메뉴 건너뛰기




Volumn 50, Issue 6, 2013, Pages 523-545

Pharmacometabonomics and personalized medicine

Author keywords

Metabolomics; Metabonomics; Pharmacometabolomics; Pharmacometabonomics; Predictive metabonomics

Indexed keywords

ATENOLOL; CAPECITABINE; CISPLATIN; GALACTOSAMINE; ISONIAZID; PARACETAMOL; SIMVASTATIN; TACROLIMUS; TRIPTOLIDE;

EID: 84893779701     PISSN: 00045632     EISSN: 17581001     Source Type: Journal    
DOI: 10.1177/0004563213497929     Document Type: Review
Times cited : (67)

References (113)
  • 1
    • 78649705269 scopus 로고    scopus 로고
    • Systematic review of pharmacoeconomic studies of pharmacogenomic tests
    • Beaulieu M, de Denus S and Lachaine J. Systematic review of pharmacoeconomic studies of pharmacogenomic tests. Pharmacogenomics 2010; 11: 1573-1590.
    • (2010) Pharmacogenomics , vol.11 , pp. 1573-1590
    • Beaulieu, M.1    de Denus, S.2    Lachaine, J.3
  • 2
    • 0035775486 scopus 로고    scopus 로고
    • Pharmacogenomics: The inherited basis for interindividual differences in drug response
    • Lander E, Page D and Lifton R (eds)
    • Evans WE and Johnson JA. Pharmacogenomics: the inherited basis for interindividual differences in drug response. In: Lander E, Page D and Lifton R (eds) Annual review of genomics and human genetics, 2001.
    • (2001) Annual Review of Genomics and Human Genetics
    • Evans, W.E.1    Johnson, J.A.2
  • 3
    • 0035033019 scopus 로고    scopus 로고
    • Pharmacogenomics: Unlocking the human genome for better drug therapy
    • McLeod HL and Evans WE. Pharmacogenomics: unlocking the human genome for better drug therapy. Annu Rev Pharmacol Toxicol 2001; 41: 101-121.
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 101-121
    • McLeod, H.L.1    Evans, W.E.2
  • 4
    • 44649187964 scopus 로고    scopus 로고
    • A review of public policy issues in promoting the development and commercialization of pharmacogenomic applications: Challenges and implications
    • Garrison LP, Carlson RJ, Carlson JJ, et al. A review of public policy issues in promoting the development and commercialization of pharmacogenomic applications: challenges and implications. Drug Metab Rev 2008; 40: 377-401.
    • (2008) Drug Metab Rev , vol.40 , pp. 377-401
    • Garrison, L.P.1    Carlson, R.J.2    Carlson, J.J.3
  • 5
    • 0035861049 scopus 로고    scopus 로고
    • Potential role of pharmacogenomics in reducing adverse drug reactions - a systematic review
    • Phillips KA, Veenstra DL, Oren E, et al. Potential role of pharmacogenomics in reducing adverse drug reactions - a systematic review. Jama-J Am Med Assoc 2001; 286: 2270-2279.
    • (2001) Jama-J Am Med Assoc , vol.286 , pp. 2270-2279
    • Phillips, K.A.1    Veenstra, D.L.2    Oren, E.3
  • 7
    • 77957995461 scopus 로고    scopus 로고
    • Cost effectiveness of pharmacogenomics: A critical and systematic review
    • Wong WB, Carlson JJ, Thariani R, et al. Cost effectiveness of pharmacogenomics: a critical and systematic review. Pharmacoeconomics 2010; 28: 1001-1013.
    • (2010) Pharmacoeconomics , vol.28 , pp. 1001-1013
    • Wong, W.B.1    Carlson, J.J.2    Thariani, R.3
  • 8
    • 34548385836 scopus 로고    scopus 로고
    • Translating pharmacogenomics: Challenges on the road to the clinic
    • Swen JJ, Huizinga TW, Gelderblom H, et al. Translating pharmacogenomics: challenges on the road to the clinic. Plos Med 2007; 4: 1317-1324.
    • (2007) Plos Med , vol.4 , pp. 1317-1324
    • Swen, J.J.1    Huizinga, T.W.2    Gelderblom, H.3
  • 9
    • 80054880042 scopus 로고    scopus 로고
    • Pharmacoproteomics of obesity: Definitions, role and a case study of dynamics of human plasma proteome
    • Andreev VP. Pharmacoproteomics of obesity: definitions, role and a case study of dynamics of human plasma proteome. Pharmacogenomics 2011; 12: 1363-1365.
    • (2011) Pharmacogenomics , vol.12 , pp. 1363-1365
    • Andreev, V.P.1
  • 10
    • 78649629973 scopus 로고    scopus 로고
    • Pharmacoproteomics: A chess game on a protein field
    • D'Alessandro A and Zolla L. Pharmacoproteomics: a chess game on a protein field. Drug Discovery Today 2010; 15: 1015-1023.
    • (2010) Drug Discovery Today , vol.15 , pp. 1015-1023
    • D'Alessandro, A.1    Zolla, L.2
  • 11
    • 33646198860 scopus 로고    scopus 로고
    • Pharmaco-metabonomic phenotyping and personalized drug treatment
    • Clayton T, Lindon J, Cloarec O, et al. Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 2006; 440: 1073-1077.
    • (2006) Nature , vol.440 , pp. 1073-1077
    • Clayton, T.1    Lindon, J.2    Cloarec, O.3
  • 12
    • 0034368580 scopus 로고    scopus 로고
    • Metabonomics: Metabolic processes studied by NMR spectroscopy of biofluids
    • Lindon J, Nicholson J, Holmes E, et al. Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts Magn Reson 2000; 12: 289-320.
    • (2000) Concepts Magn Reson , vol.12 , pp. 289-320
    • Lindon, J.1    Nicholson, J.2    Holmes, E.3
  • 13
    • 0032694577 scopus 로고    scopus 로고
    • 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson JK, Lindon JC and Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999; 29: 1181-1189.
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 14
    • 0345470490 scopus 로고
    • Human metabolic profiles obtained by GC and GC/MS
    • Horning EC and Horning MG. Human metabolic profiles obtained by GC and GC/MS. J Chromatogr Sci 1971; 9: 129.
    • (1971) J Chromatogr Sci , vol.9 , pp. 129
    • Horning, E.C.1    Horning, M.G.2
  • 15
    • 0017528546 scopus 로고
    • Profiling of human-body fluids in healthy and diseased states using gas-chromatography and mass-spectrometry, with special reference to organic-acids
    • Jellum E. Profiling of human-body fluids in healthy and diseased states using gas-chromatography and mass-spectrometry, with special reference to organic-acids. J Chromatogr 1977; 143: 427-462.
    • (1977) J Chromatogr , vol.143 , pp. 427-462
    • Jellum, E.1
  • 16
    • 0018137689 scopus 로고
    • Quantitative metabolic profiling based on gas-chromatography
    • Gates SC and Sweeley CC. Quantitative metabolic profiling based on gas-chromatography. Clin Chem 1978; 24: 1663-1673.
    • (1978) Clin Chem , vol.24 , pp. 1663-1673
    • Gates, S.C.1    Sweeley, C.C.2
  • 17
    • 0021265851 scopus 로고
    • Spin-echo H-1NMR spectroscopy-a new method for studying penicillin metabolism
    • Everett J, Jennings K, Woodnutt G, et al. Spin-echo H-1NMR spectroscopy-a new method for studying penicillin metabolism. J Chem Soc Chem Commun 1984; 894-895.
    • (1984) J Chem Soc Chem Commun , pp. 894-895
    • Everett, J.1    Jennings, K.2    Woodnutt, G.3
  • 19
    • 84882811844 scopus 로고
    • High-resolution NMR spectroscopy of biofluids and applications in drug metabolism
    • Everett JR. High-resolution NMR spectroscopy of biofluids and applications in drug metabolism. Anal Proc 1991; 28: 181-183.
    • (1991) Anal Proc , vol.28 , pp. 181-183
    • Everett, J.R.1
  • 20
    • 18144391608 scopus 로고
    • Biofluid NMR spectroscopy in the study of the metabolism of-Lactam antibiotics
    • In: Reid E and Wilson I, Cambridge: Royal Society of Chemistry
    • Everett JR. Biofluid NMR spectroscopy in the study of the metabolism of-Lactam antibiotics. In: Reid E and Wilson I (eds) Bioanalytical approaches for drugs, including anti-asthmatics and metabolities. Cambridge: Royal Society of Chemistry, 1992, pp.3-10.
    • (1992) Bioanalytical Approaches For Drugs, Including Anti-asthmatics and Metabolities , pp. 3-10
    • Everett, J.R.1
  • 25
    • 77952205557 scopus 로고    scopus 로고
    • Global metabolic profiling procedures for urine using UPLC-MS
    • Want EJ, Wilson ID, Gika H, et al. Global metabolic profiling procedures for urine using UPLC-MS. Nat Protoc 2010; 5: 1005-1018.
    • (2010) Nat Protoc , vol.5 , pp. 1005-1018
    • Want, E.J.1    Wilson, I.D.2    Gika, H.3
  • 26
    • 66349087823 scopus 로고    scopus 로고
    • Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics
    • Lindon JC and Nicholson JK. Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics. Annu Rev Anal Chem 2008; 1: 45-69.
    • (2008) Annu Rev Anal Chem , vol.1 , pp. 45-69
    • Lindon, J.C.1    Nicholson, J.K.2
  • 27
    • 0036007687 scopus 로고    scopus 로고
    • Metabolomics-the link between genotypes and phenotypes
    • Fiehn O. Metabolomics-the link between genotypes and phenotypes. Plant Mol Biol 2002; 48: 155-171.
    • (2002) Plant Mol Biol , vol.48 , pp. 155-171
    • Fiehn, O.1
  • 28
    • 0033757963 scopus 로고    scopus 로고
    • Metabolite profiling for plant functional genomics
    • Fiehn O, Kopka J, Dormann P, et al. Metabolite profiling for plant functional genomics. Nat Biotechnol 2000; 18: 1157-1161.
    • (2000) Nat Biotechnol , vol.18 , pp. 1157-1161
    • Fiehn, O.1    Kopka, J.2    Dormann, P.3
  • 29
    • 33750719994 scopus 로고    scopus 로고
    • Global systems biology, personalized medicine and molecular epidemiology
    • Nicholson JK. Global systems biology, personalized medicine and molecular epidemiology. Mol Syst Biol 2006; 2: 52.
    • (2006) Mol Syst Biol , vol.2 , pp. 52
    • Nicholson, J.K.1
  • 32
    • 84866087835 scopus 로고    scopus 로고
    • Pharmacometabonomic characterization of xenobiotic and endogenous metabolic phenotypes that account for inter-individual variation in isoniazid-induced toxicological response
    • Cunningham K, Claus SP, Lindon JC, et al. Pharmacometabonomic characterization of xenobiotic and endogenous metabolic phenotypes that account for inter-individual variation in isoniazid-induced toxicological response. J Proteome Res 2012; 11: 4630-4642.
    • (2012) J Proteome Res , vol.11 , pp. 4630-4642
    • Cunningham, K.1    Claus, S.P.2    Lindon, J.C.3
  • 34
    • 78650737804 scopus 로고    scopus 로고
    • Advances in structure elucidation of small molecules using mass spectrometry
    • Kind T and Fiehn O. Advances in structure elucidation of small molecules using mass spectrometry. Bioanal Rev 2010; 2: 23-60.
    • (2010) Bioanal Rev , vol.2 , pp. 23-60
    • Kind, T.1    Fiehn, O.2
  • 35
    • 78649317973 scopus 로고    scopus 로고
    • LC-MS metabonomics methodology in biomarker discovery
    • In: Wang F (ed.), Totowa: Humana Press
    • Lu X and Xu G. LC-MS metabonomics methodology in biomarker discovery. In: Wang F (ed.) Biomarker methods in drug discovery and development. Totowa: Humana Press, 2008, pp.291-315.
    • (2008) Biomarker Methods In Drug Discovery and Development , pp. 291-315
    • Lu, X.1    Xu, G.2
  • 36
    • 78650907092 scopus 로고    scopus 로고
    • Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review
    • Roux A, Lison D, Junot C, et al. Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review. Clin Biochem 2011; 44: 119-135.
    • (2011) Clin Biochem , vol.44 , pp. 119-135
    • Roux, A.1    Lison, D.2    Junot, C.3
  • 37
    • 79960495785 scopus 로고    scopus 로고
    • Mass spectrometry-based holistic analytical approaches for metabolite profiling in systems biology studies
    • Theodoridis G, Gika HG and Wilson ID. Mass spectrometry-based holistic analytical approaches for metabolite profiling in systems biology studies. Mass Spectrom Rev 2011; 30: 884-906.
    • (2011) Mass Spectrom Rev , vol.30 , pp. 884-906
    • Theodoridis, G.1    Gika, H.G.2    Wilson, I.D.3
  • 38
    • 83055186403 scopus 로고    scopus 로고
    • Liquid chromatography-mass spectrometry based global metabolite profiling: A review
    • Theodoridis GA, Gika HG, Want EJ, et al. Liquid chromatography-mass spectrometry based global metabolite profiling: a review. Anal Chim Acta 2012; 711: 7-16.
    • (2012) Anal Chim Acta , vol.711 , pp. 7-16
    • Theodoridis, G.A.1    Gika, H.G.2    Want, E.J.3
  • 40
    • 13244249953 scopus 로고    scopus 로고
    • Chemical derivatization and mass spectral libraries in metabolic profiling by GC/MS and LC/MS/MS
    • Halket JM, Waterman D, Przyborowska AM, et al. Chemical derivatization and mass spectral libraries in metabolic profiling by GC/MS and LC/MS/MS. J Exp Bot 2005; 56: 219-243.
    • (2005) J Exp Bot , vol.56 , pp. 219-243
    • Halket, J.M.1    Waterman, D.2    Przyborowska, A.M.3
  • 41
    • 42749087245 scopus 로고    scopus 로고
    • Ambient desorption ionization mass spectrometry
    • Venter A, Nefliu M and Cooks RG. Ambient desorption ionization mass spectrometry. TrAC-Trends Anal Chem 2008; 27: 284-290.
    • (2008) TrAC-Trends Anal Chem , vol.27 , pp. 284-290
    • Venter, A.1    Nefliu, M.2    Cooks, R.G.3
  • 42
    • 66349087823 scopus 로고    scopus 로고
    • Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics
    • Lindon JC and Nicholson JK. Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics. Annu Rev Anal Chem (Palo Alto Calif) 2008; 1: 45-69.
    • (2008) Annu Rev Anal Chem (Palo Alto Calif) , vol.1 , pp. 45-69
    • Lindon, J.C.1    Nicholson, J.K.2
  • 43
    • 0036083139 scopus 로고    scopus 로고
    • Orthogonal projections to latent structures (O-PLS)
    • Trygg J and Wold S. Orthogonal projections to latent structures (O-PLS). J Chemom 2002; 16: 119-128.
    • (2002) J Chemom , vol.16 , pp. 119-128
    • Trygg, J.1    Wold, S.2
  • 44
    • 34247131764 scopus 로고    scopus 로고
    • Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy
    • Holmes E, Loo RL, Cloarec O, et al. Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy. Anal Chem 2007; 79: 2629-2640.
    • (2007) Anal Chem , vol.79 , pp. 2629-2640
    • Holmes, E.1    Loo, R.L.2    Cloarec, O.3
  • 45
    • 0027511147 scopus 로고
    • The correlation between urinary and liver taurine levels and between pre-dose urinary taurine and liver damage
    • Waterfield CJ, Turton JA, Scales MD, et al. The correlation between urinary and liver taurine levels and between pre-dose urinary taurine and liver damage. Toxicology 1993; 77: 1-5.
    • (1993) Toxicology , vol.77 , pp. 1-5
    • Waterfield, C.J.1    Turton, J.A.2    Scales, M.D.3
  • 46
  • 48
    • 0030200709 scopus 로고    scopus 로고
    • Different mechanism of saturation of acetaminophen sulfate conjugation in mice and rats
    • Liu L and Klaassen CD. Different mechanism of saturation of acetaminophen sulfate conjugation in mice and rats. Toxicol Appl Pharmacol 1996; 139: 128-134.
    • (1996) Toxicol Appl Pharmacol , vol.139 , pp. 128-134
    • Liu, L.1    Klaassen, C.D.2
  • 49
    • 33750202863 scopus 로고    scopus 로고
    • Can personalized drug therapy be achieved? A closer look at pharmaco-metabonomics
    • Nebert DW and Vesell ES. Can personalized drug therapy be achieved? A closer look at pharmaco-metabonomics. Trends Pharmacol Sci 2006; 27: 580-586.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 580-586
    • Nebert, D.W.1    Vesell, E.S.2
  • 51
    • 34248139693 scopus 로고    scopus 로고
    • Pharmacometabonomic phenotyping reveals different responses to xenobiotic intervention in rats
    • Li H, Ni Y, Su M, et al. Pharmacometabonomic phenotyping reveals different responses to xenobiotic intervention in rats. J Proteome Res 2007; 6: 1364-1370.
    • (2007) J Proteome Res , vol.6 , pp. 1364-1370
    • Li, H.1    Ni, Y.2    Su, M.3
  • 52
    • 79953663708 scopus 로고    scopus 로고
    • Consensus-phenotype integration of transcriptomic and metabolomic data implies a role for metabolism in the chemosensitivity of tumour cells
    • Cavill R, Kamburov A, Ellis JK, et al. Consensus-phenotype integration of transcriptomic and metabolomic data implies a role for metabolism in the chemosensitivity of tumour cells. PLoS Comput Biol 2011; 7: e1001113.
    • (2011) PLoS Comput Biol , vol.7
    • Cavill, R.1    Kamburov, A.2    Ellis, J.K.3
  • 53
    • 79951678399 scopus 로고    scopus 로고
    • Predicting idiopathic toxicity of cisplatin by a pharmacometabonomic approach
    • Kwon HN, Kim M, Wen H, et al. Predicting idiopathic toxicity of cisplatin by a pharmacometabonomic approach. Kidney Int 2011; 79: 529-537.
    • (2011) Kidney Int , vol.79 , pp. 529-537
    • Kwon, H.N.1    Kim, M.2    Wen, H.3
  • 54
    • 84859594012 scopus 로고    scopus 로고
    • Pharmacometabonomic investigation of dynamic metabolic phenotypes associated with variability in response to galactosamine hepatotoxicity
    • Coen M, Goldfain-Blanc F, Rolland-Valognes G, et al. Pharmacometabonomic investigation of dynamic metabolic phenotypes associated with variability in response to galactosamine hepatotoxicity. J Proteome Res 2012; 11: 2427-2440.
    • (2012) J Proteome Res , vol.11 , pp. 2427-2440
    • Coen, M.1    Goldfain-Blanc, F.2    Rolland-Valognes, G.3
  • 55
    • 84859773739 scopus 로고    scopus 로고
    • Impact of intestinal microbiota on intestinal luminal metabolome
    • Matsumoto M, Kibe R, Ooga T, et al. Impact of intestinal microbiota on intestinal luminal metabolome. Sci Rep 2012; 2: 233.
    • (2012) Sci Rep , vol.2 , pp. 233
    • Matsumoto, M.1    Kibe, R.2    Ooga, T.3
  • 56
    • 84865089299 scopus 로고    scopus 로고
    • Prediction of the pharmacokinetic parameters of triptolide in rats based on endogenous molecules in pre-dose baseline serum
    • Liu L, Cao B, Aa J, et al. Prediction of the pharmacokinetic parameters of triptolide in rats based on endogenous molecules in pre-dose baseline serum. PLoS One 2012; 7: e43389.
    • (2012) PLoS One , vol.7
    • Liu, L.1    Cao, B.2    Aa, J.3
  • 57
    • 79951851704 scopus 로고    scopus 로고
    • XPB, a subunit of TFIIH, is a target of the natural product triptolide
    • Titov DV, Gilman B, He Q-L, et al. XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat Chem Biol 2011; 7: 182-188.
    • (2011) Nat Chem Biol , vol.7 , pp. 182-188
    • Titov, D.V.1    Gilman, B.2    He, Q.-L.3
  • 58
    • 70149096873 scopus 로고    scopus 로고
    • Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
    • Clayton TA, Baker D, Lindon JC, et al. Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci USA 2009; 106: 14728-14733.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14728-14733
    • Clayton, T.A.1    Baker, D.2    Lindon, J.C.3
  • 59
    • 34748846290 scopus 로고    scopus 로고
    • Metabolomic mapping of atypical antipsychotic effects in schizophrenia
    • Kaddurah-Daouk R, McEvoy J, Baillie RA, et al. Metabolomic mapping of atypical antipsychotic effects in schizophrenia. Mol Psychiatry 2007; 12: 934-945.
    • (2007) Mol Psychiatry , vol.12 , pp. 934-945
    • Kaddurah-Daouk, R.1    McEvoy, J.2    Baillie, R.A.3
  • 60
    • 79955419677 scopus 로고    scopus 로고
    • Methodological quality in pharmacogenetic studies with binary assessment of treatment response: A review
    • Cobos A, Sanchez P, Aguado J, et al. Methodological quality in pharmacogenetic studies with binary assessment of treatment response: a review. Pharm Genomics 2011; 21: 243-250.
    • (2011) Pharm Genomics , vol.21 , pp. 243-250
    • Cobos, A.1    Sanchez, P.2    Aguado, J.3
  • 61
    • 0030888455 scopus 로고    scopus 로고
    • Formation of phenolic and indolic compounds by anaerobic bacteria in the human large intestine
    • Smith EA and Macfarlane GT. Formation of phenolic and indolic compounds by anaerobic bacteria in the human large intestine. Microb Ecol 1997; 33: 180-188.
    • (1997) Microb Ecol , vol.33 , pp. 180-188
    • Smith, E.A.1    Macfarlane, G.T.2
  • 62
    • 79955145983 scopus 로고    scopus 로고
    • The analysis of para-cresol production and tolerance in Clostridium difficile 027 and 012 strains
    • Dawson LF, Donahue EH, Cartman ST, et al. The analysis of para-cresol production and tolerance in Clostridium difficile 027 and 012 strains. BMC Microbiol 2011; 11: 86-95.
    • (2011) BMC Microbiol , vol.11 , pp. 86-95
    • Dawson, L.F.1    Donahue, E.H.2    Cartman, S.T.3
  • 63
    • 33846659447 scopus 로고    scopus 로고
    • P-cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical production
    • Schepers E, Meert N, Glorieux G, et al. P-cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical production. Nephrol Dial Transplant 2007; 22: 592-596.
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 592-596
    • Schepers, E.1    Meert, N.2    Glorieux, G.3
  • 64
    • 33144464115 scopus 로고    scopus 로고
    • Human sulfotransferases and their role in chemical metabolism
    • Gamage N, Barnett A, Hempel N, et al. Human sulfotransferases and their role in chemical metabolism. Toxicol Sci 2006; 90: 5-22.
    • (2006) Toxicol Sci , vol.90 , pp. 5-22
    • Gamage, N.1    Barnett, A.2    Hempel, N.3
  • 65
    • 0031136606 scopus 로고    scopus 로고
    • 0phosphosulfate (PAPS) in the regulation of sulfation
    • 0phosphosulfate (PAPS) in the regulation of sulfation. FASEB J 1997; 11: 404-418.
    • (1997) FASEB J , vol.11 , pp. 404-418
    • Klaassen, C.D.1    Boles, J.W.2
  • 66
    • 70149092771 scopus 로고    scopus 로고
    • Drugs, bugs, and personalized medicine: Pharmacometabonomics enters the ring
    • Wilson ID. Drugs, bugs, and personalized medicine: pharmacometabonomics enters the ring. Proc Natl Acad Sci USA 2009; 106: 14187-14188.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14187-14188
    • Wilson, I.D.1
  • 67
    • 79955084411 scopus 로고    scopus 로고
    • Pharmacometabonomics, pharmacogenomics and personalized medicine
    • Gutiu IA, Andries A, Mircioiu C, et al. Pharmacometabonomics, pharmacogenomics and personalized medicine. Rom J Intern Med 2010; 48: 187-191.
    • (2010) Rom J Intern Med , vol.48 , pp. 187-191
    • Gutiu, I.A.1    Andries, A.2    Mircioiu, C.3
  • 68
    • 84859383638 scopus 로고    scopus 로고
    • Pharma-metabolomics in neonatology: Is it a dream or a fact?
    • Fanos V, Barberini L, Antonucci R, et al. Pharma-metabolomics in neonatology: is it a dream or a fact? Curr Pharm Des 2012; 18: 2996-3006.
    • (2012) Curr Pharm Des , vol.18 , pp. 2996-3006
    • Fanos, V.1    Barberini, L.2    Antonucci, R.3
  • 69
    • 70350716444 scopus 로고    scopus 로고
    • Serum molecular signatures of weight change during early breast cancer chemotherapy
    • Keun HC, Sidhu J, Pchejetski D, et al. Serum molecular signatures of weight change during early breast cancer chemotherapy. Clin Cancer Res 2009; 15: 6716-6723.
    • (2009) Clin Cancer Res , vol.15 , pp. 6716-6723
    • Keun, H.C.1    Sidhu, J.2    Pchejetski, D.3
  • 70
    • 77949875295 scopus 로고    scopus 로고
    • An integrative approach for identifying a metabolic phenotype predictive of individualized pharmacokinetics of tacrolimus
    • Phapale PB, Kim SD, Lee HW, et al. An integrative approach for identifying a metabolic phenotype predictive of individualized pharmacokinetics of tacrolimus. Clin Pharmacol Ther 2010; 87: 426-436.
    • (2010) Clin Pharmacol Ther , vol.87 , pp. 426-436
    • Phapale, P.B.1    Kim, S.D.2    Lee, H.W.3
  • 71
    • 33745607004 scopus 로고    scopus 로고
    • Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily-A randomized controlled trial
    • Watkins PB, Kaplowitz N, Slattery JT, et al. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily-A randomized controlled trial. Jama-J Am Med Assoc 2006; 296: 87-93.
    • (2006) Jama-J Am Med Assoc , vol.296 , pp. 87-93
    • Watkins, P.B.1    Kaplowitz, N.2    Slattery, J.T.3
  • 72
    • 77953811759 scopus 로고    scopus 로고
    • Use of pharmacometabonomics for early prediction of acetaminopheninduced hepatotoxicity in humans
    • Winnike JH, Li Z, Wright FA, et al. Use of pharmacometabonomics for early prediction of acetaminopheninduced hepatotoxicity in humans. Clin Pharmacol Ther 2010; 88: 45-51.
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 45-51
    • Winnike, J.H.1    Li, Z.2    Wright, F.A.3
  • 73
    • 77952091681 scopus 로고    scopus 로고
    • Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study
    • Kaddurah-Daouk R, Baillie RA, Zhu HJ, et al. Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study. Metabolomics 2010; 6: 191-201.
    • (2010) Metabolomics , vol.6 , pp. 191-201
    • Kaddurah-Daouk, R.1    Baillie, R.A.2    Zhu, H.J.3
  • 74
    • 80054059835 scopus 로고    scopus 로고
    • Enteric microbiome metabolites correlate with response to simvastatin treatment
    • Kaddurah-Daouk R, Baillie RA, Zhu H, et al. Enteric microbiome metabolites correlate with response to simvastatin treatment. PLoS One 2011; 6: e25482.
    • (2011) PLoS One , vol.6
    • Kaddurah-Daouk, R.1    Baillie, R.A.2    Zhu, H.3
  • 75
    • 84863617024 scopus 로고    scopus 로고
    • Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment
    • Trupp M, Zhu H, Wikoff WR, et al. Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment. PLoS One 2012; 7: e38386.
    • (2012) PLoS One , vol.7
    • Trupp, M.1    Zhu, H.2    Wikoff, W.R.3
  • 76
    • 78650513748 scopus 로고    scopus 로고
    • Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: Pharmacometabolomics-informed pharmacogenomics
    • Ji Y, Hebbring S, Zhu H, et al. Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther 2011; 89: 97-104.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 97-104
    • Ji, Y.1    Hebbring, S.2    Zhu, H.3
  • 77
    • 84863413686 scopus 로고    scopus 로고
    • Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: Selective serotonin reuptake inhibitor response pharmacogenomics
    • Abo R, Hebbring S, Ji Y, et al. Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics. Pharmacogenet Genomics 2012; 22: 247-253.
    • (2012) Pharmacogenet Genomics , vol.22 , pp. 247-253
    • Abo, R.1    Hebbring, S.2    Ji, Y.3
  • 78
    • 79960775080 scopus 로고    scopus 로고
    • Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: A proof of concept
    • Kaddurah-Daouk R, Boyle SH, Matson W, et al. Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: a proof of concept. Transl Psychiatry 2011; 1: 1-7.
    • (2011) Transl Psychiatry , vol.1 , pp. 1-7
    • Kaddurah-Daouk, R.1    Boyle, S.H.2    Matson, W.3
  • 80
    • 79958813560 scopus 로고    scopus 로고
    • 3-Hydroxykynurenine and clinical symptoms in firstepisode neuroleptic-naive patients with schizophrenia
    • Condray R, Dougherty GG, Keshavan MS, et al. 3-Hydroxykynurenine and clinical symptoms in firstepisode neuroleptic-naive patients with schizophrenia. Int J Neuropsychopharmacolog 2011; 14: 756-767.
    • (2011) Int J Neuropsychopharmacolog , vol.14 , pp. 756-767
    • Condray, R.1    Dougherty, G.G.2    Keshavan, M.S.3
  • 81
    • 79955510058 scopus 로고    scopus 로고
    • Pharmacometabonomic profiling as a predictor of toxicity in patients with inoperable colorectal cancer treated with capecitabine
    • Backshall A, Sharma R, Clarke SJ, et al. Pharmacometabonomic profiling as a predictor of toxicity in patients with inoperable colorectal cancer treated with capecitabine. Clin Cancer Res 2011; 17: 3019-3028.
    • (2011) Clin Cancer Res , vol.17 , pp. 3019-3028
    • Backshall, A.1    Sharma, R.2    Clarke, S.J.3
  • 82
    • 84874875065 scopus 로고    scopus 로고
    • Pharmacometabolomics reveals racial differences in response to atenolol treatment
    • Wikoff WR, Frye RF, Zhu H, et al. Pharmacometabolomics reveals racial differences in response to atenolol treatment. PLoS One 2013; 8: e57639.
    • (2013) PLoS One , vol.8
    • Wikoff, W.R.1    Frye, R.F.2    Zhu, H.3
  • 83
    • 78650434645 scopus 로고    scopus 로고
    • Pharmacometabonomics as an effector for personalized medicine
    • Nicholson JK, Wilson ID and Lindon JC. Pharmacometabonomics as an effector for personalized medicine. Pharmacogenomics 2011; 12: 103-111.
    • (2011) Pharmacogenomics , vol.12 , pp. 103-111
    • Nicholson, J.K.1    Wilson, I.D.2    Lindon, J.C.3
  • 84
    • 41149099000 scopus 로고    scopus 로고
    • Symbiotic gut microbes modulate human metabolic phenotypes
    • Li M, Wang B, Zhang M, et al. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci USA 2008; 105: 2117-2122.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 2117-2122
    • Li, M.1    Wang, B.2    Zhang, M.3
  • 85
    • 84858631197 scopus 로고    scopus 로고
    • Pharmacometabolomics: An emerging "omics" tool for the personalization of anticancer treatments and identification of new valuable therapeutic targets
    • Corona G, Rizzolio F, Giordano A, et al. Pharmacometabolomics: an emerging "omics" tool for the personalization of anticancer treatments and identification of new valuable therapeutic targets. J Cell Physiol 2012; 227: 2827-2831.
    • (2012) J Cell Physiol , vol.227 , pp. 2827-2831
    • Corona, G.1    Rizzolio, F.2    Giordano, A.3
  • 86
    • 84857099651 scopus 로고    scopus 로고
    • Putting the efficacy of psychiatric and general medicine medication into perspective: Review of meta-analyses
    • Leucht S, Hierl S, Kissling W, et al. Putting the efficacy of psychiatric and general medicine medication into perspective: review of meta-analyses. Br J Psychiatry 2012; 200: 97-106.
    • (2012) Br J Psychiatry , vol.200 , pp. 97-106
    • Leucht, S.1    Hierl, S.2    Kissling, W.3
  • 87
    • 35248878864 scopus 로고    scopus 로고
    • The withdrawal of torcetrapib from drug development: Implications for the future of drugs that alter HDL metabolism
    • Howes LG and Kostner K. The withdrawal of torcetrapib from drug development: implications for the future of drugs that alter HDL metabolism. Expert Opin Invest Drugs 2007; 16: 1509-1516.
    • (2007) Expert Opin Invest Drugs , vol.16 , pp. 1509-1516
    • Howes, L.G.1    Kostner, K.2
  • 89
    • 84861870849 scopus 로고    scopus 로고
    • Personalised medicine: Not just in our genes
    • Kitsios GD and Kent DM. Personalised medicine: not just in our genes. Br Med J 2012; 344: e2161.
    • (2012) Br Med J , vol.344
    • Kitsios, G.D.1    Kent, D.M.2
  • 90
    • 84867723916 scopus 로고    scopus 로고
    • The human gut microbiome: The ghost in the machine
    • Feeney A and Sleator RD. The human gut microbiome: the ghost in the machine. Future Microbiol 2012; 7: 1235-1237.
    • (2012) Future Microbiol , vol.7 , pp. 1235-1237
    • Feeney, A.1    Sleator, R.D.2
  • 91
    • 79959894418 scopus 로고    scopus 로고
    • Understanding the role of gut microbiome-host metabolic signal disruption in health and disease
    • Holmes E, Li JV, Athanasiou T, et al. Understanding the role of gut microbiome-host metabolic signal disruption in health and disease. Trends Microbiol 2011; 19: 349-359.
    • (2011) Trends Microbiol , vol.19 , pp. 349-359
    • Holmes, E.1    Li, J.V.2    Athanasiou, T.3
  • 92
    • 84862276328 scopus 로고    scopus 로고
    • Structure, function and diversity of the healthy human microbiome
    • Huttenhower C, Gevers D, Knight R, et al. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486: 207-214.
    • (2012) Nature , vol.486 , pp. 207-214
    • Huttenhower, C.1    Gevers, D.2    Knight, R.3
  • 93
    • 52049122412 scopus 로고    scopus 로고
    • The human gut microbiome: Implications for future health care
    • Kinross JM, von Roon AC, Holmes E, et al. The human gut microbiome: implications for future health care. Curr Gastroenterol Rep 2008; 10: 396-403.
    • (2008) Curr Gastroenterol Rep , vol.10 , pp. 396-403
    • Kinross, J.M.1    von Roon, A.C.2    Holmes, E.3
  • 94
    • 67650596799 scopus 로고    scopus 로고
    • The gut microbiota as a target for improved surgical outcome and improved patient care
    • Kinross J, von Roon AC, Penney N, et al. The gut microbiota as a target for improved surgical outcome and improved patient care. Curr Pharm Des 2009; 15: 1537-1545.
    • (2009) Curr Pharm Des , vol.15 , pp. 1537-1545
    • Kinross, J.1    von Roon, A.C.2    Penney, N.3
  • 95
    • 79952712983 scopus 로고    scopus 로고
    • Gut microbiome-host interactions in health and disease
    • Kinross JM, Darzi AW and Nicholson JK. Gut microbiome-host interactions in health and disease. Genome Med 2011; 3: 14.
    • (2011) Genome Med , vol.3 , pp. 14
    • Kinross, J.M.1    Darzi, A.W.2    Nicholson, J.K.3
  • 96
    • 84862286169 scopus 로고    scopus 로고
    • A framework for human microbiome research
    • Methe BA, Nelson KE, Pop M, et al. A framework for human microbiome research. Nature 2012; 486: 215-221.
    • (2012) Nature , vol.486 , pp. 215-221
    • Methe, B.A.1    Nelson, K.E.2    Pop, M.3
  • 97
    • 84856120472 scopus 로고    scopus 로고
    • Longitudinal pharmacometabonomics for predicting patient responses to therapy: Drug metabolism, toxicity and efficacy
    • Nicholson JK, Everett JR and Lindon JC. Longitudinal pharmacometabonomics for predicting patient responses to therapy: drug metabolism, toxicity and efficacy. Expert Opin Drug Metab Toxicol 2012; 8: 135-139.
    • (2012) Expert Opin Drug Metab Toxicol , vol.8 , pp. 135-139
    • Nicholson, J.K.1    Everett, J.R.2    Lindon, J.C.3
  • 98
    • 36348990835 scopus 로고    scopus 로고
    • Human metabolic phenotypes link directly to specific dietary preferences in healthy individuals
    • Rezzi S, Ramadan Z, Martin FP, et al. Human metabolic phenotypes link directly to specific dietary preferences in healthy individuals. J Proteome Res 2007; 6: 4469-4477.
    • (2007) J Proteome Res , vol.6 , pp. 4469-4477
    • Rezzi, S.1    Ramadan, Z.2    Martin, F.P.3
  • 99
    • 84862141704 scopus 로고    scopus 로고
    • Human gut microbiome viewed across age and geography
    • Yatsunenko T, Rey FE, Manary MJ, et al. Human gut microbiome viewed across age and geography. Nature 2012; 486: 222-228.
    • (2012) Nature , vol.486 , pp. 222-228
    • Yatsunenko, T.1    Rey, F.E.2    Manary, M.J.3
  • 100
    • 84863631240 scopus 로고    scopus 로고
    • Targeting the human genome-microbiome axis for drug discovery: Inspirations from global systems biology and traditional Chinese medicine
    • Zhao L, Nicholson JK, Lu A, et al. Targeting the human genome-microbiome axis for drug discovery: inspirations from global systems biology and traditional Chinese medicine. J Proteome Res 2012; 11: 3509-3519.
    • (2012) J Proteome Res , vol.11 , pp. 3509-3519
    • Zhao, L.1    Nicholson, J.K.2    Lu, A.3
  • 101
    • 82755184864 scopus 로고    scopus 로고
    • The footprints of gut microbial-mammalian co-metabolism
    • Zheng X, Xie G, Zhao A, et al. The footprints of gut microbial-mammalian co-metabolism. J Proteome Res 2011; 10: 5512-5522.
    • (2011) J Proteome Res , vol.10 , pp. 5512-5522
    • Zheng, X.1    Xie, G.2    Zhao, A.3
  • 102
    • 84871732071 scopus 로고    scopus 로고
    • Genomic variation landscape of the human gut microbiome
    • Schloissnig S, Arumugam M, Sunagawa S, et al. Genomic variation landscape of the human gut microbiome. Nature 2013; 493: 45-50.
    • (2013) Nature , vol.493 , pp. 45-50
    • Schloissnig, S.1    Arumugam, M.2    Sunagawa, S.3
  • 103
    • 84867012919 scopus 로고    scopus 로고
    • Novel biomarkers for pre-diabetes identified by metabolomics
    • Wang-Sattler R, Yu Z, Herder C, et al. Novel biomarkers for pre-diabetes identified by metabolomics. Mol Syst Biol 2012; 8: 615.
    • (2012) Mol Syst Biol , vol.8 , pp. 615
    • Wang-Sattler, R.1    Yu, Z.2    Herder, C.3
  • 104
    • 79957857701 scopus 로고    scopus 로고
    • Metabolic phenotyping for monitoring surgical patients
    • Kinross JM, Holmes E, Darzi AW, et al. Metabolic phenotyping for monitoring surgical patients. Lancet 2011; 377: 1817-1819.
    • (2011) Lancet , vol.377 , pp. 1817-1819
    • Kinross, J.M.1    Holmes, E.2    Darzi, A.W.3
  • 105
    • 81855194269 scopus 로고    scopus 로고
    • Characterization of surgical aerosols by the compact single-particle mass spectrometer LAMPAS 3
    • Hinz KP, Gelhausen E, Schaefer KC, et al. Characterization of surgical aerosols by the compact single-particle mass spectrometer LAMPAS 3. Anal Bioanal Chem 2011; 401: 3165-3172.
    • (2011) Anal Bioanal Chem , vol.401 , pp. 3165-3172
    • Hinz, K.P.1    Gelhausen, E.2    Schaefer, K.C.3
  • 106
    • 79952143850 scopus 로고    scopus 로고
    • In situ, real-time identification of biological tissues by ultraviolet and infrared laser desorption ionization mass spectrometry
    • Schaefer K-C, Szaniszlo T, Guenther S, et al. In situ, real-time identification of biological tissues by ultraviolet and infrared laser desorption ionization mass spectrometry. Anal Chem 2011; 83: 1632-1640.
    • (2011) Anal Chem , vol.83 , pp. 1632-1640
    • Schaefer, K.-C.1    Szaniszlo, T.2    Guenther, S.3
  • 107
    • 84869049715 scopus 로고    scopus 로고
    • Metabolic phenotyping in clinical and surgical environments
    • Nicholson JK, Holmes E, Kinross JM, et al. Metabolic phenotyping in clinical and surgical environments. Nature 2012; 491: 384-392.
    • (2012) Nature , vol.491 , pp. 384-392
    • Nicholson, J.K.1    Holmes, E.2    Kinross, J.M.3
  • 108
    • 84859920644 scopus 로고    scopus 로고
    • Implementation of molecular phenotyping approaches in the personalized surgical patient journey
    • Mirnezami R, Kinross JM, Vorkas PA, et al. Implementation of molecular phenotyping approaches in the personalized surgical patient journey. Ann Surg 2012; 255: 881-889.
    • (2012) Ann Surg , vol.255 , pp. 881-889
    • Mirnezami, R.1    Kinross, J.M.2    Vorkas, P.A.3
  • 109
    • 84874622172 scopus 로고    scopus 로고
    • Metabolomics as a tool for personalizing medicine: 2012 update
    • Sun J, Beger RD and Schnackenberg LK. Metabolomics as a tool for personalizing medicine: 2012 update. Personal Med 2013; 10: 149-161.
    • (2013) Personal Med , vol.10 , pp. 149-161
    • Sun, J.1    Beger, R.D.2    Schnackenberg, L.K.3
  • 110
    • 0015136739 scopus 로고
    • Metabolic oxidation on aliphatic basic nitrogen atoms and their alpha-carbon atomssome unifying principles
    • Beckett AH, van Dyk JM, Chissick HH, et al. Metabolic oxidation on aliphatic basic nitrogen atoms and their alpha-carbon atomssome unifying principles. J Pharm Pharmacol 1971; 23: 809-812.
    • (1971) J Pharm Pharmacol , vol.23 , pp. 809-812
    • Beckett, A.H.1    van Dyk, J.M.2    Chissick, H.H.3
  • 111
    • 0032168794 scopus 로고    scopus 로고
    • Systematic functional analysis of the yeast genome
    • Oliver SG, Winson MK, Kell DB, et al. Systematic functional analysis of the yeast genome. Trends Biotechnol 1998; 16: 373-378.
    • (1998) Trends Biotechnol , vol.16 , pp. 373-378
    • Oliver, S.G.1    Winson, M.K.2    Kell, D.B.3
  • 112
    • 0043069547 scopus 로고    scopus 로고
    • Opinion: Understanding 'global' systems biology: Metabonomics and the continuum of metabolism
    • Nicholson JK and Wilson ID. Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat Rev Drug Discov 2003; 2: 668-676.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 668-676
    • Nicholson, J.K.1    Wilson, I.D.2
  • 113
    • 9244226956 scopus 로고    scopus 로고
    • Role of pharmacoproteomics in the development of personalized medicine
    • Jain KK. Role of pharmacoproteomics in the development of personalized medicine. Pharmacogenomics 2004; 5: 331-336.
    • (2004) Pharmacogenomics , vol.5 , pp. 331-336
    • Jain, K.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.