Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: Binding details and inhibition mechanism

Acta Crystallographica Section D: Biological Crystallography

Volumn 69, Issue 8, 2013, Pages 1423-1432

  Nguyen, Giang Thi Tuyet ^a   Schaefer, Susanne ^a   Gertz, Melanie ^a   Weyand, Michael ^a   Steegborn, Clemens ^a  

^a UNIVERSITY OF BAYREUTH   (Germany)

Author keywords

protein deacetylases; sirtuin 3; SRT 1720

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; CARBANICOTINAMIDE ADENINE DINUCLEOTIDE; DRUG DERIVATIVE; FUSED HETEROCYCLIC RINGS; NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRT3 PROTEIN, HUMAN; SIRTUIN 3; SRT1720;

ARTICLE; BINDING COMPETITION; BINDING SITE; CHEMISTRY; HUMAN; METABOLISM; PROTEIN CONFORMATION; PROTEIN DEACETYLASES; SRT 1720; X RAY CRYSTALLOGRAPHY;

PROTEIN DEACETYLASES; SIRTUIN 3; SRT 1720;

ADENOSINE DIPHOSPHATE RIBOSE; BINDING SITES; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; NAD; PROTEIN CONFORMATION; SIRTUIN 3;

EID: 84881281834     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444913015448     Document Type: Article

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