A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870

Bioscience Reports

Volumn 34, Issue 1, 2014, Pages 29-41

  Edgar, Alexander J ^a   Trost, Matthias ^a   Watts, Colin ^a   Zaru, Rossana ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

BI D1870; BIX 02565; Dendritic cells; p90 ribosomal S6 kinase (Rsk); Protein kinase B (PKB); Ste 20 like kinase

Indexed keywords

ANTIGEN; BI D 1870; BIX 02565; CYTOKINE; NUCLEOTIDE ACYL PHOSPHATE; PROTEIN KINASE INHIBITOR; PROTEIN MST1; PROTEIN SLK; S6 KINASE; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; 5-METHYL-1-OXO-2,3,4,5-TETRAHYDRO-1H-(1,4)DIAZEPINO(1,2-A)INDOLE-8-CARBOXYLIC ACID (1-(3-DIMETHYLAMINO-PROPYL)-1H-BENZOIMIDAZOL-2-YL)AMIDE; AZEPINE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; BI D1870; NUCLEOTIDE; PROTEIN SERINE THREONINE KINASE; PTERIDINE DERIVATIVE; SLK PROTEIN, MOUSE; STK10 PROTEIN, MOUSE; STK4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BIOTINYLATION; CELL CULTURE; CELL FUNCTION; CELL LABELING; CELL LYSATE; CHEMICAL REACTION; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG POTENCY; DRUG SPECIFICITY; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE COMPLEX; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PINOCYTOSIS; PROTEIN TARGETING; PROTEOMICS; REGULATORY MECHANISM; STABLE ISOTOPE LABELLING BY AMINO ACIDS IN CELL CULTURE; ANIMAL; ANTAGONISTS AND INHIBITORS; METABOLISM; PROCEDURES; STAINING;

ANIMALS; AZEPINES; BENZIMIDAZOLES; DENDRITIC CELLS; MICE; NUCLEOTIDES; PROTEIN-SERINE-THREONINE KINASES; PTERIDINES; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; STAINING AND LABELING;

EID: 84894439460     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20130094     Document Type: Article

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