Role of poly-(ADP-ribose) synthetase in lipopolysaccharide-induced vascular failure and acute lung injury in pigs

Journal of Critical Care

Volumn 15, Issue 2, 2000, Pages 73-83

  Albertini, Mariangela ^a   Clement, Maria G ^a   Lafortuna, Claudio L ^a   Caniatti, Mario ^a   Magder, Sheldon ^a   Abdulmalek, Kefaya ^a   Hussain, Sabah N A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; IMMUNOHISTOCHEMISTRY; LUNG HEMODYNAMICS; LUNG INJURY; LUNG MECHANICS; MALE; NONHUMAN; PATHOGENESIS; PROTEIN ANALYSIS; SWINE; VASCULAR DISEASE;

EID: 0034095543     PISSN: 08839441     EISSN: None     Source Type: Journal    
DOI: 10.1053/jcrc.2000.7903     Document Type: Article

References (25)

1. Banasik M, Ueda K. Inhibitors and activators of ADP-ribosylation reactions. Mol Cell Biochem. 138:1998;185-197
2. Szabó C, Saunders C, O'Connor M, et al. Peroxynitrite causes energy depletion and increases permeability via activation of poly (ADP-ribose) synthetase in pulmonary epithelial cells. Am J Respir Cell Mol Biol. 16:1997;105-109
3. Szabó C, Zingarelli B, Salzman A. Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Circ Res. 78:1997;1051-1063
4. Zingarelli B, Salzman A, Szabó C. Protective effects of nicotinamide against nitric oxide mediated delayed vascular failure in septic shock: Potential involvement of poly ADP ribosyl synthetase. Shock. 5:1996;258-264
5. Pheng LH, Francoeur C, Denis M. The involvement of nitric oxide in a mouse model of adult respiratory distress syndrome. Inflammation. 19:1995;599-610
6. Kristof A, Goldberg P, Laubach VE, et al. Role of inducible nitric oxide synthase in endotoxin-induced acute lung injury. Am J Resp Crit Care Med. 158:1998;1883-1889
7. Kooy NW, Royall JA, Ye YZ, et al. Evidence for in-vitro peroxynitrite production in human acute lung injury. Am J Resp Crit Care Med. 151:1995;1250-1254
8. Bates JHT, Rossi A, Milic-Emili J. Analysis of the behavior of the respiratory system with constant inspiratory flow. J Appl Physiol. 58:1985;1840-1848
9. Althaus FR, Lawrence SD, Sattler GI, et al. ADP-ribosyltransferase activity in cultured hepatocytes: Interaction with DNA repair. J Biol Chem. 257:1982;5528-5535
10. Cuzzocrea s, Zingarelli B, Constantino G, et al. Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion. Br J Pharmacol. 121:1997;1065-1074
11. Mehta S, Javeshghani D, Datta P, et al. Porcine endotoxemic shock is associated with increased expired nitric oxide. Crit Care Med. 27:1999;385-393
12. Szabó C. Alterations in nitric oxide production in various forms of circulatory shock. New Horizons. 3:1995;2-32
13. Szabó C, Salzman AL, Ischiropoulos H. Peroxynitritemediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemiareperfusion injury. FEBS Lett. 372:1995;229-232
14. Cochrane CG. Mechanisms of oxidant injury of cells. Mol Aspects Med. 12:1991;137-147
15. Javeshghani D, Magder S. It is not the amount or type of nitric oxide that counts in sepsis but the company that it keeps. Am J Resp Crit Care Med. 155:1997;A96. (abstr)
16. Zhang X, Laubach VE, Alley EW, et al. Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-gamma. J Leukoc Biol. 59:1996;575-585
17. Hales CA, Sonne L, Peterson M, et al. Role of thromboxane and prostacyclin in pulmonary vasomotor changes after endotoxin in dogs. J Clin Invest. 68:1981;497-505
18. Wanecek M, Rudehill A, Hemsen A, et al. The endothelin receptor antagonist, bosentan in combination with the cyclooxygenase inhibitor, diclofenac, counteracts pulmonary hypertension in porcine endotoxin shock. Crit Care Med. 25:1997;848-857
19. Dahm PL, Jonson B, De Robertis E, et al. The effects of nitric oxide inhalation on respiratory mechanics and gas exchange during endotoxaemia in the pig. Acta Anaesthesiol Scand. 42:1998;536-544
20. Forsgren P, Modig J. Lung mechanics with relation to pulmonary haemodynamics: Gas exchange and extravascular lung water in mechanically ventilated endotoxaemic pigs. Acta Chir Scand. 152:1986;561-568
21. Szabo A, Salzman AL, Szabó C. Poly (ADP-ribose) synthetase activation mediates pulmonary microvascular and intestinal mucosal dysfunction in endotoxin shock. Life Sci. 63:1998;2133-2139
22. Szabó C, Zingarelli B, O'Connor M, et al. DNA strand breakage, activation of poly (ADP ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells expose to peroxynitrite. Proc Natl Acad Sci USA. 93:1998;1753-1758
23. Szabó C, Lim LHK, Cuzzocrea S, et al. Inhibition of poly (ADP-ribose) synthase attenuates neutrophil recruitment and exerts anti-inflammatory effects. J Exp Med. 186:1997;1041-1049
24. Zingarelli B, Salzman AL, Szabó C. Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury. Circ Res. 83:1998;85-94
25. Le Page C, Sanceau J, Drapier JC, et al. Inhibitors of ADP-ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF Kappa B activation. Biochem Biophys Res Commun. 243:1998;451-457