PARP-1 inhibitor, DPQ, attenuates LPS-induced acute lung injury through inhibiting NF-κB-mediated inflammatory response

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Wang, Gang ^a   Huang, Xiaojia ^b   Li, Yongjin ^b   Guo, Kangkang ^a   Ning, Pengbo ^a   Zhang, Yanming ^a  

^a NORTHWEST A F UNIVERSITY   (China)

^b JIANGSU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LUNG INJURY; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELLS, CULTURED; INFLAMMATION; ISOQUINOLINES; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; PEROXIDASE; PIPERIDINES; POLY(ADP-RIBOSE) POLYMERASES; REAL-TIME POLYMERASE CHAIN REACTION; SEPSIS;

EID: 84894369735     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079757     Document Type: Article

References (60)

1. Cross LJ, Matthay MA (2011) Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury. Crit Care Clin 27: 355-377.
2. Doyle RL, Szaflarski N, Modin GW, Wiener-Kronish JP, Matthay MA (1995) Identification of patients with acute lung injury. Predictors of mortality. Am J Respir Crit Care Med 152: 1818-1824.
3. Matthay MA, Zemans RL (2011) The acute respiratory distress syndrome: pathogenesis and treatment. Annu Rev Pathol 6: 147-163.
4. Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. N Engl J Med 342: 1334-1349.
5. Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, et al. (2005) Incidence and outcomes of acute lung injury. N Engl J Med 353: 1685-1693.
6. Matute-Bello G, Frevert CW, Martin TR (2008) Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol 295: L379-399.
7. Wang HM, Bodenstein M, Markstaller K (2008) Overview of the pathology of three widely used animal models of acute lung injury. Eur Surg Res 40: 305-316.
8. Tobias PS, Mathison JC, Ulevitch RJ (1988) A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis. J Biol Chem 263: 13479-13481.
9. Ulevitch RJ, Tobias PS (1999) Recognition of gram-negative bacteria and endotoxin by the innate immune system. Curr Opin Immunol 11: 19-22.
10. Zhao YY, Gao XP, Zhao YD, Mirza MK, Frey RS, et al. (2006) Endothelial cell-restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury. J Clin Invest 116: 2333-2343.
11. Peng X, Hassoun PM, Sammani S, McVerry BJ, Burne MJ, et al. (2004) Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. Am J Respir Crit Care Med 169: 1245-1251.
12. Hong SJ, Dawson TM, Dawson VL (2004) Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling. Trends Pharmacol Sci 25: 259-264.
13. Gibson BA, Kraus WL (2012) New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. Nat Rev Mol Cell Biol 13: 411-424.
14. Ame JC, Spenlehauer C, de Murcia G (2004) The PARP superfamily. Bioessays 26: 882-893.
15. Bouchard VJ, Rouleau M, Poirier GG (2003) PARP-1, a determinant of cell survival in response to DNA damage. Exp Hematol 31: 446-454.
16. Wang M, Wu W, Rosidi B, Zhang L, Wang H, et al. (2006) PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res 34: 6170-6182.
17. Koedel U, Winkler F, Angele B, Fontana A, Pfister HW (2002) Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase. J Cereb Blood Flow Metab 22: 39-49.
18. Zingarelli B, Szabo C, Salzman AL (1999) Blockade of Poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis. Gastroenterology 116: 335-345.
19. Mukhopadhyay P, Horvath B, Kechrid M, Tanchian G, Rajesh M, et al. (2011) Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury. Free Radic Biol Med 51: 1774-1788.
20. Scott GS, Hake P, Kean RB, Virag L, Szabo C, et al. (2001) Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis. J Neuroimmunol 117: 78-86.
21. Morisugi T, Tanaka Y, Kawakami T, Kirita T (2010) Mechanical stretch enhances NF-kappaB-dependent gene expression and poly(ADP-ribose) synthesis in synovial cells. J Biochem 147: 633-644.
22. Cuzzocrea S, Chatterjee PK, Mazzon E, Dugo L, Serraino I, et al. (2002) Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation. Br J Pharmacol 135: 496-510.
23. Hageman GJ, Larik I, Pennings HJ, Haenen GR, Wouters EF, et al. (2003) Systemic poly(ADP-ribose) polymerase-1 activation, chronic inflammation, and oxidative stress in COPD patients. Free Radic Biol Med 35: 140-148.
24. Kabir K, Gelinas JP, Chen M, Chen D, Zhang D, et al. (2002) Characterization of a murine model of endotoxin-induced acute lung injury. Shock 17: 300-303.
25. Kawasaki M, Kuwano K, Hagimoto N, Matsuba T, Kunitake R, et al. (2000) Protection from lethal apoptosis in lipopolysaccharide-induced acute lung injury in mice by a caspase inhibitor. Am J Pathol 157: 597-603.
26. Hayden MS, Ghosh S (2008) Shared principles in NF-kappaB signaling. Cell 132: 344-362.
27. Lentsch AB, Czermak BJ, Bless NM, Van Rooijen N, Ward PA (1999) Essential role of alveolar macrophages in intrapulmonary activation of NF-kappaB. Am J Respir Cell Mol Biol 20: 692-698.
28. Jagtap P, Soriano FG, Virag L, Liaudet L, Mabley J, et al. (2002) Novel phenanthridinone inhibitors of poly (adenosine 5′-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents. Crit Care Med 30: 1071-1082.
29. Albertini M, Clement MG, Lafortuna CL, Caniatti M, Magder S, et al. (2000) Role of poly-(ADP-ribose) synthetase in lipopolysaccharide-induced vascular failure and acute lung injury in pigs. J Crit Care 15: 73-83.
30. Oliver FJ, Menissier-de Murcia J, Nacci C, Decker P, Andriantsitohaina R, et al. (1999) Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J 18: 4446-4454.
31. Liaudet L, Pacher P, Mabley JG, Virag L, Soriano FG, et al. (2002) Activation of poly(ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation. Am J Respir Crit Care Med 165: 372-377.
32. Soriano FG, Liaudet L, Szabo E, Virag L, Mabley JG, et al. (2002) Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1- deficient mice. Shock 17: 286-292.
33. Huang X, Zhao YY (2012) Transgenic expression of FoxM1 promotes endothelial repair following lung injury induced by polymicrobial sepsis in mice. PLoS One 7: e50094.
34. Lakshmi SP, Reddy AT, Naik MU, Naik UP, Reddy RC (2012) Effects of JAMA deficiency or blocking antibodies on neutrophil migration and lung injury in a murine model of ALI. Am J Physiol Lung Cell Mol Physiol 303: L758-766.
35. Hoth JJ, Wells JD, Hiltbold EM, McCall CE, Yoza BK (2011) Mechanism of neutrophil recruitment to the lung after pulmonary contusion. Shock 35: 604-609.
36. Xiang M, Yin L, Li Y, Xiao G, Vodovotz Y, et al. (2011) Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase. Am J Respir Cell Mol Biol 44: 333-340.
37. Le Gars M, Descamps D, Roussel D, Saussereau E, Guillot L, et al. (2013) Neutrophil elastase degrades cystic fibrosis transmembrane conductance regulator via calpains and disables channel function in vitro and in vivo. Am J Respir Crit Care Med 187: 170-179.
38. Galani V, Tatsaki E, Bai M, Kitsoulis P, Lekka M, et al. (2010) The role of apoptosis in the pathophysiology of Acute Respiratory Distress Syndrome (ARDS): an up-to-date cell-specific review. Pathol Res Pract 206: 145-150.
39. Standiford TJ, Kunkel SL, Basha MA, Chensue SW, Lynch JP 3rd, et al. (1990) Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung. J Clin Invest 86: 1945-1953.
40. Martin TR, Mathison JC, Tobias PS, Leturcq DJ, Moriarty AM, et al. (1992) Lipopolysaccharide binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide. Implications for cytokine production in normal and injured lungs. J Clin Invest 90: 2209-2219.
41. Mariappan N, Elks CM, Fink B, Francis J (2009) TNF-induced mitochondrial damage: a link between mitochondrial complex I activity and left ventricular dysfunction. Free Radic Biol Med 46: 462-470.
42. 2+ spark activation. Am J Physiol Cell Physiol 290: C964-971.
43. Arbibe L, Vial D, Rosinski-Chupin I, Havet N, Huerre M, et al. (1997) Endotoxin induces expression of type II phospholipase A2 in macrophages during acute lung injury in guinea pigs: involvement of TNF-alpha in lipopolysaccharide-induced type II phospholipase A2 synthesis. J Immunol 159: 391-400.
44. Wolthuis EK, Vlaar AP, Choi G, Roelofs JJ, Haitsma JJ, et al. (2009) Recombinant human soluble tumor necrosis factor-alpha receptor fusion protein partly attenuates ventilator-induced lung injury. Shock 31: 262-266.
45. Rovin BH, Dickerson JA, Tan LC, Fassler J (1997) Modulation of IL-1-induced chemokine expression in human mesangial cells through alterations in redox status. Cytokine 9: 178-186.
46. Olman MA, White KE, Ware LB, Cross MT, Zhu S, et al. (2002) Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1. Chest 121: 69S-70S.
47. Pugin J, Ricou B, Steinberg KP, Suter PM, Martin TR (1996) Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1. Am J Respir Crit Care Med 153: 1850-1856.
48. Feinman R, Deitch EA, Watkins AC, Abungu B, Colorado I, et al. (2010) HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol 299: G833-843.
49. Xu M, Cao F, Liu L, Zhang B, Wang Y, et al. (2011) Tanshinone IIA-induced attenuation of lung injury in endotoxemic mice is associated with reduction of hypoxia-inducible factor 1alpha expression. Am J Respir Cell Mol Biol 45: 1028-1035.
50. Csiszar A, Wang M, Lakatta EG, Ungvari Z (2008) Inflammation and endothelial dysfunction during aging: role of NF-kappaB. J Appl Physiol 105: 1333-1341.
51. Yu PJ, Li JR, Zhu ZG, Kong HY, Jin H, et al. (2013) Praeruptorin D and E attenuate lipopolysaccharide/hydrochloric acid induced acute lung injury in mice. Eur J Pharmacol 710: 39-48.
52. Nathens AB, Bitar R, Davreux C, Bujard M, Marshall JC, et al. (1997) Pyrrolidine dithiocarbamate attenuates endotoxin-induced acute lung injury. Am J Respir Cell Mol Biol 17: 608-616.
53. Ullrich O, Diestel A, Eyupoglu IY, Nitsch R (2001) Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1. Nat Cell Biol 3: 1035-1042.
54. Andreone TL, O'Connor M, Denenberg A, Hake PW, Zingarelli B (2003) Poly(ADP-ribose) polymerase-1 regulates activation of activator protein-1 in murine fibroblasts. J Immunol 170: 2113-2120.
55. Helenius M, Hanninen M, Lehtinen SK, Salminen A (1996) Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle. J Mol Cell Cardiol 28: 487-498.
56. Szabados E, Fischer GM, Toth K, Csete B, Nemeti B, et al. (1999) Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat. Free Radic Biol Med 26: 309-317.
57. Schraufstatter IU, Hinshaw DB, Hyslop PA, Spragg RG, Cochrane CG (1986) Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J Clin Invest 77: 1312-1320.
58. Zerfaoui M, Errami Y, Naura AS, Suzuki Y, Kim H, et al. (2010) Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation. J Immunol 185: 1894-1902.
59. Kameoka M, Ota K, Tetsuka T, Tanaka Y, Itaya A, et al. (2000) Evidence for regulation of NF-kappaB by poly(ADP-ribose) polymerase. Biochem J 346 Pt 3: 641-649.
60. 2 production promotes endothelial NF-kappaB activation in aged rat arteries. Am J Physiol Heart Circ Physiol 293: H37-47.