Effects of dithranol on neutrophil superoxide generation in patients with psoriasis

British Journal of Dermatology

Volumn 134, Issue 2, 1996, Pages 234-237

  Kavanagh, G M ^a,c   Burton, J L ^a   Donnell, V O ^b  

^a BRISTOL ROYAL INFIRMARY   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DITHRANOL; PHORBOL ESTER; SUPEROXIDE;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MALE; NEUTROPHIL; PRIORITY JOURNAL; PSORIASIS; SKIN INFLAMMATION;

EID: 0030048651     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2133.1996.tb07607.x     Document Type: Article

References (16)

1. Lawrence CM, Howel D, Shuster S. The inflammatory response to anthralin. Clin Exp Dermatol 1984; 9: 336-41.
2. Kemény L, Ruzicka T, Braun-Falco O. Dithranol: a review of the mechanism of action in the treatment of psoriasis vulgaris. Skin Pharmacol 1990; 3: 1-20.
3. Mustakallio KK. Irritation and staining by dithranol (anthralin) and related compounds. 1. Estimation with chamber testing and contact thermography. Derm Venereol 1979; 59: 125-32.
4. Goodfield MJD, MacDonald Hull S, Cunliffe WJ. The systemic effect of dithranol treatment in psoriasis. Acta Derm Venereol (Stockh) 1994; 74: 295-7.
5. Schröder JM, Kosfeld V, Christophers E. Multifunctional inhibition by anthralin in nonstimulated and chemotactic factor stimulated human neutrophils. J Invest Dermatol 1985; 85: 30-5.
6. Anderson R, Lukey PT, Dippenaar U et al. Dithranol mediates pro-oxidative inhibition of polymorphonuclear leukocyte migration and lymphocyte proliferation. Br J Dermatol 1987; 117: 405-18.
7. Cross AR, Parkinson JF, Jones OTG. The superoxide-generating oxidase of leucocytes. Biochem J 1984; 223: 337-44.
8. Cross AR, Higson FK, Jones OTG et al. The enzymatic reduction and kinetics of oxidation of cytochrome B of neutrophils. Biochem J 1982; 204: 479-85.
9. Müller K, Wiegrebe W, Younes M. Formation of active oxygen species by dithranol. Dithranol, active oxygen species and lipid peroxidation in vivo. Arch Pharmacol 1987; 320: 59-66.
10. Anderson R. Dithranol-mediated, dose-dependent priming and activation of luminol-enhanced chemiluminescence responses of human neutrophils in vitro. Br J Dermatol 1989; 121: 1-9.
11. van Rooijen LL, Fruchtmann R, Muller-Peddinghaus G et al. Anthralin and phorbol-12-myristate 13-acetate differentially act on the release of reactive oxygen species from human leukocytes and on protein kinase c. Clin Res 1991; 39: 543 (Abstr.).
12. Moysan A, Marquis IG, Santus R et al. Ultraviolet A - lipid peroxidation and anti-oxidant defense mechanisms in cultured human skin fibroblasts. J Invest Dermatol 1993; 100: 692-8.
13. Black HS. Potential involvement of free radical reactions in ultraviolet light mediated cutaneous damage. Photochem Photobiol 1987; 213: 221-4.
14. Schalla W, Bauer E, Scaefer H. Skin permeability of anthralin. Br J Dermatol 1981; 105 (Suppl. 20): 104-8.
15. Sullivan R, Fredette JP, Socinski M et al. Enhancement of superoxide anion release by granulocytes harvested from patients receiving granulocyte-macrophage colony-stimulating factor. Br J Haematol 1989; 71: 475-9.
16. Neta R, Monroy R, MacVittie TJ. Utility of interleukin-1 in therapy of radiation injury as studied in small and large animal models. Biotherapy 1989; 1: 301-11.