Towards endothelial cell-specific transgene expression in pigs: Characterization of the pig ICAM-2 promoter

Xenotransplantation

Volumn 13, Issue 6, 2006, Pages 514-521

  Godwin, James W ^a   Fisicaro, Nella ^a   D'Apice, Anthony J F ^a   Cowan, Peter J ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b Immunology Research Centre   (Australia)

Author keywords

Endothelial cell; Promoter; Swine; Transgenic

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 2; OCTAMER TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR GATA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SPECIFICITY; ENDOTHELIUM CELL; ENHANCER REGION; EXPRESSION VECTOR; GENE DELETION; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; INTRON; MOLECULAR CLONING; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REGULATOR GENE; REPORTER GENE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; SPECIES COMPARISON; TRANSGENE; TRANSPLANTATION;

ANIMALS; BASE SEQUENCE; CELL ADHESION MOLECULES; CELL LINE; CERCOPITHECUS AETHIOPS; ENDOTHELIAL CELLS; HUMANS; INTRONS; MOLECULAR SEQUENCE DATA; MUTATION; PROMOTER REGIONS (GENETICS); PROMOTER REGIONS, GENETIC; SWINE; TRANSGENES;

EID: 33750040231     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2006.00341.x     Document Type: Article

References (27)

1. COWAN PJ, AMINIAN A, BARLOW H et al. Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons. Transplantation 2000; 69: 2504.
2. COZZI E, BHATTI F, SCHMOECKEL M et al. Long-term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts. Transplantation 2000; 70: 15.
3. MCGREGOR CG, DAVIES WR, OI K et al. Cardiac xenotransplantation: recent preclinical progress with 3-month median survival. J Thorac Cardiovasc Surg 2005; 130: 844.
4. YAMADA K, YAZAWA K, SHIMIZU A et al. Marked prolongation of porcine renal xenograft survival in baboons through the use of a1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nature Med 2005; 11: 32.
5. KUWAKI K, TSENG YL, DOR FJ et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 2005; 11: 29.
6. CHEN D, WEBER M, MCVEY JH et al. Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium. Am J Transplant 2004; 4: 1958.
7. COWAN PJ, SOMERVILLE CA, SHINKEL TA et al. High-level endothelial expression of human CD59 prolongs heart function in an ex vivo model of xenograft rejection. Transplantation 1998; 65: 826.
8. SUN H, CHEN G, LIU W et al. The influence of baseline expression of human decay accelerating factor transgene on graft survival and acute humoral xenograft rejection. Transplantation 2005; 80: 1331.
9. COZZI E, TUCKER AW, LANGFORD GA et al. Characterization of pigs transgenic for human decay-accelerating factor. Transplantation 1997; 64: 1383.
10. BYRNE G, MCCURRY KR, MARTIN MJ et al. Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage. Transplantation 1997; 63: 149.
11. LOVELAND BE, MILLAND J, KYRIAKOU P et al. Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons. Xenotransplantation 2004; 11: 171.
12. COWAN PJ, TSANG D, PEDIC CM et al. The human ICAM-2 promoter is endothelial cell-specific in vitro and in vivo and contains critical Sp1 and GATA binding sites. J Biol Chem 1998; 273: 11737.
13. DE FOUGEROLLES AR, STACKER SA, SCHWARTING R, SPRINGER TA. Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1. J Exp Med 1991; 174: 253.
14. GODWIN JW, D'APICE AJ, COWAN PJ. Characterization of pig intercellular adhesion molecule-2 and its interaction with human LFA-1. Am J Transplant 2004; 4: 515.
15. SCHLAEGER TM, BARTUNKOVA S, LAWITTS JA et al. Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice. Proc Natl Acad Sci U S A 1997; 94: 3058.
16. HISATSUNE H, MATSUMURA K, OGAWA M et al. High level of endothelial cell-specific gene expression by a combination of the 5′ flanking region and the 5′ half of the first intron of the VE-cadherin gene. Blood 2005; 105: 4657.
17. FISH JE, MARSDEN PA. Endothelial nitric oxide synthase: insight into cell-specific gene regulation in the vascular endothelium. Cell Mol Life Sci 2006; 63: 144.
18. WEIS L, REINBERG D. Transcription by RNA polymerase II: initiator-directed formation of transcription-competent complexes. FASEB J 1992; 6: 3300.
19. ILJIN K, DUBE A, KONTUSAARI S et al. Role of Ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter. FASEB J 1999; 13: 377.
20. KAPPEL A, RONICKE V, DAMERT A et al. Identification of vascular endothelial growth factor (VEGF) receptor-2 (Flk-1) promoter/enhancer sequences sufficient for angioblast and endothelial cell specific transcription in transgenic mice. Blood 1999; 93: 4284.
21. PAN JL, MCEVER RP. Characterization of the promoter for the human P-selectin gene. J Biol Chem 1993; 268: 22600.
22. ZHANG R, MIN W, SESSA WC. Functional analysis of the human endothelial nitric oxide synthase promoter - SP1 and GATA factors are necessary for basal transcription in endothelial cells. J Biol Chem 1995; 270: 15320.
23. MCLAUGHLIN F, LUDBROOK VJ, KOLA I, CAMPBELL CJ, RANDI AM. Characterisation of the tumour necrosis factor (TNF)-α response elements in the human ICAM-2 promoter. J Cell Sci 1999; 112: 4695.
24. DEL VECCHIO I, AZZALIN A, GUIDI E et al. Functional mapping of the bovine Doppel gene promoter region. Gene 2005; 356: 101.
25. COWAN PJ, SHINKEL TA, FISICARO N et al. Targeting gene expression to endothelium in transgenic animals: a comparison of the human ICAM-2, PECAM-1 and endoglin promoters. Xenotransplantation 2003; 10: 223.
26. KO LJ, ENGEL JD. DNA-binding specificities of the GATA transcription factor family. Mol Cell Biol 1993: 13: 4011.
27. OGATA K, SATO K, TAHIROV TH. Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar. Curr Opin Struct Biol 2003; 13: 40.