Meta-analysis argues for a female-specific role of MAOA-uVNTR in panic disorder in four European populations

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 159 B, Issue 7, 2012, Pages 786-793

  Reif, Andreas ^a   Weber, Heike ^a   Domschke, Katharina ^a,b   Klauke, Benedikt ^b   Baumann, Christian ^a   Jacob, Christian P ^a   Ströhle, Andreas ^c   Gerlach, Alexander L ^d   Alpers, Georg W ^e   Pauli, Paul ^a   Hamm, Alfons ^f   Kircher, Tilo ^g   Arolt, Volker ^b   Wittchen, Hans Ulrich ^h   Binder, Elisabeth B ⁱ   Erhardt, Angelika ⁱ   Deckert, Jürgen ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

^e UNIVERSITY OF MANNHEIM   (Germany)

^f UNIVERSITY OF GREIFSWALD   (Germany)

^g PHILIPPS UNIVERSITY MARBURG   (Germany)

^h DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

ⁱ MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Association; Meta analysis; Monoamine oxidase A; Panic disorder; Promoter polymorphism

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A;

ALLELE; ARTICLE; CASE CONTROL STUDY; EPIGENETICS; ESTONIA; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; GERMANY; HIGH RISK POPULATION; HUMAN; ITALY; META ANALYSIS; METHYLATION; PANIC; POLAND; POPULATION RESEARCH; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX ROLE;

ADULT; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MINISATELLITE REPEATS; MONOAMINE OXIDASE; PANIC DISORDER; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC;

ANIMALIA;

EID: 84866315614     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.32085     Document Type: Article

References (57)

1. Bekker MH, van Mens-Verhulst J. 2007. Anxiety disorders: Sex differences in prevalence, degree, and background, but gender-neutral treatment. Gend Med 4(Suppl. B): S178-S193.
2. Bortolato M, Chen K, Godar SC, Chen G, Wu W, Rebrin I, Farrell MR, Scott AL, Wellman CL, Shih JC. 2011. Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice. Neuropsychopharmacology 36(13): 2674-2688.
3. Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA. 1993. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262(5133): 578-580.
4. Buigues J, Vallejo J. 1987. Therapeutic response to phenelzine in patients with panic disorder and agoraphobia with panic attacks. J Clin Psychiatry 48(2): 55-59.
5. Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R. 2002. Role of genotype in the cycle of violence in maltreated children. Science 297(5582): 851-854.
6. Cerda M, Sagdeo A, Johnson J, Galea S. 2010. Genetic and environmental influences on psychiatric comorbidity: A systematic review. J Affect Disord 126(1-2): 14-38.
7. Deckert J, Catalano M, Syagailo YV, Bosi M, Okladnova O, Di Bella D, Nothen MM, Maffei P, Franke P, Fritze J, et al. 1999. Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet 8(4): 621-624.
8. DerSimonian R, Laird N. 1986. Meta-analysis in clinical trials. Control Clin Trials 7(3): 177-188.
9. Dickinson JL, Sale MM, Passmore A, FitzGerald LM, Wheatley CM, Burdon KP, Craig JE, Tengtrisorn S, Carden SM, Maclean H, et al. 2006. Mutations in the NDP gene: Contribution to Norrie disease, familial exudative vitreoretinopathy and retinopathy of prematurity. Clin Experiment Ophthalmol 34(7): 682-688.
10. Domschke K, Freitag CM, Kuhlenbaumer G, Schirmacher A, Sand P, Nyhuis P, Jacob C, Fritze J, Franke P, Rietschel M, et al. 2004. Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women. Int J Neuropsychopharmacol 7(2): 183-188.
11. Domschke K, Tidow N, Kuithan H, Schwarte K, Klauke B, Reif A, Schmidt H, Arolt V, Kersting A, Zwanzger P, et al. 2012. MAO-A gene hypomethylation-A risk factor for panic disorder? Int J Neuropsychopharmacol 1-12.
12. Fleiss J. 1981. Statistical methods for rates and proportions. New York: Wiley.
13. Frazzetto G, Di Lorenzo G, Carola V, Proietti L, Sokolowska E, Siracusano A, Gross C, Troisi A. 2007. Early trauma and increased risk for physical aggression during adulthood: The moderating role of MAOA genotype. PLoS ONE 2(5): e486.
14. Freitag CM, Domschke K, Rothe C, Lee YJ, Hohoff C, Gutknecht L, Sand P, Fimmers R, Lesch KP, Deckert J. 2006. Interaction of serotonergic and noradrenergic gene variants in panic disorder. Psychiatr Genet 16(2): 59-65.
15. Gloster AT, Wittchen HU, Einsle F, Hofler M, Lang T, Helbig-Lang S, Fydrich T, Fehm L, Hamm AO, Richter J, et al. 2009. Mechanism of action in CBT (MAC): Methods of a multi-center randomized controlled trial in 369 patients with panic disorder and agoraphobia. Eur Arch Psychiatry Clin Neurosci 259(Suppl. 2): S155-S166.
16. Gregersen N, Dahl HA, Buttenschon HN, Nyegaard M, Hedemand A, Als TD, Wang AG, Joensen S, Woldbye DP, Koefoed P, et al. 2011. A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene. Eur J Hum Genet 20(1): 84-90.
17. Haavik J, Blau N, Thony B. 2008. Mutations in human monoamine-related neurotransmitter pathway genes. Hum Mutat 29(7): 891-902.
18. Haberstick BC, Lessem JM, Hopfer CJ, Smolen A, Ehringer MA, Timberlake D, Hewitt JK. 2005. Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment. Am J Med Genet B Neuropsychiatr Genet 135B(1): 59-64.
19. Halpin C, Owen G, Gutierrez-Espeleta GA, Sims K, Rehm HL. 2005. Audiologic features of Norrie disease. Ann Otol Rhinol Laryngol 114(7): 533-538.
20. Hamilton SP, Slager SL, Heiman GA, Haghighi F, Klein DF, Hodge SE, Weissman MM, Fyer AJ, Knowles JA. 2000. No genetic linkage or association between a functional promoter polymorphism in the monoamine oxidase-A gene and panic disorder. Mol Psychiatry 5(5): 465-466.
21. Hettema JM, Neale MC, Myers JM, Prescott CA, Kendler KS. 2006. A population-based twin study of the relationship between neuroticism and internalizing disorders. Am J Psychiatry 163(5): 857-864.
22. Huang YY, Cate SP, Battistuzzi C, Oquendo MA, Brent D, Mann JJ. 2004. An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences. Neuropsychopharmacology 29(8): 1498-1505.
23. Jacob CP, Muller J, Schmidt M, Hohenberger K, Gutknecht L, Reif A, Schmidtke A, Mossner R, Lesch KP. 2005. Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity. Neuropsychopharmacology 30(9): 1711-1718.
24. Jonsson EG, Norton N, Gustavsson JP, Oreland L, Owen MJ, Sedvall GC. 2000. A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers. J Psychiatr Res 34(3): 239-244.
25. Kawamura Y, Otowa T, Koike A, Sugaya N, Yoshida E, Yasuda S, Inoue K, Takei K, Konishi Y, Tanii H, et al. 2011. A genome-wide CNV association study on panic disorder in a Japanese population. J Hum Genet 56(12): 852-856.
26. Kim-Cohen J, Caspi A, Taylor A, Williams B, Newcombe R, Craig IW, Moffitt TE. 2006. MAOA, maltreatment, and gene-environment interaction predicting children's mental health: New evidence and a meta-analysis. Mol Psychiatry 11(10): 903-913.
27. Lau J, Ioannidis JP, Schmid CH. 1997. Quantitative synthesis in systematic reviews. Ann Intern Med 127(9): 820-826.
28. Levy ER, Powell JF, Buckle VJ, Hsu YP, Breakefield XO, Craig IW. 1989. Localization of human monoamine oxidase-A gene to Xp11.23-11.4 by in situ hybridization: Implications for Norrie disease. Genomics 5(2): 368-370.
29. Mantel N, Haenszel W. 1959. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22(4): 719-748.
30. Manuck SB, Flory JD, Ferrell RE, Mann JJ, Muldoon MF. 2000. A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. Psychiatry Res 95(1): 9-23.
31. Manuck SB, Flory JD, Muldoon MF, Ferrell RE. 2002. Central nervous system serotonergic responsivity and aggressive disposition in men. Physiol Behav 77(4-5): 705-709.
32. Maron E, Tasa G, Toru I, Lang A, Vasar V, Shlik J. 2004. Association between serotonin-related genetic polymorphisms and CCK-4-induced panic attacks with or without 5-hydroxytryptophan pretreatment in healthy volunteers. World J Biol Psychiatry 5(3): 149-154.
33. Maron E, Lang A, Tasa G, Liivlaid L, Toru I, Must A, Vasar V, Shlik J. 2005. Associations between serotonin-related gene polymorphisms and panic disorder. Int J Neuropsychopharmacol 8(2): 261-266.
34. Maron E, Toru I, Tasa G, Must A, Toover E, Lang A, Vasar V, Shlik J. 2008. Association testing of panic disorder candidate genes using CCK-4 challenge in healthy volunteers. Neurosci Lett 446(2-3): 88-92.
35. Maron E, Hettema JM, Shlik J. 2010. Advances in molecular genetics of panic disorder. Mol Psychiatry 15(7): 681-701.
36. McDermott R, Tingley D, Cowden J, Frazzetto G, Johnson DD. 2009. Monoamine oxidase A gene (MAOA) predicts behavioral aggression following provocation. Proc Natl Acad Sci U S A 106(7): 2118-2123.
37. Newman TK, Syagailo YV, Barr CS, Wendland JR, Champoux M, Graessle M, Suomi SJ, Higley JD, Lesch KP. 2005. Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys. Biol Psychiatry 57(2): 167-172.
38. Nordquist N, Oreland L. 2006. Monoallelic expression of MAOA in skin fibroblasts. Biochem Biophys Res Commun 348(2): 763-767.
39. Nordquist N, Oreland L. 2010. Serotonin, genetic variability, behaviour, and psychiatric disorders-A review. Ups J Med Sci 115(1): 2-10.
40. Otowa T, Yoshida E, Sugaya N, Yasuda S, Nishimura Y, Inoue K, Tochigi M, Umekage T, Miyagawa T, Nishida N, et al. 2009. Genome-wide association study of panic disorder in the Japanese population. J Hum Genet 54(2): 122-126.
41. Otowa T, Tanii H, Sugaya N, Yoshida E, Inoue K, Yasuda S, Shimada T, Kawamura Y, Tochigi M, Minato T, et al. 2010. Replication of a genome-wide association study of panic disorder in a Japanese population. J Hum Genet 55(2): 91-96.
42. Pinsonneault JK, Papp AC, Sadee W. 2006. Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: dissection of epigenetic and genetic factors. Hum Mol Genet 15(17): 2636-2649.
43. R-Development-Core-Team. 2009. R: A Language and environment for Statistical Computing. 2.10.0 ed. R Foundation for Statistical Computing. Vienna, Austria.
44. Rabe-Jablonska J, Bienkiewicz W. 1994. [Anxiety disorders in the fourth edition of the classification of mental disorders prepared by the American Psychiatric Association: diagnostic and statistical manual of mental disorders (DMS-IV) - options book]. Psychiatr Pol 28(2): 255-268.
45. Sabol SZ, Hu S, Hamer D. 1998. A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet 103(3): 273-279.
46. Samochowiec J, Hajduk A, Samochowiec A, Horodnicki J, Stepien G, Grzywacz A, Kucharska-Mazur J. 2004. Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum. Psychiatry Res 128(1): 21-26.
47. Sand P, Lesch KP, Catalano M, Bosi M, Syagailo YV, Okladnova O, Di Bella D, Maffei P, Heils A, Friess F, et al. 2000. Polymorphic MAO-A and 5-HT-transporter genes: Analysis of interactions in panic disorder. World J Biol Psychiatry 1(3): 147-150.
48. Stabellini R, de Mello JC, Hernandes LM, Pereira LV. 2009. MAOA and GYG2 are submitted to X chromosome inactivation in human fibroblasts. Epigenetics 4(6): 388-393.
49. Tadic A, Rujescu D, Szegedi A, Giegling I, Singer P, Moller HJ, Dahmen N. 2003. Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression. Am J Med Genet Part B 117B(1): 1-6.
50. Tyrer P, Shawcross C. 1988. Monoamine oxidase inhibitors in anxiety disorders. J Psychiatr Res 22(Suppl. 1): 87-98.
51. Viechtbauer W. 2009. Metafor: Meta-Analysis Package for R.Version 0.5-7.
52. Weder N, Yang BZ, Douglas-Palumberi H, Massey J, Krystal JH, Gelernter J, Kaufman J. 2009. MAOA genotype, maltreatment, and aggressive behavior: The changing impact of genotype at varying levels of trauma. Biol Psychiatry 65(5): 417-424.
53. Widom CS, Brzustowicz LM. 2006. MAOA and the "cycle of violence:" Childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior. Biol Psychiatry 60(7): 684-689.
54. Wittchen HU, Jacobi F, Rehm J, Gustavsson A, Svensson M, Jonsson B, Olesen J, Allgulander C, Alonso J, Faravelli C, et al. 2011. The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 21(9): 655-679.
55. World Health Organization. 1990. The international conference for the tenth revision of the International Classification of Diseases. Strengthening of Epidemiological and Statistical Services Unit. World Health Stat Q 43(4): 204-245.
56. World Health Organization. 1992. Alcohol use disorders and associated disabilities interview schedule: Alcohol/drug revised. World Health Organization, Geneva.
57. Zintzaras E, Hadjigeorgiou GM. 2004. Association of paraoxonase 1 gene polymorphisms with risk of Parkinson's disease: A meta-analysis. J Hum Genet 49(9): 474-481.