Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold

European Journal of Medicinal Chemistry

Volumn 52, Issue , 2012, Pages 284-294

  Manera, Clementina ^a   Saccomanni, Giuseppe ^a   Malfitano, Anna Maria ^b   Bertini, Simone ^a   Castelli, Francesca ^a   Laezza, Chiara ^c   Ligresti, Alessia ^c   Lucchesi, Valentina ^a   Tuccinardi, Tiziano ^a,d   Rizzolio, Flavio ^d,f   Bifulco, Maurizio ^b   Di Marzo, Vincenzo ^b   Giordano, Antonio ^d,e   MacChia, Marco ^a   Martinelli, Adriano ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c CNR   (Italy)

^d Temple University   (United States)

^e UNIVERSITY OF SIENA   (Italy)

^f CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

Anti proliferative; Cannabinoid; CB1 receptor; CB2 receptor

Indexed keywords

1,2 DIHYDROOXOPYRIDINE 3 CARBOXAMIDE DERIVATIVE; 1,8 NAPHTHYRIDIN 2(1H) ONE DERIVATIVE; 4 HYDROXY 2 OXO 1,2 DIHYDRO 1,8 NAPHTHYRIDINE 3 CARBOXAMIDE DERIVATIVE; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; NAPHTHYRIDINE DERIVATIVE; QUINOLIN 2(1H) ONE 3 CARBOXAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; REACTION ANALYSIS; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NAPHTHYRIDINES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; SUBSTRATE SPECIFICITY;

EID: 84860341479     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.03.031     Document Type: Article

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