Integrated analytical techniques with high sensitivity for studying brain translocation and potential impairment induced by intranasally instilled copper nanoparticles

Toxicology Letters

Volumn 226, Issue 1, 2014, Pages 70-80

  Bai, Ru ^a   Zhang, Lili ^a,b   Liu, Ying ^a   Li, Bai ^a   Wang, Liming ^a   Wang, Peng ^a   Autrup, Herman ^c   Beer, Christiane ^c   Chen, Chunying ^a  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI INSTITUTE OF APPLIED PHYSICS   (China)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

Brain translocation; Copper nanoparticles; Histopathological examination; ICP MS; SRXRF

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; COPPER; COPPER NANOPARTICLE; DOPAMINE; HOMOVANILLIC ACID; NORADRENALIN; SEROTONIN;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN DYSFUNCTION; BRAIN LEVEL; BRAIN REGION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG MEGADOSE; EXPERIMENTAL CNS INJURY; FEMALE; GENE TRANSLOCATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; MASS SPECTROMETRY; MOUSE; NANOTOXICOLOGY; NERVE CELL LESION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; STAINING; SYNCHROTRON RADIATION; TARGET CELL; TISSUE DISTRIBUTION; WEIGHT REDUCTION; X RAY FLUORESCENCE;

BRAIN TRANSLOCATION; COPPER NANOPARTICLES; HISTOPATHOLOGICAL EXAMINATION; ICP-MS; SRXRF;

ANIMALS; BIOGENIC MONOAMINES; BIOLOGICAL TRANSPORT; BODY WEIGHT; BRAIN; COPPER; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INHALATION EXPOSURE; METAL NANOPARTICLES; MICE; MICE, INBRED ICR; RISK ASSESSMENT; SYSTEMS INTEGRATION; TIME FACTORS; TISSUE DISTRIBUTION; TOXICITY TESTS;

EID: 84894307748     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.01.041     Document Type: Article

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