Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity

Molecular and Cellular Biology

Volumn 23, Issue 16, 2003, Pages 5816-5824

  McCulloch, Vicki ^a   Shadel, Gerald S ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN MITOCHONDRIAL TRANSCIPTION FACTOR B1; HUMAN MITOCHONDRIAL TRANSCRIPTION FACTOR A; HUMAN MITOCHONDRIAL TRANSCRIPTION FACTOR B2; RNA METHYLTRANSFERASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; METHYLATION; MITOCHONDRION; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION;

DNA; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; GLUTATHIONE TRANSFERASE; HELA CELLS; HUMANS; METHYLTRANSFERASES; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEAR PROTEINS; PLASMIDS; PRECIPITIN TESTS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RNA, RIBOSOMAL; S-ADENOSYLMETHIONINE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0042632864     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.16.5816-5824.2003     Document Type: Article

References (33)

1. Antoshechkin, I., and D. F. Bogenhagen. 1995. Distinct roles for two purified factors in transcription of Xenopus mitochondrial DNA. Mol. Cell. Biol. 15:7032-7042.
2. Bogenhagen, D. F. 1996. Interaction of mtTFB and mtRNA polymerase at core promoters for transcription of Xenopus laevis mtDNA. J. Biol. Chem. 271:12036-12041.
3. Bussiere, D. E., S. W. Muchmore, C. G. Dealwis, G. Schluckebier, V. L. Nienaber, R. P. Edalji, K. A. Walter, U. S. Ladror, T. F. Holzman, and C. Abad-Zapatero. 1998. Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria. Biochemistry 37:7103-7112.
4. Cliften, P. F., J. Y. Park, B. P. Davis, S. H. Jang, and J. A. Jaehning. 1997. Identification of three regions essential for interaction between a sigma-like factor and core RNA polymerase. Genes Dev. 11:2897-2909.
5. Cliften, P. F., S. H. Jang, and J. A. Jaehning. 2000. Identifying a core RNA polymerase surface critical for interactions with a sigma-like specificity factor. Mol. Cell. Biol. 20:7013-7023.
6. Dairaghi, D. J., G. S. Shadel, and D. A. Clayton. 1995. Human mitochondrial transcription factor A and promoter spacing integrity are required for transcription initiation. Biochim. Biophys. Acta 1271:127-134.
7. Dairaghi, D. J., G. S. Shadel, and D. A. Clayton. 1995. Addition of a 29 residue carboxyl-terminal tail converts a simple HMG box-containing protein into a transcriptional activator. J. Mol. Biol. 249:11-28.
8. DiMauro, S., K. Tanji, E. Bonilla, F. Pallotti, and E. A. Schon. 2002. Mitochondrial abnormalities in muscle and other aging cells: classification, causes, and effects. Muscle Nerve 26:597-607.
9. Falkenberg, M., M. Gaspari, A. Rantanen, A. Trifunovic, N. G. Larsson, and C. M. Gustafsson. 2002. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Nat. Genet. 31:289-294.
10. Fisher, R. P., and D. A. Clayton. 1985. A transcription factor required for promoter recognition by human mitochondrial RNA polymerase. Accurate initiation at the heavy- and light-strand promoters dissected and reconstituted in vitro. J. Biol. Chem. 260:11330-11338.
11. Fisher, R. P., and D. A. Clayton. 1988. Purification and characterization of human mitochondrial transcription factor 1. Mol. Cell. Biol. 8:3496-3509.
12. Fisher, R. P., T. Lisowsky, M. A. Parisi, and D. A. Clayton. 1992. DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein. J. Biol. Chem. 267:3358-3367.
13. Fisher, R. P., J. N. Topper, and D. A. Clayton. 1987. Promoter selection in human mitochondria involves binding of a transcription factor to orientation-independent upstream regulatory elements. Cell 50:247-258.
14. Hager, D. A., and R. R. Burgess. 1980. Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate, and renaturation of enzymatic activity: results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase, and other enzymes. Anal. Biochem. 109:76-86.
15. Jang, S. H., and J. A. Jaehning. 1991. The yeast mitochondrial RNA polymerase specificity factor, MTF1, is similar to bacterial sigma factors. J. Biol. Chem. 266:22671-22677.
16. Lisowsky, T., and G. Michaelis. 1988. A nuclear gene essential for mitochondrial replication suppresses a defect of mitochondrial transcription in Saccharomyces cerevisiae. Mol. Gen. Genet. 219:125-128.
17. Malone, T., R. M. Blumenthal, and X. Cheng. 1995. Structure-guided analysis reveals nine sequence motifs conserved among DNA amino-methyl-transferases, and suggests a catalytic mechanism for these enzymes. J. Mol. Biol. 253:618-632.
18. Masters, B. S., L. L. Stohl, and D. A. Clayton. 1987. Yeast mitochondrial RNA polymerase is homologous to those encoded by bacteriophages T3 and T7. Cell 51:89-99.
19. McCulloch, V., B. L. Seidel-Rogol, and G. S. Shadel. 2002. A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine. Mol. Cell. Biol. 22:1116-1125.
20. Micol, V., P. Fernandez-Silva, and G. Attardi. 1996. Isolation and assay of mitochondrial transcription termination factor from human cells. Methods Enzymol. 264:158-173.
21. Parisi, M. A., and D. A. Clayton. 1991. Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science 252:965-969.
22. Schluckebier, G., P. Zhong, K. D. Stewart, T. J. Kavanaugh, and C. Abad-Zapatero. 1999. The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism. J. Mol. Biol. 289:277-291.
23. Schubot, F. D., C. J. Chen, J. P. Rose, T. A. Dailey, H. A. Dailey, and B. C. Wang. 2001. Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. Protein Sci. 10:1980-1988.
24. Seidel-Rogol, B. L., V. McCulloch, and G. S. Shadel. 2003. Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop. Nat. Genet. 33:23-24.
25. Seidel-Rogol, B. L., and G. S. Shadel. 2002. Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells. Nucleic Acids Res. 30:1929-1934.
26. Shadel, G. S., and D. A. Clayton. 1993. Mitochondrial transcription initiation. Variation and conservation. J. Biol. Chem. 268:16083-16086.
27. Shadel, G. S., and D. A. Clayton. 1995. A Saccharomyces cerevisiae mitochondrial transcription factor, sc-mtTFB, shares features with sigma factors but is functionally distinct. Mol. Cell. Biol. 15:2101-2108.
28. Shadel, G. S., and D. A. Clayton. 1997. Mitochondrial DNA maintenance in vertebrates. Annu. Rev. Biochem. 66:409-435.
29. Shoubridge, E. A. 2001. Nuclear genetic defects of oxidative phosphorylation. Hum. Mol. Genet. 10:2277-2284.
30. Tiranti, V., A. Savoia, F. Forti, M. F. D'Apolito, M. Centra, M. Rocchi, and M. Zeviani. 1997. Identification of the gene encoding the human mitochondrial RNA polymerase (h-mtRPOL) by cyberscreening of the Expressed Sequence Tags database. Hum. Mol. Genet. 6:615-625.
31. Topper, J. N., and D. A. Clayton. 1989. Identification of transcriptional regulatory elements in human mitochondrial DNA by linker substitution analysis. Mol. Cell. Biol. 9:1200-1211.
32. Wallace, D. C. 1999. Mitochondrial diseases in man and mouse. Science 283:1482-1488.
33. Xu, B., and D. A. Clayton. 1992. Assignment of a yeast protein necessary for mitochondrial transcription initiation. Nucleic Acids Res. 20:1053-1059.