Anti-angiogenic effect of Tanshinone IIA involves inhibition of matrix invasion and modification of MMP-2/TIMP-2 secretion in vascular endothelial cells

Cancer Letters

Volumn 310, Issue 2, 2011, Pages 198-206

  Tsai, Ming Yen ^a   Yang, Rong Chi ^b   Wu, Hsiao Ting ^a   Pang, Jong Hwei S ^c   Huang, Sheng Teng ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Angiogenesis; Chick chorioallantoic membrane assay; Human vascular endothelial cells; MMP 2; Tanshinone IIA; TIMP 2

Indexed keywords

CELL PROTEIN; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; REVERSION INDUCING CYSTEINE RICH PROTEIN WITH KAZAL MOTIF; STROMELYSIN; TANSHINONE IIA; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL INVASION; CELL MIGRATION; CHICK EMBRYO; CHORIOALLANTOIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME RELEASE; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOGENESIS INHIBITORS; ANIMALS; CELL MOVEMENT; CHICK EMBRYO; CHORIOALLANTOIC MEMBRANE; DITERPENES, ABIETANE; ENDOTHELIAL CELLS; GPI-LINKED PROTEINS; HUMANS; MATRIX METALLOPROTEINASE 2; NEOVASCULARIZATION, PHYSIOLOGIC; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TUMOR NECROSIS FACTOR-ALPHA;

SALVIA MILTIORRHIZA;

EID: 80051695345     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.06.031     Document Type: Article

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