Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway

Oncology Reports

Volumn 28, Issue 1, 2012, Pages 41-48

  Cha, Jae Hun ^a   Choi, Yoon Ji ^a   Cha, Seung Heon ^a   Choi, Chang Hwa ^a   Cho, Won Ho ^a  

^a Pusan National University School of Medicine   (South Korea)

Author keywords

Allicin; Antioxidants; Apoptosis; Extracellular signal regulated kinase; U87MG cells

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALLICIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIOXIDANT; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; MITOGEN ACTIVATED PROTEIN KINASE; PD 98053; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; Z VAD FMK;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME REGULATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MITOCHONDRION; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL; U87MG CELL;

ACETYLCYSTEINE; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BUTADIENES; CASPASES; CATALASE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLIOBLASTOMA; HUMANS; IMIDAZOLES; MAP KINASE SIGNALING SYSTEM; NITRILES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRIDINES; SULFINIC ACIDS;

EID: 84861560573     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1772     Document Type: Article

References (44)

1. Kelly KA, Kirkwood JM and Kapp DS: Glioblastoma multiforme: pathology, natural history and treatment. Cancer Treat Rev 11: 1-26, 1984. (Pubitemid 16017945)
2. Kala M, Srámek V, Houdek M, Vaverka M and Zmrzlík P: [Treatment of glioblastoma multiforme]. Cas Lek Cesk 132: 653-656, 1993.
3. Holland EC: Glioblastoma multiforme: the terminator. Proc Natl Acad Sci USA 97: 6242-6244, 2000.
4. Jendrossek V, Belka C and Bamberg M: Novel chemotherapeutic agents for the treatment of glioblastoma multiforme. Expert Opin Investig Drugs 12: 1899-1924, 2003. (Pubitemid 38016165)
5. Kanu OO, Mehta A, Di C, et al: Glioblastoma multiforme: a review of therapeutic targets. Expert Opin Ther Targets 13: 701-718, 2009.
6. Cheema FA, Badr A and Iqbal J: Glioblastoma multiforme presenting as treatment-resistant depression. J Neuropsychiatry Clin Neurosci 22: 123.E126, 2010.
7. Agarwal KC: Therapeutic actions of garlic constituents. Med Res Rev 16: 111-124, 1996.
8. Butt MS, Sultan MT and Iqbal J: Garlic: nature's protection against physiological threats. Crit Rev Food Sci Nutr 49: 538-551, 2009.
9. Lissiman E, Bhasale AL and Cohen M: Garlic for the common cold. Cochrane Database Syst Rev: CD006206, 2009.
10. Oommen S, Anto RJ, Srinivas G and Karunagaran D: Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. Eur J Pharmacol 485: 97-103, 2004. (Pubitemid 38134402)
11. Seger R and Krebs EG: The MAPK signaling cascade. FASEB J 9: 726-735, 1995.
12. Lee S, Lee HS, Baek M, et al: MAPK signaling is involved in camptothecin-induced cell death. Mol Cells 14: 348-354, 2002. (Pubitemid 41582957)
13. Roux PP and Blenis J: ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 68: 320-344, 2004. (Pubitemid 38756868)
14. Zhang ZM, Yang XY, Deng SH, Xu W and Gao HQ: Anti-tumor effects of polybutylcyanoacrylate nanoparticles of diallyl trisulfide on orthotopic transplantation tumor model of hepatocellular carcinoma in BALB/c nude mice. Chin Med J (Engl) 120: 1336-1342, 2007. (Pubitemid 47335384)
15. Sun L and Wang X: Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells. World J Gastroenterol 9: 1930-1934, 2003. (Pubitemid 37168415)
16. Hirsch K, Danilenko M, Giat J, et al: Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutr Cancer 38: 245-254, 2000. (Pubitemid 32762025)
17. Prasad K, Laxdal VA, Yu M and Raney BL: Antioxidant activity of allicin, an active principle in garlic. Mol Cell Biochem 148: 183-189, 1995.
18. Oberley TD and Oberley LW: Antioxidant enzyme levels in cancer. Histol Histopathol 12: 525-535, 1997. (Pubitemid 27240324)
19. Kong Q and Lillehei KO: Antioxidant inhibitors for cancer therapy. Med Hypotheses 51: 405-409, 1998. (Pubitemid 28508678)
20. Park SY, Cho SJ, Kwon HC, Lee KR, Rhee DK and Pyo S: Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA. Cancer Lett 224: 123-132, 2005.
21. Miron T, Wilchek M, Sharp A, et al: Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells. J Nutr Biochem 19: 524-535, 2008.
22. Shrieve DC, Alexander E, Black PM, et al: Treatment of patients with primary glioblastoma multiforme with standard postoperative radiotherapy and radiosurgical boost: prognostic factors and long-term outcome. J Neurosurg 90: 72-77, 1999. (Pubitemid 29024742)
23. Henson JW: Treatment of glioblastoma multiforme: a new standard. Arch Neurol 63: 337-341, 2006.
24. Chamberlain MC: Treatment options for glioblastoma. Neurosurg Focus 20: E19, 2006.
25. Patya M, Zahalka MA, Vanichkin A, et al: Allicin stimulates lymphocytes and elicits an antitumor effect: a possible role of p21ras. Int Immunol 16: 275-281, 2004. (Pubitemid 38195658)
26. Kyung KH: Antimicrobial properties of allium species. Curr Opin Biotechnol: Sep 6, 2011 (Epub ahead of print).
27. Kerr JF, Wyllie AH and Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257, 1972.
28. Hickman JA: Apoptosis induced by anticancer drugs. Cancer Metastasis Rev 11: 121-139, 1992.
29. Yue TL, Ohlstein EH and Ruffolo RR: Apoptosis: a potential target for discovering novel therapies for cardiovascular diseases. Curr Opin Chem Biol 3: 474-480, 1999. (Pubitemid 29376110)
30. Negoescu A, Guillermet C, Lorimier P, Brambilla E and Labat-Moleur F: Importance of DNA fragmentation in apoptosis with regard to TUNEL specificity. Biomed Pharmacother 52: 252-258, 1998. (Pubitemid 28387038)
31. Nagata S: DNA degradation in development and programmed cell death. Annu Rev Immunol 23: 853-875, 2005.
32. Wieder R: TUNEL assay as a measure of chemotherapy-induced apoptosis. Methods Mol Med 111: 43-54, 2005.
33. Hewitson TD and Darby IA: In situ localization of apoptosis using TUNEL. Methods Mol Biol 611: 161-170, 2010.
34. Gross A, McDonnell JM and Korsmeyer SJ: BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13: 1899-1911, 1999. (Pubitemid 29407357)
35. Coultas L and Strasser A: The role of the Bcl-2 protein family in cancer. Semin Cancer Biol 13: 115-123, 2003. (Pubitemid 36315930)
36. Dejean LM, Martinez-Caballero S, Guo L, et al: Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Mol Biol Cell 16: 2424-2432, 2005. (Pubitemid 40632223)
37. Youle RJ and Strasser A: The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9: 47-59, 2008.
38. Ren D, Yang H and Zhang S: Cell death mediated by MAPK is associated with hydrogen peroxide production in Arabidopsis. J Biol Chem 277: 559-565, 2002. (Pubitemid 34952092)
39. Cho SJ, Rhee DK and Pyo S: Allicin, a major component of garlic, inhibits apoptosis of macrophage in a depleted nutritional state. Nutrition 22: 1177-1184, 2006.
40. MAPK in DATS-induced apoptosis of human CNE2 cells. Braz J Med Biol Res 43: 821-827, 2010.
41. Inoue M, Sakaguchi N, Isuzugawa K, Tani H and Ogihara Y: Role of reactive oxygen species in gallic acid-induced apoptosis. Biol Pharm Bull 23: 1153-1157, 2000.
42. Kannan K and Jain SK: Oxidative stress and apoptosis. Pathophysiology 7: 153-163, 2000.
43. Circu ML and Aw TY: Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 48: 749-762, 2010.
44. Cohen GM: Caspases: the executioners of apoptosis. Biochem J 326: 1-16, 1997.