메뉴 건너뛰기




Volumn 141, Issue 2, 2014, Pages 168-180

Molecular genetics of pancreatic neoplasms and their morphologic correlates: An update on recent advances and potential diagnostic applications

Author keywords

Molecular genetics; Pancreas; Pancreatic neoplasms

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; K RAS PROTEIN; PROTEIN P16; SMAD4 PROTEIN;

EID: 84895124268     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1309/AJCP0FKDP7ENVKEV     Document Type: Review
Times cited : (58)

References (109)
  • 1
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008;321:1801-1806.
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 2
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • Li C, Heidt DG, Dalerba P, et al. Identification of pancreatic cancer stem cells. Cancer Res. 2007;67:1030-1037.
    • (2007) Cancer Res , vol.67 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 3
    • 84871275135 scopus 로고    scopus 로고
    • Histopathologic assessment of pancreatic cancer: Does one size fit all?
    • Reid MD, Bagci P, Adsay NV. Histopathologic assessment of pancreatic cancer: does one size fit all? J Surg Oncol. 2013;107:67-77.
    • (2013) J Surg Oncol , vol.107 , pp. 67-77
    • Reid, M.D.1    Bagci, P.2    Adsay, N.V.3
  • 5
    • 84893550656 scopus 로고    scopus 로고
    • Molecular pathology of pancreatic cancer
    • Cheng L, Eble J, eds. New York, NY: Springer
    • Wood L, Adsay N, Hruban R. Molecular pathology of pancreatic cancer. In: Cheng L, Eble J, eds. Molecular Surgical Pathology. New York, NY: Springer; 2013:17-42.
    • (2013) Molecular Surgical Pathology , pp. 17-42
    • Wood, L.1    Adsay, N.2    Hruban, R.3
  • 6
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
    • Almoguera C, Shibata D, Forrester K, et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988;53:549-554.
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3
  • 8
    • 84875669011 scopus 로고    scopus 로고
    • Somatic mutations in exocrine pancreatic tumors: Association with patient survival
    • Rachakonda PS, Bauer AS, Xie H, et al. Somatic mutations in exocrine pancreatic tumors: association with patient survival. PLoS One. 2013;8:e60870.
    • (2013) PLoS One , vol.8
    • Rachakonda, P.S.1    Bauer, A.S.2    Xie, H.3
  • 10
    • 79959412690 scopus 로고    scopus 로고
    • INK4A and their relevance to cancer
    • INK4A and their relevance to cancer. Biochemistry. 2011;50:5566-5582.
    • (2011) Biochemistry , vol.50 , pp. 5566-5582
    • Li, J.1    Poi, M.J.2    Tsai, M.D.3
  • 12
    • 84871190631 scopus 로고    scopus 로고
    • Pathology and molecular genetics of pancreatic neoplasms
    • Wood LD, Hruban RH. Pathology and molecular genetics of pancreatic neoplasms. Cancer J. 2012;18:492-501.
    • (2012) Cancer J , vol.18 , pp. 492-501
    • Wood, L.D.1    Hruban, R.H.2
  • 13
    • 84878150670 scopus 로고    scopus 로고
    • Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia
    • Kanda M, Sadakari Y, Borges M, et al. Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia. Clin Gastroenterol Hepatol. 2012;11:719-730.
    • (2012) Clin Gastroenterol Hepatol , vol.11 , pp. 719-730
    • Kanda, M.1    Sadakari, Y.2    Borges, M.3
  • 14
    • 68049115773 scopus 로고    scopus 로고
    • SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
    • Blackford A, Serrano OK, Wolfgang CL, et al. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res. 2009;15:4674-4679.
    • (2009) Clin Cancer Res , vol.15 , pp. 4674-4679
    • Blackford, A.1    Serrano, O.K.2    Wolfgang, C.L.3
  • 15
    • 62249176551 scopus 로고    scopus 로고
    • DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
    • Iacobuzio-Donahue CA, Fu B, Yachida S, et al. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol. 2009;27:1806-1813.
    • (2009) J Clin Oncol , vol.27 , pp. 1806-1813
    • Iacobuzio-Donahue, C.A.1    Fu, B.2    Yachida, S.3
  • 16
    • 80051613675 scopus 로고    scopus 로고
    • Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: Correlation of Smad4(Dpc4) immunostaining with pattern of disease progression
    • Crane CH, Varadhachary GR, Yordy JS, et al. Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression. J Clin Oncol. 2011;29:3037-3043.
    • (2011) J Clin Oncol , vol.29 , pp. 3037-3043
    • Crane, C.H.1    Varadhachary, G.R.2    Yordy, J.S.3
  • 18
    • 62549154091 scopus 로고    scopus 로고
    • MicroRNA miR-155 is a biomarker of early pancreatic neoplasia
    • Habbe N, Koorstra JB, Mendell JT, et al. MicroRNA miR-155 is a biomarker of early pancreatic neoplasia. Cancer Biol Ther. 2009;8:340-346.
    • (2009) Cancer Biol Ther , vol.8 , pp. 340-346
    • Habbe, N.1    Koorstra, J.B.2    Mendell, J.T.3
  • 19
    • 79960248965 scopus 로고    scopus 로고
    • Elevated microRNA miR-21 levels in pancreatic cyst fluid are predictive of mucinous precursor lesions of ductal adenocarcinoma
    • Ryu JK, Matthaei H, Dal Molin M, et al. Elevated microRNA miR-21 levels in pancreatic cyst fluid are predictive of mucinous precursor lesions of ductal adenocarcinoma. Pancreatobgy. 2011;11:343-350.
    • (2011) Pancreatobgy , vol.11 , pp. 343-350
    • Ryu, J.K.1    Matthaei, H.2    Dal Molin, M.3
  • 20
    • 34248200155 scopus 로고    scopus 로고
    • MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma
    • DOI 10.1038/sj.onc.1210228, PII 1210228
    • Szafranska AE, Davison TS, John J, et al. MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma. Oncogene. 2007;26:4442-4452. (Pubitemid 47014466)
    • (2007) Oncogene , vol.26 , Issue.30 , pp. 4442-4452
    • Szafranska, A.E.1    Davison, T.S.2    John, J.3    Cannon, T.4    Sipos, B.5    Maghnouj, A.6    Labourier, E.7    Hahn, S.A.8
  • 22
    • 67349211022 scopus 로고    scopus 로고
    • Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma
    • Brody JR, Costantino CL, Potoczek M, et al. Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma. Mod Pathol. 2009;22:651-659.
    • (2009) Mod Pathol , vol.22 , pp. 651-659
    • Brody, J.R.1    Costantino, C.L.2    Potoczek, M.3
  • 23
    • 0031782102 scopus 로고    scopus 로고
    • Undifferentiated carcinoma of the pancreas: Analysis of intermediate filament profile and Ki-ras mutations provides evidence of a ductal origin
    • DOI 10.1002/(SICI)1096-9896(199805)185:1<53::AID-PA
    • Hoorens A, Prenzel K, Lemoine NR, et al. Undifferentiated carcinoma of the pancreas: analysis of intermediate filament profile and Ki-ras mutations provides evidence of a ductal origin. J Pathol. 1998;185:53-60. (Pubitemid 28266717)
    • (1998) Journal of Pathology , vol.185 , Issue.1 , pp. 53-60
    • Hoorens, A.1    Prenzel, K.2    Lemoine, N.R.3    Kloppel, G.4
  • 24
    • 0031050016 scopus 로고    scopus 로고
    • KRAS oncogene mutations suggest a common histogenetic origin for pleomorphic giant cell tumor of the pancreas, osteoclastoma of the pancreas, and pancreatic duct adenocarcinoma
    • DOI 10.1016/S0046-8177(97)90283-5
    • Gocke CD, Dabbs DJ, Benko FA, et al. KRAS oncogene mutations suggest a common histogenetic origin for pleomorphic giant cell tumor of the pancreas, osteoclastoma of the pancreas, and pancreatic duct adenocarcinoma. Hum Pathol. 1997;28:80-83. (Pubitemid 27044486)
    • (1997) Human Pathology , vol.28 , Issue.1 , pp. 80-83
    • Gocke, C.D.1    Dabbs, D.J.2    Benko, F.A.3    Silverman, J.F.4
  • 25
    • 84885018386 scopus 로고    scopus 로고
    • KRAS mutant allele-specific imbalance is associated with worse prognosis in pancreatic cancer and progression to undifferentiated carcinoma of the pancreas
    • Krasinskas AM, Moser AJ, Saka B, et al. KRAS mutant allele-specific imbalance is associated with worse prognosis in pancreatic cancer and progression to undifferentiated carcinoma of the pancreas. Mod Pathol. 2013;26:1346-1354.
    • (2013) Mod Pathol , vol.26 , pp. 1346-1354
    • Krasinskas, A.M.1    Moser, A.J.2    Saka, B.3
  • 27
    • 0032055165 scopus 로고    scopus 로고
    • Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region
    • DOI 10.1002/(SICI)1097-0142(19980401)82:7<1279::AID
    • Molberg KH, Heffess C, Delgado R, et al. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region. Cancer. 1998;82:1279-1287. (Pubitemid 28155389)
    • (1998) Cancer , vol.82 , Issue.7 , pp. 1279-1287
    • Molberg, K.H.1    Heffess, C.2    Delgado, R.3    Albores-Saavedra, J.4
  • 28
    • 27144457645 scopus 로고    scopus 로고
    • Invasive micropapillary carcinomas of the ampullo-pancreatobiliary region and their association with tumor-infiltrating neutrophils
    • DOI 10.1038/modpathol.3800460, PII 3800460
    • Khayyata S, Basturk O, Adsay NV. Invasive micropapillary carcinomas of the ampullo-pancreatobiliary region and their association with tumor-infiltrating neutrophils. Mod Pathol. 2005;18:1504-1511. (Pubitemid 41509406)
    • (2005) Modern Pathology , vol.18 , Issue.11 , pp. 1504-1511
    • Khayyata, S.1    Basturk, O.2    Adsay, N.V.3
  • 30
    • 82555191059 scopus 로고    scopus 로고
    • Tumor-infiltrating neutrophils in pancreatic neoplasia
    • Reid MD, Basturk O, Thirabanjasak D, et al. Tumor-infiltrating neutrophils in pancreatic neoplasia. Mod Pathol. 2011;24:1612-1619.
    • (2011) Mod Pathol , vol.24 , pp. 1612-1619
    • Reid, M.D.1    Basturk, O.2    Thirabanjasak, D.3
  • 36
    • 46449134676 scopus 로고    scopus 로고
    • Pancreatic cancer and the FAMMM syndrome
    • Lynch HT, Fusaro RM, Lynch JF, et al. Pancreatic cancer and the FAMMM syndrome. Fam Cancer. 2008;7:103-112.
    • (2008) Fam Cancer , vol.7 , pp. 103-112
    • Lynch, H.T.1    Fusaro, R.M.2    Lynch, J.F.3
  • 40
    • 35348992639 scopus 로고    scopus 로고
    • The genetics of hereditary colon cancer
    • DOI 10.1101/gad.1593107
    • Rustgi AK. The genetics of hereditary colon cancer. Genes Dev. 2007;21:2525-2538. (Pubitemid 47607664)
    • (2007) Genes and Development , vol.21 , Issue.20 , pp. 2525-2538
    • Rustgi, A.K.1
  • 41
    • 33750083369 scopus 로고    scopus 로고
    • Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene
    • DOI 10.1016/j.humpath.2006.06.024, PII S0046817706003844
    • Banville N, Geraghty R, Fox E, et al. Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene. Hum Pathol. 2006;37:1498-1502. (Pubitemid 44584335)
    • (2006) Human Pathology , vol.37 , Issue.11 , pp. 1498-1502
    • Banville, N.1    Geraghty, R.2    Fox, E.3    Leahy, D.T.4    Green, A.5    Keegan, D.6    Geoghegan, J.7    O'Donoghue, D.8    Hyland, J.9    Sheahan, K.10
  • 44
    • 0034039578 scopus 로고    scopus 로고
    • Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis
    • DOI 10.1038/76088
    • Witt H, Luck W, Hennies HC, et al. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet. 2000;25:213-216. (Pubitemid 30394996)
    • (2000) Nature Genetics , vol.25 , Issue.2 , pp. 213-216
    • Witt, H.1    Luck, W.2    Hennies, H.C.3    Classen, M.4    Kage, A.5    Lass, U.6    Landt, O.7    Becker, M.8
  • 46
    • 84872809716 scopus 로고    scopus 로고
    • Molecular analysis of precursor lesions in familial pancreatic cancer
    • Crnogorac-Jurcevic T, Chelala C, Barry S, et al. Molecular analysis of precursor lesions in familial pancreatic cancer. PLoS One. 2013;8:e54830.
    • (2013) PLoS One , vol.8
    • Crnogorac-Jurcevic, T.1    Chelala, C.2    Barry, S.3
  • 48
    • 81155126043 scopus 로고    scopus 로고
    • AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D
    • Dumartin L, Whiteman HJ, Weeks ME, et al. AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D. Cancer Res. 2011;71:7091-7102.
    • (2011) Cancer Res , vol.71 , pp. 7091-7102
    • Dumartin, L.1    Whiteman, H.J.2    Weeks, M.E.3
  • 49
    • 84904546508 scopus 로고    scopus 로고
    • A comparison of the morphology of familial and sporadic pancreatic cancers
    • Singhi AD, Ishada H, Klein AP, et al. A comparison of the morphology of familial and sporadic pancreatic cancers. Mod Pathol. 2013;26(suppl 2):431A.
    • (2013) Mod Pathol , vol.26 , Issue.SUPPL. 2
    • Singhi, A.D.1    Ishada, H.2    Klein, A.P.3
  • 50
    • 65949122339 scopus 로고    scopus 로고
    • Genetic mutations associated with cigarette smoking in pancreatic cancer
    • Blackford A, Parmigiani G, Kensler TW, et al. Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res. 2009;69:3681-3688.
    • (2009) Cancer Res , vol.69 , pp. 3681-3688
    • Blackford, A.1    Parmigiani, G.2    Kensler, T.W.3
  • 51
    • 0036781678 scopus 로고    scopus 로고
    • Screening and surveillance for hereditary pancreatic cancer
    • Kimmey MB, Bronner MP, Byrd DR, et al. Screening and surveillance for hereditary pancreatic cancer. Gastrointest Endosc. 2002;56(4 suppl):S82-S86.
    • (2002) Gastrointest Endosc , vol.56 , Issue.4 SUPPL.
    • Kimmey, M.B.1    Bronner, M.P.2    Byrd, D.R.3
  • 53
    • 79960660466 scopus 로고    scopus 로고
    • Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development
    • Wu J, Matthaei H, Maitra A, et al. Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development. Science Transl Med. 2011;3:92ra66.
    • (2011) Science Transl Med , vol.3
    • Wu, J.1    Matthaei, H.2    Maitra, A.3
  • 54
    • 0142072036 scopus 로고    scopus 로고
    • Clinicopathological Correlates of Pancreatic Intraepithelial Neoplasia: A Comparative Analysis of 82 Cases With and 152 Cases Without Pancreatic Ductal Adenocarcinoma
    • DOI 10.1097/01.MP.0000087422.24733.62
    • Andea A, Sarkar F, Adsay VN. Clinicopathological correlates of pancreatic intraepithelial neoplasia: a comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma. Mod Pathol. 2003;16:996-1006. (Pubitemid 37280815)
    • (2003) Modern Pathology , vol.16 , Issue.10 , pp. 996-1006
    • Andea, A.1    Sarkar, F.2    Adsay, V.N.3
  • 56
    • 18644383374 scopus 로고    scopus 로고
    • The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: Differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesis
    • Adsay NV, Merati K, Andea A, et al. The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesis. Mod Pathol. 2002;15:1087-1095.
    • (2002) Mod Pathol , vol.15 , pp. 1087-1095
    • Adsay, N.V.1    Merati, K.2    Andea, A.3
  • 60
    • 0037298925 scopus 로고    scopus 로고
    • Molecular pathogenesis of precursor lesions of pancreatic ductal adenocarcinoma
    • DOI 10.1080/003130202201472
    • Biankin AV, Kench JG, Dijkman FP, et al. Molecular pathogenesis of precursor lesions of pancreatic ductal adenocarcinoma. Pathology. 2003;35:14-24. (Pubitemid 36349941)
    • (2003) Pathology , vol.35 , Issue.1 , pp. 14-24
    • Biankin, A.V.1    Kench, J.G.2    Dijkman, F.P.3    Biankin, S.A.4    Henshall, S.M.5
  • 62
    • 84878752507 scopus 로고    scopus 로고
    • Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts
    • Kanda M, Knight S, Topazian M, et al. Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts. Gut. 2012;62:1024-1033.
    • (2012) Gut , vol.62 , pp. 1024-1033
    • Kanda, M.1    Knight, S.2    Topazian, M.3
  • 63
    • 0141742113 scopus 로고    scopus 로고
    • Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray
    • DOI 10.1097/01.MP.0000086072.56290.FB
    • Maitra A, Adsay NV, Argani P, et al. Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Mod Pathol. 2003;16:902-912. (Pubitemid 37152020)
    • (2003) Modern Pathology , vol.16 , Issue.9 , pp. 902-912
    • Maitra, A.1    Adsay, N.V.2    Argani, P.3    Iacobuzio-Donahue, C.4    De Marzo, A.5    Cameron, J.L.6    Yeo, C.J.7    Hruban, R.H.8
  • 64
    • 0030988302 scopus 로고    scopus 로고
    • p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma
    • Moskaluk CA, Hruban RH, Kern SE. p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res. 1997;57:2140-2143. (Pubitemid 27247028)
    • (1997) Cancer Research , vol.57 , Issue.11 , pp. 2140-2143
    • Moskaluk, C.A.1    Hruban, R.H.2    Kern, S.E.3
  • 66
    • 62249126574 scopus 로고    scopus 로고
    • Pancreatic cysts: Pathologic classification, differential diagnosis, and clinical implications
    • Basturk O, Coban I, Adsay NV. Pancreatic cysts: pathologic classification, differential diagnosis, and clinical implications. Arch Pathol Lab Med. 2009;133:423-438.
    • (2009) Arch Pathol Lab Med , vol.133 , pp. 423-438
    • Basturk, O.1    Coban, I.2    Adsay, N.V.3
  • 67
    • 84855851440 scopus 로고    scopus 로고
    • Clinicopathological characteristics and molecular analyses of multifocal intraductal papillary mucinous neoplasms of the pancreas
    • Matthaei H, Norris AL, Tsiatis AC, et al. Clinicopathological characteristics and molecular analyses of multifocal intraductal papillary mucinous neoplasms of the pancreas. Ann Surg. 2012;255:326-333.
    • (2012) Ann Surg , vol.255 , pp. 326-333
    • Matthaei, H.1    Norris, A.L.2    Tsiatis, A.C.3
  • 71
    • 77649197079 scopus 로고    scopus 로고
    • Preferential expression of MUC6 in oncocytic and pancreatobiliary types of intraductal papillary neoplasms highlights a pyloropancreatic pathway, distinct from the intestinal pathway, in pancreatic carcinogenesis
    • Basturk O, Khayyata S, Klimstra DS, et al. Preferential expression of MUC6 in oncocytic and pancreatobiliary types of intraductal papillary neoplasms highlights a pyloropancreatic pathway, distinct from the intestinal pathway, in pancreatic carcinogenesis. Am J Surg Pathol. 2010;34:364-370.
    • (2010) Am J Surg Pathol , vol.34 , pp. 364-370
    • Basturk, O.1    Khayyata, S.2    Klimstra, D.S.3
  • 72
    • 84862907854 scopus 로고    scopus 로고
    • Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
    • Wu J, Jiao Y, Dal Molin M, et al. Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci U S A. 2011;108:21188-21193.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 21188-21193
    • Wu, J.1    Jiao, Y.2    Dal Molin, M.3
  • 73
    • 63449085593 scopus 로고    scopus 로고
    • Global genomic analysis of intraductal papillary mucinous neoplasms of the pancreas reveals significant molecular differences compared to ductal adenocarcinoma
    • Fritz S, Fernandez-del Castillo C, Mino-Kenudson M, et al. Global genomic analysis of intraductal papillary mucinous neoplasms of the pancreas reveals significant molecular differences compared to ductal adenocarcinoma. Ann Surg. 2009;249:440-447.
    • (2009) Ann Surg , vol.249 , pp. 440-447
    • Fritz, S.1    Fernandez-del Castillo, C.2    Mino-Kenudson, M.3
  • 74
    • 0029921032 scopus 로고    scopus 로고
    • K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas
    • Satoh K, Shimosegawa T, Moriizumi S, et al. K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas. Pancreas. 1996;12:362-368.
    • (1996) Pancreas , vol.12 , pp. 362-368
    • Satoh, K.1    Shimosegawa, T.2    Moriizumi, S.3
  • 75
    • 0033807873 scopus 로고    scopus 로고
    • p53 protein expression in intraductal papillary mucinous tumors (IPMT) of the pancreas as an indicator of tumor malignancy
    • Kawahira H, Kobayashi S, Kaneko K, et al. p53 protein expression in intraductal papillary mucinous tumors (IPMT) of the pancreas as an indicator of tumor malignancy. Hepatogastroenterology. 2000;47:973-977.
    • (2000) Hepatogastroenterology , vol.47 , pp. 973-977
    • Kawahira, H.1    Kobayashi, S.2    Kaneko, K.3
  • 76
    • 79952069133 scopus 로고    scopus 로고
    • High-throughput mutation profiling in intraductal papillary mucinous neoplasm (IPMN)
    • Lubezky N, Ben-Haim M, Marmor S, et al. High-throughput mutation profiling in intraductal papillary mucinous neoplasm (IPMN). J Gastrointest Surg. 2011;15:503-511.
    • (2011) J Gastrointest Surg , vol.15 , pp. 503-511
    • Lubezky, N.1    Ben-Haim, M.2    Marmor, S.3
  • 78
    • 0036110390 scopus 로고    scopus 로고
    • INK4A and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma
    • INK4A and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma. Gut. 2002;50:861-868.
    • (2002) Gut , vol.50 , pp. 861-868
    • Biankin, A.V.1    Biankin, S.A.2    Kench, J.G.3
  • 79
    • 84865755577 scopus 로고    scopus 로고
    • miRNA biomarkers in cyst fluid augment the diagnosis and management of pancreatic cysts
    • Matthaei H, Wylie D, Lloyd MB, et al. miRNA biomarkers in cyst fluid augment the diagnosis and management of pancreatic cysts. Clin Cancer Res. 2012;18:4713-4724.
    • (2012) Clin Cancer Res , vol.18 , pp. 4713-4724
    • Matthaei, H.1    Wylie, D.2    Lloyd, M.B.3
  • 80
    • 68249090042 scopus 로고    scopus 로고
    • Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms
    • Yamaguchi H, Shimizu M, Ban S, et al. Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol. 2009;33:1164-1172.
    • (2009) Am J Surg Pathol , vol.33 , pp. 1164-1172
    • Yamaguchi, H.1    Shimizu, M.2    Ban, S.3
  • 81
    • 81355160555 scopus 로고    scopus 로고
    • Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas
    • Yamaguchi H, Kuboki Y, Hatori T, et al. Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas. Am J Surg Pathol. 2011;35:1812-1817.
    • (2011) Am J Surg Pathol , vol.35 , pp. 1812-1817
    • Yamaguchi, H.1    Kuboki, Y.2    Hatori, T.3
  • 83
    • 79961024416 scopus 로고    scopus 로고
    • Mucinous cystic neoplasms of the liver: A clinicopathological study and comparison with intraductal papillary neoplasms of the bile duct
    • Zen Y, Pedica F, Patcha VR, et al. Mucinous cystic neoplasms of the liver: a clinicopathological study and comparison with intraductal papillary neoplasms of the bile duct. Mod Pathol. 2011;24:1079-1089.
    • (2011) Mod Pathol , vol.24 , pp. 1079-1089
    • Zen, Y.1    Pedica, F.2    Patcha, V.R.3
  • 84
    • 84904544682 scopus 로고    scopus 로고
    • Carcinogenetic progression of pancreatic mucinous cystic neoplasm is of aggressive pancreatobiliary lineage
    • Jang K-T, Choi YL, Hill C, et al. Carcinogenetic progression of pancreatic mucinous cystic neoplasm is of aggressive pancreatobiliary lineage. Mod Pathol. 2013;26(suppl 2):425A.
    • (2013) Mod Pathol , vol.26 , Issue.SUPPL. 2
    • Jang, K.-T.1    Choi, Y.L.2    Hill, C.3
  • 85
    • 84904579845 scopus 로고    scopus 로고
    • Immunophenotypic and molecular alterations in the carcinogenetic progression of mucinous cystic neoplasm of the pancreas
    • Jang K-T, Choi YL, Hill C, et al. Immunophenotypic and molecular alterations in the carcinogenetic progression of mucinous cystic neoplasm of the pancreas. Mod Pathol. 2012;25(suppl 2):445A.
    • (2012) Mod Pathol , vol.25 , Issue.SUPPL. 2
    • Jang, K.-T.1    Choi, Y.L.2    Hill, C.3
  • 86
    • 0242522859 scopus 로고    scopus 로고
    • Comparison of Epigenetic and Genetic Alterations in Mucinous Cystic Neoplasm and Serous Microcystic Adenoma of Pancreas
    • DOI 10.1097/01.MP.0000094088.37888.A6
    • Kim SG, Wu TT, Lee JH, et al. Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas. Mod Pathol. 2003;16:1086-1094. (Pubitemid 37414202)
    • (2003) Modern Pathology , vol.16 , Issue.11 , pp. 1086-1094
    • Kim, S.G.1    Wu, T.-T.2    Lee, J.H.3    Yun, Y.K.4    Issa, J.-P.5    Hamilton, S.R.6    Rashid, A.7
  • 87
    • 0033497531 scopus 로고    scopus 로고
    • Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy
    • DOI 10.1097/00000658-199910000-00006
    • Jimenez RE, Warshaw AL, Z'Graggen K, et al. Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy. Ann Surg. 1999;230:501-511. (Pubitemid 30191845)
    • (1999) Annals of Surgery , vol.230 , Issue.4 , pp. 501-511
    • Jimenez, R.E.1    Warshaw, A.L.2    Z'graggen, K.3    Hartwig, W.4    Taylor, D.Z.5    Compton, C.C.6    Fernandez-Del, C.C.7
  • 88
    • 57449108764 scopus 로고    scopus 로고
    • Is serous cystadenoma of the pancreas a model of clear-cell-associated angiogenesis and tumorigenesis?
    • Thirabanjasak D, Basturk O, Altinel D, et al. Is serous cystadenoma of the pancreas a model of clear-cell-associated angiogenesis and tumorigenesis? Pancreatology. 2009;9:182-188.
    • (2009) Pancreatology , vol.9 , pp. 182-188
    • Thirabanjasak, D.1    Basturk, O.2    Altinel, D.3
  • 89
    • 84862168016 scopus 로고    scopus 로고
    • International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
    • Tanaka M, Fernandez-del Castillo C, Adsay V, et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology. 2012;12:183-197.
    • (2012) Pancreatology , vol.12 , pp. 183-197
    • Tanaka, M.1    Fernandez-del Castillo, C.2    Adsay, V.3
  • 92
    • 79952279828 scopus 로고    scopus 로고
    • DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors
    • Jiao Y, Shi C, Edil BH, et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science. 2011;331:1199-1203.
    • (2011) Science , vol.331 , pp. 1199-1203
    • Jiao, Y.1    Shi, C.2    Edil, B.H.3
  • 93
    • 79960700556 scopus 로고    scopus 로고
    • Altered telomeres in tumors with ATRX and DAXX mutations
    • Heaphy CM, de Wilde RF, Jiao Y, et al. Altered telomeres in tumors with ATRX and DAXX mutations. Science. 2011;333:425.
    • (2011) Science , vol.333 , pp. 425
    • Heaphy, C.M.1    De Wilde, R.F.2    Jiao, Y.3
  • 94
    • 84863474126 scopus 로고    scopus 로고
    • Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors
    • de Wilde RF, Heaphy CM, Maitra A, et al. Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors. Mod Pathol. 2012;25:1033-1039.
    • (2012) Mod Pathol , vol.25 , pp. 1033-1039
    • De Wilde, R.F.1    Heaphy, C.M.2    Maitra, A.3
  • 95
    • 79851500081 scopus 로고    scopus 로고
    • Everolimus for advanced pancreatic neuroendocrine tumors
    • Yao JC, Shah MH, Ito T, et al. Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med. 2011;364:514-523.
    • (2011) N Engl J Med , vol.364 , pp. 514-523
    • Yao, J.C.1    Shah, M.H.2    Ito, T.3
  • 96
    • 84857714411 scopus 로고    scopus 로고
    • Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors
    • Yachida S, Vakiani E, White CM, et al. Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors. Am J Surg Pathol. 2013;36:173-184.
    • (2013) Am J Surg Pathol , vol.36 , pp. 173-184
    • Yachida, S.1    Vakiani, E.2    White, C.M.3
  • 98
    • 84904582182 scopus 로고    scopus 로고
    • Epigenetic and genetic changes of APC gene in acinar cell carcinoma of the pancreas
    • La Rosa S, Furlan D, Sahnane N, et al. Epigenetic and genetic changes of APC gene in acinar cell carcinoma of the pancreas. Mod Pathol. 2013;26(suppl 2):427A.
    • (2013) Mod Pathol , vol.26 , Issue.SUPPL. 2
    • La Rosa, S.1    Furlan, D.2    Sahnane, N.3
  • 99
    • 69749092294 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization to visualize genetic abnormalities in interphase cells of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas
    • Dewald GW, Smyrk TC, Thorland EC, et al. Fluorescence in situ hybridization to visualize genetic abnormalities in interphase cells of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas. Mayo Clin Proc. 2009;84:801-810.
    • (2009) Mayo Clin Proc , vol.84 , pp. 801-810
    • Dewald, G.W.1    Smyrk, T.C.2    Thorland, E.C.3
  • 100
    • 0034131138 scopus 로고    scopus 로고
    • Pancreatic acinar carcinoma shows a distinct pattern of chromosomal imbalances by comparative genomic hybridization
    • DOI 10.1002/1098-2264(200007)28:3<294::AID-GCC7>
    • Taruscio D, Paradisi S, Zamboni G, et al. Pancreatic acinar carcinoma shows a distinct pattern of chromosomal imbalances by comparative genomic hybridization. Genes Chromosomes Cancer. 2000;28:294-299. (Pubitemid 30399559)
    • (2000) Genes Chromosomes and Cancer , vol.28 , Issue.3 , pp. 294-299
    • Taruscio, D.1    Paradisi, S.2    Zamboni, G.3    Rigaud, G.4    Falconi, M.5    Scarpa, A.6
  • 101
    • 84885386706 scopus 로고    scopus 로고
    • Whole genome analyses of pancreatic acinar cell carcinomas
    • Wood LD, Jiao Y, Yonescu R, et al. Whole genome analyses of pancreatic acinar cell carcinomas. Mod Pathol. 2013;26(suppl 2):440A.
    • (2013) Mod Pathol , vol.26 , Issue.SUPPL. 2
    • Wood, L.D.1    Jiao, Y.2    Yonescu, R.3
  • 103
    • 3142528293 scopus 로고    scopus 로고
    • Biotin-rich, optically clear nuclei express estrogen receptor-β: Tumors with morules may develop under the influence of estrogen and aberrant β-catenin expression
    • Nakatani Y, Masudo K, Nozawa A, et al. Biotin-rich, optically clear nuclei express estrogen receptor-β: tumors with morules may develop under the influence of estrogen and aberrant β-catenin expression. Hum Pathol. 2004;35:869-874.
    • (2004) Hum Pathol , vol.35 , pp. 869-874
    • Nakatani, Y.1    Masudo, K.2    Nozawa, A.3
  • 104
    • 0035152551 scopus 로고    scopus 로고
    • Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas: Frequent alterations in the APC/β-catenin pathway and chromosome 11p
    • Abraham SC, Wu TT, Klimstra DS, et al. Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas: frequent alterations in the APC/β-catenin pathway and chromosome 11p. Am J Pathol. 2001;159:1619-1627. (Pubitemid 33062504)
    • (2001) American Journal of Pathology , vol.159 , Issue.5 , pp. 1619-1627
    • Abraham, S.C.1    Wu, T.-T.2    Klimstra, D.S.3    Finn, L.S.4    Lee, J.-H.5    Yeo, C.J.6    Cameron, J.L.7    Hruban, R.H.8
  • 108
    • 33749073592 scopus 로고    scopus 로고
    • Accumulation of β-catenin protein, mutations in exon-3 of the β-catenin gene and a loss of heterozygosity of 5q22 in solid pseudopapillary tumor of the pancreas
    • Min Kim S, Sun CD, Park KC, et al. Accumulation of β-catenin protein, mutations in exon-3 of the β-catenin gene and a loss of heterozygosity of 5q22 in solid pseudopapillary tumor of the pancreas. J Surg Oncol. 2006;94:418-425.
    • (2006) J Surg Oncol , vol.94 , pp. 418-425
    • Min Kim, S.1    Sun, C.D.2    Park, K.C.3
  • 109
    • 38849173630 scopus 로고    scopus 로고
    • Membrane loss and aberrant nuclear localization of E-cadherin are consistent features of solid pseudopapillary tumour of the pancreas. An immunohistochemical study using two antibodies recognizing different domains of the E-cadherin molecule
    • DOI 10.1111/j.1365-2559.2007.02949.x
    • Chetty R, Serra S. Membrane loss and aberrant nuclear localization of E-cadherin are consistent features of solid pseudopapillary tumour of the pancreas: an immunohistochemical study using two antibodies recognizing different domains of the E-cadherin molecule. Histopathology. 2008;52:325-330. (Pubitemid 351208060)
    • (2008) Histopathology , vol.52 , Issue.3 , pp. 325-330
    • Chetty, R.1    Serra, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.