Fumaric acid dialkyl esters deprive cultured rat oligodendroglial cells of glutathione and upregulate the expression of heme oxygenase 1

Neuroscience Letters

Volumn 475, Issue 1, 2010, Pages 56-60

  Thiessen, Anette ^a   Schmidt, Maike M ^a   Dringen, Ralf ^a,b  

^a UNIVERSITY OF BREMEN   (Germany)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Fumaric acid esters; Glutathione; Multiple sclerosis; Oligodendrocytes; OLN 93

Indexed keywords

FUMARIC ACID; FUMARIC ACID DERIVATIVE; FUMARIC ACID DIETHYL ESTER; FUMARIC ACID DIMETHYL ESTER; GLUTATHIONE; HEME OXYGENASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BIOACCUMULATION; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; ENZYME METABOLISM; NERVE CELL CULTURE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; UPREGULATION;

ANIMALS; CELLS, CULTURED; ESTERS; FUMARATES; GLUTATHIONE; HEME OXYGENASE (DECYCLIZING); OLIGODENDROGLIA; RATS; UP-REGULATION;

EID: 77951938927     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.03.048     Document Type: Article

References (33)

1. Boyland E., Chasseau L.F. Enzyme-catalysed conjugations of glutathione with unsaturated compounds. Biochem. J. 1967, 104:95-102.
2. b subunits in oligodendrocytes and astrocytes of rat brain. J. Neurochem. 1989, 52:876-883.
3. Compston A., Coles A. Multiple sclerosis. Lancet 2008, 372:1502-1517.
4. Connor J.R., Menzies S.L. Relationship of iron to oligodendrocytes and myelination. Glia 1996, 17:83-93.
5. de Jong P., Bezemer A.C., Zomerdijk T.P.L., van de Pouw-Kraan T., Ottenhoff T.H.M., Nibbering P.H. Selective stimulation of T helper 2 cytokine responses by the anti-psoriasis agent monomethylfumarate. Eur. J. Immunol. 1996, 26:2067-2074.
6. Dringen R., Kussmaul L., Hamprecht B. Detoxification of exogenous hydrogen peroxide and organic hydroperoxides by cultured astroglial cells assessed by microtiter plate assay. Brain Res. Protoc. 1998, 2:223-228.
7. Gonsette R.E. Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicity. J. Neurol. Sci. 2008, 274:48-53.
8. Hirrlinger J., Resch A., Gutterer J.M., Dringen R. Oligodendroglial cells in culture effectively dispose of exogenous hydrogen peroxide: comparison with cultured neurones, astroglial and microglial cells. J. Neurochem. 2002, 82:635-644.
9. Hirrlinger J., Schulz J.B., Dringen R. Glutathione release from cultured brain cells: multidrug resistance protein 1 mediates the release of GSH from rat astroglial cells. J. Neurosci. Res. 2002, 69:318-326.
10. Hooper C., Pinteaux-Jones F., Fry V.A.H., Sevastou I.G., Baker D., Heales S.J., Pocock J.M. Differential effects of albumin on microglia and macrophages; implications for neurodegeneration following blood-brain barrier damage. J. Neurochem. 2009, 109:694-705.
11. Kappos L., Gold R., Miller D.H., MacManus D.G., Havrdova E., Limmroth V., Polman C.H., Schmierer K., Yousry T.A., Yang M.H., Eraksoy M., Meluzinova E., Rektor I., Dawson K.T., Sandrock A.W., O'Neill G.N. Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet 2008, 372:1463-1472. BG-12 Phase IIb Study Investigators.
12. Kranich O., Hamprecht B., Dringen R. Different preferences in the utilization of amino acids for glutathione synthesis in cultured neurons and astroglial cells derived from rat brain. Neurosci. Lett. 1996, 219:211-214.
13. 1H NMR spectroscopy. Uncatalyzed and glutathione transferase-catalyzed reactions. Chem. Res. Toxicol. 1995, 8:780-791.
14. Langston W., Circu M.L., Aw T.Y. Insulin stimulation of γ-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: influence of low glucose. Free Radic. Biol. Med. 2008, 45:1591-1599.
15. Lehmann J.C.U., Listopad J.J., Rentzsch C.U., Igney F.H., von Bonin A., Hennekes H.H., Asadullah K., Docke W.D.F. Dimethylfumarate induces immunosuppression via glutathione depletion and subsequent induction of heme oxygenase 1. J. Invest. Dermatol. 2007, 127:835-845.
16. Litjens N., van Strijen E., van Gulpen C., Mattie H., van Dissel J., Thio H.B., Nibbering P. In vitro pharmacokinetics of anti-psoriatic fumaric acid esters. BMC Pharmacol. 2004, 4:22.
17. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
18. Lu S.C. Regulation of glutathione synthesis. Mol. Aspects Med. 2009, 30:42-59.
19. Mahajan S., Atkins W.M. The chemistry and biology of inhibitors and pro-drugs targeted to glutathione S-transferases. Cell. Mol. Life Sci. 2005, 62:1221-1233.
20. Maier O., Hoekstra D., Baron W. Polarity development in oligodendrocytes: sorting and trafficking of myelin components. J. Mol. Neurosci. 2008, 35:35-53.
21. McTigue D.M., Tripathi R.B. The life, death, and replacement of oligodendrocytes in the adult CNS. J. Neurochem. 2008, 107:1-19.
22. +-dependent isocitrate dehydrogenases are expressed in cultured rat neurons, astrocytes, oligodendrocytes and microglial cells. J. Neurochem. 2003, 86:605-614.
23. Moharregh-Khiabani D., Linker R.A., Gold R., Stangel M. Fumaric acid and its esters: an emerging treatment for multiple sclerosis. Curr. Neuropharmacol. 2009, 7:60-64.
24. Nelson K.C., Carlson J.L., Newman M.L., Sternberg P., Jones D.P., Kavanagh T.J., Diaz D., Cai J., Wu M. Effect of dietary inducer dimethylfumarate on glutathione in cultured human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 1999, 40:1927-1935.
25. Ockenfels H.M., Schultewolter T., Ockenfels G., Funk R., Goos M. The antipsoriatic agent dimethylfumarate immunomodulates T-cell cytokine secretion and inhibits cytokines of the psoriatic cytokine network. Br. J. Dermatol. 1998, 139:390-395.
26. Ormerod A.D., Mrowietz U. Fumaric acid esters, their place in the treatment of psoriasis. Br. J. Dermatol. 2004, 150:630-632.
27. Richter-Landsberg C., Heinrich M. OLN-93: a new permanent oligodendroglia cell line derived from primary rat brain glial cultures. J. Neurosci. Res. 1996, 45:161-173.
28. M.M. Schmidt, R. Dringen, Fumaric acid diesters deprive cultured primary astrocytes rapidly of glutathione, Neurochem. Int., in press.
29. Schmidt T.J., Ak M., Mrowietz U. Reactivity of dimethyl fumarate and methylhydrogen fumarate towards glutathione and N-acetyl-l-cysteine-preparation of S-substituted thiosuccinic acid esters. Bioorg. Med. Chem. 2007, 15:333-342.
30. Stahnke T., Stadelmann C., Netzler A., Bruck W., Richter-Landsberg C. Differential upregulation of heme oxygenase-1 (HSP32) in glial cells after oxidative stress and in demyelinating disorders. J. Mol. Neurosci. 2007, 32:25-37.
31. Syapin P.J. Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders. Br. J. Pharmacol. 2008, 155:623-640.
32. Wierinckx A., Breve J., Mercier D., Schultzberg M., Drukarch B., Van Dam A.M. Detoxication enzyme inducers modify cytokine production in rat mixed glial cells. J. Neuroimmunol. 2005, 166:132-143.
33. Yazdi M.R., Mrowietz U. Fumaric acid esters. Clin. Dermatol. 2008, 26:522-526.