Essential oil of pinus koraiensis leaves exerts antihyperlipidemic effects via up-regulation of low-density lipoprotein receptor and inhibition of acyl-coenzyme A: Cholesterol acyltransferase

Phytotherapy Research

Volumn 26, Issue 9, 2012, Pages 1314-1319

  Kim, Ji Hyun ^a   Lee, Hyo Jung ^a   Jeong, Soo Jin ^a   Lee, Min Ho ^a   Kim, Sung Hoon ^a  

^a Kyung Hee University   (South Korea)

Author keywords

ACAT; essential oil; hyperlipidemia; LDLR; Pinus koraiensis; SREBP

Indexed keywords

ANTILIPEMIC AGENT; BORNEOL; CAMPHENE; CHOLESTEROL ACYLTRANSFERASE; ESSENTIAL OIL; FATTY ACID SYNTHASE; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIMONENE; LIPID; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; PINENE; PINUS KORAIENSIS EXTRACT; PLANT EXTRACT; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEPG2; ENZYME INHIBITION; EVERGREEN; HUMAN; HUMAN CELL; LIPID METABOLISM; LIPID OXIDATION; MASS FRAGMENTOGRAPHY; PINUS KORAIENSIS; PLANT LEAF; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

FATTY ACID SYNTHETASE COMPLEX, TYPE I; GENE EXPRESSION REGULATION; GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; HEP G2 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYPOLIPIDEMIC AGENTS; LIPID METABOLISM; OILS, VOLATILE; OXIDATION-REDUCTION; PINUS; PLANT LEAVES; RECEPTORS, LDL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEROL O-ACYLTRANSFERASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

PINUS KORAIENSIS;

EID: 84866133726     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3734     Document Type: Article

References (40)

1. Abdollahi M, Salehnia A, Mortazavi SH, et al,. 2003. Antioxidant, antidiabetic, antihyperlipidemic, reproduction stimulatory properties and safety of essential oil of Satureja khuzestanica in rat in vivo: a oxicopharmacological study. Med Sci Monit 9: BR331-BR335.
2. Adameova A, Kuzelova M, Faberova V, Svec P,. 2005. The hypolipidemic effect of a new ACAT inhibitor, VULM 1457, in diabetic-hypercholesterolaemic rats. Pharmazie 60: 714-715.
3. Adisakwattana S, Chanathong B,. 2011. Alpha-glucosidase inhibitory activity and lipid-lowering mechanisms of Moringa oleifera leaf extract. Eur Rev Med Pharmacol Sci 15: 803-808.
4. Ballantyne CM,. 1998. Low-density lipoproteins and risk for coronary artery disease. Am J Cardiol 82: 3Q-12Q.
5. Ban H, Muraoka M, Ioriya K, Ohashi N,. 2006. Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA: cholesterol acyltransferase inhibitor with improved aqueous solubility. Bioorg Med Chem Lett 16: 44-48.
6. Bavarva JH, Narasimhacharya AV,. 2008. Antihyperglycemic and hypolipidemic effects of Costus speciosus in alloxan induced diabetic rats. Phytother Res 22: 620-626.
7. Brecher P, Chan CT,. 1980. Properties of acyl-CoA: cholesterol O-acyltransferase in aortic microsomes from atherosclerotic rabbits. Biochim Biophys Acta 617: 458-471.
8. Brown MS, Herz J, Goldstein JL,. 1997. LDL-receptor structure. Calcium cages, acid baths and recycling receptors. Nature 388: 629-630.
9. Buege JA, Aust SD,. 1978. Microsomal lipid peroxidation. Methods Enzymol 52: 302-310.
10. Buhman KF, Accad M, Farese RV,. 2000. Mammalian acyl-CoA:cholesterol acyltransferases. Biochim Biophys Acta 1529: 142-154.
11. Chen X, Zhang Y, Wang Z, Zu Y,. 2011. In vivo antioxidant activity of Pinus koraiensis nut oil obtained by optimised supercritical carbon dioxide extraction. Nat Prod Res 25: 1807-1816.
12. Cianflone KM, Yasruel Z, Rodriguez MA, Vas D, Sniderman AD,. 1990. Regulation of apoB secretion from HepG2 cells: evidence for a critical role for cholesteryl ester synthesis in the response to a fatty acid challenge. J Lipid Res 31: 2045-2055.
13. Hajhashemi V, Abbasi N,. 2008. Hypolipidemic activity of Anethum graveolens in rats. Phytother Res 22: 372-375.
14. Havel RJ, Eder HA, Bragdon JH,. 1955. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34: 1345-1353.
15. Henley E, Chang L, Hollander S,. 2002. Treatment of hyperlipidemia. J Fam Pract 51: 370-376.
16. Hong EJ, Na KJ, Choi IG, Choi KC, Jeung EB,. 2004. Antibacterial and antifungal effects of essential oils from coniferous trees. Biol Pharm Bull 27: 863-866.
17. Hua X, Yokoyama C, Wu J, et al,. 1993. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc Natl Acad Sci USA 90: 11603-11607.
18. Ioriya K, Kino K, Sato YF, Ohashi N,. 2002. Effect of SMP-500, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on serum cholesterol level and LDL cholesterol clearance in hamsters with induced hyperlipidemia. Pharmacology 66: 107-114.
19. Jung UJ, Baek NI, Chung HG, et al,. 2008. Effects of the ethanol extract of the roots of Brassica rapa on glucose and lipid metabolism in C57BL/KsJ-db/db mice. Clin Nutr 27: 158-167.
20. Kim DH, Jung SJ, Chung IS, et al,. 2005. Ergosterol peroxide from flowers of Erigeron annuus L. as an anti-atherosclerosis agent. Arch Pharm Res 28: 541-545.
21. Kovanen PT,. 1987. Regulation of plasma cholesterol by hepatic low-density lipoprotein receptors. Am Heart J 113: 464-469.
22. Lee JH, Yang HY, Lee HS, Hong SK,. 2008. Chemical composition and antimicrobial activity of essential oil from cones of Pinus koraiensis. J Microbiol Biotechnol 18: 497-502.
23. Liu JF, Ma Y, Wang Y, Du ZY, Shen JK, Peng HL,. 2011. Reduction of lipid accumulation in HepG2 cells by luteolin is associated with activation of AMPK and mitigation of oxidative stress. Phytother Res 25: 588-596.
24. Liu LK, Chou FP, Chen YC, Chyau CC, Ho HH, Wang CJ,. 2009. Effects of mulberry (Morus alba L.) extracts on lipid homeostasis in vitro and in vivo. J Agric Food Chem 57: 7605-7611.
25. Ohshiro T, Matsuda D, Sakai K, et al,. 2011. Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia. Arterioscler Thromb Vasc Biol 31: 1108-1115.
26. Park CH, Jeong SJ, Lee HJ, et al,. 2010. Traditional medicine Taeeumjowitangkagambang exerts antiobesity and hypolipidemic effects via antioxidant enzyme enhancement. Phytother Res 24: 1700-1709.
27. Post SM, Zoeteweij JP, Bos MH, et al,. 1999. Acyl-coenzyme A:cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7alpha-hydroxylase in cultured rat hepatocytes and in vivo in the rat. Hepatology 30: 491-500.
28. Rahbar AR, Nabipour I,. 2010. The hypolipidemic effect of Citrullus colocynthis on patients with hyperlipidemia. Pak J Biol Sci 13: 1202-1207.
29. Shin J, Lee HJ, Jung DB, et al,. 2011. Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells. PLoS One 6: e21492.
30. Singh K, Chander R, Kapoor NK,. 1997. Guggulsterone, a potent hypolipidaemic, prevents oxidation of low density lipoprotein. Phytother Res 11: 291-294.
31. Spector AA, Mathur SN, Kaduce TL,. 1979. Role of acylcoenzyme A: cholesterol o-acyltransferase in cholesterol metabolism. Prog Lipid Res 18: 31-53.
32. Suckling KE, Stange EF,. 1985. Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism. J Lipid Res 26: 647-671.
33. Sudhof TC, Goldstein JL, Brown MS, Russell DW,. 1985. The LDL receptor gene: a mosaic of exons shared with different proteins. Science 228: 815-822.
34. Sugano M, Ikeda I, Wakamatsu K, Oka T,. 1994. Influence of Korean pine (Pinus koraiensis)-seed oil containing cis-5,cis-9,cis-12-octadecatrienoic acid on polyunsaturated fatty acid metabolism, eicosanoid production and blood pressure of rats. Br J Nutr 72: 775-783.
35. Tzang BS, Yang SF, Fu SG, Yang HC, Sun HL, Chen YC,. 2009. Effects of flaxseed oil on cholesterol metabolism of hamsters. Food Chem 114: 1450-1455.
36. Vallianou I, Peroulis N, Pantazis P, Hadzopoulou-Cladaras M,. 2011. Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity. PLoS One 6: e20516.
37. Victor Antony Santiago J, Jayachitra J, Shenbagam M, Nalini N,. 2011. Dietary d-limonene alleviates insulin resistance and oxidative stress-induced liver injury in high-fat diet and L-NAME-treated rats. Eur J Nutr in press.
38. Vijayaraj PS, Muthukumar K, Sabarirajan J, Nachiappan V,. 2011. Evaluation of antihyperlipidemic activity of ethanolic extract of Cassia auriculata flowers. Indian J Biochem Biophys 48: 54-58.
39. Yang MY, Peng CH, Chan KC, Yang YS, Huang CN, Wang CJ,. 2010. The hypolipidemic effect of Hibiscus sabdariffa polyphenols via inhibiting lipogenesis and promoting hepatic lipid clearance. J Agric Food Chem 58: 850-859.
40. Yokoyama C, Wang X, Briggs MR, et al,. 1993. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell 75: 187-197.