High glucose induced oxidative stress and apoptosis in cardiac microvascular endothelial cells are regulated by FoxO3a

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Peng, Chaoming ^a   Ma, Junli ^b   Gao, Xue ^c   Tian, Peng ^a   Li, Wenzhang ^a   Zhang, Lei ^a  

^a Cheng du Medical College   (China)

^b Department of Nephrology   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-X PROTEIN; DOWN-REGULATION; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSE; HEART; MALE; MEMBRANE PROTEINS; MICROVESSELS; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING;

EID: 84894141623     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079739     Document Type: Article

References (40)

1. Mazzone T (2010) Intensive glucose lowering and cardiovascular disease prevention in diabetes: reconciling the recent clinical trial data. Circulation 122: 2201-2211.
2. Patlak M (2002) New weapons to combat an ancient disease: treating diabetes. FASEB J 16: 1853.
3. Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820.
4. Voulgari C, Papadogiannis D, Tentolouris N (2010) Diabetic cardiomyopathy: from the pathophysiology of the cardiac myocytes to current diagnosis and management strategies. Vasc Health Risk Manag 6: 883-903.
5. Ismail-Beigi F, Craven T, Banerji MA, Basile J, Calles J, et al. (2010) Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial. Lancet 376: 419-430.
6. Li JM, Mullen AM, Shah AM (2001) Phenotypic properties and characteristics of superoxide production by mouse coronary microvascular endothelial cells. J Mol Cell Cardiol 33: 1119-1131. (Pubitemid 32579279)
7. Hao M, Li SY, Sun CK, Jingyu X, Lin Y, et al. (2011) Amelioration effects of berberine on diabetic microendothelial injury model by the combination of high glucose and advanced glycation end products in vitro. Eur J Pharmacol 654: 320-325.
8. Wei W, Liu Q, Tan Y, Liu L, Li X, et al. (2009) Oxidative stress, diabetes, and diabetic complications. Hemoglobin 33: 370-377.
9. Giacco F, Brownlee M (2010) Oxidative stress and diabetic complications. Circ Res 107: 1058-1070.
10. Huang X, Zhang J, Liu J, Sun L, Zhao H, et al. (2012) C-reactive protein promotes adhesion of monocytes to endothelial cells via NADPH oxidase-mediated oxidative stress. J Cell Biochem 113: 857-867.
11. Naudi A, Jove M, Ayala V, Cassanye A, Serrano J, et al. (2012) Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stress. Exp Diabetes Res 2012: 696215.
12. Folli F, Corradi D, Fanti P, Davalli A, Paez A, et al. (2011) The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro- and macrovascular complications: avenues for a mechanistic-based therapeutic approach. Curr Diabetes Rev 7: 313-324.
13. Scarabelli T, Stephanou A, Rayment N, Pasini E, Comini L, et al. (2001) Apoptosis of endothelial cells precedes myocyte cell apoptosis in ischemia/reperfusion injury. Circulation 104: 253-256. (Pubitemid 32666943)
14. Accili D, Arden KC (2004) FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117: 421-426. (Pubitemid 38610228)
15. Arden KC (2007) FoxOs in tumor suppression and stem cell maintenance. Cell 128: 235-237.
16. van der Horst A, Burgering BM (2007) Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 8: 440-450.
17. Skurk C, Maatz H, Kim HS, Yang J, Abid MR, et al. (2004) The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J Biol Chem 279: 1513-1525. (Pubitemid 38082681)
18. Ronnebaum SM, Patterson C (2010) The FoxO family in cardiac function and dysfunction. Annu Rev Physiol 72: 81-94.
19. Samarin J, Wessel J, Cicha I, Kroening S, Warnecke C, et al. (2010) FoxO proteins mediate hypoxic induction of connective tissue growth factor in endothelial cells. J Biol Chem 285: 4328-4336.
20. Zhang Z, Li W, Sun D, Zhao L, Zhang R, et al. (2011) Toll-like receptor 4 signaling in dysfunction of cardiac microvascular endothelial cells under hypoxia/reoxygenation. Inflamm Res 60: 37-45.
21. Luan R, Liu S, Yin T, Lau WB, Wang Q, et al. (2009) High glucose sensitizes adult cardiomyocytes to ischaemia/reperfusion injury through nitrative thioredoxin inactivation. Cardiovasc Res 83: 294-302.
22. Wang D, Luo P, Wang Y, Li W, Wang C, et al. (2013) Glucagon-Like Peptide-1 Protects Against Cardiac Microvascular Injury in Diabetes Via a cAMP/PKA/Rho-Dependent Mechanism. Diabetes.
23. Sun D, Shen M, Li J, Li W, Zhang Y, et al. (2011) Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3beta dependent pathway in experimental diabetic cardiomyopathy. Cardiovasc Diabetol 10: 4.
24. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D, et al. (2007) The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Gastroenterology 132: 1434-1446. (Pubitemid 46627569)
25. Fu Z, Tindall DJ (2008) FOXOs, cancer and regulation of apoptosis. Oncogene 27: 2312-2319. (Pubitemid 351501782)
26. Hendrickx J, Doggen K, Weinberg EO, Van Tongelen P, Fransen P, et al. (2004) Molecular diversity of cardiac endothelial cells in vitro and in vivo. Physiol Genomics 19: 198-206.
27. Mortuza R, Chen S, Feng B, Sen S, Chakrabarti S (2013) High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway. PLoS One 8: e54514.
28. Luo H, Yang Y, Duan J, Wu P, Jiang Q, et al. (2013) PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells. Cell Death Dis 4: e481.
29. Essers MA, de Vries-Smits LM, Barker N, Polderman PE, Burgering BM, et al. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308: 1181-1184. (Pubitemid 40696437)
30. Spinetti G, Cordella D, Fortunato O, Sangalli E, Losa S, et al. (2013) Global remodeling of the vascular stem cell niche in bone marrow of diabetic patients: implication of the microRNA-155/FOXO3a signaling pathway. Circ Res 112: 510-522.
31. Spinetti G, Fortunato O, Caporali A, Shantikumar S, Marchetti M, et al. (2013) MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia. Circ Res 112: 335-346.
32. Millar TM, Phan V, Tibbles LA (2007) ROS generation in endothelial hypoxia and reoxygenation stimulates MAP kinase signaling and kinase-dependent neutrophil recruitment. Free Radic Biol Med 42: 1165-1177. (Pubitemid 46428512)
33. Goyeneche AA, Harmon JM, Telleria CM (2006) Cell death induced by serum deprivation in luteal cells involves the intrinsic pathway of apoptosis. Reproduction 131: 103-111. (Pubitemid 43230708)
34. Powell-Coffman JA, Coffman CR (2010) Apoptosis: Lack of oxygen aids cell survival. Nature 465: 554-555.
35. Chen S, Mukherjee S, Chakraborty C, Chakrabarti S (2003) High glucose-induced, endothelin-dependent fibronectin synthesis is mediated via NF-kappa B and AP-1. Am J Physiol Cell Physiol 284: C263-272. (Pubitemid 36120064)
36. Rao KS (2009) Free radical induced oxidative damage to DNA: relation to brain aging and neurological disorders. Indian J Biochem Biophys 46: 9-15.
37. Liu JW, Chandra D, Rudd MD, Butler AP, Pallotta V, et al. (2005) Induction of prosurvival molecules by apoptotic stimuli: involvement of FOXO3a and ROS. Oncogene 24: 2020-2031. (Pubitemid 40516195)
38. Hagenbuchner J, Kuznetsov A, Hermann M, Hausott B, Obexer P, et al. (2012) FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3. J Cell Sci 125: 1191-1203.
39. Avogaro A, Fadini GP, Gallo A, Pagnin E, de Kreutzenberg S (2006) Endothelial dysfunction in type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis 16 Suppl 1: S39-45.
40. Bouillet P, Purton JF, Godfrey DI, Zhang LC, Coultas L, et al. (2002) BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415: 922-926. (Pubitemid 34174755)