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Volumn 13, Issue 1, 2014, Pages 11-20

Dynamic regulation of mitochondrial genome maintenance in germ cells

Author keywords

Bottleneck; Maternal inheritance; Mitochondrial DNA; Nucleoid; TFAM

Indexed keywords

MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A;

EID: 84895072434     PISSN: 14455781     EISSN: 14470578     Source Type: Journal    
DOI: 10.1007/s12522-013-0162-0     Document Type: Review
Times cited : (10)

References (101)
  • 1
    • 0013957553 scopus 로고
    • The circularity of mitochondrial DNA
    • 1:CAS:528:DyaF2sXlt1enuw%3D%3D 5230148 10.1073/pnas.56.4.1215
    • Nass MM. The circularity of mitochondrial DNA. Proc Natl Acad Sci USA. 1966;56:1215-22.
    • (1966) Proc Natl Acad Sci USA , vol.56 , pp. 1215-1222
    • Nass, M.M.1
  • 2
    • 77953359014 scopus 로고    scopus 로고
    • Does mtDNA nucleoid organization impact aging?
    • 1:CAS:528:DC%2BC3cXmslGjt7o%3D 2879461 20004238 10.1016/j.exger.2009.12. 002
    • Bogenhagen DF. Does mtDNA nucleoid organization impact aging? Exp Gerontol. 2010;45:473-7.
    • (2010) Exp Gerontol , vol.45 , pp. 473-477
    • Bogenhagen, D.F.1
  • 3
    • 78650821495 scopus 로고    scopus 로고
    • Germ-line mitochondria exhibit suppressed respiratory activity to support their accurate transmission to the next generation
    • 1:CAS:528:DC%2BC3MXkt1Gitw%3D%3D 21112323 10.1016/j.ydbio.2010.11.021
    • Kogo N, Tazaki A, Kashino Y, Morichika K, Orii H, Mochii M, et al. Germ-line mitochondria exhibit suppressed respiratory activity to support their accurate transmission to the next generation. Dev Biol. 2011;349:462-9.
    • (2011) Dev Biol. , vol.349 , pp. 462-469
    • Kogo, N.1    Tazaki, A.2    Kashino, Y.3    Morichika, K.4    Orii, H.5    Mochii, M.6
  • 4
    • 24344481280 scopus 로고    scopus 로고
    • Role of mitochondrial ribosome-dependent translation in germline formation in Drosophila embryos
    • 1:CAS:528:DC%2BD2MXpvFemtrY%3D 16125913 10.1016/j.mod.2005.06.003
    • Amikura R, Sato K, Kobayashi S. Role of mitochondrial ribosome-dependent translation in germline formation in Drosophila embryos. Mech Dev. 2005;122:1087-93.
    • (2005) Mech Dev , vol.122 , pp. 1087-1093
    • Amikura, R.1    Sato, K.2    Kobayashi, S.3
  • 5
    • 84861197034 scopus 로고    scopus 로고
    • The importance of mitochondrial metabolic activity and mitochondrial DNA replication during oocyte maturation in vitro on oocyte quality and subsequent embryo developmental competence
    • 1:CAS:528:DC%2BC38XlsFygu78%3D 22467220 10.1002/mrd.22042
    • Ge H, Tollner TL, Hu Z, Dai M, Li X, Guan H, et al. The importance of mitochondrial metabolic activity and mitochondrial DNA replication during oocyte maturation in vitro on oocyte quality and subsequent embryo developmental competence. Mol Reprod Dev. 2012;79:392-401.
    • (2012) Mol Reprod Dev , vol.79 , pp. 392-401
    • Ge, H.1    Tollner, T.L.2    Hu, Z.3    Dai, M.4    Li, X.5    Guan, H.6
  • 7
    • 79961207245 scopus 로고    scopus 로고
    • Mitochondrial function in the human oocyte and embryo and their role in developmental competence
    • 20933103 10.1016/j.mito.2010.09.012 1:CAS:528:DC%2BC3MXhtVWrsrzM
    • Van Blerkom J. Mitochondrial function in the human oocyte and embryo and their role in developmental competence. Mitochondrion. 2011;11:797-813.
    • (2011) Mitochondrion , vol.11 , pp. 797-813
    • Van Blerkom, J.1
  • 8
    • 84873088209 scopus 로고    scopus 로고
    • Towards germline gene therapy of inherited mitochondrial diseases
    • 1:CAS:528:DC%2BC38XhsFOmtL3P 3561483 23103867 10.1038/nature11647
    • Tachibana M, Amato P, Sparman M, Woodward J, Sanchis DM, Ma H, et al. Towards germline gene therapy of inherited mitochondrial diseases. Nature. 2013;493:627-31.
    • (2013) Nature , vol.493 , pp. 627-631
    • Tachibana, M.1    Amato, P.2    Sparman, M.3    Woodward, J.4    Sanchis, D.M.5    Ma, H.6
  • 9
    • 84871878032 scopus 로고    scopus 로고
    • The aging oocyte - Can mitochondrial function be improved?
    • 1:CAS:528:DC%2BC3sXhtVGkug%3D%3D 23273985 10.1016/j.fertnstert.2012.11. 031
    • Bentov Y, Casper RF. The aging oocyte - can mitochondrial function be improved? Fertil Steril. 2013;99:18-22.
    • (2013) Fertil Steril , vol.99 , pp. 18-22
    • Bentov, Y.1    Casper, R.F.2
  • 10
    • 84867522393 scopus 로고    scopus 로고
    • Heteroplasmy of mouse mtDNA is genetically unstable and results in altered behavior and cognition
    • 1:CAS:528:DC%2BC38XhsV2qtLjK 23063123 10.1016/j.cell.2012.09.004
    • Sharpley MS, Marciniak C, Eckel-Mahan K, McManus M, Crimi M, Waymire K, et al. Heteroplasmy of mouse mtDNA is genetically unstable and results in altered behavior and cognition. Cell. 2012;151:333-43.
    • (2012) Cell , vol.151 , pp. 333-343
    • Sharpley, M.S.1    Marciniak, C.2    Eckel-Mahan, K.3    McManus, M.4    Crimi, M.5    Waymire, K.6
  • 11
    • 0030447980 scopus 로고    scopus 로고
    • Misconceptions about mitochondria and mammalian fertilization: Implications for theories on human evolution
    • 1:CAS:528:DyaK28Xnt1Gmu7g%3D 8943026 10.1073/pnas.93.24.13859
    • Ankel-Simons F, Cummins JM. Misconceptions about mitochondria and mammalian fertilization: implications for theories on human evolution. Proc Natl Acad Sci USA. 1996;93:13859-63.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13859-13863
    • Ankel-Simons, F.1    Cummins, J.M.2
  • 12
    • 0021416818 scopus 로고
    • Maternal inheritance of the mouse mitochondrial genome is not mediated by a loss or gross alteration of the paternal mitochondrial DNA or by methylation of the oocyte mitochondrial DNA
    • 1:CAS:528:DyaL2cXktVCmtb0%3D 6323235 10.1016/0012-1606(84)90210-0
    • Hecht NB, Liem H, Kleene KC, Distel RJ, Ho SM. Maternal inheritance of the mouse mitochondrial genome is not mediated by a loss or gross alteration of the paternal mitochondrial DNA or by methylation of the oocyte mitochondrial DNA. Dev Biol. 1984;102:452-61.
    • (1984) Dev Biol , vol.102 , pp. 452-461
    • Hecht, N.B.1    Liem, H.2    Kleene, K.C.3    Distel, R.J.4    Ho, S.M.5
  • 13
    • 77954206550 scopus 로고    scopus 로고
    • The role of mitochondrial DNA copy number in mammalian fertility
    • 1:CAS:528:DC%2BC3cXotlWqtLo%3D 20130269 10.1095/biolreprod.109.080887
    • Wai T, Ao A, Zhang X, Cyr D, Dufort D, Shoubridge EA. The role of mitochondrial DNA copy number in mammalian fertility. Biol Reprod. 2010;83:52-62.
    • (2010) Biol Reprod , vol.83 , pp. 52-62
    • Wai, T.1    Ao, A.2    Zhang, X.3    Cyr, D.4    Dufort, D.5    Shoubridge, E.A.6
  • 14
    • 0029610067 scopus 로고
    • Uniparental inheritance of mitochondrial and chloroplast genes: Mechanisms and evolution
    • 1:CAS:528:DyaK2MXpvVOgt7s%3D 8524780 10.1073/pnas.92.25.11331
    • Birky CW Jr. Uniparental inheritance of mitochondrial and chloroplast genes: mechanisms and evolution. Proc Natl Acad Sci USA. 1995;92:11331-8.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11331-11338
    • Birky, Jr.C.W.1
  • 15
    • 0033607266 scopus 로고    scopus 로고
    • The active digestion of uniparental chloroplast DNA in a single zygote of Chlamydomonas reinhardtii is revealed by using the optical tweezer
    • 1:CAS:528:DyaK1MXnt1yqsrs%3D 10535964 10.1073/pnas.96.22.12577
    • Nishimura Y, Misumi O, Matsunaga S, Higashiyama T, Yokota A, Kuroiwa T. The active digestion of uniparental chloroplast DNA in a single zygote of Chlamydomonas reinhardtii is revealed by using the optical tweezer. Proc Natl Acad Sci USA. 1999;96:12577-82.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12577-12582
    • Nishimura, Y.1    Misumi, O.2    Matsunaga, S.3    Higashiyama, T.4    Yokota, A.5    Kuroiwa, T.6
  • 16
    • 0031040867 scopus 로고    scopus 로고
    • Down-regulation of mitochondrial transcription factor A during spermatogenesis in humans
    • 1:CAS:528:DyaK2sXht1ajtb8%3D 9063738 10.1093/hmg/6.2.185
    • Larsson NG, Oldfors A, Garman JD, Barsh GS, Clayton DA. Down-regulation of mitochondrial transcription factor A during spermatogenesis in humans. Hum Mol Genet. 1997;6:185-91.
    • (1997) Hum Mol Genet , vol.6 , pp. 185-191
    • Larsson, N.G.1    Oldfors, A.2    Garman, J.D.3    Barsh, G.S.4    Clayton, D.A.5
  • 17
    • 0034807201 scopus 로고    scopus 로고
    • Downregulation of Tfam and mtDNA copy number during mammalian spermatogenesis
    • 1:CAS:528:DC%2BD3MXnvVCrsbY%3D 11668394 10.1007/s00335-001-2052-8
    • Rantanen A, Jansson M, Oldfors A, Larsson NG. Downregulation of Tfam and mtDNA copy number during mammalian spermatogenesis. Mamm Genome. 2001;12:787-92.
    • (2001) Mamm Genome , vol.12 , pp. 787-792
    • Rantanen, A.1    Jansson, M.2    Oldfors, A.3    Larsson, N.G.4
  • 18
    • 31944444556 scopus 로고    scopus 로고
    • Active digestion of sperm mitochondrial DNA in single living sperm revealed by optical tweezers
    • 1:CAS:528:DC%2BD28Xhs1Gnsr4%3D 16432229 10.1073/pnas.0506911103
    • Nishimura Y, Yoshinari T, Naruse K, Yamada T, Sumi K, Mitani H, et al. Active digestion of sperm mitochondrial DNA in single living sperm revealed by optical tweezers. Proc Natl Acad Sci USA. 2006;103:1382-7.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1382-1387
    • Nishimura, Y.1    Yoshinari, T.2    Naruse, K.3    Yamada, T.4    Sumi, K.5    Mitani, H.6
  • 19
    • 84858200622 scopus 로고    scopus 로고
    • Barriers to male transmission of mitochondrial DNA in sperm development
    • 1:CAS:528:DC%2BC38XjslertLk%3D 3306594 22421049 10.1016/j.devcel.2011.12. 021
    • DeLuca SZ, O'Farrell PH. Barriers to male transmission of mitochondrial DNA in sperm development. Dev Cell. 2012;22:660-8.
    • (2012) Dev Cell , vol.22 , pp. 660-668
    • Deluca, S.Z.1    O'Farrell, P.H.2
  • 20
    • 0029076820 scopus 로고
    • Elimination of paternal mitochondrial DNA in intraspecific crosses during early mouse embryogenesis
    • 1:CAS:528:DyaK2MXls1aksbw%3D 7753839 10.1073/pnas.92.10.4542
    • Kaneda H, Hayashi J, Takahama S, Taya C, Lindahl KF, Yonekawa H. Elimination of paternal mitochondrial DNA in intraspecific crosses during early mouse embryogenesis. Proc Natl Acad Sci USA. 1995;92:4542-6.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4542-4546
    • Kaneda, H.1    Hayashi, J.2    Takahama, S.3    Taya, C.4    Lindahl, K.F.5    Yonekawa, H.6
  • 21
    • 0033766565 scopus 로고    scopus 로고
    • Selective and continuous elimination of mitochondria microinjected into mouse eggs from spermatids, but not from liver cells, occurs throughout embryogenesis
    • 1:CAS:528:DC%2BD3cXosFSntrw%3D 11063701
    • Shitara H, Kaneda H, Sato A, Inoue K, Ogura A, Yonekawa H, et al. Selective and continuous elimination of mitochondria microinjected into mouse eggs from spermatids, but not from liver cells, occurs throughout embryogenesis. Genetics. 2000;156:1277-84.
    • (2000) Genetics , vol.156 , pp. 1277-1284
    • Shitara, H.1    Kaneda, H.2    Sato, A.3    Inoue, K.4    Ogura, A.5    Yonekawa, H.6
  • 22
    • 0031887129 scopus 로고    scopus 로고
    • Maternal inheritance of mouse mtDNA in interspecific hybrids: Segregation of the leaked paternal mtDNA followed by the prevention of subsequent paternal leakage
    • 1:CAS:528:DyaK1cXks1eisbY%3D 9504930
    • Shitara H, Hayashi JI, Takahama S, Kaneda H, Yonekawa H. Maternal inheritance of mouse mtDNA in interspecific hybrids: segregation of the leaked paternal mtDNA followed by the prevention of subsequent paternal leakage. Genetics. 1998;148:851-7.
    • (1998) Genetics , vol.148 , pp. 851-857
    • Shitara, H.1    Hayashi, J.I.2    Takahama, S.3    Kaneda, H.4    Yonekawa, H.5
  • 23
    • 0021869570 scopus 로고
    • Morphogenesis and fate of the residual body in human spermiogenesis
    • 1:STN:280:DyaL2M3gtFKisw%3D%3D 3995554 10.1007/BF00222339
    • Breucker H, Schafer E, Holstein AF. Morphogenesis and fate of the residual body in human spermiogenesis. Cell Tissue Res. 1985;240:303-9.
    • (1985) Cell Tissue Res , vol.240 , pp. 303-309
    • Breucker, H.1    Schafer, E.2    Holstein, A.F.3
  • 25
    • 51449114031 scopus 로고    scopus 로고
    • Expression of mitochondrial transcription factor A (TFAM) during porcine gametogenesis and preimplantation embryo development
    • 1:CAS:528:DC%2BD1cXht1elt7%2FI 18636550 10.1002/jcp.21528
    • Antelman J, Manandhar G, Yi YJ, Li R, Whitworth KM, Sutovsky M, et al. Expression of mitochondrial transcription factor A (TFAM) during porcine gametogenesis and preimplantation embryo development. J Cell Physiol. 2008;217:529-43.
    • (2008) J Cell Physiol , vol.217 , pp. 529-543
    • Antelman, J.1    Manandhar, G.2    Yi, Y.J.3    Li, R.4    Whitworth, K.M.5    Sutovsky, M.6
  • 26
    • 0037774827 scopus 로고    scopus 로고
    • Ubiquitination of prohibitin in mammalian sperm mitochondria: Possible roles in the regulation of mitochondrial inheritance and sperm quality control
    • 1:CAS:528:DC%2BD3sXkvFCntb4%3D 12646488 10.1095/biolreprod.102.010975
    • Thompson WE, Ramalho-Santos J, Sutovsky P. Ubiquitination of prohibitin in mammalian sperm mitochondria: possible roles in the regulation of mitochondrial inheritance and sperm quality control. Biol Reprod. 2003;69:254-60.
    • (2003) Biol Reprod , vol.69 , pp. 254-260
    • Thompson, W.E.1    Ramalho-Santos, J.2    Sutovsky, P.3
  • 27
    • 82255183165 scopus 로고    scopus 로고
    • Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission
    • 1:CAS:528:DC%2BC3MXhsV2mu7jO 22033522 10.1126/science.1211878
    • Al Rawi S, Louvet-Vallee S, Djeddi A, Sachse M, Culetto E, Hajjar C, et al. Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission. Science. 2011;334:1144-7.
    • (2011) Science. , vol.334 , pp. 1144-1147
    • Al Rawi, S.1    Louvet-Vallee, S.2    Djeddi, A.3    Sachse, M.4    Culetto, E.5    Hajjar, C.6
  • 28
    • 82255192465 scopus 로고    scopus 로고
    • Degradation of paternal mitochondria by fertilization-triggered autophagy in C. Elegans embryos
    • 1:CAS:528:DC%2BC3MXhsV2mu7jN 21998252 10.1126/science.1210333
    • Sato M, Sato K. Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans embryos. Science. 2011;334:1141-4.
    • (2011) Science , vol.334 , pp. 1141-1144
    • Sato, M.1    Sato, K.2
  • 29
    • 82655187112 scopus 로고    scopus 로고
    • Elimination of paternal mitochondria through the lysosomal degradation pathway in C. Elegans
    • 1:CAS:528:DC%2BC3MXhsFKms7bF 22105480 10.1038/cr.2011.182
    • Zhou Q, Li H, Xue D. Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans. Cell Res. 2011;21:1662-9.
    • (2011) Cell Res , vol.21 , pp. 1662-1669
    • Zhou, Q.1    Li, H.2    Xue, D.3
  • 30
    • 3242839663 scopus 로고
    • Unequal partitioning of bovine mitochondrial genotypes among siblings
    • 1:CAS:528:DyaL1MXitVWi 2460862 10.1073/pnas.85.21.8107
    • Laipis PJ, Van de Walle MJ, Hauswirth WW. Unequal partitioning of bovine mitochondrial genotypes among siblings. Proc Natl Acad Sci USA. 1988;85:8107-10.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 8107-8110
    • Laipis, P.J.1    Van De Walle, M.J.2    Hauswirth, W.W.3
  • 31
    • 0024425725 scopus 로고
    • Rapid segregation of heteroplasmic bovine mitochondria
    • 1:CAS:528:DyaL1MXmtFanuro%3D 334812 2798094 10.1093/nar/17.18.7325
    • Ashley MV, Laipis PJ, Hauswirth WW. Rapid segregation of heteroplasmic bovine mitochondria. Nucleic Acids Res. 1989;17:7325-31.
    • (1989) Nucleic Acids Res , vol.17 , pp. 7325-7331
    • Ashley, M.V.1    Laipis, P.J.2    Hauswirth, W.W.3
  • 32
    • 0030910828 scopus 로고    scopus 로고
    • Skewed segregation of the mtDNA nt 8993 (T - >g) mutation in human oocytes
    • 1:CAS:528:DyaK2sXktlOquro%3D 1716104 9199572 10.1086/515453
    • Blok RB, Gook DA, Thorburn DR, Dahl HH. Skewed segregation of the mtDNA nt 8993 (T - >G) mutation in human oocytes. Am J Hum Genet. 1997;60:1495-501.
    • (1997) Am J Hum Genet , vol.60 , pp. 1495-1501
    • Blok, R.B.1    Gook, D.A.2    Thorburn, D.R.3    Dahl, H.H.4
  • 33
    • 0026620865 scopus 로고
    • Segregation and manifestations of the mtDNA tRNA(Lys) A - >g(8344) mutation of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome
    • 1:CAS:528:DyaK3sXitlWmurY%3D 1682923 1463006
    • Larsson NG, Tulinius MH, Holme E, Oldfors A, Andersen O, Wahlstrom J, et al. Segregation and manifestations of the mtDNA tRNA(Lys) A - >G(8344) mutation of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am J Hum Genet. 1992;51:1201-12.
    • (1992) Am J Hum Genet , vol.51 , pp. 1201-1212
    • Larsson, N.G.1    Tulinius, M.H.2    Holme, E.3    Oldfors, A.4    Andersen, O.5    Wahlstrom, J.6
  • 34
    • 0021028363 scopus 로고
    • Nucleotide sequence evidence for rapid genotypic shifts in the bovine mitochondrial DNA D-loop
    • 1:CAS:528:DyaL2cXjtVentw%3D%3D 6646218 10.1038/306400a0
    • Olivo PD, Van de Walle MJ, Laipis PJ, Hauswirth WW. Nucleotide sequence evidence for rapid genotypic shifts in the bovine mitochondrial DNA D-loop. Nature. 1983;306:400-2.
    • (1983) Nature , vol.306 , pp. 400-402
    • Olivo, P.D.1    Van De Walle, M.J.2    Laipis, P.J.3    Hauswirth, W.W.4
  • 35
    • 38649091334 scopus 로고    scopus 로고
    • A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes
    • 1:CAS:528:DC%2BD1cXhsVSjsbs%3D 18223651 10.1038/ng.2007.63
    • Cree LM, Samuels DC, de Sousa Lopes SC, Rajasimha HK, Wonnapinij P, Mann JR, et al. A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes. Nat Genet. 2008;40:249-54.
    • (2008) Nat Genet. , vol.40 , pp. 249-254
    • Cree, L.M.1    Samuels, D.C.2    De Sousa Lopes, S.C.3    Rajasimha, H.K.4    Wonnapinij, P.5    Mann, J.R.6
  • 36
    • 56749180593 scopus 로고    scopus 로고
    • The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes
    • 1:CAS:528:DC%2BD1cXhsVWhu7nJ 19029901 10.1038/ng.258
    • Wai T, Teoli D, Shoubridge EA. The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes. Nat Genet. 2008;40:1484-8.
    • (2008) Nat Genet , vol.40 , pp. 1484-1488
    • Wai, T.1    Teoli, D.2    Shoubridge, E.A.3
  • 37
    • 33847248347 scopus 로고    scopus 로고
    • The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells
    • 1:CAS:528:DC%2BD2sXitVOktr0%3D 17293866 10.1038/ng1970
    • Cao L, Shitara H, Horii T, Nagao Y, Imai H, Abe K, et al. The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells. Nat Genet. 2007;39:386-90.
    • (2007) Nat Genet , vol.39 , pp. 386-390
    • Cao, L.1    Shitara, H.2    Horii, T.3    Nagao, Y.4    Imai, H.5    Abe, K.6
  • 38
    • 74249105479 scopus 로고    scopus 로고
    • New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice
    • 2777314 19997484 10.1371/journal.pgen.1000756 1:CAS:528: DC%2BD1MXhsFejurrL
    • Cao L, Shitara H, Sugimoto M, Hayashi J, Abe K, Yonekawa H. New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice. PLoS Genet. 2009;5:e1000756.
    • (2009) PLoS Genet , vol.5 , pp. 1000756
    • Cao, L.1    Shitara, H.2    Sugimoto, M.3    Hayashi, J.4    Abe, K.5    Yonekawa, H.6
  • 39
    • 84868211657 scopus 로고    scopus 로고
    • Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission
    • 1:CAS:528:DC%2BC38XhsVKitL3M 3492742 23042113 10.1038/ng.2427
    • Freyer C, Cree LM, Mourier A, Stewart JB, Koolmeister C, Milenkovic D, et al. Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission. Nat Genet. 2012;44:1282-5.
    • (2012) Nat Genet , vol.44 , pp. 1282-1285
    • Freyer, C.1    Cree, L.M.2    Mourier, A.3    Stewart, J.B.4    Koolmeister, C.5    Milenkovic, D.6
  • 40
    • 79961211249 scopus 로고    scopus 로고
    • The implications of mitochondrial DNA copy number regulation during embryogenesis
    • 1:CAS:528:DC%2BC3MXhtVWrsr7J 21635974 10.1016/j.mito.2011.05.004
    • Carling PJ, Cree LM, Chinnery PF. The implications of mitochondrial DNA copy number regulation during embryogenesis. Mitochondrion. 2011;11:686-92.
    • (2011) Mitochondrion , vol.11 , pp. 686-692
    • Carling, P.J.1    Cree, L.M.2    Chinnery, P.F.3
  • 41
    • 0030664064 scopus 로고    scopus 로고
    • Mammalian mitochondrial genetics: Heredity, heteroplasmy and disease
    • 1:CAS:528:DyaK2sXnsValt7k%3D 9385842 10.1016/S0168-9525(97)01266-3
    • Lightowlers RN, Chinnery PF, Turnbull DM, Howell N. Mammalian mitochondrial genetics: heredity, heteroplasmy and disease. Trends Genet. 1997;13:450-5.
    • (1997) Trends Genet , vol.13 , pp. 450-455
    • Lightowlers, R.N.1    Chinnery, P.F.2    Turnbull, D.M.3    Howell, N.4
  • 42
    • 33644674439 scopus 로고    scopus 로고
    • The organization and inheritance of the mitochondrial genome
    • 1:CAS:528:DC%2BD2MXhtFygt7%2FM 16304597 10.1038/nrg1708
    • Chen XJ, Butow RA. The organization and inheritance of the mitochondrial genome. Nat Rev Genet. 2005;6:815-25.
    • (2005) Nat Rev Genet , vol.6 , pp. 815-825
    • Chen, X.J.1    Butow, R.A.2
  • 43
    • 41249098355 scopus 로고    scopus 로고
    • The layered structure of human mitochondrial DNA nucleoids
    • 1:CAS:528:DC%2BD1cXhtlyitb8%3D 18063578 10.1074/jbc.M708444200
    • Bogenhagen DF, Rousseau D, Burke S. The layered structure of human mitochondrial DNA nucleoids. J Biol Chem. 2008;283:3665-75.
    • (2008) J Biol Chem , vol.283 , pp. 3665-3675
    • Bogenhagen, D.F.1    Rousseau, D.2    Burke, S.3
  • 44
    • 84864357812 scopus 로고    scopus 로고
    • Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis
    • 1:CAS:528:DC%2BC38XhtFSlsL3O 3401451 22453275 10.1093/nar/gks266
    • He J, Cooper HM, Reyes A, Di Re M, Sembongi H, Litwin TR, et al. Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis. Nucleic Acids Res. 2012;40:6109-21.
    • (2012) Nucleic Acids Res , vol.40 , pp. 6109-6121
    • He, J.1    Cooper, H.M.2    Reyes, A.3    Di Re, M.4    Sembongi, H.5    Litwin, T.R.6
  • 45
    • 33846407653 scopus 로고    scopus 로고
    • The AAA + protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization
    • 1:CAS:528:DC%2BD2sXpt1ehug%3D%3D 17210950 10.1083/jcb.200609158
    • He J, Mao CC, Reyes A, Sembongi H, Di Re M, Granycome C, et al. The AAA + protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization. J Cell Biol. 2007;176:141-6.
    • (2007) J Cell Biol , vol.176 , pp. 141-146
    • He, J.1    Mao, C.C.2    Reyes, A.3    Sembongi, H.4    Di Re, M.5    Granycome, C.6
  • 46
    • 33748746678 scopus 로고    scopus 로고
    • Human mitochondrial DNA nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane
    • 1:CAS:528:DC%2BD28XoslKltLg%3D 16825194 10.1074/jbc.M604501200
    • Wang Y, Bogenhagen DF. Human mitochondrial DNA nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane. J Biol Chem. 2006;281:25791-802.
    • (2006) J Biol Chem , vol.281 , pp. 25791-25802
    • Wang, Y.1    Bogenhagen, D.F.2
  • 47
    • 79960227074 scopus 로고    scopus 로고
    • Actin and myosin contribute to mammalian mitochondrial DNA maintenance
    • 1:CAS:528:DC%2BC3MXoslOgtr8%3D 3130256 21398640 10.1093/nar/gkr052
    • Reyes A, He J, Mao CC, Bailey LJ, Di Re M, Sembongi H, et al. Actin and myosin contribute to mammalian mitochondrial DNA maintenance. Nucleic Acids Res. 2011;39:5098-108.
    • (2011) Nucleic Acids Res , vol.39 , pp. 5098-5108
    • Reyes, A.1    He, J.2    Mao, C.C.3    Bailey, L.J.4    Di Re, M.5    Sembongi, H.6
  • 48
    • 33745752671 scopus 로고    scopus 로고
    • Interactions of mitochondria with the actin cytoskeleton
    • 1:CAS:528:DC%2BD28Xmslyksb8%3D 16624426 10.1016/j.bbamcr.2006.02.014
    • Boldogh IR, Pon LA. Interactions of mitochondria with the actin cytoskeleton. Biochim Biophys Acta. 2006;1763:450-62.
    • (2006) Biochim Biophys Acta , vol.1763 , pp. 450-462
    • Boldogh, I.R.1    Pon, L.A.2
  • 49
    • 22244476422 scopus 로고    scopus 로고
    • Localization of mitochondrial DNA base excision repair to an inner membrane-associated particulate fraction
    • 1:CAS:528:DC%2BD2MXmsV2hsL4%3D 1174906 16006620 10.1093/nar/gki683
    • Stuart JA, Mayard S, Hashiguchi K, Souza-Pinto NC, Bohr VA. Localization of mitochondrial DNA base excision repair to an inner membrane-associated particulate fraction. Nucleic Acids Res. 2005;33:3722-32.
    • (2005) Nucleic Acids Res , vol.33 , pp. 3722-3732
    • Stuart, J.A.1    Mayard, S.2    Hashiguchi, K.3    Souza-Pinto, N.C.4    Bohr, V.A.5
  • 50
    • 0025829045 scopus 로고
    • Similarity of human mitochondrial transcription factor 1 to high mobility group proteins
    • 1:CAS:528:DyaK38XltlyrtA%3D%3D 2035027 10.1126/science.2035027
    • Parisi MA, Clayton DA. Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science. 1991;252:965-9.
    • (1991) Science , vol.252 , pp. 965-969
    • Parisi, M.A.1    Clayton, D.A.2
  • 51
    • 0029070402 scopus 로고
    • Addition of a 29 residue carboxyl-terminal tail converts a simple HMG box-containing protein into a transcriptional activator
    • 1:CAS:528:DyaK2MXmt1Wnsbs%3D 7776365 10.1006/jmbi.1995.9889
    • Dairaghi DJ, Shadel GS, Clayton DA. Addition of a 29 residue carboxyl-terminal tail converts a simple HMG box-containing protein into a transcriptional activator. J Mol Biol. 1995;249:11-28.
    • (1995) J Mol Biol , vol.249 , pp. 11-28
    • Dairaghi, D.J.1    Shadel, G.S.2    Clayton, D.A.3
  • 52
    • 0042632864 scopus 로고    scopus 로고
    • Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity
    • 1:CAS:528:DC%2BD3sXmt1SrtLk%3D 166325 12897151 10.1128/MCB.23.16.5816- 5824.2003
    • McCulloch V, Shadel GS. Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. Mol Cell Biol. 2003;23:5816-24.
    • (2003) Mol Cell Biol , vol.23 , pp. 5816-5824
    • McCulloch, V.1    Shadel, G.S.2
  • 53
    • 34248632009 scopus 로고    scopus 로고
    • The C-terminal tail of mitochondrial transcription factor a markedly strengthens its general binding to DNA
    • 1:CAS:528:DC%2BD2sXltF2it7Y%3D 17167045 10.1093/jb/mvm020
    • Ohgaki K, Kanki T, Fukuoh A, Kurisaki H, Aoki Y, Ikeuchi M, et al. The C-terminal tail of mitochondrial transcription factor a markedly strengthens its general binding to DNA. J Biochem. 2007;141:201-11.
    • (2007) J Biochem , vol.141 , pp. 201-211
    • Ohgaki, K.1    Kanki, T.2    Fukuoh, A.3    Kurisaki, H.4    Aoki, Y.5    Ikeuchi, M.6
  • 54
    • 33847792061 scopus 로고    scopus 로고
    • Mitochondrial transcription and its regulation in mammalian cells
    • 1:CAS:528:DC%2BD2sXisleisLg%3D 17291767 10.1016/j.tibs.2007.01.003
    • Asin-Cayuela J, Gustafsson CM. Mitochondrial transcription and its regulation in mammalian cells. Trends Biochem Sci. 2007;32:111-7.
    • (2007) Trends Biochem Sci , vol.32 , pp. 111-117
    • Asin-Cayuela, J.1    Gustafsson, C.M.2
  • 55
    • 80555128721 scopus 로고    scopus 로고
    • The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA
    • 1:CAS:528:DC%2BC3MXhtl2gs7fF 3210390 22037171 10.1038/nsmb.2159
    • Ngo HB, Kaiser JT, Chan DC. The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA. Nat Struct Mol Biol. 2011;18:1290-6.
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 1290-1296
    • Ngo, H.B.1    Kaiser, J.T.2    Chan, D.C.3
  • 56
  • 57
    • 0037443884 scopus 로고    scopus 로고
    • Human mitochondrial DNA is packaged with TFAM
    • 1:CAS:528:DC%2BD3sXit1yks7c%3D 12626705 10.1093/nar/gkg251
    • Alam TI, Kanki T, Muta T, Ukaji K, Abe Y, Nakayama H, et al. Human mitochondrial DNA is packaged with TFAM. Nucleic Acids Res. 2003;31:1640-5.
    • (2003) Nucleic Acids Res , vol.31 , pp. 1640-1645
    • Alam, T.I.1    Kanki, T.2    Muta, T.3    Ukaji, K.4    Abe, Y.5    Nakayama, H.6
  • 58
    • 34548495323 scopus 로고    scopus 로고
    • The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures
    • 1:CAS:528:DC%2BD2sXhtVWnt7jP 1951767 17581862 10.1091/mbc.E07-05-0404
    • Kaufman BA, Durisic N, Mativetsky JM, Costantino S, Hancock MA, Grutter P, et al. The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures. Mol Biol Cell. 2007;18:3225-36.
    • (2007) Mol Biol Cell , vol.18 , pp. 3225-3236
    • Kaufman, B.A.1    Durisic, N.2    Mativetsky, J.M.3    Costantino, S.4    Hancock, M.A.5    Grutter, P.6
  • 59
    • 84866082674 scopus 로고    scopus 로고
    • Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A
    • 22910359 10.1038/ncomms2001 1:CAS:528:DC%2BC38Xhslart7zF
    • Farge G, Laurens N, Broekmans OD, van den Wildenberg SM, Dekker LC, Gaspari M, et al. Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A. Nat Commun. 2012;3:1013.
    • (2012) Nat Commun. , vol.3 , pp. 1013
    • Farge, G.1    Laurens, N.2    Broekmans, O.D.3    Van Den Wildenberg, S.M.4    Dekker, L.C.5    Gaspari, M.6
  • 60
    • 84864293013 scopus 로고    scopus 로고
    • Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number
    • 1:CAS:528:DC%2BC38Xlt1Kkur8%3D 22465614 10.1016/j.bbagrm.2012.03.002
    • Campbell CT, Kolesar JE, Kaufman BA. Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number. Biochim Biophys Acta. 2012;1819:921-9.
    • (2012) Biochim Biophys Acta , vol.1819 , pp. 921-929
    • Campbell, C.T.1    Kolesar, J.E.2    Kaufman, B.A.3
  • 61
    • 2442431673 scopus 로고    scopus 로고
    • Mitochondrial transcription factor A regulates mtDNA copy number in mammals
    • 1:CAS:528:DC%2BD2cXivFyhur0%3D 15016765 10.1093/hmg/ddh109
    • Ekstrand MI, Falkenberg M, Rantanen A, Park CB, Gaspari M, Hultenby K, et al. Mitochondrial transcription factor A regulates mtDNA copy number in mammals. Hum Mol Genet. 2004;13:935-44.
    • (2004) Hum Mol Genet , vol.13 , pp. 935-944
    • Ekstrand, M.I.1    Falkenberg, M.2    Rantanen, A.3    Park, C.B.4    Gaspari, M.5    Hultenby, K.6
  • 62
    • 7644237446 scopus 로고    scopus 로고
    • Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA
    • 1:CAS:528:DC%2BD2cXpslOntb4%3D 525493 15509786 10.1128/MCB.24.22.9823- 9834.2004
    • Kanki T, Ohgaki K, Gaspari M, Gustafsson CM, Fukuoh A, Sasaki N, et al. Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA. Mol Cell Biol. 2004;24:9823-34.
    • (2004) Mol Cell Biol , vol.24 , pp. 9823-9834
    • Kanki, T.1    Ohgaki, K.2    Gaspari, M.3    Gustafsson, C.M.4    Fukuoh, A.5    Sasaki, N.6
  • 63
    • 0031930319 scopus 로고    scopus 로고
    • Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
    • 1:CAS:528:DyaK1cXhtlKktL8%3D 9500544 10.1038/ng0398-231
    • Larsson NG, Wang J, Wilhelmsson H, Oldfors A, Rustin P, Lewandoski M, et al. Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet. 1998;18:231-6.
    • (1998) Nat Genet , vol.18 , pp. 231-236
    • Larsson, N.G.1    Wang, J.2    Wilhelmsson, H.3    Oldfors, A.4    Rustin, P.5    Lewandoski, M.6
  • 64
    • 0041731714 scopus 로고    scopus 로고
    • Functional domains of chicken mitochondrial transcription factor A for the maintenance of mitochondrial DNA copy number in lymphoma cell line DT40
    • 1:CAS:528:DC%2BD3sXmtFeqtbk%3D 12759347 10.1074/jbc.M303842200
    • Matsushima Y, Matsumura K, Ishii S, Inagaki H, Suzuki T, Matsuda Y, et al. Functional domains of chicken mitochondrial transcription factor A for the maintenance of mitochondrial DNA copy number in lymphoma cell line DT40. J Biol Chem. 2003;278:31149-58.
    • (2003) J Biol Chem , vol.278 , pp. 31149-31158
    • Matsushima, Y.1    Matsumura, K.2    Ishii, S.3    Inagaki, H.4    Suzuki, T.5    Matsuda, Y.6
  • 65
    • 33847656213 scopus 로고    scopus 로고
    • Mitochondrial transcription factor A (TFAM): Roles in maintenance of mtDNA and cellular functions
    • 1:CAS:528:DC%2BD2sXisl2rsbw%3D 17280879 10.1016/j.mito.2006.11.017
    • Kang D, Kim SH, Hamasaki N. Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions. Mitochondrion. 2007;7:39-44.
    • (2007) Mitochondrion , vol.7 , pp. 39-44
    • Kang, D.1    Kim, S.H.2    Hamasaki, N.3
  • 66
    • 78649464413 scopus 로고    scopus 로고
    • Human mitochondrial transcription factor A is required for the segregation of mitochondrial DNA in cultured cells
    • 1:CAS:528:DC%2BC3cXhsV2jur3J 20955698 10.1016/j.yexcr.2010.10.008
    • Kasashima K, Sumitani M, Endo H. Human mitochondrial transcription factor A is required for the segregation of mitochondrial DNA in cultured cells. Exp Cell Res. 2011;317:210-20.
    • (2011) Exp Cell Res , vol.317 , pp. 210-220
    • Kasashima, K.1    Sumitani, M.2    Endo, H.3
  • 67
    • 77954158731 scopus 로고    scopus 로고
    • High mitochondrial DNA copy number has detrimental effects in mice
    • 1:CAS:528:DC%2BC3cXntlGjsr0%3D 20413656 10.1093/hmg/ddq163
    • Ylikallio E, Tyynismaa H, Tsutsui H, Ide T, Suomalainen A. High mitochondrial DNA copy number has detrimental effects in mice. Hum Mol Genet. 2010;19:2695-705.
    • (2010) Hum Mol Genet , vol.19 , pp. 2695-2705
    • Ylikallio, E.1    Tyynismaa, H.2    Tsutsui, H.3    Ide, T.4    Suomalainen, A.5
  • 68
    • 73349095758 scopus 로고    scopus 로고
    • Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53
    • 1:CAS:528:DC%2BD1MXhsVajt7%2FE 2777442 19755502 10.1093/nar/gkp750
    • Wong TS, Rajagopalan S, Freund SM, Rutherford TJ, Andreeva A, Townsley FM, et al. Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53. Nucleic Acids Res. 2009;37:6765-83.
    • (2009) Nucleic Acids Res , vol.37 , pp. 6765-6783
    • Wong, T.S.1    Rajagopalan, S.2    Freund, S.M.3    Rutherford, T.J.4    Andreeva, A.5    Townsley, F.M.6
  • 69
    • 1542373685 scopus 로고    scopus 로고
    • Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
    • 1:CAS:528:DC%2BD2cXitlWnurg%3D 15004004 10.1101/gad.1177604
    • Kelly DP, Scarpulla RC. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 2004;18:357-68.
    • (2004) Genes Dev , vol.18 , pp. 357-368
    • Kelly, D.P.1    Scarpulla, R.C.2
  • 70
    • 78649842154 scopus 로고    scopus 로고
    • Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM)
    • 1:CAS:528:DC%2BC3cXhtl2ktr3P 20930118 10.1073/pnas.1008924107
    • Matsushima Y, Goto Y, Kaguni LS. Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM). Proc Natl Acad Sci USA. 2010;107:18410-5.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 18410-18415
    • Matsushima, Y.1    Goto, Y.2    Kaguni, L.S.3
  • 71
    • 84872271398 scopus 로고    scopus 로고
    • Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA(+) Lon protease
    • 1:CAS:528:DC%2BC38XhslKqsrbI 23201127 3586414
    • Lu B, Lee J, Nie X, Li M, Morozov YI, Venkatesh S, et al. Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA(+) Lon protease. Mol Cell. 2013;49:121-32.
    • (2013) Mol Cell , vol.49 , pp. 121-132
    • Lu, B.1    Lee, J.2    Nie, X.3    Li, M.4    Morozov, Y.I.5    Venkatesh, S.6
  • 72
    • 33845970253 scopus 로고    scopus 로고
    • Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2
    • 1:CAS:528:DC%2BD28Xht1ajt7zF 17008324 10.1074/jbc.M605260200
    • Kasashima K, Ohta E, Kagawa Y, Endo H. Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2. J Biol Chem. 2006;281:36401-10.
    • (2006) J Biol Chem , vol.281 , pp. 36401-36410
    • Kasashima, K.1    Ohta, E.2    Kagawa, Y.3    Endo, H.4
  • 73
    • 56349102165 scopus 로고    scopus 로고
    • Prohibitin function within mitochondria: Essential roles for cell proliferation and cristae morphogenesis
    • 1:CAS:528:DC%2BD1cXhsVWrtL3K 18558096 10.1016/j.bbamcr.2008.05.013
    • Merkwirth C, Langer T. Prohibitin function within mitochondria: essential roles for cell proliferation and cristae morphogenesis. Biochim Biophys Acta. 2009;1793:27-32.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 27-32
    • Merkwirth, C.1    Langer, T.2
  • 74
    • 39549085742 scopus 로고    scopus 로고
    • Human prohibitin 1 maintains the organization and stability of the mitochondrial nucleoids
    • 1:CAS:528:DC%2BD1cXisVWjur0%3D 18258228 10.1016/j.yexcr.2008.01.005
    • Kasashima K, Sumitani M, Satoh M, Endo H. Human prohibitin 1 maintains the organization and stability of the mitochondrial nucleoids. Exp Cell Res. 2008;314:988-96.
    • (2008) Exp Cell Res , vol.314 , pp. 988-996
    • Kasashima, K.1    Sumitani, M.2    Satoh, M.3    Endo, H.4
  • 75
    • 0032954927 scopus 로고    scopus 로고
    • Prohibitins regulate membrane protein degradation by the m-AAA protease in mitochondria
    • 1:CAS:528:DyaK1MXislSlur8%3D 84136 10207067
    • Steglich G, Neupert W, Langer T. Prohibitins regulate membrane protein degradation by the m-AAA protease in mitochondria. Mol Cell Biol. 1999;19:3435-42.
    • (1999) Mol Cell Biol , vol.19 , pp. 3435-3442
    • Steglich, G.1    Neupert, W.2    Langer, T.3
  • 76
    • 84870679012 scopus 로고    scopus 로고
    • Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration
    • 1:CAS:528:DC%2BC38XhslCisrbF 3493444 23144624 10.1371/journal.pgen. 1003021
    • Merkwirth C, Martinelli P, Korwitz A, Morbin M, Bronneke HS, Jordan SD, et al. Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration. PLoS Genet. 2012;8:e1003021.
    • (2012) PLoS Genet , vol.8 , pp. 1003021
    • Merkwirth, C.1    Martinelli, P.2    Korwitz, A.3    Morbin, M.4    Bronneke, H.S.5    Jordan, S.D.6
  • 77
    • 84865305875 scopus 로고    scopus 로고
    • Maintenance of mitochondrial genome distribution by mitochondrial AAA + protein ClpX
    • 1:CAS:528:DC%2BC38XhtFKmsbrL 22841477 10.1016/j.yexcr.2012.07.012
    • Kasashima K, Sumitani M, Endo H. Maintenance of mitochondrial genome distribution by mitochondrial AAA + protein ClpX. Exp Cell Res. 2012;318:2335-43.
    • (2012) Exp Cell Res , vol.318 , pp. 2335-2343
    • Kasashima, K.1    Sumitani, M.2    Endo, H.3
  • 78
    • 3242705680 scopus 로고    scopus 로고
    • The functional organization of mitochondrial genomes in human cells
    • 425603 15157274 10.1186/1741-7007-2-9
    • Iborra FJ, Kimura H, Cook PR. The functional organization of mitochondrial genomes in human cells. BMC Biol. 2004;2:9.
    • (2004) BMC Biol , vol.2 , pp. 9
    • Iborra, F.J.1    Kimura, H.2    Cook, P.R.3
  • 79
    • 0036242518 scopus 로고    scopus 로고
    • Cell cycle dependent morphology changes and associated mitochondrial DNA redistribution in mitochondria of human cell lines
    • 1:CAS:528:DC%2BD38XktVKntL8%3D 16120295 10.1016/S1567-7249(02)00006-5
    • Margineantu DH, GregoryCox W, Sundell L, Sherwood SW, Beechem JM, Capaldi RA. Cell cycle dependent morphology changes and associated mitochondrial DNA redistribution in mitochondria of human cell lines. Mitochondrion. 2002;1:425-35.
    • (2002) Mitochondrion. , vol.1 , pp. 425-435
    • Margineantu, D.H.1    Gregorycox, W.2    Sundell, L.3    Sherwood, S.W.4    Beechem, J.M.5    Capaldi, R.A.6
  • 80
    • 0035695958 scopus 로고    scopus 로고
    • Detection of mitochondrial DNA in living animal cells with fluorescence microscopy
    • 1:CAS:528:DC%2BD38XitFCgsQ%3D%3D 11903796 10.1046/j.1365-2818.2001.00954. x
    • Dellinger M, Geze M. Detection of mitochondrial DNA in living animal cells with fluorescence microscopy. J Microsc. 2001;204:196-202.
    • (2001) J Microsc , vol.204 , pp. 196-202
    • Dellinger, M.1    Geze, M.2
  • 81
    • 0036533665 scopus 로고    scopus 로고
    • Discrimination of DNA and RNA in cells by a vital fluorescent probe: Lifetime imaging of SYTO13 in healthy and apoptotic cells
    • 11933012 10.1002/cyto.10076
    • van Zandvoort MA, de Grauw CJ, Gerritsen HC, Broers JL, oude Egbrink MG, Ramaekers FC, et al. Discrimination of DNA and RNA in cells by a vital fluorescent probe: lifetime imaging of SYTO13 in healthy and apoptotic cells. Cytometry. 2002;47:226-35.
    • (2002) Cytometry. , vol.47 , pp. 226-235
    • Van Zandvoort, M.A.1    De Grauw, C.J.2    Gerritsen, H.C.3    Broers, J.L.4    Oude Egbrink, M.G.5    Ramaekers, F.C.6
  • 82
    • 0028262917 scopus 로고
    • Human mitochondria and mitochondrial genome function as a single dynamic cellular unit
    • 1:CAS:528:DyaK2cXitV2qsrY%3D 8138574 10.1083/jcb.125.1.43
    • Hayashi J, Takemitsu M, Goto Y, Nonaka I. Human mitochondria and mitochondrial genome function as a single dynamic cellular unit. J Cell Biol. 1994;125:43-50.
    • (1994) J Cell Biol , vol.125 , pp. 43-50
    • Hayashi, J.1    Takemitsu, M.2    Goto, Y.3    Nonaka, I.4
  • 83
    • 77953261294 scopus 로고    scopus 로고
    • Visualization of mitochondrial and apicoplast nucleoids in the human malaria parasite Plasmodium falciparum by SYBR Green i and PicoGreen staining
    • 1:CAS:528:DC%2BC3cXhtVSlu7fF 10.1508/cytologia.74.449
    • Maeda-Sano K, Sato S, Ueda T, Yui R, Ito K, Hata M, et al. Visualization of mitochondrial and apicoplast nucleoids in the human malaria parasite Plasmodium falciparum by SYBR Green I and PicoGreen staining. Cytologia. 2009;74:449-55.
    • (2009) Cytologia. , vol.74 , pp. 449-455
    • Maeda-Sano, K.1    Sato, S.2    Ueda, T.3    Yui, R.4    Ito, K.5    Hata, M.6
  • 84
    • 77953248054 scopus 로고    scopus 로고
    • Technical note visualization of mitochondrial nucleoids in living human cells using SYBR Green i
    • Ozawa S, Sasaki N. Technical note visualization of mitochondrial nucleoids in living human cells using SYBR Green I. Cytologia. 2009;74:366.
    • (2009) Cytologia. , vol.74 , pp. 366
    • Ozawa, S.1    Sasaki, N.2
  • 85
    • 12344293822 scopus 로고    scopus 로고
    • Detection of mitochondrial DNA depletion in living human cells using PicoGreen staining
    • 1:CAS:528:DC%2BD2MXkvVCluw%3D%3D 15652355 10.1016/j.yexcr.2004.10.013
    • Ashley N, Harris D, Poulton J. Detection of mitochondrial DNA depletion in living human cells using PicoGreen staining. Exp Cell Res. 2005;303:432-46.
    • (2005) Exp Cell Res , vol.303 , pp. 432-446
    • Ashley, N.1    Harris, D.2    Poulton, J.3
  • 86
    • 0042976304 scopus 로고    scopus 로고
    • Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replication
    • 1:CAS:528:DC%2BD3sXltFCntLg%3D 12679881 10.1007/s00294-003-0393-4
    • Okamaoto M, Ohsato T, Nakada K, Isobe K, Spelbrink JN, Hayashi J, et al. Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replication. Curr Genet. 2003;43:364-70.
    • (2003) Curr Genet , vol.43 , pp. 364-370
    • Okamaoto, M.1    Ohsato, T.2    Nakada, K.3    Isobe, K.4    Spelbrink, J.N.5    Hayashi, J.6
  • 88
    • 79955399911 scopus 로고    scopus 로고
    • Biochemical properties of Caenorhabditis elegans HMG-5, a regulator of mitochondrial DNA
    • 1:CAS:528:DC%2BC3MXlt1Gnsr0%3D 21258070 10.1093/jb/mvr008
    • Sumitani M, Kasashima K, Matsugi J, Endo H. Biochemical properties of Caenorhabditis elegans HMG-5, a regulator of mitochondrial DNA. J Biochem. 2011;149:581-9.
    • (2011) J Biochem , vol.149 , pp. 581-589
    • Sumitani, M.1    Kasashima, K.2    Matsugi, J.3    Endo, H.4
  • 89
    • 77953717381 scopus 로고    scopus 로고
    • Mitochondrial single-stranded DNA binding protein is required for maintenance of mitochondrial DNA and 7S DNA but is not required for mitochondrial nucleoid organisation
    • 1:CAS:528:DC%2BC3cXntlaitLY%3D 20434493 10.1016/j.bbamcr.2010.04.008
    • Ruhanen H, Borrie S, Szabadkai G, Tyynismaa H, Jones AW, Kang D, et al. Mitochondrial single-stranded DNA binding protein is required for maintenance of mitochondrial DNA and 7S DNA but is not required for mitochondrial nucleoid organisation. Biochim Biophys Acta. 2010;1803:931-9.
    • (2010) Biochim Biophys Acta , vol.1803 , pp. 931-939
    • Ruhanen, H.1    Borrie, S.2    Szabadkai, G.3    Tyynismaa, H.4    Jones, A.W.5    Kang, D.6
  • 90
    • 33644635644 scopus 로고    scopus 로고
    • DNA polymerase gamma in mitochondrial DNA replication and repair
    • 1:CAS:528:DC%2BD28XnsFOm 16464011 10.1021/cr040463d
    • Graziewicz MA, Longley MJ, Copeland WC. DNA polymerase gamma in mitochondrial DNA replication and repair. Chem Rev. 2006;106:383-405.
    • (2006) Chem Rev , vol.106 , pp. 383-405
    • Graziewicz, M.A.1    Longley, M.J.2    Copeland, W.C.3
  • 91
    • 84864306114 scopus 로고    scopus 로고
    • Human mitochondrial RNA polymerase: Structure-function, mechanism and inhibition
    • 1:CAS:528:DC%2BC38XmvFKisb0%3D 22551784 10.1016/j.bbagrm.2012.04.002
    • Arnold JJ, Smidansky ED, Moustafa IM, Cameron CE. Human mitochondrial RNA polymerase: structure-function, mechanism and inhibition. Biochim Biophys Acta. 2012;1819:948-60.
    • (2012) Biochim Biophys Acta , vol.1819 , pp. 948-960
    • Arnold, J.J.1    Smidansky, E.D.2    Moustafa, I.M.3    Cameron, C.E.4
  • 92
    • 70449807055 scopus 로고    scopus 로고
    • TFB2 is a transient component of the catalytic site of the human mitochondrial RNA polymerase
    • 1:CAS:528:DC%2BC3cXksFWksg%3D%3D 2806307 19945377 10.1016/j.cell.2009.10. 031
    • Sologub M, Litonin D, Anikin M, Mustaev A, Temiakov D. TFB2 is a transient component of the catalytic site of the human mitochondrial RNA polymerase. Cell. 2009;139:934-44.
    • (2009) Cell , vol.139 , pp. 934-944
    • Sologub, M.1    Litonin, D.2    Anikin, M.3    Mustaev, A.4    Temiakov, D.5
  • 93
    • 63449105579 scopus 로고    scopus 로고
    • Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome
    • 1:CAS:528:DC%2BD1MXlsFyru7k%3D 19356719 10.1016/j.cmet.2009.03.001
    • Metodiev MD, Lesko N, Park CB, Camara Y, Shi Y, Wibom R, et al. Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome. Cell Metab. 2009;9:386-97.
    • (2009) Cell Metab , vol.9 , pp. 386-397
    • Metodiev, M.D.1    Lesko, N.2    Park, C.B.3    Camara, Y.4    Shi, Y.5    Wibom, R.6
  • 94
    • 84864305019 scopus 로고    scopus 로고
    • Hitting the brakes: Termination of mitochondrial transcription
    • 1:CAS:528:DC%2BC38XhtVyktr%2FN 3408806 22137970 10.1016/j.bbagrm.2011.11. 004
    • Guja KE, Garcia-Diaz M. Hitting the brakes: termination of mitochondrial transcription. Biochim Biophys Acta. 2012;1819:939-47.
    • (2012) Biochim Biophys Acta , vol.1819 , pp. 939-947
    • Guja, K.E.1    Garcia-Diaz, M.2
  • 95
    • 0034938364 scopus 로고    scopus 로고
    • Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria
    • 1:STN:280:DC%2BD3MznsV2jsQ%3D%3D 11431692 10.1038/90058
    • Spelbrink JN, Li FY, Tiranti V, Nikali K, Yuan QP, Tariq M, et al. Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria. Nat Genet. 2001;28:223-31.
    • (2001) Nat Genet , vol.28 , pp. 223-231
    • Spelbrink, J.N.1    Li, F.Y.2    Tiranti, V.3    Nikali, K.4    Yuan, Q.P.5    Tariq, M.6
  • 96
    • 75649152422 scopus 로고    scopus 로고
    • Human mitochondrial RNA turnover caught in flagranti: Involvement of hSuv3p helicase in RNA surveillance
    • 1:CAS:528:DC%2BC3cXhtF2gsg%3D%3D 2800237 19864255 10.1093/nar/gkp903
    • Szczesny RJ, Borowski LS, Brzezniak LK, Dmochowska A, Gewartowski K, Bartnik E, et al. Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance. Nucleic Acids Res. 2010;38:279-98.
    • (2010) Nucleic Acids Res , vol.38 , pp. 279-298
    • Szczesny, R.J.1    Borowski, L.S.2    Brzezniak, L.K.3    Dmochowska, A.4    Gewartowski, K.5    Bartnik, E.6
  • 97
    • 34547117627 scopus 로고    scopus 로고
    • Roles for the human ATP-dependent Lon protease in mitochondrial DNA maintenance
    • 1:CAS:528:DC%2BD2sXmt1eksLs%3D 17420247 10.1074/jbc.M611540200
    • Lu B, Yadav S, Shah PG, Liu T, Tian B, Pukszta S, et al. Roles for the human ATP-dependent Lon protease in mitochondrial DNA maintenance. J Biol Chem. 2007;282:17363-74.
    • (2007) J Biol Chem , vol.282 , pp. 17363-17374
    • Lu, B.1    Yadav, S.2    Shah, P.G.3    Liu, T.4    Tian, B.5    Pukszta, S.6
  • 98
    • 54849425967 scopus 로고    scopus 로고
    • Mitochondrial topoisomerase i sites in the regulatory D-loop region of mitochondrial DNA
    • 1:CAS:528:DC%2BD1cXhtFygtLfJ 2597090 18826252 10.1021/bi800774b
    • Zhang H, Pommier Y. Mitochondrial topoisomerase I sites in the regulatory D-loop region of mitochondrial DNA. Biochemistry. 2008;47:11196-203.
    • (2008) Biochemistry , vol.47 , pp. 11196-11203
    • Zhang, H.1    Pommier, Y.2
  • 99
    • 84857192195 scopus 로고    scopus 로고
    • LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs
    • 1:CAS:528:DC%2BC3MXhtl2gsLjP 22045337 10.1038/emboj.2011.392
    • Ruzzenente B, Metodiev MD, Wredenberg A, Bratic A, Park CB, Camara Y, et al. LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs. EMBO J. 2012;31:443-56.
    • (2012) EMBO J , vol.31 , pp. 443-456
    • Ruzzenente, B.1    Metodiev, M.D.2    Wredenberg, A.3    Bratic, A.4    Park, C.B.5    Camara, Y.6
  • 100
    • 77956136985 scopus 로고    scopus 로고
    • Leucine-rich pentatricopeptide-repeat containing protein regulates mitochondrial transcription
    • 1:CAS:528:DC%2BC3cXhtVahtrvE 2932791 20677761 10.1021/bi1008479
    • Sondheimer N, Fang JK, Polyak E, Falk MJ, Avadhani NG. Leucine-rich pentatricopeptide-repeat containing protein regulates mitochondrial transcription. Biochemistry. 2010;49:7467-73.
    • (2010) Biochemistry , vol.49 , pp. 7467-7473
    • Sondheimer, N.1    Fang, J.K.2    Polyak, E.3    Falk, M.J.4    Avadhani, N.G.5
  • 101
    • 34548159301 scopus 로고    scopus 로고
    • Mammalian mitochondrial nucleoids: Organizing an independently minded genome
    • 1:CAS:528:DC%2BD2sXpvFGqsL8%3D 17698423 10.1016/j.mito.2007.06.004
    • Holt IJ, He J, Mao CC, Boyd-Kirkup JD, Martinsson P, Sembongi H, et al. Mammalian mitochondrial nucleoids: organizing an independently minded genome. Mitochondrion. 2007;7:311-21.
    • (2007) Mitochondrion , vol.7 , pp. 311-321
    • Holt, I.J.1    He, J.2    Mao, C.C.3    Boyd-Kirkup, J.D.4    Martinsson, P.5    Sembongi, H.6


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