Reactive oxygen species-mediated activation of AMP-activated protein kinase and c-jun N-terminal kinase plays a critical role in beta-sitosterol-induced apoptosis in multiple myeloma U266 cells

Phytotherapy Research

Volumn 28, Issue 3, 2014, Pages 387-394

  Sook, Song Hyo ^a   Lee, Hyo Jung ^a,b   Kim, Ji Hyun ^a   Sohn, Eun Jung ^a   Jung, Ji Hoon ^a   Kim, Bonglee ^a   Kim, Jin Hyoung ^a   Jeong, Soo Jin ^a   Kim, Sung Hoon ^a  

^a Kyung Hee University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

AMPK; apoptosis; beta sitosterol; JNK; ROS; U266

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYL COENZYME A CARBOXYLASE; ACETYLCYSTEINE; ADENOSINE DIPHOSPHATE RIBOSE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 9; CYCLOOXYGENASE 2; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; S6 KINASE; SITOSTEROL; STRESS ACTIVATED PROTEIN KINASE; VASCULOTROPIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CELL STRAIN U266; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MULTIPLE MYELOMA; NONHUMAN; ONCOGENE; ONCOGENE AMPK; ONCOGENE JNK; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SOLVENT EXTRACTION;

MAMMALIA;

AMPK; APOPTOSIS; BETA-SITOSTEROL; JNK; ROS; U266;

ACETYL-COA CARBOXYLASE; ACETYLCYSTEINE; AMP-ACTIVATED PROTEIN KINASES; ANTHRACENES; APOPTOSIS; CASPASE 3; CASPASE 9; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CYCLOOXYGENASE 2; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MULTIPLE MYELOMA; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; SITOSTEROLS;

EID: 84895798982     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4999     Document Type: Article

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