Hind limb unloading of mice modulates gene expression at the protein and mRNA level in mesenchymal bone cells

BMC Musculoskeletal Disorders

Volumn 11, Issue , 2010, Pages

  Visigalli, Davide ^a   Strangio, Antonella ^a   Palmieri, Daniela ^a   Manduca, Paola ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CHEMOKINE RECEPTOR CXCR4; INTERSTITIAL COLLAGENASE; MESSENGER RNA; OSTEOCALCIN; PROCOLLAGENASE; PROTEIN;

ARTICLE; BONE CELL; BONE DEVELOPMENT; EXTRACELLULAR MATRIX; GENE EXPRESSION; HINDLIMB; MALE; MESENCHYME CELL; MOUSE; NONHUMAN; ANIMAL; BIOSYNTHESIS; BONE MARROW CELL; BONE REMODELING; C57BL MOUSE; CHONDROGENESIS; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; IMMOBILIZATION; IN SITU HYBRIDIZATION; MECHANICAL STRESS; MESENCHYMAL STEM CELL; METABOLISM; OSTEOBLAST; PHYSIOLOGY; TIBIA; WEIGHT BEARING;

ANIMALS; BONE MARROW CELLS; BONE REMODELING; CHONDROGENESIS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HINDLIMB SUSPENSION; HOMEOSTASIS; IN SITU HYBRIDIZATION; MALE; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED C57BL; OSTEOBLASTS; OSTEOGENESIS; PROTEINS; RNA, MESSENGER; STRESS, MECHANICAL; TIBIA; WEIGHT-BEARING;

EID: 77954165207     PISSN: None     EISSN: 14712474     Source Type: Journal    
DOI: 10.1186/1471-2474-11-147     Document Type: Article

References (41)

1. Skeletal response to simulated weightlessness: a comparison of suspension techniques. TJ Wronski ER Morey-Holton, Aviat Space Environ Med 1987 58 63 8 3814035
2. A brief review of bone adaptation to unloading. P Zhang K Hamamura H Yokota, Genomics Proteomics Bioinformatics 2008 6 4 7 10.1016/S1672-0229(08) 60016-9 18558381
3. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. JI Aguirre LI Plotkin SA Stewart RS Weinstein AM Parfitt SC Manolagas T Bellido, J Bone Miner Res 2006 21 605 15 10.1359/jbmr.060107 16598381
4. Histomorphometric analysis of rat skeleton following spaceflight. TJ Wronski ER Morey-Holton SB Doty AC Maese CC Walsh, Am J Physiol 1987 252 252 5 3812763
5. Runx2 is a target of mechanical unloading to alter osteoblastic activity and bone formation in vivo. R Salingcarnboriboon K Tsuji T Komori K Nakashima Y Ezura M Noda, Endocrinology 2006 147 2296 2305 10.1210/en.2005-1020 16455780
6. Effect of simulated weightlessness on osteoprogenitor cell number and proliferation in young and adult rats. N Basso CG Bellows JN Heersche, Bone 2005 36 173 83 10.1016/j.bone.2004.09.016 15664015
7. Identification of mechanosensitive genes in osteoblasts by comparative microarray studies using the rotating wall vessel and the random positioning machine. MJ Patel W Liu MC Sykes NE Ward SA Risin D Risin H Jo, J Cell Biochem 2007 101 587 99 10.1002/jcb.21218 17243119
8. Simulated microgravity using the Random Positioning Machine inhibits differentiation and alters gene expression profiles of 2T3 preosteoblasts. SJ Pardo MJ Patel MC Sykes MO Platt NL Boyd GP Sorescu M Xu JJ van Loon MD Wang H Jo, Am J Physiol Cell Physiol 2005 288 1211 21 10.1152/ajpcell.00222.2004 15689415
9. Gene expression related to the differentiation of osteoblastic cells is altered by microgravity. G Carmeliet G Nys I Stockmans R Bouillon, Bone 1998 22 139S 143S 10.1016/S8756-3282(98)00007-6 9600771
10. Modeled microgravity inhibits osteogenic differentiation of human mesenchymal stem cells and increases adipogenesis. M Zayzafoon WE Gathings JM McDonald, Endocrinology 2004 145 2421 32 10.1210/en.2003-1156 14749352 (Pubitemid 38535071)
11. Microgravity and hypergravity effects on collagen biosynthesis of human dermal fibroblasts. U Seitzer M Bodo PK Müller Y Açil B Bätge, Cell Tissue Res 1995 282 513 7 10.1007/BF00318883 8581945
12. Resistance to unloading-induced three dimensional bone loss in osteopontin-deficient mice. M Ishijima K Tsuji SR Rittling T Yamashita H Kurosawa DT Denhardt A Nifuji M Noda, J Bone Miner Res 2002 17 661 7 10.1359/jbmr.2002.17.4.661 11918223
13. Constitutively active parathyroid hormone receptor signaling in cells in osteoblastic lineage suppresses mechanical unloading-induced bone resorption. N Ono K Nakashima E Schipani T Hayata Y Ezura K Soma HM Kronenberg M Noda, J Biol Chem 2007 282 25509 16 10.1074/jbc.M610782200 17500070
14. Changes in serum 1,25-dihydroxyvitamin D3 and mRNAs for osteocalcin and alkaline phosphatase in femur unloaded by tail suspension in rats. T Ito S Ohmori K Kanda S Kawano Y Murata H Seo, Environ Med 1994 38 103 6 12703522
15. The bone morphogenetic protein 1/Tolloid like metalloproteinases. DR Hopkins S Keles DS Greenspan, Matrix Biol 2007 26 508 23 10.1016/j.matbio.2007. 05.004 17560775
16. Substrate-specific modulation of a multisubstrate proteinase. C-terminal processing of fibrillar procollagens is the only BMP-1 dependent activity to be enhanced by PCPE-1. C Moali B Font F Ruggiero D Eichenberger P Rousselle V Francois A Oldberg L Bruckner-Tuderman DJ Hulmes, J Biol Chem 2005 280 24188 94 10.1074/jbc.M501486200 15834133
17. Matrix sialoprotein of developing bone. LW Fisher SW Whitson LV Avioli JD Termine, J Biol Chem 1983 258 12723 7 6355090
18. Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis. L Malaval NM Wade-Guéye M Boudiffa J Fei R Zirngibl F Chen N Laroche JP Roux B Burt-Pichat F Duboeuf G Bolvin P Jurdic MH Lafage-Proust J Amédée L Vico J Rossant JE Aubin, J Exp Med 2008 205 1145 1153 10.1084/jem.20071294 18458111
19. Procollagen C proteinase enhancer 1 genes are important determinants of the mechanical properties and geometry of bone and the ultrastructure of connective tissues. BM Steiglitz JM Kreider EP Frankenburg WN Pappano GG Hoffman JA Meganck X Liang M Höök DE Birk SA Goldstein DS Greenspan, Mol Cell Biol 2006 26 238 49 10.1128/MCB.26.1.238-249.2006 16354695
20. MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadeguate collagen turnover. K Holmbeck P Bianco J Caterina S Yamada M Kromer SA Kuznetsov M Mankani PG Robey AR Poole I Pidoux JM Ward H Birkedal-Hansen, Cell 1999 99 81 92 10.1016/S0092-8674(00) 80064-1 10520996
21. The expression of metalloproteinase-2, -9, and -14 and of tissue inhibitors-1 and -2 is developmentally modulated during osteogenesis in vitro. C Filanti GR Dickson D Di Martino V Ulivi C Sanguineti P Romano C Palermo P Manduca, J Bone Miner Res 2000 15 2154 68 10.1359/jbmr.2000.15.11.2154 11092396
22. Role of MT1-MMP in the osteogenic differentiation. P Manduca A Castagnino D Lombardini S Marchisio S Soldano V Ulivi S Zanotti C Garbi N Ferrari D Palmieri, Bone 2009 44 251 265 10.1016/j.bone.2008.10.046 19027888
23. RECK: a novel suppressor of malignancy linking oncogenic signaling to extracellular matrix remodeling. M Noda J Oh R Takahashi S Kondo H Kitayama C Takahashi, Cancer Metastasis Rev 2003 22 167 175 10.1023/A:1023043315031 12784995
24. Ascorbate-induced osteoblast differentiation recruits distinct MMP-inhibitors: RECK and TIMP-2. WF Zambuzzi CL Yano AD Cavagis MP Peppelenbosch JM Granjeiro CV Ferreira, Mol Cell Biochem 2009 322 143 50 10.1007/s11010-008- 9951-x 18989628
25. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. T Sugiyama H Kohara M Noda T Nagasawa, Immunity 2006 25 977 988 10.1016/j.immuni.2006.10.016 17174120
26. Circulating bone marrow-derived osteoblast progenitor cells are recruited to the bone-forming site by the CXCR4/stromal cell-derived factor-1 pathway. S Otsuru K Tamai T Yamazaki H Yoshikawa Y Kaneda, Stem Cells 2008 26 223 34 10.1634/stemcells.2007-0515 17932420
27. Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice. A Dar O Kollet T Lapidot, Exp Hematol 2006 34 967 75 10.1016/j.exphem.2006.04.002 16863903
28. Stromal cell-derived factor-1 binding to its chemokine receptor CXCR4 on precursor cells promotes the chemotactic recruitment, development and survival of human osteoclasts. LM Wright W Maloney X Yu L Kindle P Collin-Osdoby P Osdoby, Bone 2005 36 840 53 10.1016/j.bone.2005.01.021 15794931
29. Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. S Shi S Gronthos, J Bone Miner Res 2003 18 696 704 10.1359/jbmr.2003.18.4.696 12674330
30. Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. PJ Simmons B Torok-Storb, Blood 1991 78 55 62 2070060
31. Hindlimb unloading rodent model: technical aspects. ER Morey-Holton RK Globus, J Appl physiol 2002 92 1367 77 10.1063/1.1492860 11895999
32. Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance. S Pierno JF Desaphy A Liantonio De Luca A Zarrilli L Mastrofrancesco G Procino G Valenti D Conte Camerino, J Physiol 2007 584 983 95 10.1113/jphysiol.2007.141358 17855757
33. Central interleukin-1 receptor signaling regulates bone growth and mass. A Bajayo I Goshen S Feldman V Csernus K Iverfeldt E Shohami R Yirmiya I Bab, Proc Natl Acad Sci USA 2005 102 12956 12961 10.1073/pnas.0502562102 16126903
34. Human parathyroid hormone 1-34 reverses bone loss in ovariectomized mice. JM Alexander I Bab S Fish R Mueller T Uchiyama G Gronowicz M Nahounou Q Zhao DW White M Chorev D Gazit M Rosenblatt, J Bone Min Res 2001 16 1665 1673 10.1359/jbmr.2001.16.9.1665
35. The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression. C Desbois DA Hogue G Karsenty, J Biol Chem 1994 269 1183 90 8288580
36. Alkaline fixation drastically improves the signal of in situ hybridization. E Basyuk E Bertrand L Journot, Nucleic Acids Res 2000 28 46 10.1093/nar/28.10.e46 10773094
37. In situ hybridization - theory and practice. SS Kadkol WR Gage GR Pasternack, Mol Diagn 1999 4 169 83 10.1016/S1084-8592(99)80021-6 10553018
38. RNA-RNA in situ hybridization using digoxigenin-labeled probes: the use of high-molecular-weight polyvinyl alcohol in the alkaline phosphatase indoxyl-nitroblue tetrazolium reaction. M De Block D Debrouwer, Anal Biochem 1993 215 86 9 10.1006/abio.1993.1558 7507651
39. Membrane type-1 matrix metalloproteinase is induced following cyclic compression of in vitro grown bovine chondrocytes. JN De Croos B Jang SS Dhaliwal MD Grynpas RM Pilliar Kandel, Osteoarthritis Cartilage 2007 15 1301 10 10.1016/j.joca.2007.04.006 17548215
40. Microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced EGR1 expression. MV Barbolina BP Adley EV Ariztia Y Liu MS Stack, J Biol Chem 2007 282 4924 31 10.1074/jbc.M608428200 17158885
41. PPAR Gamma Activity and Control of Bone Mass in Skeletal Unloading. PJ Marie K Kaabeche, PPAR Res 2006 64807 17259667