Genetic risk factors for depression in Alzheimer's disease patients

Current Alzheimer Research

Volumn 10, Issue 1, 2013, Pages 72-81

  Arlt, Sönke ^a   Demiralay, Cüneyt ^a   Tharun, Björn ^a   Geisel, Olga ^a,c   Storm, Niels ^b   Eichenlaub, Martin ^a   Lehmbeck, Jan T ^a   Wiedemann, Klaus ^a   Leuenberger, Boris ^b   Jahn, Holger ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b Bioglobe GmbH   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Alzheimer's disease; Comorbidity; Dementia; Genetic polymorphism; Genetic risk factor; Major depression

Indexed keywords

5 HYDROXYTRYPTAMINE RECEPTOR 2A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; APOLIPOPROTEIN E; BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; CORTICOTROPIN; CORTICOTROPINE RELEASING HORMONE RECEPTOR 1; DIPEPTIDYL CARBOXYPEPTIDASE; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 5; LIGAND GATED ION CHANNEL; LIGAND GATED ION CHANNEL 7; MONOAMINE OXIDASE INHIBITOR; MONOAMINE OXIDASE INHIBITOR A; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 3; PURINERGIC P2X RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; TRYPTOPHAN HYDROXYLASE; UNCLASSIFIED DRUG;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DEPRESSION; DISEASE ASSOCIATION; DISEASE DURATION; DNA DETERMINATION; DSM-IV; EMOTIONAL DISORDER; FEMALE; GENE AMPLIFICATION; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; GERIATRIC DEPRESSION SCALE; HUMAN; INDEL MUTATION; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; NERVE DEGENERATION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROMOTER REGION; VARIABLE NUMBER OF TANDEM REPEAT; GENETIC PREDISPOSITION; GENETICS; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEINS E; CROSS-SECTIONAL STUDIES; DEPRESSION; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84882372511     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/1567205011310010010     Document Type: Article

References (43)

1. Wragg RE, Jeste DV. Overview of depression and psychosis in Alzheimer's disease. Am J Psychiatry 146(5):577-587 (1989).
2. Muller-Thomsen T, Arlt S, Mann U, Mass R, Ganzer S. Detecting depression in Alzheimer's disease: evaluation of four different scales. Arch Clin Neuropsychol 20(2):271-276 (2005).
3. Jorm AF. Is depression a risk factor for dementia or cognitive decline? A review. Gerontology 46(4):219-227 (2000).
4. Zweig RM, Ross CA, Hedreen JC, Steele C, Cardillo JE, White-house PJ et al. Neuropathology of aminergic nuclei in Alzheimer's disease. Prog Clin Biol Res 317:353-365 (1989).
5. Christiansen L, Tan Q, Iachina M, Bathum L, Kruse TA, McGue M et al. Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Biol Psychiatry 61(2):223-230 (2007).
6. Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43(8):1467-1472 (1993).
7. Delano-Wood L, Houston WS, Emond JA, Marchant NL, Salmon DP, Jeste DV et al. APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study. Int J Geriatr Psychiatry 23(6):632-636 (2008).
8. Class CA, Unverzagt FW, Gao S, Sahota A, Hall KS, Hendrie HC. The association between Apo E genotype and depressive symptoms in elderly African-American subjects. Am J Geriatr Psychiatry 5(4):339-343 (1997).
9. Garcia-Pena C, Juarez-Cedillo T, Cruz-Robles D, Fragoso JM, Sanchez-Garcia S, Rodriguez-Perez JM et al. Depressive symptoms and APOE polymorphisms in an elderly population-based sample. Psychiatr Genet 20(5):215-220 (2010).
10. Giltay EJ, van Reedt Dortland AK, Nissinen A, Giampaoli S, van Veen T, Zitman FG et al. Serum cholesterol, apolipoprotein E genotype and depressive symptoms in elderly European men: the FINE study. J Affect Disord 115(3):471-477 (2009).
11. Surtees PG, Wainwright NW, Bowman R, Luben RN, Wareham NJ, Khaw KT et al. No association between APOE and major depressive disorder in a community sample of 17,507 adults. J Psy-chiatr Res 43(9):843-847 (2009).
12. Sheik JY, Geriatric Depression Scale (GDS): recent evidence and development of a shorter version. Clinical Gerontologist 5:165-173 (1986).
13. Sequenom Inc., San Diego, U.S.A., www.MySequenom.com.
14. Storm N, Darnhofer-Patel B, van den Boom D, Rodi CP. MALDI-TOF mass spectrometry-based SNP genotyping. Methods Mol Biol 212:241-262 (2003).
15. Yacubian J, Sommer T, Schroeder K, Glascher J, Kalisch R, Leuenberger B et al. Gene-gene interaction associated with neural reward sensitivity. Proc Natl Acad Sci U S A 104(19):8125-8130 (2007).
16. Hixson JE, Vernier DT. Restriction isotyping of human apolipopro-tein E by gene amplification and cleavage with HhaI. J Lipid Res 31(3):545-548 (1990).
17. Online Encyclopedia for Genetic Epidemiology studies. http://www.oege.org/software/hardy-weinberg.html
18. Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39(2):175-191 (2007).
19. Zubenko GS, Maher B, Hughes HB, Zubenko WN, Stiffler JS, Kaplan BB et al. Genome-wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depression. Am J Med Genet B Neu-ropsychiatr Genet 123B(1):1-18 (2003).
20. Steffens DC, Fisher GG, Langa KM, Potter GG, Plassman BL. Prevalence of depression among older Americans: the Aging, Demographics and Memory Study. Int Psychogeriatr 21(5):879-888 (2009).
21. Newman SC. The prevalence of depression in Alzheimer's disease and vascular dementia in a population sample. J Affect Disord 52(1-3):169-176 (1999).
22. Verkaik R, Francke AL, van Meijel B, Ribbe MW, Bensing JM. Comorbid depression in dementia on psychogeriatric nursing home wards: which symptoms are prominent? Am J Geriatr Psychiatry 17(7):565-573 (2009).
23. Fukumoto N, Fujii T, Combarros O, Kamboh MI, Tsai SJ, Matsushita S et al. Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis. Am J Med Genet B Neuropsychiatr Genet 153B(1):235-242 (2010).
24. Grunblatt E, Zehetmayer S, Bartl J, Loffler C, Wichart I, Rainer MK et al. Genetic risk factors and markers for Alzheimer's disease and/or depression in the VITA study. J Psychiatr Res 43(3):298-308 (2009).
25. National Center for Biotechnology Information (NCBI) SNP database, http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=1360780#Diversity.
26. Gizatullin R, Zaboli G, Jonsson EG, Asberg M, Leopardi R. Haplo-type analysis reveals tryptophan hydroxylase (TPH) 1 gene variants associated with major depression. Biol Psychiatry 59(4):295-300 (2006).
27. Wang YC, Tsai SJ, Liu TY, Liu HC, Hong CJ. No association between tryptophan hydroxylase gene polymorphism and Alzheimer's disease. Neuropsychobiology 43(1):1-4 (2001).
28. Schulze TG, Muller DJ, Krauss H, Scherk H, Ohlraun S, Syagailo YV et al. Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder. Am J Med Genet 96(6):801-803 (2000).
29. Yu YW, Tsai SJ, Hong CJ, Chen TJ, Chen MC, Yang CW. Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response. Neuropsychopharmacology 30(9):1719-1723 (2005).
30. Brummett BH, Krystal AD, Siegler IC, Kuhn C, Surwit RS, Zuch-ner S et al. Associations of a regulatory polymorphism of mono-amine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality. Psychosom Med 69(5):396-401 (2007).
31. Doornbos B, Dijck-Brouwer DA, Kema IP, Tanke MA, van Goor SA, Muskiet FA et al. The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT. Prog Neuropsychopharmacol Biol Psychiatry 33(7):1250-1254 (2009).
32. Camarena B, Rinetti G, Cruz C, Gomez A, de La Fuente JR, Nicolini H. Additional evidence that genetic variation of MAO-A gene supports a gender subtype in obsessive-compulsive disorder. Am J Med Genet 105(3):279-282 (2001).
33. Sarginson JE, Lazzeroni LC, Ryan HS, Schatzberg AF, Murphy GM, Jr. FKBP5 polymorphisms and antidepressant response in geriatric depression. Am J Med Genet B Neuropsychiatr Genet (2009).
34. Tatro ET, Everall IP, Kaul M, Achim CL. Modulation of glucocor-ticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: implications for major depressive disorder. Brain Res 1286:1-12 (2009).
35. Hwang JP, Tsai SJ, Hong CJ, Yang CH, Lirng JF, Yang YM. The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiol Aging 27(12):1834-1837 (2006).
36. Borroni B, Archetti S, Costanzi C, Grassi M, Ferrari M, Radeghieri A et al. Role of BDNF Val66Met functional polymorphism in Alzheimer's disease-related depression. Neurobiol Aging 30(9):1406-1412 (2009).
37. Ventriglia M, Bocchio Chiavetto L, Benussi L, Binetti G, Zanetti O, Riva MA et al. Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease. Mol Psychiatry 7(2):136-137 (2002).
38. Tsai SJ, Hong CJ, Liu HC, Liu TY, Hsu LE, Lin CH. Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset. Neuropsychobi-ology 49(1):10-12 (2004).
39. Lee HB, Lyketsos CG. Depression in Alzheimer's disease: heterogeneity and related issues. Biol Psychiatry 54(3):353-362 (2003).
40. Sotiropoulos I, Cerqueira JJ, Catania C, Takashima A, Sousa N, Almeida OF. Stress and glucocorticoid footprints in the brain-the path from depression to Alzheimer's disease. Neurosci Biobehav Rev 32(6):1161-1173 (2008).
41. Rosenberg PB, Drye LT, Martin BK, Frangakis C, Mintzer JE, Weintraub D et al. Sertraline for the treatment of depression in Alzheimer disease. Am J Geriatr Psychiatry 18(2):136-145
42. Schneider LS, Nelson JC, Clary CM, Newhouse P, Krishnan KR, Shiovitz T et al. An 8-week multicenter, parallel-group, double-blind, placebo-controlled study of sertraline in elderly outpatients with major depression. Am J Psychiatry 160(7):1277-1285 (2003).
43. Keers R, Uher R, Huezo-Diaz P, Smith R, Jaffee S, Rietschel M et al. Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project. Pharmacogenomics J