A gene expression study of normal and damaged cartilage in anteromedial gonarthrosis, a phenotype of osteoarthritis

Osteoarthritis and Cartilage

Volumn 22, Issue 2, 2014, Pages 334-343

  Snelling, S ^a   Rout, R ^a   Davidson, R ^b   Clark, I ^b   Carr, A ^a   Hulley, P A ^a   Price, A J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Cartilage; Gene expression; Knee; Microarray; Signalling

Indexed keywords

ADAMTSL2 GENE; ANTEROMEDIAL GONARTHROSIS; ARTICLE; CARTILAGE DEGENERATION; CLINICAL ARTICLE; DOWN REGULATION; DUSP10 GENE; EXTRACELLULAR MATRIX; GENE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IGF1 GENE; INFLAMMATION; KNEE ARTHROPLASTY; KNEE OSTEOARTHRITIS; MICROARRAY ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; RARRES3 GENE; REAL TIME POLYMERASE CHAIN REACTION; SFRP3 GENE; SIGNAL TRANSDUCTION; UNICOMPARTMENTAL KNEE REPLACEMENT; UPREGULATION;

CARTILAGE; GENE EXPRESSION; KNEE; MICROARRAY; SIGNALLING;

AGED; ARTHROPLASTY, REPLACEMENT, KNEE; CARTILAGE, ARTICULAR; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOARTHRITIS, KNEE; PHENOTYPE; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTOME;

EID: 84893757201     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2013.12.009     Document Type: Article

References (46)

1. Dillon C.F., Rasch E.K., Gu Q., Hirsch R. Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991-94. JRheumatol 2006, 33:2271-2279.
2. Goldring M.B., Goldring S.R. Osteoarthritis. JCell Physiol 2007, 213:626-634.
3. Aigner T., Fundel K., Saas J., Gebhard P.M., Haag J., Weiss T., et al. Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheum 2006, 54:3533-3544.
4. Appleton C.T., Pitelka V., Henry J., Beier F. Global analyses of gene expression in early experimental osteoarthritis. Arthritis Rheum 2007, 56:1854-1868.
5. Fukui N., Miyamoto Y., Nakajima M., Ikeda Y., Hikita A., Furukawa H., et al. Zonal gene expression of chondrocytes in osteoarthritic cartilage. Arthritis Rheum 2008, 58:3843-3853.
6. Ijiri K., Zerbini L.F., Peng H., Otu H.H., Tsuchimochi K., Otero M., et al. Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Arthritis Rheum 2008, 58:2075-2087.
7. Karlsson C., Dehne T., Lindahl A., Brittberg M., Pruss A., Sittinger M., et al. Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis. Osteoarthritis Cartilage 2010, 18:581-592.
8. Sato T., Konomi K., Yamasaki S., Aratani S., Tsuchimochi K., Yokouchi M., et al. Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage. Arthritis Rheum 2006, 54:808-817.
9. Davidson R.K., Waters J.G., Kevorkian L., Darrah C., Cooper A., Donell S.T., et al. Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage. Arthritis Res Ther 2006, 8:R124.
10. Longo U.G., Loppini M., Fumo C., Rizzello G., Khan W.S., Maffulli N., et al. Osteoarthritis: new insights in animal models. Open Orthop J 2012, 6:558-563.
11. Loeser R.F., Olex A.L., McNulty M.A., Carlson C.S., Callahan M.F., Ferguson C.M., et al. Microarray analysis reveals age-related differences in gene expression during the development ofosteoarthritis in mice. Arthritis Rheum 2012, 64:705-717.
12. Rout R., McDonnell S., Hulley P., Jayadev C., Khan T., Carr A., et al. The pattern of cartilage damage in antero-medial osteoarthritis of the knee and its relationship to the anterior cruciate ligament. JOrthop Res 2013, 31:908-913.
13. Rout R., McDonnell S., Benson R., Athanasou N., Carr A., Doll H., et al. The histological features of anteromedial gonarthrosis-the comparison of two grading systems in a human phenotype of osteoarthritis. Knee 2011, 18:172-176.
14. Xu Y., Barter M.J., Swan D.C., Rankin K.S., Rowan A.D., Santibanez-Koref M., et al. Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA. Osteoarthritis Cartilage 2012, 20:1029-1038.
15. Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet 2012, 380:815-823.
16. Kerkhof H.J., Lories R.J., Meulenbelt I., Jonsdottir I., Valdes A.M., Arp P., et al. Agenome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum 2010, 62:499-510.
17. Nakajima M., Takahashi A., Kou I., Rodriguez-Fontenla C., Gomez-Reino J.J., Furuichi T., et al. New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study. PLoS One 2010, 5:e9723.
18. Burleigh A., Chanalaris A., Gardiner M.D., Driscoll C., Boruc O., Saklatvala J., et al. Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression invivo. Arthritis Rheum 2012, 64:2278-2288.
19. Wei T., Kulkarni N.H., Zeng Q.Q., Helvering L.M., Lin X., Lawrence F., et al. Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage. Osteoarthritis Cartilage 2010, 18:992-1000.
20. Jenniskens Y.M., Koevoet W., de Bart A.C., Weinans H., Jahr H., Verhaar J.A., et al. Biochemical and functional modulation of the cartilage collagen network by IGF1, TGFbeta2 and FGF2. Osteoarthritis Cartilage 2006, 14:1136-1146.
21. Burrage P.S., Mix K.S., Brinckerhoff C.E. Matrix metalloproteinases: role in arthritis. Front Biosci 2006, 11:529-543.
22. Moore E.E., Bendele A.M., Thompson D.L., Littau A., Waggie K.S., Reardon B., et al. Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. Osteoarthritis Cartilage 2005, 13:623-631.
23. Upton A.R., Holding C.A., Dharmapatni A.A., Haynes D.R. The expression of RANKL and OPG in the various grades of osteoarthritic cartilage. Rheumatol Int 2012, 32:535-540.
24. Kadri A., Ea H.K., Bazille C., Hannouche D., Liote F., Cohen-Solal M.E. Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis. Arthritis Rheum 2008, 58:2379-2386.
25. Berenbaum F., Eymard F., Houard X. Osteoarthritis, inflammation and obesity. Curr Opin Rheumatol 2013, 25:114-118.
26. Haseeb A., Haqqi T.M. Immunopathogenesis of osteoarthritis. Clin Immunol 2013, 146:185-196.
27. Leigh D.R., Abreu E.L., Derwin K.A. Changes in gene expression of individual matrix metalloproteinases differ in response to mechanical unloading of tendon fascicles in explant culture. JOrthop Res 2008, 26:1306-1312.
28. Sun H.B. CITED2 mechanoregulation of matrix metalloproteinases. Ann N Y Acad Sci 2010, 1192:429-436.
29. Visigalli D., Strangio A., Palmieri D., Manduca P. Hind limb unloading of mice modulates gene expression at the protein and mRNA level in mesenchymal bone cells. BMC Musculoskelet Disord 2010, 11:147.
30. Wang Q., Rozelle A.L., Lepus C.M., Scanzello C.R., Song J.J., Larsen D.M., et al. Identification of a central role for complement in osteoarthritis. Nat Med 2011, 17:1674-1679.
31. Brunet L.J., McMahon J.A., McMahon A.P., Harland R.M. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science 1998, 280:1455-1457.
32. Lories R.J., Daans M., Derese I., Matthys P., Kasran A., Tylzanowski P., et al. Noggin haploinsufficiency differentially affects tissue responses in destructive and remodeling arthritis. Arthritis Rheum 2006, 54:1736-1746.
33. Oldknow K.J., Seebacher J., Goswami T., Villen J., Pitsillides A.A., O'Shaughnessy P.J., et al. Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor beta (TGFbeta) signaling is essential for testicular aging and regulating testis size. Endocrinology 2013, 154:1310-1320.
34. Nakayama N., Han C.Y., Cam L., Lee J.I., Pretorius J., Fisher S., et al. Anovel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. Development 2004, 131:229-240.
35. Binnerts M.E., Wen X., Cante-Barrett K., Bright J., Chen H.T., Asundi V., et al. Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins. Biochem Biophys Res Commun 2004, 315:272-280.
36. Zhang J.L., Patterson L.J., Qiu L.Y., Graziussi D., Sebald W., Hammerschmidt M. Binding between Crossveinless-2 and Chordin von Willebrand factor type C domains promotes BMP signaling by blocking Chordin activity. PLoS One 2010, 5:e12846.
37. Blaney Davidson E.N., Remst D.F., Vitters E.L., van Beuningen H.M., Blom A.B., Goumans M.J., et al. Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice. JImmunol 2009, 182:7937-7945.
38. Blaney Davidson E.N., Vitters E.L., van der Kraan P.M., van den Berg W.B. Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation. Ann Rheum Dis 2006, 65:1414-1421.
39. Yang X., Chen L., Xu X., Li C., Huang C., Deng C.X. TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. JCell Biol 2001, 153:35-46.
40. Zhu M., Chen M., Zuscik M., Wu Q., Wang Y.J., Rosier R.N., et al. Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. Arthritis Rheum 2008, 58:2053-2064.
41. Zhu M., Tang D., Wu Q., Hao S., Chen M., Xie C., et al. Activation of β-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult β-catenin conditional activation mice. JBone Miner Res 2009, 24:12-21.
42. Lories R.J., Peeters J., Bakker A., Tylzanowski P., Derese I., Schrooten J., et al. Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum 2007, 56:4095-4103.
43. Theodosiou A., Smith A., Gillieron C., Arkinstall S., Ashworth A. MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases. Oncogene 1999, 18:6981-6988.
44. Wu J., Mei C., Vlassara H., Striker G.E., Zheng F. Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells. Am J Physiol Renal Physiol 2009, 297:F1622-F1631.
45. James C.G., Woods A., Underhill T.M., Beier F. The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription. BMC Mol Biol 2006, 7:30.
46. Gulati A., Chau R., Beard D.J., Price A.J., Gill H.S., Murray D.W. Localization of the full-thickness cartilage lesions in medial and lateral unicompartmental knee osteoarthritis. JOrthop Res 2009, 27:1339-1346.