Molecular pathology of pancreatic cancer

Molecular Surgical Pathology

Volumn , Issue , 2014, Pages 17-42

  Wood, Laura D ^a   Adsay, N Volkan ^b   Hruban, Ralph H ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84893550656     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-4900-3_2     Document Type: Chapter

References (13)

1. Abraham SC, Klimstra DC, Wilentz RE, et al.Solid pseduopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations.Am J Pathol.2002a;160:1361-9.
2. Abraham SC, Wu TT, Hruban RH, et al.Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway.Am J Pathol.2002b;160:953-62.
3. Abraham SC, Wu TT, Klimstra DC, et al.Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas: frequentalterations in the APC/beta-catenin pathway and chromosome 11p.Am J Pathol.2001;159:1619-27.
4. Hruban RH, Adsay NV, Albores-Saavedra J, et al.Pancreatic intraepithelial neoplasia: a new nomenclature and classi fi cation system for pancreatic duct lesions.Am J Surg Pathol.2001;25:579-86.
5. Hruban RH, Boffetta P, Hiraoka N, et al.Tumours of the pancreas.In: Bosman FT, Carneiro F, Hruban RH, Theise N, editors.WHO classi fi cation of tumours of the digestive system.Lyon, France: International Agency for Research on Cancer; 2010a.p.279-337.
6. Hruban RH, Canto MI, Goggins M, et al.Update on familial pancreatic cancer.Adv Surg.2010b;44:293-311.
7. Hruban RH, Pittman MC, Klimstra DS.AFIP atlas of tumor pathology: tumors of the pancreas.Washington, DC: American Registry of Pathology; 2007.
8. Jiao Y, Shi C, Edil BH, et al.DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.Science.2011;331:1199-203.
9. Jones S, Zhang X, Parsons DW, et al.Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.Science.2008;321:1801-6.
10. Vogelstein B, Kinzler KW.Cancer genes and the pathways they control.Nat Med.2004;10:789-99.
11. Vortmeyer AO, Lubensky IA, Fogt F, et al.Allelic deletion and mutation of the von Hippel-Lindau (VHL) tumor suppressor gene in pancreatic microcystic adenomas.Am J Pathol.1997;151:951-6.
12. Wu J, Jiao Y, Dal Molin M, et al.Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.Proc Natl Acad Sci USA.2011a;108: 1188-93.
13. Wu J, Matthaei H, Maitra A, et al.Recurrent GNAS mutations de fi ne an unexpected pathway for pancreatic cyst development.Sci Transl Med.2011b;3:92ra66.