Investigation of association of serotonin transporter and monoamine oxidase-A genes with Alzheimer's disease and depression in the VITA study cohort: A 90-month longitudinal study

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 165, Issue 2, 2014, Pages 184-191

  Scholz, Claus Jürgen ^a   Jungwirth, Susanne ^b   Danielczyk, Walter ^b   Weber, Heike ^a   Wichart, Ildiko ^b   Tragl, Karl Heinz ^b   Fischer, Peter ^b,c   Riederer, Peter ^a   Deckert, Jürgen ^a   Grünblatt, Edna ^a,b,d  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c DANUBE HOSPITAL   (Austria)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Alzheimer's disease; Depression; MAOA; Polymorphism; Serotonin transporter; SLC6A4

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; GENOMIC DNA; SEROTONIN TRANSPORTER;

ALLELE; ALZHEIMER DISEASE; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DEPRESSION; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENOTYPE; GERIATRIC DEPRESSION SCALE; HAMILTON SCALE; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MUTATION; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; PROMOTER REGION; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; STATE TRAIT ANXIETY INVENTORY; TELEPHONE INTERVIEW;

ALZHEIMER'S DISEASE; DEPRESSION; MAOA; POLYMORPHISM; SEROTONIN TRANSPORTER; SLC6A4;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; DEPRESSION; FEMALE; GENOTYPE; HUMANS; LONGITUDINAL STUDIES; MALE; MONOAMINE OXIDASE; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84893796504     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.32220     Document Type: Article

References (55)

1. Arlt S, Demiralay C, Tharun B, Geisel O, Storm N, Eichenlaub M, Lehmbeck JT, Wiedemann K, Leuenberger B, Jahn H. 2013. Genetic risk factors for depression in Alzheimer's disease patients. Curr Alzheimer Res 10(1):72-81.
2. Barnes DE, Yaffe K, Byers AL, McCormick M, Schaefer C, Whitmer RA. 2012. Midlife vs late-life depressive symptoms and risk of dementia: Differential effects for Alzheimer disease and vascular dementia. Arch Gen Psychiatry 69(5):493-498.
3. Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE. 2007. Systematic meta-analyses of Alzheimer disease genetic association studies: The AlzGene database. Nat Genet 39(1):17-23.
4. Bertram L, Tanzi RE. 2012. The genetics of Alzheimer's disease. Prog Mol Biol Transl Sci 107:79-100.
5. Caraci F, Copani A, Nicoletti F, Drago F. 2010. Depression and Alzheimer's disease: Neurobiological links and common pharmacological targets. Eur J Pharmacol 626(1):64-71.
6. Clark L, Cools R, Robbins TW. 2004. The neuropsychology of ventral prefrontal cortex: Decision-making and reversal learning. Brain Cogn 55(1):41-53.
7. Clarke H, Flint J, Attwood AS, Munafo MR. 2010. Association of the 5-HTTLPR genotype and unipolar depression: A meta-analysis. Psychol Med 40(11):1767-1778.
8. Clarke HF, Walker SC, Crofts HS, Dalley JW, Robbins TW, Roberts AC. 2005. Prefrontal serotonin depletion affects reversal learning but not attentional set shifting. J Neurosci 25(2):532-538.
9. Deckert J, Catalano M, Syagailo YV, Bosi M, Okladnova O, Di Bella D, Nothen MM, Maffei P, Franke P, Fritze J, Maier W, Propping P, Beckmann H, Bellodi L, Lesch KP. 1999. Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet 8(4):621-624.
10. Enge S, Fleischhauer M, Lesch KP, Reif A, Strobel A. 2011. Serotonergic modulation in executive functioning: Linking genetic variations to working memory performance. Neuropsychologia 49(13):3776-3785.
11. Fan M, Liu B, Jiang T, Jiang X, Zhao H, Zhang J. 2012. Meta-analysis of the association between the monoamine oxidase-A gene and mood disorders. Psychiatr Genet 20(1):1-7.
12. Feher A, Juhasz A, Laszlo A, Pakaski M, Kalman J, Janka Z. 2013. Serotonin transporter and serotonin receptor 2A gene polymorphisms in Alzheimer's disease. Neurosci Lett 534:233-236.
13. Fischer P, Jungwirth S, Krampla W, Weissgram S, Kirchmeyr W, Schreiber W, Huber K, Rainer M, Bauer P, Tragl KH. 2002. Vienna Transdanube Aging "VITA": Study design, recruitment strategies and level of participation. J Neural Transm Suppl (62):105-116.
14. Folstein MF, Robins LN, Helzer JE. 1983. The Mini-Mental State Examination. Arch Gen Psychiatry 40(7):812.
15. Fuld PA. 1980. Guaranteed stimulus-processing in the evaluation of memory and learning. Cortex 16(2):255-271.
16. Gondo Y, Hirose N, Arai Y, Yamamura K, Shimizu K, Takayama M, Ebihara Y, Nakazawa S, Inagaki H, Masui Y, Kitagawa K. 2005. Contribution of an affect-associated gene to human longevity: Prevalence of the long-allele genotype of the serotonin transporter-linked gene in Japanese centenarians. Mech Ageing Dev 126(11):1178-1184.
17. Grünblatt E, Hupp E, Bambula M, Zehetmayer S, Jungwirth S, Tragl KH, Fischer P, Riederer P. 2006a. Association study of BDNF and CNTF polymorphism to depression in non-demented subjects of the "VITA" study. J Affect Disord 96(1-2):111-116.
18. Grünblatt E, Loffler C, Zehetmayer S, Jungwirth S, Tragl KH, Riederer P, Fischer P. 2006b. Association study of the 5-HTTLPR polymorphism and depression in 75-year-old nondemented subjects from the Vienna Transdanube Aging (VITA) Study. J Clin Psychiatry 67(9):1373-1378.
19. Grünblatt E, Schlößer R, Fischer P, Fischer MO, Li J, Koutsilieri E, Wichart I, Sterba N, Rujescu D, Moller HJ, Adamcyk W, Dittrich B, Muller F, Oberegger K, Gatterer G, Jellinger KJ, Mostafaie N, Jungwirth S, Huber K, Tragl KH, Danielczyk W, Riederer P. 2005. Oxidative stress related markers in the "VITA" and the centenarian projects. Neurobiol Aging 26(4):429-438.
20. Grünblatt E, Zehetmayer S, Bartl J, Löffler C, Wichart I, Rainer MK, Jungwirth S, Bauer P, Danielczyk W, Tragl KH, Riederer P, Fischer P. 2009. Genetic risk factors and markers for Alzheimer's disease and/or depression in the VITA study. J Psychiatr Res 43(3):298-308.
21. Gutierrez B, Arias B, Gasto C, Catalan R, Papiol S, Pintor L, Fananas L. 2004. Association analysis between a functional polymorphism in the monoamine oxidase A gene promoter and severe mood disorders. Psychiatr Genet 14(4):203-208.
22. Haenisch B, Herms S, Mattheisen M, Steffens M, Breuer R, Strohmaier J, Degenhardt F, Schmal C, Lucae S, Maier W, Rietschel M, Nothen MM, Cichon S. 2013. Genome-wide association data provide further support for an association between 5-HTTLPR and major depressive disorder. J Affect Disord 146(3):438-440.
23. Holsinger RM, Brown R, Richmond R, Kay-Lambkin F, Law J, Kirby AC, Chan DK. 2012. Prevalence of the long-allele genotype of the serotonin transporter-linked gene in female centenarians. J Am Geriatr Soc 60(9):1786-1788.
24. Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD, Xu K, Arnold PD, Richter MA, Kennedy JL, Murphy DL, Goldman D. 2006. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 78(5):815-826.
25. Jungwirth S, Zehetmayer S, Bauer P, Weissgram S, Tragl KH, Fischer P. 2009. Prediction of Alzheimer dementia with short neuropsychological instruments. J Neural Transm 116(11):1513-1521.
26. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. 2005. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62(6):617-627.
27. Korten NC, Comijs HC, Lamers F, Penninx BW. 2012. Early and late onset depression in young and middle aged adults: Differential symptomatology, characteristics and risk factors? J Affect Disord 138(3):259-267.
28. Laks J, Engelhardt E. 2010. Peculiarities of geriatric psychiatry: A focus on aging and depression. CNS Neurosci Ther 16(6):374-379.
29. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274(5292):1527-1531.
30. Li T, Holmes C, Sham PC, Vallada H, Birkett J, Kirov G, Lesch KP, Powell J, Lovestone S, Collier D. 1997. Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease. Neuroreport 8(3):683-686.
31. Lopez-Leon S, Janssens AC, Gonzalez-Zuloeta Ladd AM, Del-Favero J, Claes SJ, Oostra BA, van Duijn CM. 2008. Meta-analyses of genetic studies on major depressive disorder. Mol Psychiatry 13(8):772-785.
32. Lorenzi C, Marcone A, Pirovano A, Marino E, Cordici F, Cerami C, Delmonte D, Cappa SF, Bramanti P, Smeraldi E. 2010. Serotonin transporter and saitohin genes in risk of Alzheimer's disease and frontotemporal lobar dementia: Preliminary findings. Neurol Sci 31(6):741-749.
33. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. 1984. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34(7):939-944.
34. Menashe I, Rosenberg PS, Chen BE. 2008. PGA: Power calculator for case-control genetic association analyses. BMC Genet 9:36.
35. Mossaheb N, Zehetmayer S, Jungwirth S, Weissgram S, Rainer M, Tragl KH, Fischer P. 2012. Are specific symptoms of depression predictive of alzheimer's dementia? J Clin Psychiatry 73(7):1009-1015.
36. Nishimura AL, Guindalini C, Oliveira JR, Nitrini R, Bahia VS, de Brito-Marques PR, Otto PA, Zatz M. 2005. Monoamine oxidase a polymorphism in Brazilian patients: Risk factor for late-onset Alzheimer's disease? J Mol Neurosci 27(2):213-217.
37. O'Hara R, Marcus P, Thompson WK, Flournoy J, Vahia I, Lin X, Hallmayer J, Depp C, Jeste DV. 2012. 5-HTTLPR short allele, resilience, and successful aging in older adults. Am J Geriatr Psychiatry 20(5):452-456.
38. Oliveira JR, Gallindo RM, Maia LG, Brito-Marques PR, Otto PA, Passos-Bueno MR, Morais MA Jr, Zatz M. 1998. The short variant of the polymorphism within the promoter region of the serotonin transporter gene is a risk factor for late onset Alzheimer's disease. Mol Psychiatry 3(5):438-441.
39. Ownby RL, Crocco E, Acevedo A, John V, Loewenstein D. 2006. Depression and risk for Alzheimer disease: Systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry 63(5):530-538.
40. Polito L, Prato F, Rodilossi S, Ateri E, Galimberti D, Scarpini E, Clerici F, Mariani C, Forloni G, Albani D. 2012. A novel study and meta-analysis of the genetic variation of the serotonin transporter promoter in the italian population do not support a large effect on Alzheimer's disease risk. Int J Alzheimers Dis 2011:312341.
41. Preuss UW, Siafarikas N, Petrucci M, Wong WM. 2009. Depressive disorders in dementia and mild cognitive impairments: Is comorbidity a cause or a risk factor?. Fortschr Neurol Psychiatr 77(7):399-406.
42. Priess-Groben HA, Hyde JS. 2013. 5-HTTLPR X stress in adolescent depression: Moderation by MAOA and gender. J Abnorm Child Psychol 41(2):281-294.
43. Prince M, Jackson J. 2009. World Alzheimer Report 2009, 2009ed. London, UK: Alzheimer's Disease International. p 92.
44. Reif A, Weber H, Domschke K, Klauke B, Baumann C, Jacob CP, Strohle A, Gerlach AL, Alpers GW, Pauli P, Hamm A, Kircher T, Arolt V, Wittchen HU, Binder EB, Erhardt A, Deckert J. 2012. Meta-analysis argues for a female-specific role of MAOA-uVNTR in panic disorder in four European populations. Am J Med Genet B Neuropsychiatr Genet 159B(7):786-793.
45. Sabol SZ, Hu S, Hamer D. 1998. A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet 103(3):273-279.
46. Schulze TG, Muller DJ, Krauss H, Scherk H, Ohlraun S, Syagailo YV, Windemuth C, Neidt H, Grassle M, Papassotiropoulos A, Heun R, Nothen MM, Maier W, Lesch KP, Rietschel M. 2000. Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder. Am J Med Genet 96(6):801-803.
47. Spielberger CD, Vagg PR. 1984. Psychometric properties of the STAI: A reply to Ramanaiah, Franzen, and Schill. J Pers Assess 48(1):95-97.
48. Stockmeier CA. 2003. Involvement of serotonin in depression: Evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter. J Psychiatr Res 37(5):357-373.
49. Tsuno N, Homma A. 2009. What is the association between depression and Alzheimer's disease? Expert Rev Neurother 9(11):1667-1676.
50. Ward A, Crean S, Mercaldi CJ, Collins JM, Boyd D, Cook MN, Arrighi HM. 2012. Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer's disease: A systematic review and meta-analysis. Neuroepidemiology 38(1):1-17.
51. Wendland JR, Martin BJ, Kruse MR, Lesch KP, Murphy DL. 2006. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry 11(3):224-226.
52. Wilhelm K, Mitchell P, Slade T, Brownhill S, Andrews G. 2003. Prevalence and correlates of DSM-IV major depression in an Australian national survey. J Affect Disord 75(2):155-162.
53. Williams JB. 1988. A structured interview guide for the Hamilton Depression Rating Scale. Arch Gen Psychiatry 45(8):742-747.
54. World Health Organization. 2012. Dementia. World Health Organization. ISBN: 978 92 4 156445 8 http://www.who.int/mental_health/publications/dementia_report_2012/en/
55. Yesavage JA. 1988. Geriatric Depression Scale. Psychopharmacol Bull 24(4):709-711.