Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: Consequences in receptor affinity and functionality

Journal of Medicinal Chemistry

Volumn 50, Issue 22, 2007, Pages 5471-5484

  Stern, Eric ^a,b   Muccioli, Giulio G ^b   Bosier, Barbara ^b   Hamtiaux, Laurie ^b   Millet, Régis ^a   Poupaert, Jacques H ^b   Hénichart, Jean Pierre ^a   Depreux, Patrick ^a   Goossens, Jean François ^c   Lambert, Didier M ^b  

^a Faculté des Sciences Pharmaceutiques et Biologiques Université de Lille   (France)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c UNIV LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 OXO 1,4 DIHYDROCINNOLINE DERIVATIVE; 4 OXO 1,4 DIHYDRONAPHTHYRIDINE; 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXAMIDE DERIVATIVE; 6 CHLORO 4 OXO 1,4 DIHYDROQUINOLINE DERIVATIVE; 7 CHLORO 4 OXO 1,4 DIHYDROQUINOLINE DERIVATIVE; 8 CHLORO 4 OXO 1,4 DIHYDROQUINOLINE DERIVATIVE; AMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CINNOLINE DERIVATIVE; LIGAND; NAPHTHYRIDINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN FUNCTION; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; CRICETULUS; DRUG INVERSE AGONISM; HUMANS; LIGANDS; QUINOLINES; RADIOLIGAND ASSAY; RECEPTOR, CANNABINOID, CB2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35848957071     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070387h     Document Type: Article

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