Glutathione replacement preserves the functional surfactant phospholipid pool size and decreases sepsis-mediated lung dysfunction in ethanol-fed rats

Alcoholism: Clinical and Experimental Research

Volumn 26, Issue 8, 2002, Pages 1245-1251

  Velasquez, Alvaro ^a   Bechara, Rabih I ^a   Lewis, James F ^b   Malloy, Jaret ^b   McCaig, Lynda ^b   Brown, Lou Ann S ^a   Guidot, David M ^a,c  

^a EMORY UNIVERSITY   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

Alcohol; Alveolar epithelium; ARDS; Respiratory failure; Surfactant

Indexed keywords

GLUTATHIONE; SURFACTANT; ALCOHOL; LUNG SURFACTANT; PHOSPHOLIPID;

ADULT RESPIRATORY DISTRESS SYNDROME; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; EPITHELIUM CELL; GAS EXCHANGE; HYPOXEMIA; LUNG ALVEOLUS EPITHELIUM; LUNG DISEASE; LUNG INJURY; NONHUMAN; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; RAT; ANIMAL; CECUM; COMPARATIVE STUDY; DIET; LIGATION; MALE; METABOLISM; MICROBIOLOGY; PATHOPHYSIOLOGY; PUNCTURE; SEPSIS; SPRAGUE DAWLEY RAT;

ANIMALIA;

ANIMALS; CECUM; DIET; ETHANOL; GLUTATHIONE; LIGATION; LUNG DISEASES; MALE; PHOSPHOLIPIDS; PULMONARY SURFACTANTS; PUNCTURES; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS;

EID: 0036667841     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2002.tb02663.x     Document Type: Article

References (23)

1. N-Acetylcysteine in experimental and clinical acute lung injury
2. Glutathione (GSH) repletion by N-acetylcysteine in patients with the adult respiratory distress syndrome
3. Effect of chronic ethanol ingestion on alveolar type II cell glutathione and inflammatory mediator-induced apoptosis
4. Chronic ethanol ingestion potentiates TNF-mediated oxidative stress and apoptosis in rat alveolar type II cells
5. A rapid sensitive method for determining phospholipid phosphorous involving digestion with magnesium nitrate
6. Pulsating bubble technique for evaluating pulmonary surfactant
7. Mitochondrial glutathione replacement restores surfactant synthesis and secretion in alveolar epithelial cells of ethanol-fed rats
8. Ethanol ingestion via glutathione depletion impairs alveolar epithelial barrier function in rats
9. Chronic ethanol ingestion impairs alveolar type II cell glutathione homeostasis and function and predisposes to endotoxin-mediated acute edematous lung injury in rats
10. Anti-oxidant treatment with N-acetylcysteine during adult respiratory distress syndrome: A prospective, randomized, placebo controlled study
11. Surfactant and the adult respiratory distress syndrome
12. Ethanol ingestion increases activation of matrix metalloproteinases in rat lungs during acute endotoxemia
13. Alterations of the endogenous surfactant system in septic adult rats
14. Fluorimetric determination of oxidized and reduced glutathione in cells and tissues by high-performance liquid chromatography following derivatization with dansyl chloride
15. Significance of glutathione in lung disease and implications for therapy
16. The role of chronic alcohol abuse in the development of acute respiratory distress syndrome in adults
17. The effects of chronic alcohol abuse on pulmonary glutathione homeostasis
18. High performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide and related thiols and disulfides
19. The effect of acute alcohol intoxication and chronic alcohol abuse on outcome from trauma
20. N-Acetylcysteine enhances recovery from acute lung injury in man: A randomized, double blind, placebo-controlled clinical study
21. The acute respiratory distress syndrome
22. Sepsis and septic shock: A review of laboratory models and a proposal