Endothelial cell-restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury

Journal of Clinical Investigation

Volumn 116, Issue 9, 2006, Pages 2333-2343

  Zhao, You Yang ^a   Gao, Xiao Pei ^a   Zhao, Yidan D ^a   Mirza, Muhammad K ^a   Frey, Randall S ^a   Kalinichenko, Vladimir V ^b   Wang, I Ching ^a   Costa, Robert H ^a   Malik, Asrar B ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYTOKINE; LIPOPOLYSACCHARIDE; PROTEIN FORKHEAD BOX M1; PROTEIN TYROSINE PHOSPHATASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL INJURY; BLOOD VESSEL PERMEABILITY; BONE MARROW CELL; CARDIOVASCULAR SYSTEM; CELL CYCLE PROGRESSION; CELL DISRUPTION; CELL ISOLATION; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE DELETION; INFLAMMATION; MORTALITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; BASE SEQUENCE; BONE MARROW TRANSPLANTATION; CAPILLARY PERMEABILITY; CELL CYCLE; CELLS, CULTURED; CHEMOKINES; CYTOKINES; DNA PRIMERS; ENDOTHELIUM, VASCULAR; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION PROFILING; HUMANS; LIPOPOLYSACCHARIDES; MICE; MICE, TRANSGENIC; PULMONARY CIRCULATION; RNA, SMALL INTERFERING;

EID: 33748302966     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI27154     Document Type: Article

References (37)

1. Cines, D.B., et al. 1998. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood. 91:3527-3561.
2. Ross, R. 1999. Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340:115-126.
3. Libby, P., Ridker, P.M., and Maseri, A. 2002. Inflammation and atherosclerosis. Circulation. 105:1135-1143.
4. Austin, G.E., Ratliff, N.B., Hollman, J., Tabei, S., and Phillips, D.F. 1985. Intimal proliferation of smooth muscle cells as an explanation for recurrent coronary artery stenosis after percutaneous transluminal coronary angioplasty. J. Am. Coll. Cardiol. 6:369-375.
5. Schwartz, R.S., Holmes, D.R., Jr., and Topol, E.J. 1992. The restenosis paradigm revisited: an alternative proposal for cellular mechanisms. J. Am. Coll. Cardiol. 20:1284-1293.
6. McFadden, E.P., et al. 1993. Response of human coronary arteries to serotonin after injury by coronary angioplasty. Circulation. 88:2076-2085.
7. Ware, L.B., and Matthay, M.A. 2000. The acute respiratory distress syndrome. N. Engl. J. Med. 342:1334-1349.
8. Kaestner, K.H., Knochel, W., and Martinez, D.E. 2000. Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev. 14:142-146.
9. Clark, K.L., Halay, E.D., Lai, E., and Burley, S.K. 1993. Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Nature. 364:412-420.
10. Korver, W., Roose, J., and Clevers, H. 1997. The winged-helix transcription factor Trident is expressed in cycling cells. Nucleic Acids Res. 25:1715-1719.
11. Ye, H., et al. 1997. Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. Mol. Cell. Biol. 17:1626-1641.
12. Yao, K.M., Sha, M., Lu, Z., and Wong, G.G. 1997. Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain. J. Biol. Chem. 272:19827-19836.
13. Wang, X., Kiyokawa, H., Dennewitz, M.B., and Costa, R.H. 2002. The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration. Proc. Natl. Acad. Sci. U. S. A. 99:16881-16886.
14. Kalinichenko, V.V., et al. 2004. Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev. 18:830-850.
15. Kalinichenko, V.V., et al. 2003. Ubiquitous expression of the forkhead box M1B transgene accelerates proliferation of distinct pulmonary cell types following lung injury. J. Biol. Chem. 278:37888-37894.
16. Krupczak-Hollis, K., et al. 2004. The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Dev. Biol. 276:74-88.
17. Laoukili, J., et al. 2005. FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat. Cell Biol. 7:126-136.
18. Costa, R.H. 2005. FoxM1 dances with mitosis. Nat. Cell Biol. 7:108-110.
19. Wang, I.-C., et al. 2005. Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol. Cell. Biol. 25:10875-10894.
20. Kisanuki, Y.Y., et al. 2001. Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev. Biol. 230:230-242.
21. Liao, Y., Day, K.H., Damon, D.N., and Duling, B.R. 2001. Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice. Proc. Natl. Acad. Sci. U. S. A. 98:9989-9994.
22. Kondo, T., et al. 2003. Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J. Clin. Invest. 111:1835-1842. doi:10.1172/JCI200317455.
23. Kim, I.M., et al. 2005. The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature. J. Biol. Chem. 280:22278-22286.
24. Gao, X., et al. 2001. Differential role of CD18 integrins in mediating lung neutrophil sequestration and increased microvascular permeability induced by Escherichia coli in mice. J. Immunol. 167:2895-2901.
25. Tiruppathi, C., et al. 2002. Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability. Circ. Res. 91:70-76.
26. Windsor, A.C., Mullen, P.G., and Fowler, A.A. 1993. Acute lung injury: what have we learned from animal models? Am. J. Med. Sci. 306:111-116.
27. Ware, L.B., and Matthay, M.A. 2000. The acute respiratory distress syndrome. N. Engl. J. Med. 342:1334-1349.
28. Fujita, M., et al. 1998. Endothelial cell apoptosis in lipopolysaccharide-induced lung injury in mice. Int. Arch. Allergy Immunol. 117:202-208.
29. Kitamura, Y., et al. 2001. Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice. Am. J. Respir. Crit. Care Med. 163:762-769.
30. Wiener-Kronish, J.P., Albertine, K.H., and Matthay, M.A. 1991. Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin. J. Clin. Invest. 88:864-875.
31. Koni, P.A., et al. 2001. Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J. Exp. Med. 193:741-753.
32. Sherr, C.J., and Roberts, J.M. 1999. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1501-1512.
33. Abid, M.R., et al. 2004. Vascular endothelial growth factor activates PI3K/Akt/Forkhead signaling in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 24:294-300.
34. Massague, J. 2004. G1 cell-cycle control and cancer. Nature. 432:298-306.
35. Nilsson, I., and Hoffman, I. 2000. Cell cycle regulation by the Cdc25 phosphatase family. Prog. Cell Cycle Res. 4:107-114.
36. Zhao, Y.Y., et al. 2002. Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc. Natl. Acad. Sci. U. S. A. 99:11375-11380.
37. Frey, R.S., Rahman, A., Kefer, J.C., Minshall, R.D., and Malik, A.B. 2002. PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells. Circ. Res. 90:1012-1019.