1,2-Dihydro-2-oxopyridine-3-carboxamides: The C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor

European Journal of Medicinal Chemistry

Volumn 74, Issue , 2014, Pages 524-532

  Lucchesi, Valentina ^a   Parkkari, Teija ^b   Savinainen, Juha R ^b   Malfitano, Anna Maria ^c   Allarà, Marco ^d   Bertini, Simone ^a   Castelli, Francesca ^a   Del Carlo, Sara ^a   Laezza, Chiara ^d   Ligresti, Alessia ^d   Saccomanni, Giuseppe ^a   Bifulco, Maurizio ^c   Di Marzo, Vincenzo ^d   Macchia, Marco ^a   Manera, Clementina ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITY OF SALERNO   (Italy)

^d CNR   (Italy)

Author keywords

Cannabinoid; CB1 receptor; CB2 receptor; CB2 receptor inverse agonist; CB2 receptor neutral antagonist

Indexed keywords

CANNABINOID; CB1 RECEPTOR; CB2 RECEPTOR; CB2 RECEPTOR INVERSE AGONIST; CB2 RECEPTOR NEUTRAL ANTAGONIST;

HEK293 CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PROTEIN BINDING; PYRIDINES; RECEPTOR, CANNABINOID, CB2;

EID: 84893842477     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.070     Document Type: Article

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