High HSP70-membrane expression on leukemic cells from patients with acute myeloid leukemia is associated with a worse prognosis [19]

Leukemia

Volumn 20, Issue 11, 2006, Pages 2076-2079

  Steiner, K ^a   Graf, M ^a   Hecht, K ^a   Reif, S ^b   Rossbacher, L ^c   Pfister, K ^c   Kolb, H J ^a,d   Schmetzer, H M ^a,d   Multhoff, G ^c  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; HEAT SHOCK PROTEIN 70; TUMOR MARKER;

ACUTE GRANULOCYTIC LEUKEMIA; BLAST CELL; BONE MARROW BIOPSY; CELL SPECIFICITY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOGENETICS; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; HUMAN; HUMAN CELL; LETTER; LEUKEMIA CELL; LEUKEMIA RELAPSE; LEUKEMIA REMISSION; MAJOR CLINICAL STUDY; MONOCYTIC LEUKEMIA; MONONUCLEAR CELL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RISK ASSESSMENT;

EID: 33750354943     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404391     Document Type: Letter

References (9)

1. Morimoto RI, Tissieres A, Geropolous C. Stress Proteins in Biology and Medicine. Cold Spring Harbor Laboratory Press: New York, 1990, pp 1-36.
2. Gehrmann M, Schmetzer H, Eissner G, Haferlach T, Hiddemann W, Multhoff G. Membrane-bound Hsp70 in acute myeloid leukemia: A tumor-specific recognition structure for the cytolytic activity of autologous NK cells. Haematologica 2003; 88: 473-475.
3. Graf M, Reif S, Hecht K, Pfister K, Nüssler V, Schmetzer H. Low CD62L-expression in Acute Myeloid Leukemia (AML) correlates with a bad cytogenetic risk. Eur J Haematol 2003; 71: 366-376.
4. Hantschel M, Pfister K, Jordan A, Scholz R, Andreesen R, Schmitz G et al. Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients. Cell Stress Chaperones 2000; 5: 438-442.
5. Ciocca D, Calderwood S. Heat shock proteins in cancer: Diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 2005; 10: 86-103.
6. Shotar A. P53 and heat shock protein 70 expressions in colorectal adenocarcinoma. Saudi Med J 2005; 26: 1602-1606.
7. Luk J, Lam C, Siu A, Lam B, Ng I, Hu M et al. Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values. Proteomics 2006; 6: 1049-1057.
8. Thomas X, Campos L, Mounier C, Cornillon J, Flandrin P, Le Q et al. Expression of heat-shock proteins is associated with major adverse prognostic factors in acute myeloid leukemia. Leukemia Res 2005; 29: 1049-1058.
9. Multhoff G, Mizzen L, Winchester CC, Milner CM, Wenk S, Kampinga HH et al. Heat shock protein 70 (HSP70) stimulates proliferation and cytolytic activity of NK cells. Exp Hematol 1999; 27: 1627-1636.