Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 7, 2013, Pages 2045-2055

  Kusakabe, Ken Ichi ^a   Tada, Yukio ^a   Iso, Yasuyoshi ^a   Sakagami, Masahiro ^a   Morioka, Yasuhide ^a   Chomei, Nobuo ^a   Shinonome, Satomi ^a   Kawamoto, Keiko ^a   Takenaka, Hideyuki ^a   Yasui, Kiyoshi ^a   Hamana, Hiroshi ^b   Hanasaki, Kohji ^a  

^a SHIONOGI AND CO LTD   (Japan)

^b CHIBA INSTITUTE OF SCIENCE   (Japan)

Author keywords

Agonist; Cannabinoid; CB2; Homology model; Pyridine 2 one; Pyridone

Indexed keywords

2 PYRIDONE DERIVATIVE; 3 (BENZO[D]OXAZOL 2 YLOXY) 1 BUTYL 4 METHYLPYRIDINE 2(1H) THIONE; 3 (BENZO[D]OXAZOL 2 YLOXY) 1 BUTYL 5 METHYLPYRIDINE 2(1H) THIONE; 3 (BENZO[D]OXAZOL 2 YLOXY) 1 BUTYL 5,6 DIMETHYLPYRIDINE 2(1H) THIONE; 3 (BENZO[D]OXAZOL 2 YLOXY) 1 BUTYLPYRIDINE 2(1H) THIONE; 3 (BENZO[D]OXAZOL 2 YLOXY) 1 ETHYL 5,6 DIMETHYLPYRIDINE 2(1H) THIONE; 3 (BENZO[D]OXAZOL 2 YLOXY) 1 HEXYL 5,6 DIMETHYLPYRIDINE 2(1H) THIONE; 3 (BENZO[D]OXAZOL 2 YLOXY) 5,6 DIMETHYL 1 PENTYLPYRIDINE 2(1H) THIONE; 3 (BENZO[D]OXAZOL 2 YLOXY) 5,6 DIMETHYL 1 PROPYLPYRIDINE 2(1H) THIONE; 5,6 DIMETHYLPYRIDONE; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; N (1 BUTYL 5,6 DIMETHYL 2 OXO 1,2 DIHYDROPYRIDIN 3 YL) 1 NAPHTHAMIDE; N (1 BUTYL 5,6 DIMETHYL 2 OXO 1,2 DIHYDROPYRIDIN 3 YL) 2 CHLOROBENZAMIDE; N (1 BUTYL 5,6 DIMETHYL 2 OXO 1,2 DIHYDROPYRIDIN 3 YL) 2 FLUOROBENZAMIDE; N (1 BUTYL 5,6 DIMETHYL 2 OXO 1,2 DIHYDROPYRIDIN 3 YL) 2 METHYLBENZAMIDE; N (1 BUTYL 5,6 DIMETHYL 2 OXO 1,2 DIHYDROPYRIDIN 3 YL) 2 NAPHTHAMIDE; N (1 BUTYL 5,6 DIMETHYL 2 OXO 1,2 DIHYDROPYRIDIN 3 YL) 2 PHENYLACETAMIDE; N (1 BUTYL 5,6 DIMETHYL 2 OXO 1,2 DIHYDROPYRIDIN 3 YL) 3 METHYLBENZAMIDE; N (1 BUTYL 5,6 DIMETHYL 2 OXO 1,2 DIHYDROPYRIDIN 3 YL) 4 METHYLBENZAMIDE; N (1 BUTYL 5,6 DIMETHYL 2 OXO 1,2 DIHYDROPYRIDIN 3 YL)ACETAMIDE; N (1 BUTYL 5,6 DIMETHYL 2 OXO 1,2 DIHYDROPYRIDIN 3 YL)BENZAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; MOLECULAR DOCKING; NONHUMAN; PREDICTION; STRUCTURE ACTIVITY RELATION;

CATALYTIC DOMAIN; DRUG DESIGN; HUMANS; MOLECULAR DOCKING SIMULATION; PYRIDONES; RECEPTOR, CANNABINOID, CB2; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875220979     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.006     Document Type: Article

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