New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice

PLoS Genetics

Volumn 5, Issue 12, 2009, Pages

  Cao, Liqin ^a,b   Shitara, Hiroshi ^a   Sugimoto, Michihiko ^b   Hayashi, Jun Ichi ^c   Abe, Kuniya ^b   Yonekawa, Hiromichi ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b RIKEN BIORESOURCE CENTER   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA; ALKALINE PHOSPHATASE; BIOLOGICAL MARKER; DPPA3 PROTEIN, MOUSE; PHOTOPROTEIN; PRDM1 PROTEIN, MOUSE; RED FLUORESCENT PROTEIN; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLIMP1 GENE; CELL DIVISION; CELL MATURATION; CONTROLLED STUDY; GENE; GENOME; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OOCYTE; OOCYTE DEVELOPMENT; PRIMORDIAL GERM CELL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SEGREGATION ANALYSIS; SOMATIC CELL; VALIDATION STUDY; ANIMAL; ANIMAL EMBRYO; CELL SEPARATION; CYTOLOGY; ENZYMOLOGY; GENE DOSAGE; GENE EXPRESSION REGULATION; GENETICS; GERM CELL; METABOLISM; MITOCHONDRION; REPRODUCIBILITY; STAINING; TRANSGENIC MOUSE;

MAMMALIA; MUS; MUS MUSCULUS;

ALKALINE PHOSPHATASE; ANIMALS; BIOLOGICAL MARKERS; CELL SEPARATION; DNA, MITOCHONDRIAL; EMBRYO, MAMMALIAN; GENE DOSAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GERM CELLS; LUMINESCENT PROTEINS; MICE; MICE, TRANSGENIC; MITOCHONDRIA; REPRESSOR PROTEINS; REPRODUCIBILITY OF RESULTS; STAINING AND LABELING; TRANSCRIPTION FACTORS;

EID: 74249105479     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000756     Document Type: Article

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