Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: Exploring a new clinical entity

American Journal of Gastroenterology

Volumn 107, Issue 12, 2012, Pages 1898-1906

  Carroccio, Antonio ^a   Mansueto, Pasquale ^b   Iacono, Giuseppe ^c   Soresi, Maurizio ^b   D'Alcamo, Alberto ^b   Cavataio, Francesca ^c   Brusca, Ignazio ^d   Florena, Ada M ^b   Ambrosiano, Giuseppe ^b   Seidita, Aurelio ^b   Pirrone, Giuseppe ^b   Rini, Giovanni Battista ^b  

^a Hospital of Sciacca   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c Di Cristina Hospital   (Italy)

^d Buccheri La Ferla Hospital   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLIADIN ANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; PLACEBO;

ABDOMINAL PAIN; ANEMIA; ATOPY; BASOPHIL; BLOATING; CELIAC DISEASE; CELL ASSAY; CELL INFILTRATION; CLINICAL FEATURE; COLON BIOPSY; COLON MUCOSA; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DUODENUM; ENTERITIS; EOSINOPHIL; FECES; FEMALE; FOOD ALLERGY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN BLOOD LEVEL; IN VITRO STUDY; INFANT DISEASE; IRRITABLE COLON; LEUKOCYTE ACTIVATION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NON CELIAC DISEASE WHEAT SENSITIVITY; NUTRITIONAL INTOLERANCE; PRIORITY JOURNAL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; REVIEW; SCORING SYSTEM; SELF REPORT; WEIGHT REDUCTION;

ADULT; AGED; ANEMIA, HYPOCHROMIC; AUTOANTIBODIES; CELIAC DISEASE; DIAGNOSIS, DIFFERENTIAL; DOUBLE-BLIND METHOD; FEMALE; FOOD HYPERSENSITIVITY; GLIADIN; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IRRITABLE BOWEL SYNDROME; MALE; MIDDLE AGED; RESEARCH DESIGN; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TRITICUM; WEIGHT LOSS;

EID: 84870855766     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2012.236     Document Type: Review

References (33)

1. Walker-Smith JA, Guandalini S, Schmitz J et al. Revised criteria for diagnosis of coeliac disease. Arch Dis Child 1990; 65: 909-11.
2. Mäki M, Mustalahti K, Kokkonen J et al. Prevalence of celiac disease among children in Finland. N Engl J Med 2003; 348: 2517-24.
3. Green PH, Cellier C. Celiac disease. N Engl J Med 2007; 357: 1731-43.
4. Verdu EF, Armstrong D, Murray JA. Between celiac disease and irritable bowel syndrome: the no man's land of gluten sensitivity. Am J Gastroenterol 2009; 104: 1587-94.
5. Troncone R, Jabri B. Celiac disease and gluten-sensitivity. J Intern Med 2011; 269: 582-90.
6. Sapone A, Bai J, Ciacci C et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med 2012; 10: 13.
7. Th ompson WG, Longstreth GF, Drossman DA et al. Functional bowel disorders and functional abdominal pain. Gut 1999; 45 (Suppl. 2): 43-7.
8. Carroccio A, Vitale G, Di Prima L et al. Comparison of anti-transglutaminase ELISAs and anti-endomysial antibody assay in the diagnosis of celiac disease: a prospective study. Clin Chem 2002; 48: 1546-50.
9. Carroccio A, Iacono G, Montalto G et al. Immunologic and absorptive tests in celiac disease: can they replace intestinal biopsies? Scand J Gastroenterol 1993; 28: 673-6.
10. Picarelli A, Maiuri L, Frate A et al. Production of antiendomysial antibodies aft er in-vitro gliadin challenge of small intestine biopsy samples from patients with coeliac disease. Lancet 1996; 348: 1065-7.
11. Carroccio A, Di Prima L, Pirrone G et al. Anti-transglutaminase antibody assay of the culture medium of intestinal biopsy specimens can improve the accuracy of celiac disease diagnosis. Clin Chem 2006; 52: 1175-80.
12. Carroccio A, Iacono G, Di Prima L et al. Antiendomysium antibodies assay in the culture medium of intestinal mucosa: an accurate method for celiac disease diagnosis. Eur J Gastroenterol Hepatol 2011; 23: 1018-23.
13. Oberhuber G, Granditsch G, Vogelsang H. Th e histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol 1999; 11: 1185-94.
14. Iacono G, Ravelli A, Di Prima L et al. Colonic lymphoid nodular hyperplasia in children: relationship to food hypersensitivity. Clin Gastroenterol Hepatol 2007; 5: 361-6.
15. Iacono G, Cavataio F, Montalto G et al. Intolerance of cow's milk and chronic constipation in children. N Engl J Med 1998; 338: 1100-4.
16. Carroccio A, Brusca I, Mansueto P et al. A cytological assay for diagnosis of food hypersensitivity in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2010; 8: 254-60.
17. Cochran WG. Sampling Techniques, 3rd edn John Wiley: New York, p 428.
18. Drossman DA. Review article: an integrated approach to the irritable bowel syndrome. Alim Pharmacol Th er 1999; 13: 3-14.
19. Lu CL, Chang FY. Placebo eff ect in patients with irritable bowel syndrome. J Gastroenterol Hepatol 2011; 26 (Suppl. 3): 116-8.
20. Biesiekierski JR, Newnham ED, Irving PM et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol 2011; 106: 508-14.
21. Sampson HA, Sicherer SH, Birnbaum AH. AGA technical review on the evaluation of food allergy in gastrointestinal disorders. American Gastroenterological Association. Gastroenterology 2001; 120: 1026-40.
22. Boyce JA, Assa ' ad A, Burks AW et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J All Clin Immunol 2010; 126 (Suppl. 6): S1-S58.
23. Sapone A, Lammers KM, Mazzarella G et al. Diff erential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int Arch Allergy Immunol 2010; 152: 75-80.
24. Volta U, Tovoli F, Cigola R et al. Serological tests in gluten-sensitivity. J Clin Gastroenterol; published online 5 December 2011 [e-pub ahead of print].
25. Kurppa K, Collin P, Viljamaa M et al. Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study. Gastroenterology 2009; 136: 816-23.
26. Salmi TT, Collin P, Korponay-Szabo IR et al. Endomysial antibody-negative coeliac disease: clinical characteristics and intestinal autoantibody deposits. Gut 2006; 55: 1746-53.
27. Verdu EF, Huang XX, Natividad J et al. Gliadin-dependent neuromuscular and epithelial secretory responses in the gut. Am J Physiol Gastrointest Liver Physiol 2008; 294: G217-25.
28. Natividad JM, Huang X, Slack E et al. Host responses to intestinal microbial antigens in gluten-sensitive mice. PLoS One 2009; 4: e6472.
29. Lebwohl B, Kapel RC, Neugut AI et al. Adherence to biopsy guidelines increases celiac disease diagnosis. Gastrointest Endosc 2011; 74: 103-9.
30. Evans KE, Aziz I, Cross SS et al. A prospective study of duodenal bulb biopsy in newly diagnosed and established adult celiac disease. Am J Gastroenterol 2011; 106: 1837-42.
31. Aziz I, Evans KE, Hopper AD et al. A prospective study into the etiology of lymphocytic duodenosis. Alim Pharmacol Th er 2010; 32: 1392-7.
32. Vande Voort JL, Murray JA, Lahr BD et al. Lymphocytic duodenosis and the spectrum of celiac disease. Am J Gastroenterol 2009; 104: 142-8.
33. Shepherd SJ, Parker FC, Muir JG et al. Dietary triggers of abdominal symptoms in patients with irritable bowel syndrome: randomized placebocontrolled evidence. Clin Gastroenterol Hepatol 2008; 6: 765-71.