The dose-dependent toxicological effects and potential perturbation on the neurotransmitter secretion in brain following intranasal instillation of copper nanoparticles

Nanotoxicology

Volumn 6, Issue 5, 2012, Pages 562-575

  Zhang, Lili ^a   Ru, Bai ^a   Liu, Ying ^a   Li, Meng ^a   Li, Bai ^b   Wang, Liming ^a   Xu, Ligeng ^a   Le Guyader, Laurent ^a   Chen, Chunying ^a  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^b INSTITUTE OF HIGH ENERGY PHYSICS   (China)

Author keywords

Copper nanoparticles; Intranasal instillation; Mouse; Neurotoxicity; Neurotransmitter; Pathological lesion; Systemic toxicity

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; COPPER; DOPAMINE; HOMOVANILLIC ACID; NANOPARTICLE; NEUROTRANSMITTER; NORADRENALIN; SEROTONIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; LIVER LEVEL; LUNG; MOUSE; NANOTOXICOLOGY; NEUROTOXICITY; NEUROTRANSMITTER RELEASE; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; TOXICITY TESTING;

ACETYLCHOLINESTERASE; ADMINISTRATION, INTRANASAL; ANALYSIS OF VARIANCE; ANIMALS; BODY WEIGHT; BRAIN CHEMISTRY; COPPER; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUTAMIC ACID; HISTOCYTOCHEMISTRY; METAL NANOPARTICLES; MICE; MICE, INBRED ICR; NEUROTRANSMITTER AGENTS; NITRIC OXIDE; TISSUE DISTRIBUTION;

MUS;

EID: 84863802851     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2011.590906     Document Type: Article

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