Duodenal cytotoxic lymphocytes in cow's milk protein sensitive enteropathy and coeliac disease

Scandinavian Journal of Gastroenterology

Volumn 40, Issue 12, 2005, Pages 1398-1406

  Augustin, Merja T ^a   Kokkonen, Jorma ^b   Karttunen, Tuomo J ^a  

^a UNIVERSITY OF OULU   (Finland)

^b OULU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Children; Coeliac disease; Cytotoxic lymphocyte; Food hypersensitivity; Granzyme; Perforin; TIA 1

Indexed keywords

CD3 ANTIGEN; GRANZYME A; GRANZYME B; PERFORIN; PROTEIN; PROTEIN TIA 1; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; CELIAC DISEASE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; COW MILK PROTEIN SENSITIVE ENTEROPATHY; CYTOTOXIC LYMPHOCYTE; CYTOTOXICITY; DUODENUM MUCOSA; ENDOSCOPY; ENTEROPATHY; FEMALE; GASTROINTESTINAL ENDOSCOPY; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE VILLUS ATROPHY; MALE; MILK ALLERGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING;

ADOLESCENT; CASE-CONTROL STUDIES; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; DUODENUM; FEMALE; GASTROINTESTINAL DISEASES; GRANZYMES; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MILK HYPERSENSITIVITY; MILK PROTEINS; PORE FORMING CYTOTOXIC PROTEINS; RNA-BINDING PROTEINS; SERINE ENDOPEPTIDASES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 29744463933     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520510023765     Document Type: Article

References (38)

1. Kokkonen J, Haapalahti M, Laurila K, Karttunen TJ, Maki M. Cow's milk protein-sensitive enteropathy at school age. J Pediatr 2001;139:797-803.
2. Kokkonen J, Haapalahti M, Tikkanen S, Karttunen R, Savilahti E. Gastrointestinal complaints and diagnosis in children. A population based study. Acta Pediatr 2004;93:880-6.
3. Kokkonen J, Karttunen TJ, Niinimaki A. Lymphonodular hyperplasia as a sign of food allergy in children. J Pediatr Gastroenterol Nutr 1999;29:57-62.
4. Kokkonen J, Holm K, Karttunen TJ, Maki M. Children with untreated food allergy express a relative increment in the density of duodenal gammadelta+ T cells. Scand J Gastroenterol 2000;35:1137-42.
5. Spencer J, MacDonald TT, Diss TC, Walker-Smith JA, Ciclitira PJ, Isaacson PG. Changes in intraepithelial lymphocyte subpopulations in coeliac disease and enteropathy associated T cell lymphoma (malignant histiocytosis of the intestine). Gut 1989;30:339-46.
6. Kuitunen P, Visakorpi JK, Savilahti E, Pelkonen P. Malabsorption syndrome with cow's milk intolerance. Clinical findings and course in 54 cases. Arch Dis Child 1975;50:351-6.
7. Kokkonen J, Tikkanen S, Savilahti E. Residual intestinal disease after milk allergy in infancy. J Pediatr Gastroenterol Nutr 2001;32:156-61.
8. Eiras P, Leon F, Camarero C, Lombardia M, Roldan E, Bootello A, et al. Intestinal intraepithelial lymphocytes contain a CD3-CD7+ subset expressing natural killer markers and a singular pattern of adhesion molecules. Scand J Immunol 2000;52:1-6.
9. Russell GJ, Nagler-Anderson C, Anderson P, Bhan AK. Cytotoxic potential of intraepithelial lymphocytes (IELs). Presence of TIA-1, the cytolytic granule-associated protein, in human IELs in normal and diseased intestine. Am J Pathol 1993;143:350-4.
10. Leon F, Roldan E, Sanchez L, Camarero C, Bootello A, Roy G. Human small-intestinal epithelium contains functional natural killer lymphocytes. Gastroenterology 2003;125:345-56.
11. Kummer JA, Kamp AM, van Katwijk M, Brakenhoff JP, Radosevic K, van Leeuwen AM, et al. Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins. J Immunol Methods 1993;163:77-83.
12. Lichtenheld MG, Olsen KJ, Lu P, Lowrey DM, Hameed A, Hengartner H, et al. Structure and function of human perform. Nature 1988;335:448-51.
13. Russell JH, Ley TJ. Lymphocyte-mediated cytotoxicity. Annu Rev Immunol 2002;20:323-70.
14. Oberhuber G, Vogelsang H, Stolte M, Muthenthaler S, Kummer AJ, Radaszkiewicz T. Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis Am J Pathol 1996;148:1351-7.
15. Zimmer KP, Naim H, Weber P, Ellis HJ, Ciclitira PJ. Targeting of gliadin peptides, CD8, alpha/beta-TCR, and gamma/delta-TCR to golgi complexes and vacuoles within celiac disease enterocytes. FASEB J 1998;12:1349-57.
16. Shiner M, Eran M, Freier S, Faber J, Branski D. Are intraepithelial lymphocytes in celiac mucosa responsible for inducing programmed cell death (apoptosis) in enterocytes? Histochemical demonstration of performs in cytoplasmic granules of intraepithelial lymphocytes. J Pediatr Gastroenterol Nutr 1998;27:393-6.
17. Ciccocioppo R, Di Sabatino A, Parroni R, D'alo S, Pistoia MA, Doglioni C, et al. Cytolytic mechanisms of intraepithelial lymphocytes in coeliac disease (CoD). Clin Exp Immunol 2000;120:235-40.
18. Ciccocioppo R, D'Alo S, Di Sabatino A, Parroni R, Rossi M, Doglioni C, et al. Mechanisms of villous atrophy in autoimmune enteropathy and coeliac disease. Clin Exp Immunol 2002;128:88-93.
19. Maiuri L, Ciacci C, Raia V, Vacca L, Ricciardelli I, Raimondi F, et al. FAS engagement drives apoptosis of enterocytes of coeliac patients. Gut 2001;48:418-24.
20. Ciccocioppo R, Di Sabatino A, Parroni R, Muzi P, D'Alo S, Ventura T, et al. Increased enterocyte apoptosis and fas-fas ligand system in celiac disease. Am J Clin Pathol 2001;115:494-503.
21. Di Sabatino A, Ciccocioppo R, D'Alo S, Parroni R, Millimaggi D, Cifone MG, et al. Intraepithelial and lamina propria lymphocytes show distinct patterns of apoptosis whereas both populations are active in fas based cytotoxicity in coeliac disease. Gut 2001;49:380-6.
22. Strater J, Moller P. Fas (CD95)-mediated apoptosis in celiac disease. Am J Clin Pathol 2001;116:616-8.
23. Augustin MT, Kokkonen J, Karttunen R, Karttunen TJ. Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and coeliac disease. J Allergy Clin Immunol 2005;115:157-62.
24. Augustin M, Karttunen TJ, Kokkonen J. TIA1 and mast cell tryptase in food allergy of children: increase of intraepithelial lymphocytes expressing TIA1 associates with allergy. J Pediatr Gastroenterol Nutr 2001;32:11-8.
25. Augustin MT, Kokkonen J, Karttunen TJ. Evidence for increased apoptosis of duodenal intraepithelial lymphocytes in cow's milk sensitive enteropathy. J Pediatr Gastroenterol Nutr 2005;40:352-8.
26. Oberhuber G. Histopathology of celiac disease. Biomed Pharmacother 2000;54:368-72.
27. Green PH, Jabri B. Coeliac disease. Lancet 2003;362:383-91.
28. Sabattini E, Bisgaard K, Ascani S, Poggi S, Piccioli M, Ceccarelli C, et al. The EnVision++ system: a new immunohistochemical method for diagnostics and research. Critical comparison with the APAAP, ChemMate, CSA, LABC, and SABC techniques. J Clin Pathol 1999;51:506-11.
29. Chott A, Gerdes D, Spooner A, Mosberger I, Kummer JA, Ebert EC, et al. Intraepithelial lymphocytes in normal human intestine do not express proteins associated with cytolytic function. Am J Pathol 1997;151:435-42.
30. Melgar S, Bas A, Hammarstrom S, Hammarstrom ML. Human small intestinal mucosa harbours a small population of cytolytically active CD8+ alphabeta T lymphocytes. Immunology 2002;106:476-85.
31. Camarero C, Eiras P, Asensio A, Leon F, Olivares F, Escobar H, et al. Intraepithelial lymphocytes and coeliac disease: permanent changes in CD3-/CD7 + and T cell receptor gammadelta subsets studied by flow cytometry. Acta Paediatr 2000;89:285-90.
32. Nakajima H, Park HL, Henkart PA. Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin. J Exp Med 1995;181(3):1037-46.
33. Bonamico M, Mariani P, Thanasi E, Ferri M, Nenna R, Tiberti C, et al. Patchy villous atrophy of the duodenum in childhood celiac disease. J Pediatr Gastroenterol Nutr 2004;38:204-7.
34. Kokkonen J, Ruuska T, Karttunen TJ, Maki M. Lymphonodular hyperplasia of the terminal ileum associated with colitis shows an increase gammadelta+ T-cell density in children. Am J Gastroenterol 2002;97:667-72.
35. Goldstein NS, Underhill J. Morphologic features suggestive of gluten sensitivity in architecturally normal duodenal biopsy specimens. Am J Clin Pathol 2001;116:63-71.
36. Jarvinen TT, Collin P, Rasmussen M, Kyronpalo S, Maki M, Partanen J, et al. Villous tip intraepithelial lymphocytes as markers of early-stage coeliac disease. Scand J Gastroenterol 2004;39:428-33.
37. Goldstein NS. Proximal small-bowel mucosal villous intraepithelial lymphocytes. Histopathology 2004;44:199-205.
38. Biagi F, Luinetti O, Campanella J, Klersy C, Zambelli C, Villanacci V, et al. Intraepithelial lymphocytes in the villous tip: do they indicate potential coeliac disease? J Clin Pathol 2004;57:835-9.