Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas

American Journal of Surgical Pathology

Volumn 35, Issue 12, 2011, Pages 1812-1817

  Yamaguchi, Hiroshi ^a   Kuboki, Yuko ^a   Hatori, Takashi ^a   Yamamoto, Masakazu ^a   Shiratori, Keiko ^a   Kawamura, Shunji ^a   Kobayashi, Makio ^a   Shimizu, Michio ^a   Ban, Shinichi ^a,b   Koyama, Isamu ^c   Higashi, Morihiro ^c   Shin, Nobuhiro ^c   Ishida, Kazuyuki ^d   Morikawa, Takanori ^e   Motoi, Fuyuhiko ^e   Unno, Michiaki ^e   Kanno, Atsushi ^f   Satoh, Kennichi ^f   Shimosegawa, Tooru ^g   Orikasa, Hideki ^g   Watanabe, Tomoo ^h   Nishimura, Kazuhiko ^h   Harada, Youji ⁱ   Furukawa, Toru ^a   more..

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b Saiseikai Kawaguchi General Hospital   (Japan)

^c SAITAMA MEDICAL UNIVERSITY INTERNATIONAL MEDICAL CENTER   (Japan)

^d SAITAMA MEDICAL UNIVERSITY   (Japan)

^e TOHOKU UNIVERSITY HOSPITAL   (Japan)

^f TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^g Tobu Chiiki Hospital ^*  (Japan)

^h Tokyo Metropolitan Health and Medical Treatment Corporation   (Japan)

ⁱ Toda Chuo General Hospital   (Japan)

Author keywords

AKT; KRAS; pancreatic cancer; phosphatidylinositol 3 kinase; PTEN

Indexed keywords

KRAS PROTEIN, HUMAN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3CA PROTEIN, HUMAN; PROTEIN KINASE B; RAS PROTEIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; ENZYME ACTIVATION; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MIDDLE AGED; MUTATION; NUCLEOTIDE SEQUENCE; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY;

ADULT; AGED; CARCINOMA, PANCREATIC DUCTAL; DNA MUTATIONAL ANALYSIS; ENZYME ACTIVATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; PANCREATIC NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RAS PROTEINS; TUMOR MARKERS, BIOLOGICAL;

EID: 81355160555     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31822769a0     Document Type: Article

References (27)

1. Adams JR, Xu K, Liu JC, et al. Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation. Cancer Res. 2011;71:2706-2717.
2. Adsay NV, Fukushima N, Furukawa T, et al. Intraductal neoplasms of the pancreas. In: Bosman FT, Hruban RH, Carneiro F, et al, eds. WHO Classification of Tumours of the Digestive System. Lyon: IARC; 2010:304-313.
3. Almoguera C, Shibata D, Forrester K, et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988;53:549-554.
4. Bleeker FE, Felicioni L, Buttitta F, et al. AKT1(E17K) in human solid tumours. Oncogene. 2008;27:5648-5650.
5. Calhoun ES, Jones JB, Ashfaq R, et al. BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. Am J Pathol. 2003;163: 1255-1260. (Pubitemid 37175075)
6. Carpten JD, Faber AL, Horn C, et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature. 2007; 448:439-444. (Pubitemid 47123510)
7. Di Nicolantonio F, Arena S, Tabernero J, et al. Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus. J Clin Invest. 2010;120:2858-2866.
8. Engelman JA, Chen L, Tan X, et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med. 2008;14:1351-1356.
9. Esposito I, Bauer A, Hoheisel JD, et al. Microcystic tubulopapillary carcinoma of the pancreas: a new tumor entity? Virchows Arch. 2004;444:447-453. (Pubitemid 38703761)
10. Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med. 2007;356:2271-2281. (Pubitemid 46849157)
11. Kang S, Bader AG, Vogt PK. Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci USA. 2005;102:802-807. (Pubitemid 40282746)
12. Klimstra DS, Adsay NV, Dhall D, et al. Intraductal tubular carcinoma of the pancreas: Clinicopathologic and immunohistochemical analysis of 18 cases. Mod Pathol. 2007;20:285A.
13. Kong D, Suzuki A, Zou TT, et al. PTEN1 is frequently mutated in primary endometrial carcinomas. Nat Genet. 1997;17:143-144.
14. Konigsrainer I, Glatzle J, Kloppel G, et al. Intraductal and cystic tubulopapillary adenocarcinoma of the pancreas: a possible variant of intraductal tubular carcinoma. Pancreas. 2008;36:92-95.
15. Kozaki K, Imoto I, Pimkhaokham A, et al. PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma. Cancer Sci. 2006;97:1351-1358. (Pubitemid 44614987)
16. Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 1997;275:1943-1947. (Pubitemid 27148818)
17. Mizoguchi M, Nutt CL, Mohapatra G, et al. Genetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas. Brain Pathol. 2004;14:372-377. (Pubitemid 39524966)
18. Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet. 2008;372:449-456.
19. Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science. 2004;304:554. (Pubitemid 38541907)
20. Schö nleben F, Qiu W, Ciau NT, et al. PIK3CA mutations in intraductal papillary mucinous neoplasm/carcinoma of the pancreas. Clin Cancer Res. 2006;12:3851-3855. (Pubitemid 44000267)
21. Schö nleben F, Allendorf JD, Qiu W, et al. Mutational analyses of multiple oncogenic pathways in intraductal papillary mucinous neoplasms of the pancreas. Pancreas. 2008;36:168-172.
22. Shayesteh L, Lu Y, Kuo WL, et al. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet. 1999;21:99-102. (Pubitemid 29036292)
23. Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, et al. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res. 2008;68:6084-6091.
24. Tajiri T, Tate G, Inagaki T, et al. Intraductal tubular neoplasms of the pancreas: histogenesis and differentiation. Pancreas. 2005;30:115-121. (Pubitemid 40289449)
25. Xiao HD, Yamaguchi H, Dias-Santagata D, et al. Molecular characteristics and biological behaviors of the oncocytic and pancreatobiliary subtypes of intraductal papillary mucinous neoplasms. J Pathol. Article first published online: 5 MAY 2011 DOI: 10.1002/path.2875
26. Yamaguchi H, Shimizu M, Ban S, et al. Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol. 2009;33:1164-1172.
27. Yanagisawa A, Ohtake K, Ohashi K, et al. Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation. Cancer Res. 1993;53:953-956. (Pubitemid 23087890)