Regulatory Sequences of the Porcine THBD Gene Facilitate Endothelial-Specific Expression of Bioactive Human Thrombomodulin in Single- and Multitransgenic Pigs

Transplantation

Volumn 97, Issue 2, 2014, Pages 138-147

  Wuensch, Annegret ^a   Baehr, Andrea ^a   Bongoni, Anjan K ^b   Kemter, Elisabeth ^a   Blutke, Andreas ^a   Baars, Wiebke ^c   Haertle, Sonja ^a   Zakhartchenko, Valeri ^a   Kurome, Mayuko ^a,d   Kessler, Barbara ^a   Faber, Claudius ^a   Abicht, Jan Michael ^a   Reichart, Bruno ^a   Wanke, Ruediger ^a   Schwinzer, Reinhard ^c   Nagashima, Hiroshi ^d   Rieben, Robert ^b   Ayares, David ^e   Wolf, Eckhard ^a,d   Klymiuk, Nikolai ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d MEIJI UNIVERSITY   (Japan)

^e REVIVICOR INC   (United States)

Author keywords

Coagulation incompatibility; Human thrombomodulin; Thrombomodulin; Transgenic donor pigs; Transgenic donors; Xenotransplantation

Indexed keywords

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, CD31; ANTIGENS, CD46; ENDOTHELIAL CELLS; GENETIC VECTORS; HUMANS; REGULATORY SEQUENCES, NUCLEIC ACID; SWINE; THROMBOMODULIN; TRANSPLANTATION, HETEROLOGOUS;

EID: 84895124188     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3182a95cbc     Document Type: Article

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