5-HTTLPR short allele, resilience, and successful aging in older adults

American Journal of Geriatric Psychiatry

Volumn 20, Issue 5, 2012, Pages 452-456

  O'Hara, Ruth ^a,b   Marcus, Peter ^a,c   Thompson, Wesley K ^d,e   Flournoy, John ^a,b   Vahia, Ipsit ^d,e   Lin, Xiaoyan ^a   Hallmayer, Joachim ^a   Depp, Colin ^d,e   Jeste, Dilip V ^d,e  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Sierra Pacific Mental Illness   (United States)

^c PALO ALTO UNIVERSITY   (United States)

^d San Diego   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

5 HTTLPR; Cognition; Resilience; Serotonin transporter polymorphism; Stress; Successful aging

Indexed keywords

BIOLOGICAL MARKER;

ADULT; AGED; AGING; ALLELE; ARTICLE; COGNITION; EMOTION; FEMALE; GENETIC RISK; GENOTYPE; HUMAN; MALE; MENTAL STRESS; RATING SCALE; SELF REPORT; SEROTONIN TRANSPORTER POLYMORPHISM;

EID: 84860222017     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1097/JGP.0b013e31823e2d03     Document Type: Article

References (19)

1. Stein MB, Campbell-Sills L, Gelernter J: Genetic variation in 5HTTLPR is associated with emotional resilience. Am J Med Genet B Neuropsychiatr Genet 2009; 150B:900-906
2. Bonanno GA: Loss, trauma and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? Am Psychol 2004; 59:20-28 (Pubitemid 38161473)
3. Caspi A, Sugden K, Moffitt TE, et al: Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301:386-389 (Pubitemid 36877077)
4. Reichstadt J, Depp CA, Palinkas LA, et al: Building blocks of successful aging: a focus group study of older adults' perceived contributors to successful aging. Am J Geriatr Psychiatry 2007; 15(3):194-201
5. Lamond AJ, Depp CA, Allison M, et al: Measurement and predictors of resilience among community-dwelling older women. J Psychiatr Res 2008; 43(2):148-154
6. O'Hara R, Schr̈oder CM, Mahadevan R, et al: Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: association and interaction with cortisol. Mol Psychiatry 2007; 12;544-555 (Pubitemid 46816773)
7. O'Hara R, Hallmayer JF: Serotonin transporter polymorphism and stress: a view across the lifespan. Curr Psychiatry Rep 2007; 9(3):173-175
8. Folstein MF, Folstein SE, McHugh PR: "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189-198
9. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Washington, DC, American Psychiatric Association, 2000
10. Connor KM, Davidson JR: Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). Depress Anxiety 2003; 18:76-82 (Pubitemid 37175584)
11. Montross LP, Depp C, Daly J, et al: Correlates of self-rated successful aging among community-dwelling older adults. Am J Geriatr Psychiatry 2006; 14(1):43-51 (Pubitemid 43122173)
12. Moore DJ, Sitzer D, Depp CA, et al: Self-administered cognitive screening for a study of successful aging among communitydwelling seniors: a preliminary study. Int J Geriatr Psychiatry 2007; 22(4):327-331 (Pubitemid 46690906)
13. Swearer JM, Drachman DA, Li L, et al: Screening for dementia in "real world" settings: the Cognitive Assessment Screening Test: CAST. Clin Neuropsychol 2002; 16:128-135 (Pubitemid 34983602)
14. Ware JE, Sherbourne CD: The MOS 36-item Short-Form Health Survey (SF-36). I. Conceptual framework and item selection. Med Care 1992; 30:473-483
15. Hu XZ, Lipsky RH, Zhu G, et al: Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 2006; 78(5): 815-826
16. Carstensen LL, Turan B, Scheibe S, et al: Emotional experience improves with age: evidence based on over 10 years of experience sampling. Psychol Aging 2010; 26(1):21-33
17. Smith GS, Lotrich FE, Malhotra AK, et al: Effects of serotonin transporter promoter polymorphisms on serotonin function. Neuropsychopharmacology 2004; 29: 2226-2234 (Pubitemid 39578914)
18. Fiedorowicz JF, Moser DJ, Hynes SM, et al: LA allelic heterozygosity of the 5HTTLPR polymorphism is associated with higher cognitive function and lower interpersonal sensitivity. Psychiatr Genet 2007; 17(1):3-4 (Pubitemid 44953336)
19. Canli T, Omura K, Haas BW, et al: Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proc Natl Acad Sci USA 2005; 102(34):12224-12229 (Pubitemid 41291156)