First inducible transgene expression in porcine large animal models

FASEB Journal

Volumn 26, Issue 3, 2012, Pages 1086-1099

  Klymiuk, Nikolai ^a   Böcker, Wolfgang ^b   Schönitzer, Veronika ^b   Bähr, Andrea ^a   Radic, Tamara ^b   Fröhlich, Thomas ^a   Wünsch, Annegret ^a   Keßler, Barbara ^a   Kurome, Mayuko ^a   Schilling, Eleonore ^a   Herbach, Nadja ^a   Wanke, Rüdiger ^a   Nagashima, Hiroshi ^c   Mutschler, Wolf ^b   Arnold, Georg J ^a   Schwinzer, Reinhard ^d   Schieker, Matthias ^b   Wolf, Eckhard ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c MEIJI UNIVERSITY   (Japan)

^d HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

CTLA 4Ig; RANKL; Tet on system

Indexed keywords

BETA ACTIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DOXYCYCLINE; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BREEDING; CELL TRANSFER; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOTOXIC T LYMPHOCYTE; DNA RESPONSIVE ELEMENT; GENE EXPRESSION; GENE VECTOR; GENETIC TRANSFECTION; LIMIT OF DETECTION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; PROTEIN BINDING; SOMATIC CELL NUCLEAR TRANSFER; TRANSACTIVATION; TRANSACTIVATOR RESPONSE ELEMENT; TRANSGENIC PIG; TRANSGENICS; TRANSLATION INITIATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANIMALS, NEWBORN; CELLS, CULTURED; CHICKENS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXYCYCLINE; EMBRYO TRANSFER; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION; IMMUNOCONJUGATES; KIDNEY; MALE; MODELS, ANIMAL; OOCYTES; PRIMARY CELL CULTURE; RANK LIGAND; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SWINE; TRANSFECTION; TRANSGENES;

ANIMALIA; SUIDAE; SUS;

EID: 84857730442     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-185041     Document Type: Article

References (30)

1. Aigner, B., Renner, S., Kessler, B., Klymiuk, N., Kurome, M., Wunsch, A., and Wolf, E. (2010) Transgenic pigs as models for translational biomedical research. J. Mol. Med. 88, 653-664
2. Rogers, C. S., Stoltz, D. A., Meyerholz, D. K., Ostedgaard, L. S., Rokhlina, T., Taft, P. J., Rogan, M. P., Pezzulo, A. A., Karp, P. H., Itani, O. A., Kabel, A. C., Wohlford-Lenane, C. L., Davis, G. J., Hanfland, R. A., Smith, T. L., Samuel, M., Wax, D., Murphy, C. N., Rieke, A., Whitworth, K., Uc, A., Starner, T. D., Brogden, K. A., Shilyansky, J., McCray, P. B., Jr., Zabner, J., Prather, R. S., and Welsh, M. J. (2008) Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science 321, 1837-1841
3. Renner, S., Fehlings, C., Herbach, N., Hofmann, A., von Waldthausen, D. C., Kessler, B., Ulrichs, K., Chodnevskaja, I., Moskalenko, V., Amselgruber, W., Goke, B., Pfeifer, A., Wanke, R., and Wolf, E. (2010) Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function. Diabetes 59, 1228-1238
4. Wine, J. J. (2010) The development of lung disease in cystic fibrosis pigs. Sci. Transl. Med. 2, 29ps20
5. Kulkarni, R. N. (2010) GIP: no longer the neglected incretin twin? Sci. Transl. Med. 2, 49ps47
6. Kues, W. A., Schwinzer, R., Wirth, D., Verhoeyen, E., Lemme, E., Herrmann, D., Barg-Kues, B., Hauser, H., Wonigeit, K., and Niemann, H. (2006) Epigenetic silencing and tissue independent expression of a novel tetracycline-inducible system in double-transgenic pigs. FASEB J. 20, 1200-1202
7. Mizuno, A., Kanno, T., Hoshi, M., Shibata, O., Yano, K., Fujise, N., Kinosaki, M., Yamaguchi, K., Tsuda, E., Murakami, A., Yasuda, H., and Higashio, K. (2002) Transgenic mice overexpressing soluble osteoclast differentiation factor (sODF) exhibit severe osteoporosis. J. Bone Miner. Metab. 20, 337-344 (Pubitemid 40645655)
8. Phelps, C. J., Ball, S. F., Vaught, T. D., Vance, A. M., Mendicino, M., Monahan, J. A., Walters, A. H., Wells, K. D., Dandro, A. S., Ramsoondar, J. J., Cooper, D. K., and Ayares, D. L. (2009) Production and characterization of transgenic pigs expressing porcine CTLA4-Ig. Xenotransplantation 16, 477-485
9. Gossen, M., and Bujard, H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. U. S. A. 89, 5547-5551
10. Saunders, T. L. (2011) Inducible transgenic mouse models. Methods Mol. Biol. 693, 103-115
11. Matsuda, T., and Cepko, C. L. (2004) Electroporation and RNA interference in the rodent retina in vivo and in vitro. Proc. Natl. Acad. Sci. U. S. A. 101, 16-22 (Pubitemid 38084195)
12. Tybulewicz, V. L., Crawford, C. E., Jackson, P. K., Bronson, R. T., and Mulligan, R. C. (1991) Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65, 1153-1163 (Pubitemid 121001329)
13. Liu, P., Jenkins, N. A., and Copeland, N. G. (2003) A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res. 13, 476-484 (Pubitemid 36395405)
14. Larsen, C. P., Pearson, T. C., Adams, A. B., Tso, P., Shirasugi, N., Strobert, E., Anderson, D., Cowan, S., Price, K., Naemura, J., Emswiler, J., Greene, J., Turk, L. A., Bajorath, J., Townsend, R., Hagerty, D., Linsley, P. S., and Peach, R. J. (2005) Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am. J. Transplant. 5, 443-453 (Pubitemid 40313335)
15. Kurome, M., Ueda, H., Tomii, R., Naruse, K., and Nagashima, H. (2006) Production of transgenic-clone pigs by the combination of ICSI-mediated gene transfer with somatic cell nuclear transfer. Transgenic Res. 15, 229-240
16. Yin, X. J., Tani, T., Yonemura, I., Kawakami, M., Miyamoto, K., Hasegawa, R., Kato, Y., and Tsunoda, Y. (2002) Production of cloned pigs from adult somatic cells by chemically assisted removal of maternal chromosomes. Biol. Reprod. 67, 442-446 (Pubitemid 34803927)
17. Besenfelder, U., Modl, J., Muller, M., and Brem, G. (1997) Endoscopic embryo collection and embryo transfer into the oviduct and the uterus of pigs. Theriogenology 47, 1051-1060 (Pubitemid 28137066)
18. Ching, S., Zhang, H., Belevych, N., He, L., Lai, W., Pu, X. A., Jaeger, L. B., Chen, Q., and Quan, N. (2007) Endothelialspecific knockdown of interleukin-1 (IL-1) type 1 receptor differentially alters CNS responses to IL-1 depending on its route of administration. J. Neurosci. 27, 10476-10486 (Pubitemid 47502007)
19. Lange, V., Picotti, P., Domon, B., and Aebersold, R. (2008) Selected reaction monitoring for quantitative proteomics: a tutorial. Mol. Syst. Biol. 4, 222
20. Frohlich, T., and Arnold, G. J. (2011) Quantifying attomole amounts of proteins from complex samples by nano-LC and selected reaction monitoring. Methods Mol. Biol. 790, 141-164
21. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254
22. Plege, A., Borns, K., Baars, W., and Schwinzer, R. (2009) Suppression of human T-cell activation and expansion of regulatory T cells by pig cells overexpressing PD-ligands. Transplantation 87, 975-982
23. Meier, C., Meinhardt, U., Greenfield, J. R., De Winter, J., Nguyen, T. V., Dunstan, C. R., and Seibel, M. J. (2006) Serum cathepsin K concentrations reflect osteoclastic activity in women with postmenopausal osteoporosis and patients with Paget's disease. Clin. Lab. 52, 1-10 (Pubitemid 43245859)
24. Shearwin, K. E., Callen, B. P., and Egan, J. B. (2005) Transcriptional interference - a crash course. Trends Genet. 21, 339-345 (Pubitemid 40726391)
25. Wilmut, I., Schnieke, A. E., McWhir, J., Kind, A. J., and Campbell, K. H. (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385, 810-813 (Pubitemid 27106068)
26. Lacey, D. L., Timms, E., Tan, H. L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., Hsu, H., Sullivan, J., Hawkins, N., Davy, E., Capparelli, C., Eli, A., Qian, Y. X., Kaufman, S., Sarosi, I., Shalhoub, V., Senaldi, G., Guo, J., Delaney, J., and Boyle, W. J. (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93, 165-176 (Pubitemid 28180851)
27. Uemura, H., Yasui, T., Miyatani, Y., Yamada, M., Hiyoshi, M., Arisawa, K., and Irahara, M. (2008) Circulating profiles of osteoprotegerin and soluble receptor activator of nuclear factor-κB ligand in post-menopausal women. J. Endocrinol. Invest. 31, 163-168 (Pubitemid 351596978)
28. Kendler, D. L., Roux, C., Benhamou, C. L., Brown, J. P., Lillestol, M., Siddhanti, S., Man, H. S., San Martin, J., and Bone, H. G. (2010) Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy. J. Bone Miner. Res. 25, 72-81
29. Dennison, E., and Cooper, C. (2000) Epidemiology of osteoporotic fractures. Horm. Res. 54(Suppl. 1), 58-63 (Pubitemid 32037589)
30. Pearce, A. I., Richards, R. G., Milz, S., Schneider, E., and Pearce, S. G. (2007) Animal models for implant biomaterial research in bone: a review. Eur. Cell. Mater. 13, 1-10 (Pubitemid 46890447)