Curcumin p38-dependently enhances the anticancer activity of valproic acid in human leukemia cells

European Journal of Pharmaceutical Sciences

Volumn 41, Issue 2, 2010, Pages 210-218

  Chen, Jie ^a   Wang, Guiying ^b   Wang, Libing ^a   Kang, Jiuhong ^b   Wang, Jianmin ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b TONGJI UNIVERSITY   (China)

Author keywords

Bax; Curcumin; Histone deacetylase; Leukemia; P38; Valproic acid

Indexed keywords

CURCUMIN; DNA; HISTONE H3; HISTONE H4; I KAPPA B; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; VALPROIC ACID;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CELL STRAIN HL 60; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA FRAGMENTATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ACETYLATION; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CHROMATIN IMMUNOPRECIPITATION; CURCUMIN; DNA PRIMERS; DRUG SYNERGISM; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; VALPROIC ACID;

EID: 77955846351     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.06.011     Document Type: Article

References (27)

1. Aggarwal B.B., Kumar A., Bharti A.C. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003, 23:363-396.
2. Anto R.J., Mukhopadhyay A., Denning K., Aggarwal B.B. Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis 2002, 23:143-150.
3. Bhaumik S., Anjum R., Rangaraj N., Pardhasaradhi B.V., Khar A. Curcumin mediated apoptosis in AK-5 tumor cells involves the production of reactive oxygen intermediates. FEBS Lett. 1999, 456:311-314.
4. Chaudhary L.R., Hruska K.A. Inhibition of cell surviva signal protein kinase B/Akt by curcumin in human prostate cancer cells. J. Cell. Biochem. 2003, 89:1-5.
5. Chen J., Wan M.D., Zhang D., Liu Q., Kang J. Water-soluble antioxidants improve the antioxidant and anticancer activity of low concentrations of curcumin in human leukemia cells. Pharmazie 2005, 60:57-61.
6. Clayton A.L., Hazzalin C.A., Mahadevan L.C. Enhanced histone acetylation and transcription: a dynamic perspective. Mol. Cell 2006, 23:289-296.
7. Duvoix A., Morceau F., Delhalle S., et al. Induction of apoptosis by curcumin: mediation by glutathione S-transferase P1-1 inhibition. Biochem. Pharmacol. 2003, 66:1475-1483.
8. Göttlicher M., Minucci S., Zhu P., et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J. 2001, 20:6969-6978.
9. Hadi S.M., Asad S.F., Singh S., Ahmad A. Putative mechanism for anticancer and apoptosis-inducing properties of plant-derived polyphenolic compounds. IUBMB Life 2000, 50:167-171.
10. Hayun R., Okun E., Berrebi A., et al. Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells. Leuk. Lymphoma 2009, 50:625-632.
11. Jabbour E., O'Brien S., Kantarjian H., et al. Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia. Blood 2007, 109:3214-3218.
12. Johannessen C.U., Johannessen S.I. Valproate: past, present, and future. CNS Drug. Rev. 2003, 9:199-216.
13. Kepp O., Rajalingam K., Kimmig S., Rude T. Bak and Bax are non-redundant during infection- and DNA damage-induced apoptosis. EMBO J. 2007, 26:825-834.
14. Kim M.S., Kang H.J., Moon A. Inhibition of invasion and induction of apoptosis by curcumin in H-ras-transformed MCF10A human breast epithelial cells. Arch. Pharm. Res. 2001, 24:349-354.
15. Kortenhorst M.S., Isharwal S., van Diest P.J., et al. Valproic acid causes dose- and time-dependent changes in nuclear structure in prostate cancer cells in vitro and in vivo. Mol. Cancer Ther. 2009, 8:802-808.
16. Kuendgen A., Gattermann N. Valproic acid for the treatment of myeloid malignancies. Cancer 2007, 110:943-954.
17. -ΔΔCT method. Methods 2001, 25:402-408.
18. Mukherjee S., Ghosh U., Bhattacharyya N.P., Bhattacharya R.K., Roy M. Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells. Mutat. Res. 2006, 596:81-90.
19. Mukherjee S., Ghosh U., Bhattacharyya N.P., Bhattacharya R.K., Dey S., Roy M. Curcumin induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Mol. Cell. Biochem. 2007, 297:31-39.
20. Munster P., Marchion D., Bicaku E., et al. Clinical and biological effects of valproic acid as a histone deacetylase inhibitor on tumor and surrogate tissues: phase I/II trial of valproic acid and epirubicin/FEC. Clin. Cancer Res. 2009, 15:2488-2496.
21. Phiel C.J., Zhang F., Huang E.Y., et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J. Biol. Chem. 2001, 276:36734-36741.
22. Roy M., Chakraborty S., Siddiqi M., Bhattacharya R.K. Induction of apoptosis in tumor cells by natural phenolic compounds. Asian Pac. J. Cancer Prev. 2002, 3:61-67.
23. Sarkar F.H., Li Y., Wang Z., Kong D. Cellular signaling perturbation by natural products. Cell. Signal. 2009, 21:1541-1547.
24. Shah P., Mato A., Luger S.M. Valproic acid for the treatment of myeloid malignancies. Cancer 2008, 112:2324-2325.
25. Trullemans F., Grignard F., van Camp B., Schots R. Clinical findings and magnetic resonance imaging in severe cyclosporine-related neurotoxicity after allogeneic bone marrow transplantation. Eur. J. Haematol. 2001, 67:94-99.
26. Ura K., Kurumizaka H., Dimitrov S., Almouzni G., Wolffe A.P. Histone acetylation: influence on transcription, nucleosome mobility and positioning, and linker histone-dependent transcriptional repression. EMBO J. 1997, 16:2096-2107.
27. Woo J.H., Kim Y.H., Choi Y.J., et al. Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, downregulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis 2003, 24:1199-1208.