Association study of the 5-HTTLPR polymorphism and depression in 75-year-old nondemented subjects from the Vienna Transdanube Aging (VITA) study

Journal of Clinical Psychiatry

Volumn 67, Issue 9, 2006, Pages 1373-1378

  Grünblatt, Edna ^a,b   Löffler, Christiane ^a   Zehetmayer, Sonja ^c   Jungwirth, Susanne ^a   Tragl, Karl Heinz ^a   Riederer, Peter ^a,b   Fischer, Peter ^a,c  

^a LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN; SEROTONIN UPTAKE INHIBITOR;

AGED; AGING; ALLELE; ARTICLE; COGNITION; CONTROLLED STUDY; DEMENTIA; DEPRESSION; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; GEOGRAPHIC DISTRIBUTION; HAMILTON SCALE; HEALTH STATUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCORING SYSTEM;

EID: 33750044049     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.v67n0907     Document Type: Article

References (41)

1. Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003;301:386-389
2. Weizman A, Weizman R. Serotonin transporter polymorphism and response to SSRIs in major depression and relevance to anxiety disorders and substance abuse. Pharmacogenomics 2000;1:335-341
3. Lesch KP, Gutknecht L. Pharmacogenetics of the serotonin transporter. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:1062-1073
4. Kraft JB, Slager SL, McGrath PJ, et al. Sequence analysis of the serotonin transporter and associations with antidepressant response. Biol Psychiatry 2005;58:374-381
5. Lesch KP, Balling U, Gross J, et al. Organization of the human serotonin transporter gene. J Neural Transm Gen Sect 1994;95:157-162
6. Lesch KP, Gross J, Franzek E, et al. Primary structure of the serotonin transporter in unipolar depression and bipolar disorder. Biol Psychiatry 1995;37:215-223
7. Lesch KP, Bengel D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-1531
8. Heils A, Teufel A, Petri S, et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996;66:2621-2624
9. Willis-Owen SA, Turri MG, Munafo MR, et al. The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association. Biol Psychiatry 2005;58:451-456
10. Kendler KS, Kuhn JW, Vittum J, et al. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch Gen Psychiatry 2005;62:529-535
11. Hranilovic D, Stefulj J, Furac I, et al. Serotonin transporter gene promoter (5-HTTLPR) and intron 2 (VNTR) polymorphisms in Croatian suicide victims. Biol Psychiatry 2003;54:884-889
12. Du L, Bakish D, Hrdina PD. Gender differences in association between serotonin transporter gene polymorphism and personality traits. Psychiatr Genet 2000;10:159-164
13. Deckert J, Catalano M, Heils A, et al. Functional promoter polymorphism of the human serotonin transporter: lack of association with panic disorder. Psychiatr Genet 1997;7:45-47
14. Collier DA, Stober G, Li T, et al. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1996;1:453-460
15. Greenberg BD, Li Q, Lucas FR, et al. Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet 2000;96:202-216
16. Yu YW, Tsai SJ, Chen TJ, et al. Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders. Mol Psychiatry 2002; 7:1115-1119
17. Willeit M, Praschak-Rieder N, Neumeister A, et al. A polymorphism (5-HTTLPR) in the serotonin transporter promoter gene is associated with DSM-IV depression subtypes in seasonal affective disorder. Mol Psychiatry 2003;8:942-946
18. Hoefgen B, Schulze TG, Ohlraun S, et al. The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder. Biol Psychiatry 2005;57:247-251
19. Frisch A, Postilnick D, Rockah R, et al. Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways. Mol Psychiatry 1999;4:389-392
20. Fischer P, Jungwirth S, Krampla W, et al. Vienna Transdanube Aging "VITA": study design, recruitment strategies and level of participation. J Neural Transm Suppl 2002;62:105-116
21. Grünblatt E, Schlößer R, Fischer P, et al. Oxidative stress related markers in the "VITA" and the centenarian projects. Neurobiol Aging 2005;26:429-438
22. Blasko I, Kemmler G, Krampla W, et al. Plasma amyloid beta protein 42 in non-demented persons aged 75 years: effects of concomitant medication and medial temporal lobe atrophy. Neurobiol Aging 2005;26: 1135-1143
23. Wittchen H, Zaudig M, Fydrich T, ed. Strukturiertes Klinisches Interview für DSM-IV (SKID-I und SKID-II). Göttingen, Germany: Hogrefe; 1997
24. Williams JB, Gibbon M, First MB, et al. The Structured Clinical Interview for DSM-III-R (SCID), 2: multisite test-retest reliability. Arch Gen Psychiatry 1992;49:630-636
25. First MB, Gibbon M, Spitzer RL, et al. Structured Clinical Interview for DSM-IV Axis I Disorders SCID I, Clinical Version, Administration Booklet. Washington, DC: American Psychiatric Press; 1997
26. Zanarini MC, Frankenburg FR. Attainment and maintenance of reliability of axis I and II disorders over the course of a longitudinal study. Compr Psychiatry 2001;42:369-374
27. Judd LL, Rapaport MH, Paulus MP, et al. Subsyndromal symptomatic depression: a new mood disorder? J Clin Psychiatry 1994;55(suppl 4): 18-28
28. Sasieni PD. From genotypes to genes: doubling the sample size. Biometrics 1997;53:1253-1261
29. Menza MA, Palermo B, DiPaola R, et al. Depression and anxiety in Parkinson's disease: possible effect of genetic variation in the serotonin transporter. J Geriatr Psychiatry Neurol 1999;12:49-52
30. Lenze EJ, Munin MC, Ferrell RE, et al. Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture. Am J Geriatr Psychiatry 2005;13:428-432
31. Gillespie NA, Whitfield JB, Williams B, et al. The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychol Med 2005;35:101-111
32. Serretti A, Cusin C, Lattuada E, et al. No interaction between serotonin transporter gene and dopamine receptor D4 gene in symptomatology of major psychoses. Am J Med Genet 1999;88:481-485
33. Arango V, Underwood MD, Mann JJ. Serotonin brain circuits involved in major depression and suicide. Prog Brain Res 2002;136:443-453
34. Mössner R, Henneberg A, Schmitt A, et al. Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease. Mol Psychiatry 2001;6:350-352
35. Mortensen OV, Thomassen M, Larsen MB, et al. Functional analysis of a novel human serotonin transporter gene promoter in immortalized raphe cells. Brain Res Mol Brain Res 1999;68:141-148
36. Little KY, McLaughlin DP, Zhang L, et al. Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am J Psychiatry 1998;155:207-213
37. Greenberg BD, Tolliver TJ, Huang SJ, et al. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet 1999;88:83-87
38. Williams RB, Marchuk DA, Gadde KM, et al. Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology 2003;28:533-541
39. Williams RB, Marchuk DA, Gadde KM, et al. Central nervous system serotonin function and cardiovascular responses to stress. Psychosom Med 2001;63:300-305
40. Heinz A, Jones DW, Mazzanti C, et al. A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry 2000;47:643-649
41. Mann JJ, Huang YY, Underwood MD, et al. A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry 2000; 57:729-738