Update on celiac disease - etiology, differential diagnosis, drug targets, and management advances

Clinical and Experimental Gastroenterology

Volumn 4, Issue 1, 2011, Pages 297-311

  Scanlon, Samantha A ^a   Murray, Joseph A ^a  

^a MAYO CLINIC   (United States)

Author keywords

CD diagnosis; Epidemiology; Gliadin; Gluten; Immune mediated enteropathy; Therapy

Indexed keywords

ALV 003; AZATHIOPRINE; BUDESONIDE; CHEMOKINE RECEPTOR CXCR3; CYANOCOBALAMIN; ENZYME INHIBITOR; FOLIC ACID; GAMMA INTERFERON; GLUTEN; HLA DQ2 ANTIGEN; LARAZOTIDE; NEXVAX 2; PEPTIDE VACCINE; PREDNISONE; PROLYL ENDOPEPTIDASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE INHIBITOR; PROTEINASE; PYRIDOXINE; UNCLASSIFIED DRUG;

AGE DISTRIBUTION; BALLOON ASSISTED ENDOSCOPY; CELIAC DISEASE; CHROMOENDOSCOPY; CLINICAL FEATURE; CYTOKINE RELEASE; DESENSITIZATION; DIFFERENTIAL DIAGNOSIS; DISEASE CLASSIFICATION; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG MECHANISM; DRUG TARGETING; DRUG TOLERABILITY; DRUG TREATMENT FAILURE; ENVIRONMENTAL FACTOR; ENZYME DEGRADATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FOLLOW UP; FOOD COMPOSITION; GENETIC SUSCEPTIBILITY; GEOGRAPHIC DISTRIBUTION; GLUTEN FREE DIET; HISTOPATHOLOGY; HUMAN; HYPERPLASIA; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOPATHOGENESIS; INTESTINE BIOPSY; INTESTINE CRYPT; INTESTINE ENDOSCOPY; INTESTINE EPITHELIUM; INTESTINE MUCOSA PERMEABILITY; INTESTINE VILLUS; LYMPHOCYTOSIS; MALABSORPTION; MICROSCALE ENDOSCOPY; MORBIDITY; NONHUMAN; OAT; ONSET AGE; PREVALENCE; PROGNOSIS; RECURRENT DISEASE; REVIEW; SURVIVAL RATE; SURVIVAL TIME; VIDEO CAPSULE ENDOSCOPY; VITAMIN SUPPLEMENTATION; WATER IMMERSION ENDOSCOPY; WHEAT;

EID: 84856192092     PISSN: None     EISSN: 11787023     Source Type: Journal    
DOI: None     Document Type: Review

References (87)

1. Tack GJ, Verbeek W, Schreurs M, Mulder C. The spectrum of celiac disease: epidemiology, clinical aspects and treatment. Nat Rev Gastroenterol Hepatol. 2010;7(4):204-213.
2. Murray JA, Van Dyke C, Plevak MF, Dierkhising RA, Zinsmeister AR, Melton LJ. Trends in the identification and clinical features of celiac disease in a North American community, 1950-2001. Clin Gastroenterol Hepatol. 2003;1:19-27.
3. Dube C, Rostom A, Sy R, et al. The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review. Gastroenterology. 2005;128:S57-S67.
4. Rubio-Tapia A, Kyle RA, Kaplan EL, et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology. 2009;137:88-93.
5. Cranney A, Rostom A, Sy R, et al. Consequences of testing for celiac disease. Gastroenterology. 2005;128:S109-S120.
6. Godfrey JD, Brantner TL, Brinjikji W, et al. Morbidity and mortality among older individuals with undiagnosed celiac disease. Gastroenterology. 2010;139(3):763-769.
7. Walker MM, Murray JA, Ronkainen J, et al. Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study. Gastroenterology. 2010;139:112-119.
8. Catassi C, Kryszak D, Bhatti B, et al. Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med. 2010;42:530-538.
9. Lohi S, Mustalahti K, Kaukinen K, et al. Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther. 2007;26(9):1217-1225.
10. Marti T, Molberg O, Li Q, Gray GM, Khosla C, Sollid LM. Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterization. J Pharmacol Exp Ther. 2004;312:19-26.
11. Schumann M, Richter JF, Wedell I, et al. Mechanisms of epithelial translocation of the alpha-2-gliadin-33 mer in coeliac sprue. Gut. 2008;57:747-754.
12. Tripathi A, Lammers K, Goldblum S, et al. Identif ication of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci. 2009;106:16799-16804.
13. Marietta EV, Rashtak S, Murray J. Correlation analysis of celiac sprue tissue transglutaminase and deamidated gliadin IgG/IgA. World J Gastroenterol. 2009;15:845-848.
14. Pyle GG, Paaso B, Anderson BE, et al. Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue. Clin Gastroenterol Hepatol. 2005;3:687-694.
15. Lewis NR, Scotta BB. Meta-analysis: deamidated gliadin peptide antibody and tissue transglutaminase antibody compared as screening tests for coeliac disease. Aliment Pharmacol Ther. 2009;31:73-81.
16. Hovhannisvan Z, Weiss A, Martin A, et al. The role of HLA-DQ8 beta57 polymorphism in the anti-gluten T-cell response in coeliac disease. Nature. 2008;456:534-538.
17. Schuppan D, Junker Y, Barisani D. Celiac disease: from pathogenesis to novel therapies. Gastroenterology. 2009;137:1912-1933.
18. Vivas S, Ruiz de Morales JG, Riestra S, et al. Duodenal biopsy may be avoided when high transglutaminase antibody titers are present. World J Gastroenterol. 2009;15:4775-4780.
19. Romanos J, Van Diemen CC, Nolte IM, et al. Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease. Gastroenterology. 2009;137:834-840.
20. Garner CP, Murray JA, Ding YC, Tien Z, van Heel DA, Neuhausen SL. Replication of celiac disease UK genome-wide association study results in a US population. Hum Mol Genet. 2009;18:4219-4225.
21. Selimoglu MA, Karabiber H. Celiac disease prevention and treatment. J Clin Gastroenterol. 2010;44:4-8.
22. Norris JM, Barriga K, Hoffenberg, et al. Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease. JAMA. 2005;293:2343-2351.
23. Roma E, Panayiotou J, Karantana H, et al. Changing pattern in the clinical presentation of pediatric celiac disease: a 30-year study. Digestion. 2009;80:185-191.
24. Kurppa K, Collin P, Vijamma M, et al. Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study. Gastroenterology. 2009;136:816-823.
25. Ravikumara M, Tuthill DP, Jenkins HR. The changing clinical presentation of coeliac disease. Arch Dis Child. 2006;91:969-971.
26. Murray JA, Rubio-Tapia A, Van Dyke CT, et al. Mucosal atrophy in celiac disease: extent of involvement, correlation with clinical presentation, and response to treatment. Clin Gastroenterol Hepatol. 2008;6:186-193.
27. Lo W, Sano K, Lebwohl B, Diamond B, Green PH. Changing presentation of adult celiac disease. Dig Dis Sci. 2003;48:395-398.
28. Rostom A, Murray JA, Kagnoff MF. American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease. Gastroenterology. 2006;131:1981-2002.
29. Chorzelski TP, Sulej J, Tchorzewska H, Jablonska A, Beutner EH, Kumar V. IgA class endomysium antibodies in dermatitis herpetiformis and coeliac disease. Ann NY Acad Sci. 1983;420:325-334.
30. Lewis NR, Scott BB. Systematic review: the use of serology to exclude or diagnosed coeliac disease (a comparison of the endomysial and tissue transglutaminase antibody tests). Aliment Pharmacol Ther. 2006;24:47-54.
31. Rashtak S, Ettore MW, Homburger HA, Murray JA. Comparative usefulness of deamidated gliadin antibodies in the diagnosis of celiac disease. Clin Gastroenterol Hepatol. 2008;6:426-432.
32. Vivas S, Ruiz de Moralas JG, Riestra S, et al. Duodenal biopsy may be avoided when high transglutaminase antibody titers are present. World J Gastroenterol. 2009;15:4775-4780.
33. Leong RWL, Nguyen NQ, Meredith CG, et al. In vivo confocal endomicroscopy in the diagnosis and evaluation of celiac disease. Gastroenterology. 2008;135:1870-1876.
34. Oberhuber G. Histopathology of celiac disease. Biomed Pharmacother. 2000;54:368-372.
35. Corazza GR, Villanacci V. Coeliac disease. J Clin Pathol. 2005;58:573-574.
36. Cummins AG, Alexander BG, Chung A, et al. Morphometric evaluation of duodenal biopsies in celiac disease. Am J Gastroenterol. 2010;106:145-150.
37. Vande Voort JL, Murray JA, Lahr BD, et al. Lymphocytic duodenosis and the spectrum of celiac disease. Am J Gastroenterol. 2009;104:142-148.
38. Walker MM, Murray JA, Ronkainen J, et al. Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study. Gastroenterology. 2010;139(1):112-119.
39. Rubio-Tapia A, Murray JA. Classification and management of refractory coeliac disease. Gut. 2010;59:547-557.
40. Cammarota G, Cesaro P, Cazzato A, et al. The water immersion technique is easy to learn for routine use during EGD for duodenal villous evaluation: a single-center 2-year experience. J Clin Gastroenterol. 2009;43:244-248.
41. Cammarota G, Fedeli P, Gasbarrini A. Emerging technologies in upper gastrointestinal endoscopy and celiac disease. Nat Clin Pract Gastroenterol Hepatol. 2009;6:47-56.
42. Nguyen NQ, Leong RWL. Current application of confocal endomicroscopy in gastrointestinal disorders. J Gastroenterol Hepatol. 2008;23:1483-1491.
43. Pohl H, Rosch T, Tanczos BT, Rudolph B, Shluns K, Baumgart DC. Endocytoscopy for the detection of microstructural features in adult patients with celiac sprue: a prospective, blinded endocytoscopy-conventional histology correlation study. Gastrointest Endosc. 2009;70:933-941.
44. Cammarota G, Cazzato A, Genovese O, et al. Water-immersion technique during standard upper endoscopy may be useful to drive the biopsy sampling of duodenal mucosa in children with celiac disease. J Pediatr Gastroenterol Nutr. 2009;49:411-416.
45. Masci E, Mangiavillano B, Albarello L, Mariani A, Doglioni C, Testoni PA. Pilot study on the correlation of optical coherence tomography with histology in celiac disease and normal subjects. J Gastroenterol Hepatol. 2007;22:2256-2260.
46. Masci E, Mangiavillano B, Barera G, et al. Optical coherence tomography in pediatric patients: a feasible technique for diagnosing celiac disease in children with villous atrophy. Dig Liver Dis. 2009;41:639-643.
47. Hadithi M, Akol H, Al-Toma A, Jacobs M, Mulder CJ. Indigo carmine chromoendoscopic appearances of enteropathy-associated T-cell lymphoma during double-balloon endoscopy in a patient with celiac disease. Endoscopy. 2007;39:E212-E213.
48. Neumann H, Fry LC, Belluti M, Malfertheiner P, Monkemuller K. Double-balloon enteroscopy-assisted virtual chromoendoscopy for small-bowel disorders-a case series. Endoscopy. 2009;41:468-471.
49. Rondonotti E, Spada C, Cave D, et al. Video capsule enteroscopy in the diagnosis of celiac disease: a multicenter study. Am J Gastroenterol. 2007;102:1624-1631.
50. Lidums I, Cumins AG, Teo E. The role of capsule endoscopy in suspected celiac disease patients with positive celiac serology. Dig Dis Sci. 2011;56(2):499-505.
51. Ciaccio EJ, Tennyson CA, Lewis SK, Krishnareddy S, Bhagat G, Green PH. Distinguishing patients with celiac disease by quantitative analysis of videocapsule endoscopy images. Comput Methods Programs Biomed. 2010;9:44.
52. Kav T, Bayraktar Y. Five years' experience with capsule endoscopy in a single center. World J Gastroenterol. 2009;15:1934-1942.
53. Fry LC, Bellutti M, Neumann H, Malfertheiner P, Monkemuller. Utility of double-balloon enteroscopy for the evaluation of malabsorption. Dig Dis. 2008;26:134-139.
54. Monkemuller K, Belluti M, Fry LC, Malfertheiner P. Enteroscopy. Best Pract Res Clin Gastroenterol. 2008;22:789-811.
55. Hadithi M, Al-Toma A, Oudejans J, van Bodegraven AA, Mulder CJ, Jacobs M. The value of double-balloon enteroscopy in patients with refractory celiac disease. Am J Gastroenterol. 2007;102:987-996.
56. Gunther U, Daum S, Heller F, et al. Diagnostic value of confocal endomicroscopy in celiac disease. Endoscopy. 2010;42:197-202.
57. Matysiak-Budnik T, Coron E, Mosnier JF, Le Rhun M, Inoue H, Galmiche JP. In vivo real-time imaging of human duodenal mucosal structures in celiac disease using endocytoscopy. Endoscopy. 2010;42:191-196.
58. Catassi C, Fabiani E, Iacono G, et al. A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. Am J Clin Nutr. 2007;85:160-166.
59. Thompson T, Lee AR, Grace T. Gluten contamination of grains, seeds, and flours in the United States: a pilot study. J Am Diet Assoc. 2010;110:937-940.
60. Kemppainen TA, Heikkinen MT, Ristikankare MK, et al. Unkilned and large amounts of oats in the coeliac disease diet: a randomized, controlled study. Scand J Gastroenterol. 2008;43:1094-1101.
61. Guttormsen V, Lǿvik A, Bye A, Bratlie J, Mǿrkrid, Lundin KE. No induction of anti-avenin IgA by oats in adult, diet-treated coeliac disease. Scand J Gastroenterol. 2008;43:161-165.
62. Hallert C, Svensson M, Tholstrup J, Hultbergs B. Clinical trial: B vitamins improve health in patients with celiac disease living on a gluten free diet. Aliment Pharmacol Ther. 2009;29:811-816.
63. Jafri MR, Nordstrom CW, Murray JA, et al. Long-term fracture risk in patients with celiac disease: a population-based study in Olmsted County, Minnesota. Dig Dis Sci. 2008;53(4):964-971.
64. Murray JA, Watson T, Clearman B, Mitros F. Effect of a gluten-free diet on gastrointestinal symptoms in celiac disease. Am J Clin Nutr. 2004;79:669-773.
65. George JBE, Leffler DA, Dennis MD, Franko DL, Blom-Hoffman J, Kelly CP. Psychological correlates of gluten-free diet adherence in adults with celiac disease. J Clin Gastroenterol. 2009;43:301-306.
66. Leffler DA, Dennis M, Edwards George JB, et al. A simple validated gluten-free diet adherence survey for adults with celiac disease. Clin Gastroenterol Hepatol. 2009;7:530-536.
67. Vahedi K, Mascart F, Mary JY, et al. Reliability of antitransglutaminase antibodies as predictors of gluten-free diet compliance in adult celiac disease. Am J Gastroenterol. 2003;98:1079-1087.
68. Rubio-Tapia A, Rahim MW, See JA, Lahr BD, Wu T, Murray JA. Mucosal recovery and mortality in adults with celiac disease after treatment with a gluten-free diet. Am J Gastroenterol. 2010;105:1412-1420.
69. Lerner A. New therapeutic strategies for celiac disease. Autoimm Rev. 2010;9:144-147.
70. Tye-Din JA, Anderson RP, Ffrench RA, et al. The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo. Clin Immunol. 2010;134:289-295.
71. Pinier M, Fuhrmann G, Verdu EF, Leroux JC. Prevention measures and exploratory pharmacological treatments of celiac disease. Am J Gastroenterol. 2010;105:2551-2561.
72. Paterson BM, Lammers KM, Arrieta MC, Fasano A, Meddings JB. The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in celiac disease subjects: a proof of concept study. Aliment Pharmacol Ther. 2007;26:757-766.
73. Choi K, Siegel M, Piper J, et al. Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. Chem Biol. 2005;12:469-475.
74. ClinicalTrials. gov. Inoculating celiac disease patients with the human hookworm Necator Americanus: evaluating immunity and gluten-sensitivity. Available from: http://clinicaltrials.gov/ct2/show/ NCT00671138. Accessed May 27, 2011.
75. ClinicalTrials. gov. Safety study of Nexvax2 in subjects with coeliac disease. Available from: http://clinicaltrials.gov/ct2/show/NCT00879749. Accessed May 27, 2011.
76. Leffler DA, Dennis M, Hyett B, Kelly E, Schuppan D, Kelly CP. Etiologies and predictors of diagnosis in nonresponsive celiac disease. Clin Gastroenterol Hepatol. 2007;5:445-450.
77. Rubio-Tapia A, Barton SH, Murray JA. Celiac disease and persistent symptoms. Clin Gastroenterol Hepatol. 2011;9:13-17.
78. Rubio-Tapia A, Murray JA. Classification and management of refractory coeliac disease. Gut. 2010;59:547-557.
79. Schweiger GD, Murray JA. Postbulbar duodenal ulceration and stenosis associated with celiac disease. Abdom Imaging. 1998;23:347-349.
80. Leffler DA, George JBE, Dennis M, Cook EF, Schuppan D, Kelly CP. A prospective comparative study of five measures of gluten-free diet adherence in adults with coeliac disease. Aliment Pharmacol Ther. 2007;26:1227-1235.
81. Al-toma A, Visser OJ, van Roessel HM, et al. Autologous hematopoeitic stems cell transplantation in refractory celiac disease with aberrant T cells. Blood. 2007;109:2243-2249.
82. Rubio-Tapia A, Kelly DG, Lahr BD, Dogan A, Wu T, Murray JA. Clinical staging and survival in refractory celiac disease: a single center experience. Gastroenterology. 2009;136:99-107.
83. Sieniawski M, Angamuthu N, Boyd K, et al. Evaluation of enteropathyassociated T-cell lymphoma comparing standard therapies with a novel regimen including autologous stem cell transplantation. Blood. 2010;15:3664-3670.
84. Ludvigsson JF, Montgomery SM, Ekbom A, Brandt L, Granath F. Small-intestinal histopathology and mortality risk in celiac disease. JAMA. 2009;302:1171-1178.
85. Solaymani-Dodarin M, West J, Logan RF. Long-term mortality in people with celiac disease diagnosed in childhood compared with adulthood: a population-based cohort study. Am J Gastroenterol. 2007;102:864-870.
86. Rubio-Tapia A, Kyle RA, Kaplan EL, et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology. 2009;137:88-93.
87. Lohi S, Maki M, Rissanen H, Knekt P, Reunanen A, Kaukinen K. Prognosis of unrecognized coeliac disease as regards mortality: a population-based cohort study. Ann Med. 2009:1-8.