Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis

Arthritis and Rheumatism

Volumn 58, Issue 8, 2008, Pages 2379-2386

  Kadri, A ^a   Ea, H K ^a   Bazille, C ^a   Hannouche, D ^b   Liote F ^a   Cohen Solal, M E ^a,c  

^a INSERM   (France)

^b Paris university   (France)

^c HÔPITAL LARIBOISIÈRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMTS 4 PROTEIN; ADAMTS 5 PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; METALLOPROTEINASE; OSTEOPROTEGERIN; PHOSPHATE BUFFERED SALINE; PROTEOGLYCAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE DEGENERATION; CONTROLLED STUDY; EXPLANT; KNEE; MALE; MENISCECTOMY; MOUSE; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRABECULAR BONE;

EID: 49449084869     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.23638     Document Type: Article

References (28)

1. Pelletier JP, Boileau C, Brunet J, Boily M, Lajeunesse D, Reboul P, et al. The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K. Bone 2004;34:527-38.
2. Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, Ma HL, et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 2005;434:644-8.
3. Goldring MB, Berenbaum F. The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide [review]. Clin Orthop Relat Res 2004(427 Suppl):S37-46.
4. Pelletier JP, Caron JP, Evans C, Robbins PD, Georgescu HI, Jovanovic D, et al. In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy. Arthritis Rheum 1997;40:1012-9.
5. Arend WP, Dayer JM. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor α in rheumatoid arthritis [review]. Arthritis Rheum 1995;38:151-60.
6. Radin EL, Rose RM. Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res 1986:213:34-40.
7. Beuf O, Ghosh S, Newitt DC, Link TM, Steinbach L, Ries M, et al. Magnetic resonance imaging of normal and osteoarthritic trabecular bone structure in the human knee. Arthritis Rheum 2002;46: 385-93.
8. Day JS, Ding M, van der Linden JC, Hvid I, Sumner DR, Weinans H. A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage. J Orthop Res 2001;19:914-8.
9. Kamibayashi L, Wyss UP, Cooke TD, Zee B. Trabecular microstructure in the medial condyle of the proximal tibia of patients with knee osteoarthritis. Bone 1995;17:27-35.
10. Hayami T, Pickarski M, Zhuo Y, Wesolowski GA, Rodan GA, Duong le T. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone 2006;38: 234-43.
11. Kamekura S, Hoshi K, Shimoaka T, Chung U, Chikuda H, Yamada T, et al. Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis Cartilage 2005;13:632-41.
12. Ding M, Odgaard A, Hvid I. Changes in the three-dimensional microstructure of human tibial cancellous bone in early osteoarthritis. J Bone Joint Surg Br 2003;85:906-12.
13. Felson DT, Neogi T. Osteoarthritis: is it a disease of cartilage or of bone? [editorial]. Arthritis Rheum 2004;50:341-4.
14. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997;89:309-19.
15. Nakamura I, Jimi E. Regulation of osteoclast differentiation and function by interleukin-1 [review]. Vitam Horm 2006;74:357-70.
16. Mankin HJ, Dorfman H, Lipiello L, Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 1971;53:523-37.
17. Farndale RW, Buttle DJ, Barrett AJ. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta 1986;883:173-7.
18. Glasson SS, Blanchet TJ, Morris EA. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage 2007;15:1061-9.
19. Sandy JD. A contentious issue finds some clarity: on the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis [review]. Osteoarthritis Cartilage 2006;14:95-100.
20. Glasson SS, Askew R, Sheppard B, Carito BA, Blanchet T, Ma HL, et al. Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. Arthritis Rheum 2004;50:2547-58.
21. Song RH, Tortorella MD, Malfait AM, Alston JT, Yang Z, Arner EC, et al. Aggrecan degradation in human articular cartilage expiants is mediated by both ADAMTS-4 and ADAMTS-5. Arthritis Rheum 2007;56:575-85.
22. Pastoureau P, Leduc S, Chomel A, De Ceuninck F. Quantitative assessment of articular cartilage and subchondral bone histology in the meniscectomized guinea pig model of osteoarthritis. Osteoarthritis Cartilage 2003;11:412-23.
23. Botter SM, van Osch GJ, Waarsing JH, Day JS, Verhaar JA, Pols HA, et al. Quantification of subchondral bone changes in a murine osteoarthritis model using micro-CT. Biorheology 2006;43:379-88.
24. Komuro H, Olee T, Kuhn K, Quach J, Brinson DC, Shikhman A, et al. The osteoprotegerin/receptor activator of nuclear factor κB/receptor activator of nuclear factor KB ligand system in cartilage. Arthritis Rheum 2001;44:2768-76.
25. Sakakura Y, Tsuruga E, Irie K, Hosokawa Y, Nakamura H, Yajima T. Immunolocalization of receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) in Meckel's cartilage compared with developing endochondral bones in mice. J Anat 2005;207:325-37.
26. Shimizu S, Asou Y, Itoh S, Chung UI, Kawaguchi H, Shinomiya K, et al. Prevention of cartilage destruction with intraarticular osteoclastogenesis inhibitory factor/osteoprotegerin in a murine model of osteoarthritis. Arthritis Rheum 2007;56:3358-65.
27. Jacques C, Gosset M, Berenbaum F, Gabay C. The role of IL-1 and IL-1Ra in joint inflammation and cartilage degradation [review]. Vitam Horm 2006;74:371-403.
28. Clements KM, Price JS, Chambers MG, Visco DM, Poole AR, Mason RM. Gene deletion of either interleukin-1β, interleukin-1β-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy. Arthritis Rheum 2003;48: 3452-63.