boveris A. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem J. 1980;191(2): 421-427.
    • (1980) Biochem J. , vol.191 , Issue.2 , pp. 421-427
    • Turrens, J.F.1    Boveris, A.2
  • 16
    • 0033796250 scopus 로고    scopus 로고
    • Mitochondrial free radical generation, oxidative stress, and aging
    • Cadenas E, Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med. 2000;29(3-4):222-230.
    • (2000) Free Radic Biol Med. , vol.29 , Issue.3-4 , pp. 222-230
    • Cadenas, E.1    Davies, K.J.2
  • 17
    • 0034456720 scopus 로고    scopus 로고
    • Mitochondrial production of hydrogen peroxide regulation by nitric oxide and the role of ubisemiquinone
    • Boveris A, Cadenas E. Mitochondrial production of hydrogen peroxide regulation by nitric oxide and the role of ubisemiquinone. IUBMB Life. 2000;50(4-5):245-250.
    • (2000) IUBMB Life. , vol.50 , Issue.4-5 , pp. 245-250
    • Boveris, A.1    Cadenas, E.2
  • 18
    • 84867034260 scopus 로고    scopus 로고
    • Role of Nrf2 in oxidative stress and toxicity
    • Ma Q. Role of Nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol. 2013;53:401-426.
    • (2013) Annu Rev Pharmacol Toxicol. , vol.53 , pp. 401-426
    • Ma, Q.1
  • 19
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    • Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev. 2007;87(1):245-313.
    • (2007) Physiol Rev. , vol.87 , Issue.1 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 20
    • 0032924640 scopus 로고    scopus 로고
    • Oxidative stress in brain ischemia
    • Love S. Oxidative stress in brain ischemia. Brain Pathol. 1999;9(1): 119-131.
    • (1999) Brain Pathol. , vol.9 , Issue.1 , pp. 119-131
    • Love, S.1
  • 21
    • 0033655446 scopus 로고    scopus 로고
    • Regulation of glutathione synthesis
    • Lu SC. Regulation of glutathione synthesis. Curr Top Cell Regul. 2000;36:95-116.
    • (2000) Curr Top Cell Regul. , vol.36 , pp. 95-116
    • Lu, S.C.1
  • 22
    • 0030768236 scopus 로고    scopus 로고
    • The pharmacology of the antioxidant lipoic acid
    • Biewenga GP, Haenen GR, Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol. 1997;29(3):315-331.
    • (1997) Gen Pharmacol. , vol.29 , Issue.3 , pp. 315-331
    • Biewenga, G.P.1    Haenen, G.R.2    Bast, A.3
  • 25
    • 11844264954 scopus 로고    scopus 로고
    • Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis
    • Hendriks JJ, Alblas J, van der Pol SM, van Tol EA, Dijkstra CD, de Vries HE. Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis. J Exp Med. 2004;200(12):1667-1672.
    • (2004) J Exp Med. , vol.200 , Issue.12 , pp. 1667-1672
    • Hendriks, J.J.1    Alblas, J.2    van der Pol, S.M.3    van Tol, E.A.4    Dijkstra, C.D.5    de Vries, H.E.6
  • 26
    • 0032950964 scopus 로고    scopus 로고
    • Demyelination: The role of reactive oxygen and nitrogen species
    • Smith KJ, Kapoor R, Felts PA. Demyelination: the role of reactive oxygen and nitrogen species. Brain Pathol. 1999;9(1):69-92.
    • (1999) Brain Pathol. , vol.9 , Issue.1 , pp. 69-92
    • Smith, K.J.1    Kapoor, R.2    Felts, P.A.3
  • 27
    • 1042287039 scopus 로고    scopus 로고
    • Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease
    • van Meeteren ME, Hendriks JJ, Dijkstra CD, van Tol EA. Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease. Biochem Pharmacol. 2004;67(5):967-975.
    • (2004) Biochem Pharmacol. , vol.67 , Issue.5 , pp. 967-975
    • van Meeteren, M.E.1    Hendriks, J.J.2    Dijkstra, C.D.3    van Tol, E.A.4
  • 28
    • 0037226838 scopus 로고    scopus 로고
    • Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases
    • Aboul-Enein F, Rauschka H, Kornek B, et al. Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases. J Neuropathol Exp Neurol. 2003;62(1):25-33.
    • (2003) J Neuropathol Exp Neurol. , vol.62 , Issue.1 , pp. 25-33
    • Aboul-Enein, F.1    Rauschka, H.2    Kornek, B.3
  • 29
    • 79959723400 scopus 로고    scopus 로고
    • Oxidative damage in multiple sclerosis lesions
    • Haider L, Fischer MT, Frischer JM, et al. Oxidative damage in multiple sclerosis lesions. Brain. 2011;134(Pt 7):1914-1924.
    • (2011) Brain. , vol.134 , Issue.PART 7 , pp. 1914-1924
    • Haider, L.1    Fischer, M.T.2    Frischer, J.M.3
  • 30
    • 0027068020 scopus 로고
    • Studies of lipid peroxidation products in cerebrospinal fluid and serum in multiple sclerosis and other conditions
    • Naidoo R, Knapp ML. Studies of lipid peroxidation products in cerebrospinal fluid and serum in multiple sclerosis and other conditions. Clin Chem. 1992;38(12):2449-2454.
    • (1992) Clin Chem. , vol.38 , Issue.12 , pp. 2449-2454
    • Naidoo, R.1    Knapp, M.L.2
  • 31
    • 56349160121 scopus 로고    scopus 로고
    • Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression
    • van Horssen J, Schreibelt G, Drexhage J, et al. Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression. Free Radic Biol Med. 2008;45(12):1729-1737.
    • (2008) Free Radic Biol Med. , vol.45 , Issue.12 , pp. 1729-1737
    • van Horssen, J.1    Schreibelt, G.2    Drexhage, J.3
  • 32
    • 51349137371 scopus 로고    scopus 로고
    • Elevated myeloperoxidase activity in white matter in multiple sclerosis
    • Gray E, Thomas TL, Betmouni S, Scolding N, Love S. Elevated myeloperoxidase activity in white matter in multiple sclerosis. Neurosci Lett. 2008;444(2):195-198.
    • (2008) Neurosci Lett. , vol.444 , Issue.2 , pp. 195-198
    • Gray, E.1    Thomas, T.L.2    Betmouni, S.3    Scolding, N.4    Love, S.5
  • 33
    • 38349125335 scopus 로고    scopus 로고
    • Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis
    • Gray E, Thomas TL, Betmouni S, Scolding N, Love S. Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis. Brain Pathol. 2008;18(1):86-95.
    • (2008) Brain Pathol. , vol.18 , Issue.1 , pp. 86-95
    • Gray, E.1    Thomas, T.L.2    Betmouni, S.3    Scolding, N.4    Love, S.5
  • 34
    • 35649018602 scopus 로고    scopus 로고
    • Lesion genesis in a subset of patients with multiple sclerosis: A role for innate immunity?
    • Marik C, Felts PA, Bauer J, Lassmann H, Smith KJ. Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity? Brain. 2007;130(Pt 11):2800-2815.
    • (2007) Brain. , vol.130 , Issue.PART 11 , pp. 2800-2815
    • Marik, C.1    Felts, P.A.2    Bauer, J.3    Lassmann, H.4    Smith, K.J.5
  • 35
    • 0032146352 scopus 로고    scopus 로고
    • Peroxynitrite formation within the central nervous system in active multiple sclerosis
    • Cross AH, Manning PT, Keeling RM, Schmidt RE, Misko TP. Peroxynitrite formation within the central nervous system in active multiple sclerosis. J Neuroimmunol. 1998;88(1-2):45-56.
    • (1998) J Neuroimmunol. , vol.88 , Issue.1-2 , pp. 45-56
    • Cross, A.H.1    Manning, P.T.2    Keeling, R.M.3    Schmidt, R.E.4    Misko, T.P.5
  • 36
    • 0034965383 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions
    • Liu JS, Zhao ML, Brosnan CF, Lee SC. Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions. Am J Pathol. 2001;158(6):2057-2066.
    • (2001) Am J Pathol. , vol.158 , Issue.6 , pp. 2057-2066
    • Liu, J.S.1    Zhao, M.L.2    Brosnan, C.F.3    Lee, S.C.4
  • 37
    • 0013292906 scopus 로고    scopus 로고
    • The role of nitric oxide in multiple sclerosis
    • Smith KJ, Lassmann H. The role of nitric oxide in multiple sclerosis. Lancet Neurol. 2002;1(4):232-241.
    • (2002) Lancet Neurol. , vol.1 , Issue.4 , pp. 232-241
    • Smith, K.J.1    Lassmann, H.2
  • 38
    • 77950269262 scopus 로고    scopus 로고
    • Inhibiting poly(ADP-ribose) polymerase: A potential therapy against oligodendrocyte death
    • Veto S, Acs P, Bauer J, et al. Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death. Brain. 2010;133(Pt 3):822-834.
    • (2010) Brain. , vol.133 , Issue.PART 3 , pp. 822-834
    • Veto, S.1    Acs, P.2    Bauer, J.3
  • 39
    • 70349135156 scopus 로고    scopus 로고
    • Enhanced number and activity of mitochondria in multiple sclerosis lesions
    • Witte ME, Bo L, Rodenburg RJ, et al. Enhanced number and activity of mitochondria in multiple sclerosis lesions. J Pathol. 2009;219(2): 193-204.
    • (2009) J Pathol. , vol.219 , Issue.2 , pp. 193-204
    • Witte, M.E.1    Bo, L.2    Rodenburg, R.J.3
  • 40
    • 33644817756 scopus 로고    scopus 로고
    • Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
    • Dutta R, McDonough J, Yin X, et al. Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Ann Neurol. 2006;59(3):478-489.
    • (2006) Ann Neurol. , vol.59 , Issue.3 , pp. 478-489
    • Dutta, R.1    McDonough, J.2    Yin, X.3
  • 41
    • 78549234073 scopus 로고    scopus 로고
    • Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis
    • Dutta R, Trapp BD. Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis. Prog Neurobiol. 2011;93(1):1-12.
    • (2011) Prog Neurobiol. , vol.93 , Issue.1 , pp. 1-12
    • Dutta, R.1    Trapp, B.D.2
  • 42
    • 46849122006 scopus 로고    scopus 로고
    • Mitochondrial defects in acute multiple sclerosis lesions
    • Mahad D, Ziabreva I, Lassmann H, Turnbull D. Mitochondrial defects in acute multiple sclerosis lesions. Brain. 2008;131(Pt 7):1722-1735.
    • (2008) Brain. , vol.131 , Issue.PART 7 , pp. 1722-1735
    • Mahad, D.1    Ziabreva, I.2    Lassmann, H.3    Turnbull, D.4
  • 43
    • 79959750950 scopus 로고    scopus 로고
    • Increased mitochondrial content in remyelinated axons: Implications for multiple sclerosis
    • Zambonin JL, Zhao C, Ohno N, et al. Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis. Brain. 2011;134(Pt 7):1901-1913.
    • (2011) Brain. , vol.134 , Issue.PART 7 , pp. 1901-1913
    • Zambonin, J.L.1    Zhao, C.2    Ohno, N.3
  • 44
    • 66549118688 scopus 로고    scopus 로고
    • Mitochondrial changes within axons in multiple sclerosis
    • Mahad DJ, Ziabreva I, Campbell G, et al. Mitochondrial changes within axons in multiple sclerosis. Brain. 2009;132(Pt 5):1161-1174.
    • (2009) Brain. , vol.132 , Issue.PART 5 , pp. 1161-1174
    • Mahad, D.J.1    Ziabreva, I.2    Campbell, G.3
  • 45
    • 79953761792 scopus 로고    scopus 로고
    • A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis
    • Nikic I, Merkler D, Sorbara C, et al. A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med. 2011;17(4):495-499.
    • (2011) Nat Med. , vol.17 , Issue.4 , pp. 495-499
    • Nikic, I.1    Merkler, D.2    Sorbara, C.3
  • 46
    • 0028208495 scopus 로고
    • Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes
    • Volterra A, Trotti D, Tromba C, Floridi S, Racagni G. Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J Neurosci. 1994;14(5 Pt 1):2924-2932.
    • (1994) J Neurosci. , vol.14 , Issue.5 PART 1 , pp. 2924-2932
    • Volterra, A.1    Trotti, D.2    Tromba, C.3    Floridi, S.4    Racagni, G.5
  • 48
    • 0032544047 scopus 로고    scopus 로고
    • Characteristics of acute and chronic kainate excitotoxic damage to the optic nerve
    • Matute C. Characteristics of acute and chronic kainate excitotoxic damage to the optic nerve. Proc Natl Acad Sci U S A. 1998;95(17): 10229-10234.
    • (1998) Proc Natl Acad Sci U S A. , vol.95 , Issue.17 , pp. 10229-10234
    • Matute, C.1
  • 49
    • 0031952612 scopus 로고    scopus 로고
    • Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity
    • McDonald JW, Althomsons SP, Hyrc KL, Choi DW, Goldberg MP. Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity. Nat Med. 1998;4(3):291-297.
    • (1998) Nat Med. , vol.4 , Issue.3 , pp. 291-297
    • McDonald, J.W.1    Althomsons, S.P.2    Hyrc, K.L.3    Choi, D.W.4    Goldberg, M.P.5
  • 51
    • 84875527422 scopus 로고    scopus 로고
    • Preventive and therapeutic effects of MG132 by activating Nrf2-ARE signaling pathway on oxidative stress-induced cardiovascular and renal injury
    • Cui W, Bai Y, Luo P, Miao L, Cai L. Preventive and therapeutic effects of MG132 by activating Nrf2-ARE signaling pathway on oxidative stress-induced cardiovascular and renal injury. Oxid Med Cell Longev. 2013;2013:306073.
    • (2013) Oxid Med Cell Longev. , vol.2013 , pp. 306073
    • Cui, W.1    Bai, Y.2    Luo, P.3    Miao, L.4    Cai, L.5
  • 52
    • 63549121490 scopus 로고    scopus 로고
    • NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer
    • Hayes JD, McMahon M. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci. 2009;34(4):176-188.
    • (2009) Trends Biochem Sci. , vol.34 , Issue.4 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 53
    • 0037377144 scopus 로고    scopus 로고
    • Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2
    • Alam J, Killeen E, Gong P, et al. Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2. Am J Physiol Renal Physiol. 2003;284(4):F743-F752.
    • (2003) Am J Physiol Renal Physiol. , vol.284 , Issue.4
    • Alam, J.1    Killeen, E.2    Gong, P.3
  • 54
    • 0037462651 scopus 로고    scopus 로고
    • Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium
    • Stewart D, Killeen E, Naquin R, Alam S, Alam J. Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium. J Biol Chem. 2003;278(4):2396-2402.
    • (2003) J Biol Chem. , vol.278 , Issue.4 , pp. 2396-2402
    • Stewart, D.1    Killeen, E.2    Naquin, R.3    Alam, S.4    Alam, J.5
  • 55
    • 0037015035 scopus 로고    scopus 로고
    • Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    • Dinkova-Kostova AT, Holtzclaw WD, Cole RN, et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci U S A. 2002;99(18):11908-11913.
    • (2002) Proc Natl Acad Sci U S A. , vol.99 , Issue.18 , pp. 11908-11913
    • Dinkova-Kostova, A.T.1    Holtzclaw, W.D.2    Cole, R.N.3
  • 56
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • Itoh K, Wakabayashi N, Katoh Y, et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 1999;13(1):76-86.
    • (1999) Genes Dev. , vol.13 , Issue.1 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3
  • 57
    • 12444257799 scopus 로고    scopus 로고
    • Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles
    • Itoh K, Wakabayashi N, Katoh Y, Ishii T, O'Connor T, Yamamoto M. Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells. 2003;8(4):379-391.
    • (2003) Genes Cells. , vol.8 , Issue.4 , pp. 379-391
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    O'Connor, T.5    Yamamoto, M.6
  • 58
    • 84869076474 scopus 로고    scopus 로고
    • Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks
    • Hirotsu Y, Katsuoka F, Funayama R, et al. Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks. Nucleic Acids Res. 2012;40(20):10228-10239.
    • (2012) Nucleic Acids Res. , vol.40 , Issue.20 , pp. 10228-10239
    • Hirotsu, Y.1    Katsuoka, F.2    Funayama, R.3
  • 59
    • 21744445077 scopus 로고    scopus 로고
    • Nrf2, a multi-organ protector?
    • Lee JM, Li J, Johnson DA, et al. Nrf2, a multi-organ protector? FASEB J. 2005;19(9):1061-1066.
    • (2005) FASEB J. , vol.19 , Issue.9 , pp. 1061-1066
    • Lee, J.M.1    Li, J.2    Johnson, D.A.3
  • 60
    • 59949106172 scopus 로고    scopus 로고
    • Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis
    • Trapp BD, Stys PK. Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis. Lancet Neurol. 2009;8(3):280-291.
    • (2009) Lancet Neurol. , vol.8 , Issue.3 , pp. 280-291
    • Trapp, B.D.1    Stys, P.K.2
  • 61
    • 0034564557 scopus 로고    scopus 로고
    • Corticosteroids or ACTH for acute exacerbations in multiple sclerosis
    • Filippini G, Brusaferri F, Sibley WA, et al. Corticosteroids or ACTH for acute exacerbations in multiple sclerosis. Cochrane Database Syst Rev. 2000;(4):CD001331.
    • (2000) Cochrane Database Syst Rev , Issue.4
    • Filippini, G.1    Brusaferri, F.2    Sibley, W.A.3
  • 62
    • 0024436219 scopus 로고
    • Double-blind study of true vs sham plasma exchange in patients treated with immunosuppression for acute attacks of multiple sclerosis
    • Weiner HL, Dau PC, Khatri BO, et al. Double-blind study of true vs sham plasma exchange in patients treated with immunosuppression for acute attacks of multiple sclerosis. Neurology. 1989;39(9):1143-1149.
    • (1989) Neurology. , vol.39 , Issue.9 , pp. 1143-1149
    • Weiner, H.L.1    Dau, P.C.2    Khatri, B.O.3
  • 63
    • 0032758846 scopus 로고    scopus 로고
    • A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease
    • Weinshenker BG, O'Brien PC, Petterson TM, et al. A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease. Ann Neurol. 1999;46(6):878-886.
    • (1999) Ann Neurol. , vol.46 , Issue.6 , pp. 878-886
    • Weinshenker, B.G.1    O'Brien, P.C.2    Petterson, T.M.3
  • 64
    • 79958108785 scopus 로고    scopus 로고
    • The mechanism of action of interferon-beta in relapsing multiple sclerosis
    • Kieseier BC. The mechanism of action of interferon-beta in relapsing multiple sclerosis. CNS Drugs. 2011;25(6):491-502.
    • (2011) CNS Drugs. , vol.25 , Issue.6 , pp. 491-502
    • Kieseier, B.C.1
  • 65
    • 0029082566 scopus 로고
    • Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind placebo-controlled trial
    • The Copolymer 1 Multiple Sclerosis Study Group
    • Johnson KP, Brooks BR, Cohen JA, et al. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. The Copolymer 1 Multiple Sclerosis Study Group. Neurology. 1995;45(7):1268-1276.
    • (1995) Neurology. , vol.45 , Issue.7 , pp. 1268-1276
    • Johnson, K.P.1    Brooks, B.R.2    Cohen, J.A.3
  • 66
    • 62449132771 scopus 로고    scopus 로고
    • Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte
    • Chen PC, Vargas MR, Pani AK, et al. Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: critical role for the astrocyte. Proc Natl Acad Sci U S A. 2009;106(8):2933-2938.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , Issue.8 , pp. 2933-2938
    • Chen, P.C.1    Vargas, M.R.2    Pani, A.K.3
  • 67
    • 79551626268 scopus 로고    scopus 로고
    • Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease
    • Ellrichmann G, Petrasch-Parwez E, Lee DH, et al. Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease. PloS One. 2011;6(1):e16172.
    • (2011) PloS One. , vol.6 , Issue.1
    • Ellrichmann, G.1    Petrasch-Parwez, E.2    Lee, D.H.3
  • 68
    • 84863284276 scopus 로고    scopus 로고
    • Effect of BG-12 on contrast-enhanced lesions in patients with relapsing-remitting multiple sclerosis: Subgroup analyses from the phase 2b study
    • Kappos L, Gold R, Miller DH, et al. Effect of BG-12 on contrast-enhanced lesions in patients with relapsing-remitting multiple sclerosis: subgroup analyses from the phase 2b study. Mult Scler. 2012;18(3):314-321.
    • (2012) Mult Scler. , vol.18 , Issue.3 , pp. 314-321
    • Kappos, L.1    Gold, R.2    Miller, D.H.3
  • 69
    • 54149116366 scopus 로고    scopus 로고
    • Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: A multicentre, randomised, double-blind, placebo-controlled phase IIb study
    • Kappos L, Gold R, Miller DH, et al. Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet. 2008;372(9648):1463-1472.
    • (2008) Lancet. , vol.372 , Issue.9648 , pp. 1463-1472
    • Kappos, L.1    Gold, R.2    Miller, D.H.3
  • 70
    • 68149150032 scopus 로고    scopus 로고
    • TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system
    • Bittner S, Meuth SG, Gobel K, et al. TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system. Brain. 2009;132(Pt 9):2501-2516.
    • (2009) Brain. , vol.132 , Issue.PART 9 , pp. 2501-2516
    • Bittner, S.1    Meuth, S.G.2    Gobel, K.3
  • 71
    • 77949655624 scopus 로고    scopus 로고
    • Chitosan prevents oxidative stress-induced amyloid beta formation and cytotoxicity in NT2 neurons: Involvement of transcription factors Nrf2 and NF-kappaB
    • Khodagholi F, Eftekharzadeh B, Maghsoudi N, Rezaei PF. Chitosan prevents oxidative stress-induced amyloid beta formation and cytotoxicity in NT2 neurons: involvement of transcription factors Nrf2 and NF-kappaB. Mol Cell Biochem. 2010;337(1-2):39-51.
    • (2010) Mol Cell Biochem. , vol.337 , Issue.1-2 , pp. 39-51
    • Khodagholi, F.1    Eftekharzadeh, B.2    Maghsoudi, N.3    Rezaei, P.F.4
  • 72
    • 70349314704 scopus 로고    scopus 로고
    • Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro
    • Lewerenz J, Albrecht P, Tien ML, et al. Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro. J Neurochem. 2009;111(2):332-343.
    • (2009) J Neurochem. , vol.111 , Issue.2 , pp. 332-343
    • Lewerenz, J.1    Albrecht, P.2    Tien, M.L.3
  • 73
    • 41849146057 scopus 로고    scopus 로고
    • Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3
    • Rachakonda G, Xiong Y, Sekhar KR, Stamer SL, Liebler DC, Freeman ML. Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3. Chem Res Toxicol. 2008;21(3):705-710.
    • (2008) Chem Res Toxicol. , vol.21 , Issue.3 , pp. 705-710
    • Rachakonda, G.1    Xiong, Y.2    Sekhar, K.R.3    Stamer, S.L.4    Liebler, D.C.5    Freeman, M.L.6
  • 74
    • 77951938927 scopus 로고    scopus 로고
    • Fumaric acid dialkyl esters deprive cultured rat oligodendroglial cells of glutathione and upregulate the expression of heme oxygenase 1
    • Thiessen A, Schmidt MM, Dringen R. Fumaric acid dialkyl esters deprive cultured rat oligodendroglial cells of glutathione and upregulate the expression of heme oxygenase 1. Neurosci Lett. 2010;475(1): 56-60.
    • (2010) Neurosci Lett. , vol.475 , Issue.1 , pp. 56-60
    • Thiessen, A.1    Schmidt, M.M.2    Dringen, R.3
  • 75
    • 0030048651 scopus 로고    scopus 로고
    • Effects of dithranol on neutrophil superoxide generation in patients with psoriasis
    • Kavanagh GM, Burton JL, Donnell VO. Effects of dithranol on neutrophil superoxide generation in patients with psoriasis. Br J Dermatol. 1996;134(2):234-237.
    • (1996) Br J Dermatol. , vol.134 , Issue.2 , pp. 234-237
    • Kavanagh, G.M.1    Burton, J.L.2    Donnell, V.O.3
  • 76
  • 77
    • 84866355653 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis
    • Fox RJ, Miller DH, Phillips JT, et al. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med. 2012;367(12):1087-1097.
    • (2012) N Engl J Med. , vol.367 , Issue.12 , pp. 1087-1097
    • Fox, R.J.1    Miller, D.H.2    Phillips, J.T.3
  • 78
    • 84866423965 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis
    • Gold R, Kappos L, Arnold DL, et al. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med. 2012;367(12):1098-1107.
    • (2012) N Engl J Med. , vol.367 , Issue.12 , pp. 1098-1107
    • Gold, R.1    Kappos, L.2    Arnold, D.L.3
  • 79
    • 84858648216 scopus 로고    scopus 로고
    • Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway
    • Scannevin RH, Chollate S, Jung MY, et al. Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J Pharmacol Exp Ther. 2012;341(1):274-284.
    • (2012) J Pharmacol Exp Ther. , vol.341 , Issue.1 , pp. 274-284
    • Scannevin, R.H.1    Chollate, S.2    Jung, M.Y.3
  • 80
    • 84866900065 scopus 로고    scopus 로고
    • Mechanisms of oxidative damage in multiple sclerosis and neurodegenerative diseases: Therapeutic modulation via fumaric acid esters
    • Lee DH, Gold R, Linker RA. Mechanisms of oxidative damage in multiple sclerosis and neurodegenerative diseases: therapeutic modulation via fumaric acid esters. Int J Mol Sci. 2012;13(9):11783-11803.
    • (2012) Int J Mol Sci. , vol.13 , Issue.9 , pp. 11783-11803
    • Lee, D.H.1    Gold, R.2    Linker, R.A.3
  • 81
    • 77956228055 scopus 로고    scopus 로고
    • Fumaric acid diesters deprive cultured primary astrocytes rapidly of glutathione
    • Schmidt MM, Dringen R. Fumaric acid diesters deprive cultured primary astrocytes rapidly of glutathione. Neurochem Int. 2010;57(4): 460-467.
    • (2010) Neurochem Int. , vol.57 , Issue.4 , pp. 460-467
    • Schmidt, M.M.1    Dringen, R.2
  • 82
    • 27644562277 scopus 로고    scopus 로고
    • A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
    • Chauhan D, Catley L, Li G, et al. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer Cell. 2005;8(5):407-419.
    • (2005) Cancer Cell. , vol.8 , Issue.5 , pp. 407-419
    • Chauhan, D.1    Catley, L.2    Li, G.3
  • 83
    • 0037455147 scopus 로고    scopus 로고
    • Salinosporamide A: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora
    • Feling RH, Buchanan GO, Mincer TJ, Kauffman CA, Jensen PR, Fenical W. Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora. Angew Chem Int Ed Engl. 2003;42(3):355-357.
    • (2003) Angew Chem Int Ed Engl. , vol.42 , Issue.3 , pp. 355-357
    • Feling, R.H.1    Buchanan, G.O.2    Mincer, T.J.3    Kauffman, C.A.4    Jensen, P.R.5    Fenical, W.6
  • 84
    • 79951684725 scopus 로고    scopus 로고
    • Marizomib, a proteasome inhibitor for all seasons: Preclinical profile and a framework for clinical trials
    • Potts BC, Albitar MX, Anderson KC, et al. Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Curr Cancer Drug Targets. 2011;11(3):254-284.
    • (2011) Curr Cancer Drug Targets. , vol.11 , Issue.3 , pp. 254-284
    • Potts, B.C.1    Albitar, M.X.2    Anderson, K.C.3
  • 85
    • 0033621047 scopus 로고    scopus 로고
    • Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity
    • Meng L, Mohan R, Kwok BH, Elofsson M, Sin N, Crews CM. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci U S A. 1999;96(18):10403-10408.
    • (1999) Proc Natl Acad Sci U S A. , vol.96 , Issue.18 , pp. 10403-10408
    • Meng, L.1    Mohan, R.2    Kwok, B.H.3    Elofsson, M.4    Sin, N.5    Crews, C.M.6


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