Non-Celiac Gluten Sensitivity: Literature Review

Journal of the American College of Nutrition

Volumn 33, Issue 1, 2014, Pages 39-54

  Mansueto, Pasquale ^a   Seidita, Aurelio ^a   D'Alcamo, Alberto ^a   Carroccio, Antonio ^b  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

celiac disease; flow cytometric basophil activation test; food allergy; HLA; innate immune response; non celiac gluten sensitivity; wheat allergy

Indexed keywords

CELIAC DISEASE; DIET, GLUTEN-FREE; FOOD HYPERSENSITIVITY; GASTROINTESTINAL DISEASES; GLUTENS; HUMANS; TRITICUM;

EID: 84894077435     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2014.869996     Document Type: Article

References (128)

1. Shewry, P R. 2009. Wheat. J Exp Bot, 60: 1537 - 1553.
2. Losowsky, M S. 2008. A history of coeliac disease. Dig Dis, 26: 112 - 120.
3. Martin, S. 2008. Against the grain: an overview of celiac disease. J Am Acad Nurse Pract, 20: 243 - 250.
4. Reilly, N R and Green, P H. 2012. Epidemiology and clinical presentations of celiac disease. Semin Immunopathol, 34: 473 - 478.
5. Rewers, M. 2005. Epidemiology of celiac disease: what are the prevalence, incidence, and progression of celiac disease?. Gastroenterology, 128 (4 SUPPL. 1): S47 - S51.
6. Mustalahti, K, Catassi, C, Reunanen, A, Fabiani, E, Heier, M, McMillan, S, Murray, L, Metzger, M H, Gasparin, M, Bravi, E, Mäki, M and the Coeliac EU Cluster, Project Epidemiology. 2010. The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann Med, 42: 587 - 595.
7. Riddle, M S, Murray, J A and Porter, C K. 2012. The incidence and risk of celiac disease in a healthy US adult population. Am J Gastroenterol, 107: 1248 - 1255.
8. Rubio-Tapia, A, Ludvigsson, J F, Brantner, T L, Murray, J A and Everhart, J E. 2012. The prevalence of celiac disease in the United States. Am J Gastroenterol, 107: 1538 - 1544.
9. Volta, U and De Giorgio, R. 2012. New understanding of gluten sensitivity. Nat Rev Gastroenterol Hepatol, 9: 295 - 299.
10. Aziz, I and Sanders, D S. 2012. Emerging concepts: from coeliac disease to non-coeliac gluten sensitivity. Proc Nutr Soc, 71: 576 - 580.
11. Bizzaro, N, Tozzoli, R, Villalta, D, Fabris, M and Tonutti, E. 2012. Cutting-edge issues in celiac disease and in gluten intolerance. Clin Rev Allergy Immunol, 42: 279 - 287.
12. Di Sabatino, A and Corazza, G R. 2012. Nonceliac gluten sensitivity: sense or sensibility?. Ann Intern Med, 156: 309 - 311.
13. Lyndsey, L. 3 years after deadline, FDA still hasn't defined 'gluten-free'. The Washington Post April 29, 2011. Accessed at: http://www.washingtonpost.com/politics/3-years-after-deadline-fda-still-hasnt-defined-gluten-free/2011/04/22/AFRq6i8E_story.html
14. Verdu, E F, Armstrong, D and Murray, J A. 2009. Between celiac disease and irritable bowel syndrome: the "no man's land" of gluten sensitivity. Am J Gastroenterol, 104: 1587 - 1594.
15. Ball, A J, Hadjivassiliou, M and Sanders, D S. 2010. Is gluten sensitivity a "no man's land" or a "fertile crescent" for research?. Am J Gastroenterol, 105: 222 - 223.
16. Battais, F, Richard, C, Jacquenet, S, Denery-Papini, S and Moneret-Vautrin, D A. 2008. Wheat grain allergies: an update on wheat allergens. Eur Ann Allergy Clin Immunol, 40: 67 - 76.
17. Wieser, H. 2007. Chemistry of gluten proteins. Food Microbiol, 24: 115 - 119.
18. Howdle, P D. 2006. Gliadin, glutenin or both? The search for the Holy Grail in coeliac disease. Eur J Gastroenterol Hepatol, 18: 703 - 706.
19. Black, J L and Orfila, C. 2011. Impact of coeliac disease on dietary habits and quality of life. J Hum Nutr Diet, 24: 582 - 587.
20. Hyams, J S. 2002. Diet and gastrointestinal disease. Curr Opin Pediatr, 14: 567 - 569.
21. Scanlon, S A and Murray, J A. 2011. Update on celiac disease-etiology, differential diagnosis, drug targets, and management advances. Clin Exp Gastroenterol, 4: 297 - 311.
22. Diaz-Amigo, C and Popping, B. 2012. Gluten and gluten-free: issues and considerations of labeling regulations, detection methods, and assay validation. J AOAC Int, 95: 337 - 348.
23. Sapone, A, Bai, J C, Ciacci, C, Dolinsek, J, Green, P H, Hadjivassiliou, M, Kaukinen, K, Rostami, K, Sanders, D S, Schumann, M, Ullrich, R, Villalta, D, Volta, U, Catassi, C and Fasano, A. 2012. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med, 10: 13
24. Troncone, R and Jabri, B. 2011. Coeliac disease and gluten sensitivity. J Intern Med, 269: 582 - 590.
25. Volta, U, Tovoli, F, Cicola, R, Parisi, C, Fabbri, A, Piscaglia, M, Fiorini, E and Caio, G. 2012. Serological tests in gluten sensitivity (nonceliac gluten intolerance). J Clin Gastroenterol, 46: 680 - 685.
26. Ludvigsson, J F, Leffler, D A, Bai, J C, Biagi, F, Fasano, A, Green, P H, Hadjivassiliou, M, Kaukinen, K, Kelly, C P, Leonard, J N, Lundin, K E, Murray, J A, Sanders, D S, Walker, M M, Zingone, F and Ciacci, C. 2013. The Oslo definitions for coeliac disease and related terms. Gut, 62: 43 - 52.
27. Giersiepen, K, Lelgemann, M, Stuhldreher, N, Ronfani, L, Husby, S, Koletzko, S, Korponay-Szabó, I R and the ESPGHAN Working Group on Coeliac Disease Diagnosis. 2012. Accuracy of diagnostic antibody tests for coeliac disease in children: summary of an evidence report. J Pediatr Gastroenterol Nutr, 54: 229 - 241.
28. Kaukinen, K, Turjanmaa, K, Mäki, M, Partanen, J, Venäläinen, R, Reunala, T and Collin, P. 2000. Intolerance to cereals is not specific for coeliac disease. Scand J Gastroenterol, 35: 942 - 946.
29. Cooper, B T, Holmes, G K, Ferguson, R, Thompson, R A, Allan, R N and Cooke, W T. 1980. Gluten-sensitive diarrhea without evidence of celiac disease. Gastroenterology, 79: 801 - 806.
30. Ribes-Koninckx, C, Mearin, M L, Korponay-Szabó, I R, Shamir, R, Husby, S, Ventura, A, Branski, D, Catassi, C, Koletzko, S, Mäki, M, Troncone, R, Zimmer, K P and the ESPGHAN Working Group on Coeliac Disease Diagnosis: Coeliac disease diagnosis. 2012. ESPGHAN 1990 criteria or need for a change? Results of a questionnaire. J Pediatr Gastroenterol Nutr, 54: 15 - 19.
31. Cianci, R, Pagliari, D, Landolfi, R, Frosali, S, Colagiovanni, A, Cammarota, G and Pandolfi, F. 2012. New insights on the role of T cells in the pathogenesis of celiac disease. J Biol Regul Homeost Agents, 26: 171 - 179.
32. Qiao, S W, Iversen, R, Ráki, M and Sollid, L M. 2012. The adaptive immune response in celiac disease. Semin Immunopathol, 34: 523 - 540.
33. Di Sabatino, A, Vanoli, A, Giuffrida, P, Luinetti, O, Solcia, E and Corazza, G R. 2012. The function of tissue transglutaminase in celiac disease. Autoimmun Rev, 11: 746 - 753.
34. Inomata, N. 2009. Wheat allergy. Curr Opin Allergy Clin Immunol, 9: 238 - 243.
35. Keet, C A, Matsui, E C, Dhillon, G, Lenehan, P, Paterakis, M and Wood, R A. 2009. The natural history of wheat allergy. Ann Allergy Asthma Immunol, 102: 410 - 415.
36. Fraser, J S, Engel, W, Ellis, H J, Moodie, S J, Pollock, E L, Wieser, H and Ciclitira, P J. 2003. Coeliac disease: in vivo toxicity of the putative immunodominant epitope. Gut, 52: 1698 - 1702.
37. Moron, B, Bethune, M T, Comino, I, Manyani, H, Ferragud, M, Lopez, M C, Cebolla, A, Khosla, C and Sousa, C. 2008. Toward the assessment of food toxicity for celiac patients: characterization of monoclonal antibodies to a main immunogenic gluten peptide. PLoS One, 3: e2294
38. Dolfini, E, Roncoroni, L, Elli, L, Fumagalli, C, Colombo, R, Ramponi, S, Forlani, F and Bardella, M T. 2005. Cytoskeleton reorganization and ultrastructural damage induced by gliadin in a three-dimensional in vitro model. World J Gastroenterol, 11: 7597 - 7601.
39. Clemente, M G, De Virgiliis, S, Kang, J S, Macatagney, R, Musu, M P, Di Pierro, M R, Drago, S, Congia, M and Fasano, A. 2003. Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut, 52: 218 - 223.
40. Drago, S, El Asmar, R, Di Pierro, M, Grazia Clemente, M, Tripathi, A, Sapone, A, Thakar, M, Iacono, G, Carroccio, A, D'Agate, C, Not, T, Zampini, L, Catassi, C and Fasano, A. 2006. Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand J Gastroenterol, 41: 408 - 419.
41. Fasano, A. 2012. Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clin Gastroenterol Hepatol, 10: 1096 - 1100.
42. Elli, L, Dolfini, E and Bardella, M T. 2003. Gliadin cytotoxicity and in vitro cell cultures. Toxicol Lett, 146: 1 - 8.
43. Reinke, Y, Behrendt, M, Schmidt, S, Zimmer, K P and Naim, H Y. 2011. Impairment of protein trafficking by direct interaction of gliadin peptides with actin. Exp Cell Res, 317: 2124 - 2135.
44. Luciani, A, Villella, V R, Vasaturo, A, Giardino, I, Pettoello-Mantovani, M, Guido, S, Cexus, O N, Peake, N, Londei, M, Quaratino, S and Maiuri, L. 2010. Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARgamma downregulation in intestinal epithelial cells and coeliac mucosa. Gut, 59: 311 - 319.
45. Ertekin, V, Selimoǧlu, M A, Türkan, Y and Akçay, F. 2005. Serum nitric oxide levels in children with celiac disease. J Clin Gastroenterol, 39: 782 - 785.
46. Mazzarella, G, Stefanile, R, Camarca, A, Giliberti, P, Cosentini, E, Marano, C, Iaquinto, G, Giardullo, N, Auricchio, S, Sette, A, Troncone, R and Gianfrani, C. 2008. Gliadin activates HLA class I-restricted CD8+ T cells in celiac disease intestinal mucosa and induces the enterocyte apoptosis. Gastroenterology, 134: 1017 - 1027.
47. Verdu, E F, Huang, X, Natividad, J, Lu, J, Blennerhassett, P A, David, C S, McKay, D M and Murray, J A. 2008. Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice. Am J Physiol Gastrointest Liver Physiol, 294: G217 - G225.
48. Choi, S, DiSilvio, B, Fernstrom, M H and Fernstrom, J D. 2011. The chronic ingestion of diets containing different proteins produces marked variations in brain tryptophan levels and serotonin synthesis in the rat. Neurochem Res, 36: 559 - 565.
49. Lavö, B, Knutson, L, Lööf, L, Odlind, B, Venge, P and Hällgren, R. 1989. Challenge with gliadin induces eosinophil and mast cell activation in the jejunum of patients with celiac disease. Am J Med, 87: 655 - 660.
50. Tursi, A. 2004. Gastrointestinal motility disturbances in celiac disease. J Clin Gastroenterol, 38: 642 - 645.
51. Sanders, D S, Carter, M J, Hurlstone, D P, Pearce, A, Ward, A M, McAlindon, M E and Lobo, A J. 2001. Association of adult coeliac disease with irritable bowel syndrome: a case-control study in patients fulfilling ROME II criteria referred to secondary care. Lancet, 358: 1504 - 1508.
52. Sanders, D. 2002. Irritable bowel syndrome and coeliac disease. Lancet, 359: 1436 - 1437.
53. Sanders, D S and Azmy, I A. 2004. Celiac disease serology and irritable bowel syndrome: does the relationship merit further evaluation?. Mayo Clin Proc, 79: 1209 - 1210.
54. Benini, L, Sembenini, C, Salandini, L, Dall'O, E, Bonfante, F and Vantini, I. 2001. Gastric emptying of realistic meals with and without gluten in patients with celiac disease. Effect of jejunal mucosal recovery. Scand J Gastroenterol, 36: 1044 - 1048.
55. Perri, F, Pastore, M, Zicolella, A, Annese, V, Quitadamo, M and Andriulli, A. 2000. Gastric emptying of solids is delayed in celiac disease and normalizes after gluten withdrawal. Acta Paediatr, 89: 921 - 925.
56. Rocco, A, Sarnelli, G, Compare, D, de Colibus, P, Micheli, P, Somma, P, Marotti, B, Cuomo, R and Nardone, G. 2008. Tissue ghrelin level and gastric emptying rate in adult patients with celiac disease. Neurogastroenterol Motil, 20: 884 - 890.
57. Spiller, R C, Lee, Y C, Edge, C, Ralphs, D N, Stewart, J S, Bloom, S R and Silk, D B. 1987. Delayed mouth-caecum transit of a lactulose labelled liquid test meal in patients with steatorrhoea caused by partially treated coeliac disease. Gut, 28: 1275 - 1282.
58. Vazquez-Roque, M I, Camilleri, M, Carlson, P, McKinzie, S, Murray, J A, Brantner, T L, Burton, D D and Zinsmeister, A R. 2011. HLA-DQ genotype is associated with accelerated small bowel transit in patients with diarrhea-predominant irritable bowel syndrome. Eur J Gastroenterol Hepatol, 23: 481 - 487.
59. Wahnschaffe, U, Ullrich, R, Riecken, E O and Schulzke, J D. 2001. Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome. Gastroenterology, 121: 1329 - 1338.
60. Biesiekierski, J R, Rosella, O, Rose, R, Liels, K, Barrett, J S, Shepherd, S J, Gibson, P R and Muir, J G. 2011. Quantification of fructans, galacto-oligosaccharides and other short-chain carbohydrates in processed grains and cereals. J Hum Nutr Diet, 24: 154 - 176.
61. Barrett, J S and Gibson, P R. 2012. Fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) and nonallergic food intolerance: FODMAPs or food chemicals?. Therap Adv Gastroenterol, 5: 261 - 268.
62. Natividad, J M, Huang, X, Slack, E, Jury, J, Sanz, Y, David, C, Denou, E, Yang, P, Murray, J, McCoy, K D and Verdú, E F. 2009. Host responses to intestinal microbial antigens in gluten-sensitive mice. PLoS One, 4: e6472
63. Sapone, A, Lammers, K M, Casolaro, V, Cammarota, M, Giuliano, M T, De Rosa, M, Stefanile, R, Mazzarella, G, Tolone, C, Russo, M I, Esposito, P, Ferraraccio, F, Cartenì, M, Riegler, G, de Magistris, L and Fasano, A. 2011. Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med, 9: 23
64. Sapone, A, Lammers, K M, Mazzarella, G, Mikhailenko, I, Cartenì, M, Casolaro, V and Fasano, A. 2010. Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int Arch Allergy Immunol, 152: 75 - 80.
65. Volta, U, Tovoli, F, Cicola, R, Parisi, C, Fabbri, A, Piscaglia, M, Fiorini, E and Caio, G. 2012. Serological tests in gluten sensitivity (nonceliac gluten intolerance). J Clin Gastroenterol, 46: 680 - 685.
66. León, F, Sánchez, L, Camarero, C and Roy, G. 2005. Cytokine production by intestinal intraepithelial lymphocyte subsets in celiac disease. Dig Dis Sci, 50: 593 - 600.
67. Fernández, S, Molina, I J, Romero, P, González, R, Peña, J, Sánchez, F, Reynoso, F R, Pérez-Navero, J L, Estevez, O, Ortega, C and Santamaría, M. 2011. Characterization of gliadin-specific Th17 cells from the mucosa of celiac disease patients. Am J Gastroenterol, 106: 528 - 538.
68. Monteleone, I, Sarra, M, Del Vecchio Blanco, G, Paoluzi, O A, Franzè, E, Fina, D, Fabrizi, A, MacDonald, T T, Pallone, F and Monteleone, G. 2010. Characterization of IL-17A-producing cells in celiac disease mucosa. J Immunol, 184: 2211 - 2218.
69. Fina, D, Sarra, M, Caruso, R, Del Vecchio Blanco, G, Pallone, F, MacDonald, T T and Monteleone, G. 2008. Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease. Gut, 57: 887 - 892.
70. Hmida, N B, Ben Ahmed, M, Moussa, A, Rejeb, M B, Said, Y, Kourda, N, Meresse, B, Abdeladhim, M, Louzir, H and Cerf-Bensussan, N. 2012. Impaired control of effector T cells by regulatory T cells: a clue to loss of oral tolerance and autoimmunity in celiac disease?. Am J Gastroenterol, 107: 604 - 611.
71. Josefowicz, S Z, Lu, L F and Rudensky, A Y. 2012. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol, 30: 531 - 564.
72. Sakaguchi, S, Wing, K, Onishi, Y, Prieto-Martin, P and Yamaguchi, T. 2009. Regulatory T cells: how do they suppress immune responses?. Int Immunol, 21: 1105 - 1111.
73. Granzotto, M, dal Bo, S, Quaglia, S, Tommasini, A, Piscianz, E, Valencic, E, Ferrara, F, Martelossi, S, Ventura, A and Not, T. 2009. Regulatory T-cell function is impaired in celiac disease. Dig Dis Sci, 54: 1513 - 1519.
74. Zanzi, D, Stefanile, R, Santagata, S, Iaffaldano, L, Iaquinto, G, Giardullo, N, Lania, G, Vigliano, I, Vera, A R, Ferrara, K, Auricchio, S, Troncone, R and Mazzarella, G. 2011. IL-15 interferes with suppressive activity of intestinal regulatory T cells expanded in Celiac disease. Am J Gastroenterol, 106: 1308 - 1317.
75. Vorobjova, T, Uibo, O, Heilman, K, Rägo, T, Honkanen, J, Vaarala, O, Tillmann, V, Ojakivi, I and Uibo, R. 2009. Increased FOXP3 expression in small-bowel mucosa of children with coeliac disease and type I diabetes mellitus. Scand J Gastroenterol, 44: 422 - 430.
76. Hansson, T, Ulfgren, A K, Lindroos, E, DannAEus, A, Dahlbom, I and Klareskog, L. 2002. Transforming growth factor-beta (TGF-beta) and tissue transglutaminase expression in the small intestine in children with coeliac disease. Scand J Immunol, 56: 530 - 537.
77. Eiró, N, González-Reyes, S, González, L, González, L O, Altadill, A, Andicoechea, A, Fresno-Forcelledo, M F, Rodrigo-Sáez, L and Vizoso, F J. 2012. Duodenal expression of toll-like receptors and interleukins are increased in both children and adult celiac patients. Dig Dis Sci, 57: 2278 - 2285.
78. Szebeni, B, Veres, G, Dezsofi, A, Rusai, K, Vannay, A, Bokodi, G, Vásárhelyi, B, Korponay-Szabó, I R, Tulassay, T and Arató, A. 2007. Increased mucosal expression of toll-like receptor (TLR)2 and TLR4 in coeliac disease. J Pediatr Gastroenterol Nutr, 45: 187 - 193.
79. Kalliomäki, M, Satokari, R, Lähteenoja, H, Vähämiko, S, Grönlund, J, Routi, T and Salminen, S. 2012. Expression of microbiota, toll-like receptors, and their regulators in the small intestinal mucosa in celiac disease. J Pediatr Gastroenterol Nutr, 54: 727 - 732.
80. Camilleri, M, Madsen, K, Spiller, R, Van Meerveld, B G and Verne, G N. 2012. Intestinal barrier function in health and gastrointestinal disease. Neurogastroenterol Motil, 24: 503 - 512.
81. Bertolazzi, S, Lanzarotto, F, Zanini, B, Ricci, C, Villanacci, V and Lanzini, A. 2011. Bio-physical characteristics of gastrointestinal mucosa of celiac patients: comparison with control subjects and effect of gluten free diet. BMC Gastroenterol, 11: 119
82. Visser, J, Rozing, J, Sapone, A, Lammers, K and Fasano, A. 2009. Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms. Ann N Y Acad Sci, 1165: 195 - 205.
83. Biesiekierski, J R, Newnham, E D, Irving, P M, Barrett, J S, Haines, M, Doecke, J D, Shepherd, S J, Muir, J G and Gibson, P R. 2011. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol, 106: 508 - 514.
84. Sander, G R, Cummins, A G, Henshall, T and Powell, B C. 2005. Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins. FEBS Lett, 579: 4851 - 4855.
85. Ciccocioppo, R, Finamore, A, Ara, C, Di Sabatino, A, Mengheri, E and Corazza, G R. 2006. Altered expression, localization, and phosphorylation of epithelial junctional proteins in celiac disease. Am J Clin Pathol, 125: 502 - 511.
86. Assimakopoulos, S F, Papageorgiou, I and Charonis, A. 2011. Enterocytes' tight junctions: from molecules to diseases. World J Gastrointest Pathophysiol, 2: 123 - 137.
87. Carroccio, A, Mansueto, P, Iacono, G, Soresi, M, D'Alcamo, A, Cavataio, F, Brusca, I, Florena, A M, Ambrosiano, G, Seidita, A, Pirrone, G and Rini, G B. 2012. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity. Am J Gastroenterol, 107: 1898 - 1906.
88. Kokkonen, J, Holm, K, Karttunen, T J and Mäki, M. 2000. Children with untreated food allergy express a relative increment in the density of duodenal gammadelta+ T cells. Scand J Gastroenterol, 35: 1137 - 1142.
89. Augustin, M T, Kokkonen, J and Karttunen, T J. 2005. Duodenal cytotoxic lymphocytes in cow's milk protein sensitive enteropathy and coeliac disease. Scand J Gastroenterol, 40: 1398 - 1406.
90. Kokkonen, T S, Augustin, M T, Kokkonen, J, Karttunen, R and Karttunen, T J. 2012. Serum and tissue CD23, IL-15, and FasL in cow's-milk protein-sensitive enteropathy and in coeliac disease. J Pediatr Gastroenterol Nutr, 54: 525 - 531.
91. Knippels, L M, van Wijk, F and Penninks, A H. 2004. Food allergy: what do we learn from animal models?. Curr Opin Allergy Clin Immunol, 4: 205 - 209.
92. Perrier, C, Thierry, A C, Mercenier, A and Corthésy, B. 2010. Allergen-specific antibody and cytokine responses, mast cell reactivity and intestinal permeability upon oral challenge of sensitized and tolerized mice. Clin Exp Allergy, 40: 153 - 162.
93. Oboki, K, Ohno, T, Saito, H and Nakae, S. 2008. Th17 and allergy. Allergol Int, 57: 121 - 134.
94. Herberth, G, Daegelmann, C, Röder, S, Behrendt, H, Krämer, U, Borte, M, Heinrich, J, Herbarth, O, Lehmann, I and the LISAplus Study Group. 2010. IL-17E but not IL-17A is associated with allergic sensitization: results from the LISA study. Pediatr Allergy Immunol, 21: 1086 - 1090.
95. Krogulska, A, Borowiec, M, Polakowska, E, Dynowski, J, Młynarski, W and Wasowska-Królikowska, K. 2011. FOXP3, IL-10, and TGF-β genes expression in children with IgE-dependent food allergy. J Clin Immunol, 31: 205 - 215.
96. Westerholm-Ormio, M, Vaarala, O, Tiittanen, M and Savilahti, E. 2010. Infiltration of Foxp3- and toll-like receptor-4-positive cells in the intestines of children with food allergy. J Pediatr Gastroenterol Nutr, 50: 367 - 376.
97. Brazowski, E, Cohen, S, Yaron, A, Filip, I and Eisenthal, A. 2010. FOXP3 expression in duodenal mucosa in pediatric patients with celiac disease. Pathobiology, 77: 328 - 334.
98. Sicherer, S H, Wood, R A, Stablein, D, Burks, A W, Liu, A H, Jones, S M, Fleischer, D M, Leung, D Y, Grishin, A, Mayer, L, Shreffler, W, Lindblad, R and Sampson, H A. 2010. Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy. J Allergy Clin Immunol, 125: 1077 - 1083.
99. Galli, E, Ciucci, A, Cersosimo, S, Pagnini, C, Avitabile, S, Mancino, G, Delle Fave, G and Corleto, V D. 2010. Eczema and food allergy in an Italian pediatric cohort: no association with TLR-2 and TLR-4 polymorphisms. Int J Immunopathol Pharmacol, 23: 671 - 675.
100. Prescott, S L, Noakes, P, Chow, B W, Breckler, L, Thornton, C A, Hollams, E M, Ali, M, van den Biggelaar, A H and Tulic, M K. 2008. Presymptomatic differences in toll-like receptor function in infants who have allergy. J Allergy Clin Immunol, 122: 391 - 399.
101. Bashir, M E, Louie, S, Shi, H N and Nagler-Anderson, C. 2004. Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy. J Immunol, 172: 6978 - 6987.
102. Ventura, M T, Polimeno, L, Amoruso, A C, Gatti, F, Annoscia, E, Marinaro, M, Di Leo, E, Matino, M G, Buquicchio, R, Bonini, S, Tursi, A and Francavilla, A. 2006. Intestinal permeability in patients with adverse reactions to food. Dig Liver Dis, 38: 732 - 736.
103. Laudat, A, Arnaud, P, Napoly, A and Brion, F. 1994. The intestinal permeability test applied to the diagnosis of food allergy in paediatrics. West Indian Med J, 43: 87 - 88.
104. Troncone, R, Caputo, N, Florio, G and Finelli, E. 1994. Increased intestinal sugar permeability after challenge in children with cow's milk allergy or intolerance. Allergy, 49: 142 - 146.
105. Staiano, A, Troncone, R, Simeone, D, Mayer, M, Finelli, E, Cella, A and Auricchio, S. 1995. Differentiation of cows' milk intolerance and gastro-oesophageal reflux. Arch Dis Child, 73: 439 - 442.
106. Pizzuti, D, Senzolo, M, Buda, A, Chiarelli, S, Giacomelli, L, Mazzon, E, Curioni, A, Faggian, D and De Lazzari, F. 2011. In vitro model for IgE mediated food allergy. Scand J Gastroenterol, 46: 177 - 187.
107. Digiacomo, D V, Tennyson, C A, Green, P H and Demmer, R T. 2013. Prevalence of gluten-free diet adherence among individuals without celiac disease in the USA: results from the Continuous National Health and Nutrition Examination Survey 2009-2010. Scand J Gastroenterol, 48: 921 - 925.
108. Brottveit, M, Vandvik, P O, Wojniusz, S, Løvik, A, Lundin, K E and Boye, B. 2012. Absence of somatization in non-coeliac gluten sensitivity. Scand J Gastroenterol, 47: 770 - 777.
109. Jackson, J R, Eaton, W W, Cascella, N G, Fasano, A and Kelly, D L. 2012. Neurologic and psychiatric manifestations of celiac disease and gluten sensitivity. Psychiatr Q, 83: 91 - 102.
110. Carroccio, A, Iacono, G, Di Prima, L, Pirrone, G, Cavataio, F, Ambrosiano, G, Sciumè, C, Geraci, G, Florena, A, Teresi, S, Barbaria, F, Pepe, I, Campisi, G, Mansueto, P, Soresi, M and Di Fede, G. 2011. Antiendomysium antibodies assay in the culture medium of intestinal mucosa: an accurate method for celiac disease diagnosis. Eur J Gastroenterol Hepatol, 23: 1018 - 1023.
111. Carroccio, A, Iacono, G, D'Amico, D, Cavataio, F, Teresi, S, Caruso, C, Di, P L, Colombo, A, D'Arpa, F, Florena, A, Notarbartolo, A and Montalto, G. 2002. Production of anti-endomysial antibodies in cultured duodenal mucosa: usefulness in celiac disease diagnosis. Scand J Gastroenterol, 37: 32 - 38.
112. Dezi, R, Niveloni, S, Sugai, E, Pedreira, S, Smecuol, E, Vazquez, H, Doldan, I, Cabanne, A, Boerr, L, Valero, J, Kogan, Z, Mauriño, E and Bai, J C. 1992. Gluten sensitivity in the rectal mucosa of first-degree relatives of celiac disease patients. Am J Gastroenterol, 92: 1326 - 1330.
113. Troncone, R, Mazzarella, G, Leone, N, Mayer, M, De Vincenzi, M, Greco, L and Auricchio, S. 1998. Gliadin activates mucosal cell mediated immunity in cultured rectal mucosa from coeliac patients and a subset of their siblings. Gut, 43: 484 - 489.
114. Rostami, K, Kerckhaert, JP6, Tiemessen, R, Meijer, J W and Mulder, C J. 1999. The relationship between anti-endomysium antibodies and villous atrophy in coeliac disease using both monkey and human substrate. Eur J Gastroenterol Hepatol, 11: 439 - 442.
115. Kurppa, K, Collin, P, Viljamaa, M, Haimila, K, Saavalainen, P, Partanen, J, Laurila, K, Huhtala, H, Paasikivi, K, Mäki, M and Kaukinen, K. 2009. Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study. Gastroenterology, 136: 816 - 823.
116. Wahnschaffe, U, Schulzke, J D, Zeitz, M and Ullrich, R. 2007. Predictors of clinical response to gluten-free diet in patients diagnosed with diarrhea-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol, 5: 844 - 850.
117. Marie, I, Lecomte, F, Hachulla, E, Antonietti, M, François, A, Levesque, H and Courtois, H. 2001. An uncommon association: celiac disease and dermatomyositis in adults. Clin Exp Rheumatol, 19: 201 - 203.
118. Pellegrini, G, Scotta, M S, Soardo, S, Avanzini, M A, Ravelli, A, Burgio, G R and Martini, A. 1991. Elevated IgA anti-gliadin antibodies in juvenile chronic arthritis. Clin Exp Rheumatol, 9: 653 - 656.
119. Sima, H, Hekmatdoost, A, Ghaziani, T, Alavian, S M, Mashayekh, A and Zali, M R. 2010. The prevalence of celiac autoantibodies in hepatitis patients. Iran J Allergy Asthma Immunol, 9: 157 - 162.
120. Czaja, A J. 1998. Frequency and significance of anti-gliadin and anti-endomysial antibodies in autoimmune hepatitis. Dig Dis Sci, 43: 2190 - 2195.
121. Volta, U, Bellentani, S, Bianchi, F B, Brandi, G, De Franceschi, L, Miglioli, L, Granito, A, Balli, F and Tiribelli, C. 2001. High prevalence of celiac disease in Italian general population. Dig Dis Sci, 46: 1500 - 1505.
122. Hadjivassiliou, M, Gibson, A, Davies-Jones, G A, Lobo, A J, Stephenson, T J and Milford-Ward, A. 1996. Does cryptic gluten sensitivity play a part in neurological illness?. Lancet, 347: 369 - 371.
123. Carroccio, A, Brusca, I, Mansueto, P, Pirrone, G, Barrale, M, Di Prima, L, Ambrosiano, G, Iacono, G, Lospalluti, M L, La Chiusa, S M and Di Fede, G. 2010. A cytologic assay for diagnosis of food hypersensitivity in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol, 8: 254 - 260.
124. Brown, I, Mino-Kenudson, M, Deshpande, V and Lauwers, G Y. 2006. Intraepithelial lymphocytosis in architecturally preserved proximal small intestinal mucosa: an increasing diagnostic problem with a wide differential diagnosis. Arch Pathol Lab Med, 130: 1020 - 1025.
125. Chang, F, Mahadeva, U and Deere, H. 2005. Pathological and clinical significance of increased intraepithelial lymphocytes (IELs) in small bowel mucosa. APMIS, 113: 385 - 399.
126. Robert, M E. 2005. Gluten sensitive enteropathy and other causes of small intestinal lymphocytosis. Semin Diagn Pathol, 22: 284 - 294.
127. Inomata, N. 2009. Wheat allergy: Curr Opin Allergy. Clin Immunol, 9: 238 - 243.
128. Pourpak, Z, Mansouri, M, Mesdaghi, M, Kazemnejad, A and Farhoudi, A. 2004. Wheat allergy: clinical and laboratory findings. Int Arch Allergy Immunol, 133: 168 - 173.