Molecular Analysis of Precursor Lesions in Familial Pancreatic Cancer

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Crnogorac Jurcevic, Tatjana ^a   Chelala, Claude ^a   Barry, Sayka ^a   Harada, Tomohiko ^a   Bhakta, Vipul ^a   Lattimore, Sam ^a   Jurcevic, Stipo ^b   Bronner, Mary ^c   Lemoine, Nicholas R ^a   Brentnall, Teresa A ^d  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CANCER GROWTH; CLINICAL ARTICLE; CONTROLLED STUDY; FAMILIAL CANCER; FEMALE; FROZEN SECTION; GENE CONTROL; GENE IDENTIFICATION; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; MALE; PANCREAS ADENOCARCINOMA; PANCREAS ADENOMA; PANCREAS CANCER; PANCREAS RESECTION; STROMA; TUMOR MICROENVIRONMENT;

ADULT; CARCINOMA; CARCINOMA IN SITU; CLUSTER ANALYSIS; DISEASE PROGRESSION; GENE EXPRESSION PROFILING; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; PANCREATIC NEOPLASMS; PEDIGREE; TUMOR MARKERS, BIOLOGICAL;

EID: 84872809716     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054830     Document Type: Article

References (61)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, et al. (2008) Cancer statistics, 2008. CA Cancer J Clin 58: 71-96.
2. Yachida S, Jones S, Bozic I, Antal T, Leary R, et al. (2010) Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467: 1114-1117.
3. Hruban RH, Adsay NV, Albores-Saavedra J, Compton C, Garrett ES, et al. (2001) Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 25: 579-586.
4. Real FX, Cibrian-Uhalte E, Martinelli P, (2008) Pancreatic cancer development and progression: remodeling the model. Gastroenterology 135: 724-728.
5. Buchholz M, Braun M, Heidenblut A, Kestler HA, Kloppel, G,et al. (2005) Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions. Oncogene 24: 6626-6636.
6. Brentnall TA, Bronner MP, Byrd DR, Haggitt RC, Kimmey MB, (1999) Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancer. Ann Intern Med 131: 247-255.
7. Rulyak SJ, Brentnall TA, (2004) Inherited pancreatic cancer: improvements in our understanding of genetics and screening. Int J Biochem Cell Biol 36: 1386-1392.
8. Lynch HT, Smyrk T, Kern SE, Hruban RH, Lightdale CJ, et al. (1996) Familial pancreatic cancer: a review. Semin Oncol 23: 251-275.
9. Bartsch DK, Gress TM, Langer P, (2012) Familial pancreatic cancer-current knowledge. Nat. Rev. Gastroenterol. Hepatol. 9: 445-453.
10. Evans JP, Burke W, Chen R, Bennett RL, Schmidt RA, et al. (1995) Familial pancreatic adenocarcinoma: association with diabetes and early molecular diagnosis. J Med Genet 32: 330-335.
11. Pogue-Geile KL, Chen R, Bronner MP, Crnogorac-Jurcevic T, Moyes KW, et al. (2006) Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism. PLoS Med 3: e516.
12. Pan S, Chen R, Reimel BA, Crispin DA, Mirzaei H, et al. (2009) Quantitative proteomics investigation of pancreatic intraepithelial neoplasia. Electrophoresis 30: 1132-1144.
13. Meckler KA, Brentnall TA, Haggitt RC, Crispin D, Byrd DR, et al. (2001) Familial fibrocystic pancreatic atrophy with endocrine cell hyperplasia and pancreatic carcinoma. Am J Surg Pathol 25: 1047-1053.
14. Hanahan D, Weinberg RA, (2000) The hallmarks of cancer. Cell 100: 57-70.
15. Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A, (2009) Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30: 1073-1081.
16. Hanahan D, Weinberg RA, (2011) Hallmarks of cancer: The Next Generation. Cell 144: 646-674.
17. Han SB, Moratz C, Huang NN, Kelsall B, Cho H, et al. (2005) Rgs1 and Gnai2 regulate the entrance of B lymphocytes into lymph nodes and B cell motility within lymph node follicles. Immunity 22: 343-354.
18. Schebesta M, Heavey B, Busslinger M, (2002) Transcriptional control of B-cell development. Curr Opin Immunol 14: 216-223.
19. Saadi A, Shannon NB, Lao-Sirieix P, O'Donovan M, Walker E, et al. (2010) Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers. Proc Natl Acad Sci U S A 107: 2177-2182.
20. Sims GP, Rowe DC, Rietdijk ST, Herbst R, Coyle AJ, (2010) HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol 28: 367-388.
21. Tang D, Kang R, Zeh HJ III, Lotze MT, (2010) High-mobility group box 1 and cancer. Biochim Biophys Acta. 1799: 131-140.
22. Chung HW, Lim JB, Jang S, Lee KJ, Park KH, et al. (2012) Serum high mobility group box-1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma. Cancer Science 103 (9): 1714-1721.
23. Crnogorac-Jurcevic T, Missiaglia E, Blaveri E, Gangeswaran R, Jones M, et al. (2003) Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent. J Pathol 201: 63-74.
24. Dowen SE, Crnogorac-Jurcevic T, Gangeswaran R, Hansen M, Eloranta JJ, et al. (2005) Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer. Am J Pathol 166: 81-92.
25. Buchholz M, Kestler HA, Holzmann K, Ellenrieder V, Schneiderhan W, et al. (2005) Transcriptome analysis of human hepatic and pancreatic stellate cells: organ-specific variations of a common transcriptional phenotype. J Mol Med 83: 795-805.
26. Erkan M, Weis N, Pan Z, Schwager C, Samkharadze T, et al. (2010) Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells. Mol Cancer 9: 88.
27. Prasad NB, Biankin AV, Fukushima N, Maitra A, Dhara S, et al. (2005) Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. Cancer Res 65: 1619-1626.
28. Shintani Y, Hollingsworth MA, Wheelock MJ, Johnson KR, (2006) Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression. Cancer Res 66: 11745-11753.
29. Tobita K, Kijima H, Dowaki S, Oida Y, Kashiwagi H, et al. (2002) Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. Int J Oncol 21: 1189-1195.
30. Takeuchi Y, Nakao A, Harada A, Nonami T, Fukatsu T, et al. (1993) Expression of plasminogen activators and their inhibitors in human pancreatic carcinoma: immunohistochemical study. Am J Gastroenterol 88: 1928-1933.
31. Motoyama M, Yamazaki S, Eto-Kimura A, Takeshige K, Muta T, (2005) Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein. J Biol Chem 280: 7444-7451.
32. Shioya M, Andoh A, Kakinoki S, Nishida A, Fujiyama Y, (2008) Interleukin 22 receptor 1 expression in pancreas islets. Pancreas 36: 197-199.
33. Furusato B, Mohamed A, Uhlen M, Rhim JS, (2010) CXCR4 and cancer. Pathol Int 60: 497-505.
34. Marechal R, Demetter P, Nagy N, Berton A, Decaestecker C, et al. (2009) High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinoma. Br J Cancer 100: 1444-1451.
35. Zhang YW, Ding LS, Lai MD, (2003) Reg gene family and human diseases. World J Gastroenterol 9: 2635-2641.
36. Dumartin L, Whiteman HJ, Weeks ME, Hariharan D, Dmitrovic B, et al. (2011) AGR2 is a Novel Surface Antigen that Promotes the Dissemination of Pancreatic Cancer Cells through Regulation of Cathepsins B and D. Cancer Res. 71(22): 7091-102.
37. Arumugam T, Brandt W, Ramachandran V, Moore TT, Wang H, et al. (2011) Trefoil factor 1 stimulates both pancreatic cancer and stellate cells and increases metastasis. Pancreas. 40(6): 815-22.
38. Sommers SC, Murphy SA, Warren S, (1954) Pancreatic duct hyperplasia and cancer. Gastroenterology 27: 629-640.
39. Cubilla AL, Fitzgerald PJ, (1976) Morphological lesions associated with human primary invasive nonendocrine pancreas cancer. Cancer Res 36: 2690-2698.
40. Brat DJ, Lillemoe KD, Yeo CJ, Warfield PB, Hruban RH, (1998) Progression of pancreatic intraductal neoplasias to infiltrating adenocarcinoma of the pancreas. Am J Surg Pathol 22: 163-169.
41. Andea A, Sarkar F, Adsay VN, (2003) Clinicopathological correlates of pancreatic intraepithelial neoplasia: a comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma. Mod Pathol 16: 996-1006.
42. Shi C, Klein AP, Goggins M, Maitra A, Canto M, et al. (2009) Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients. Clin Cancer Res 15: 7737-7743.
43. Zhang L, Sanderson SO, Lloyd RV, Smyrk TC, (2007) Pancreatic intraepithelial neoplasia in heterotopic pancreas: evidence for the progression model of pancreatic ductal adenocarcinoma. Am J Surg Pathol 31: 1191-1195.
44. Baumgart M, Werther M, Bockholt A, Scheurer M, Ruschoff J, et al. (2010) Genomic instability at both the base pair level and the chromosomal level is detectable in earliest PanIN lesions in tissues of chronic pancreatitis. Pancreas 39: 1093-1103.
45. Brune K, Hong SM, Li A, Yachida S, Abe T, et al. (2008) Genetic and epigenetic alterations of familial pancreatic cancers. Cancer Epidemiol Biomarkers Prev 17: 3536-3542.
46. Brune K, Abe T, Canto M, O'Malley L, Klein AP, et al. (2006) Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer. Am J Surg Pathol 30: 1067-1076.
47. Schwartz AM, Henson DE, (2007) Familial and sporadic pancreatic carcinoma, epidemiologic concordance. Am J Surg Pathol 31: 645-646.
48. Iacobuzio-Donahue CA, Ashfaq R, Maitra A, Adsay NV, Shen-Ong GL, et al. (2003) Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res 63: 8614-8622.
49. Yasuda A, Sawai H, Takahashi H, Ochi N, Matsuo Y, et al. (2006) The stem cell factor/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cells. Mol Cancer 5: 46.
50. Esposito I, Menicagli M, Funel N, Bergmann F, Boggi U, et al. (2004) Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma. J Clin Pathol 57: 630-636.
51. Strouch MJ, Cheon EC, Salabat MR, Krantz SB, Gounaris E, et al. (2010) Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression. Clin Cancer Res 16: 2257-2265.
52. Theoharides TC, (2008) Mast cells and pancreatic cancer. N Engl J Med 358: 1860-1861.
53. Ma XJ, Dahiya S, Richardson E, Erlander M, Sgroi DC, (2009) Gene expression profiling of the tumor microenvironment during breast cancer progression. Breast Cancer Res 11: R7.
54. Chu GC, Kimmelman AC, Hezel AF, DePinho RA, (2007) Stromal biology of pancreatic cancer. J Cell Biochem 101: 887-907.
55. Mahadevan D, Von Hoff DD, (2007) Tumor-stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther 6: 1186-1197.
56. Sitek B, Luttges J, Marcus K, Kloppel G, Schmiegel W, et al. (2005) Application of fluorescence difference gel electrophoresis saturation labelling for the analysis of microdissected precursor lesions of pancreatic ductal adenocarcinoma. Proteomics 5: 2665-2679.
57. Haque I, Mehta S, Majumder M, Dhar K, De A, et al. (2011) Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis. Molecular Cancer 10: 8.
58. Stratford JK, Bentrem DJ, Anderson JM, Fan C, Volmar KA, et al. (2010) A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma. PLoS Med 7: e1000307.
59. Cutts RJ, Gadaleta E, Hahn SA, Crnogorac-Jurcevic T, Lemoine NR, et al. (2011) The Pancreatic Expression database: 2011 update. Nucleic Acids Res 39: D1023-1028.
60. Smyth GK, Michaud J, Scott HS, (2005) Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics 21: 2067-2075.
61. Smyth GK, (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article3.