Species-specific transcription in mice carrying human chromosome 21

Science

Volumn 322, Issue 5900, 2008, Pages 434-438

  Wilson, Michael D ^a   Barbosa Morais, Nuno L ^a,b   Schmidt, Dominic ^a,b   Conboy, Caitlin M ^c   Vanes, Lesley ^d   Tybulewicz, Victor L J ^d   Fisher, Elizabeth M C ^e   Tavaré, Simon ^a,b,f   Odom, Duncan T ^a,b  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b HUTCHISON MRC RESEARCH CENTRE   (United Kingdom)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

CHROMOSOME; GENE EXPRESSION; RODENT;

ANEUPLOIDY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL NUCLEUS; CHROMOSOME 21; EPIGENETICS; GENE EXPRESSION; GENE SEQUENCE; HUMAN; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPECIES DIFFERENCE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; CELL NUCLEUS; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOMES, HUMAN, PAIR 21; DISEASE MODELS, ANIMAL; DOWN SYNDROME; GENE EXPRESSION REGULATION; HEPATOCYTE NUCLEAR FACTORS; HEPATOCYTES; HISTONES; HUMANS; METHYLATION; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REGULATORY SEQUENCES, NUCLEIC ACID; SPECIES SPECIFICITY; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC;

MUS;

EID: 54249099196     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1160930     Document Type: Article

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31. We are grateful to E. Jacobsen, R. Stark, I. Spiteri, B. Liu, J. Marioni, A. Lynch, J. Hadfield, N. Matthews, the Cambridge Research Institute (CRI) Genomics Core, CRI Bioinformatics Core, and Camgrid for technical assistance, and B. Gottgens and J. Ferrer for insightful advice. Supported by the European Research Council (D.T.O.); Royal Society Wolfson Research Merit Award (S.T.); Hutchison Whampoa (D.T.O., ST); Medical Research Council (E.F., VT); Wellcome Trust (E.F., V.T.); University of Cambridge (D.T.O., D.S., N.B.M., S.T.); and Cancer Research U.K. (D.T.O., M.D.W., N.B.M., S.T., D.S.). Data deposited under ArrayExpress accession numbers E-TABM-473 and E-TABM-474. M.D.W., N.B.M., D.S., D.T.O., and C.M.C. designed and performed experiments; N.B.M., M.D.W., and D.S. analyzed the data; L.V., V.T., M.D.W., and E.F. created, prepared, and provided Tc1 mouse tissues; and M.D.W., N.B.M., D.T.O., and S.T. wrote the manuscript. D.T.O. oversaw the work. The authors declare no competing interests.