Transforming growth factor β expression and activation is in the alcoholic rat lung

American Journal of Respiratory and Critical Care Medicine

Volumn 170, Issue 2, 2004, Pages 188-194

  Bechara, Rabih I ^b   Brown, Lou Ann S ^b   Roman, Jesse ^b   Joshi, Pratibha C ^b   Guidot, David M ^a  

^a ATLANTA VA MEDICAL CENTER   (United States)

^b NONE

Author keywords

Acute respiratory distress syndrome; Alcoholism; Alveolar type II cell; Epithelium; Sepsis

Indexed keywords

ALCOHOL; CYTOKINE; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME LINKED IMMUNOSORBENT ASSAY; LUNG; LUNG ALVEOLUS EPITHELIUM; LUNG INJURY; LUNG LAVAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SEPSIS;

ALCOHOLISM; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; ETHANOL; LUNG; RATS; REFERENCE VALUES; RESPIRATORY MUCOSA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 3142762920     PISSN: 00030805     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000;342:1334-1349.
2. Harris JB, Chang LY, Crapo JD. Rat lung alveolar type I epithelial cell injury and response to hyperoxia. Am J Respir Cell Mol Biol 1991;4:115-125.
3. Tate RM, Repine JE. Neutrophils and the adult respiratory distress syndrome. Am Rev Respir Dis 1983;128:552-559.
4. Moss M, Bucher B, Moore FA, Moore EE, Parsons PE. The role of chronic alcohol abuse in the development of acute respiratory distress syndrome in adults. JAMA 1996;275:50-54.
5. Moss M, Parsons PE, Steinberg KP, Hudson LD, Guidot DM, Burnham EL, Cotsonis GA. Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock. Crit Care Med 2003;31:869-877.
6. Guidot DM, Modelska K, Lois M, Jain L, Moss IM, Pittet J-F, Brown LAS. Ethanol ingestion via glutathione depletion impairs alveolar epithelial barrier function in rats. Am J Physiol Lung Cell Mol Physiol 2000;279:L127-L135.
7. Holguin F, Moss IM, Brown LS, Guidot DM. Chronic ethanol ingestion impairs alveolar type II cell glutathione homeostasis and function and predisposes to endotoxin-mediated acute edematous lung injury in rats. J Clin invest 1998;101:761-768.
8. Brown LAS, Harris FL, Guidot DM. Chronic ethanol ingestion potentiates TNF-alpha-mediated oxidative stress and apoptosis in rat alveolar type II cells. Am J Physiol Lung Cell Mol Physiol 2001;281:L377-L386.
9. Brown LAS, Harris FL, Bechara R, Guidot DM. Effect of chronic ethanol ingestion on alveolar type II cell glutathione and inflammatory mediator-induced apoptosis. Alcohol Clin Exp Res 2001;25:1078-1085.
10. Guidot DM, Brown LAS. Mitochondrial glutathione replacement restores surfactant synthesis and secretion in alveolar epithelial cells of ethanol-fed rats. Alcohol Clin Exp Res 2000;24:1070-1076.
11. Velasquez A, Bechara R, Lewis JF, Malloy J, McCaig L, Brown LAS, Guidot DM. Glutathione replacement preserves the functional surfactant phospholipid pool size and decreases sepsis-mediated lung dysfunction in ethanol-fed rats. Alcohol Clin Exp Res 2002;26:1245-1251.
12. Pittet J-F, Griffiths MJD, Geiser T, Kaminski N, Dalton SL, Huang X, Brown LAS, Gotwals PJ, Koteliansky VE, Matthay MA, Sheppard D. TGF-beta is a critical mediator of acute lung injury. J Clin Invest 2001;107:1537-1544.
13. Hartsough MT, Mulder KM. Transforming growth factor-beta signaling in epithelial cells. Pharmacol Ther 1997;75:21-41.
14. Arsalane K, Dubois CM, Muanza T, Begin R, Boudreau F, Asselin C, Cantin AM. Transforming growth factor-beta 1 is a potent inhibitor of glutathione synthesis in the lung epithelial cell line A549: transcriptional effect on the GSH rate-limiting enzyme gamma-glutamylcysteine synthetase. Am J Respir Cell Mol Biol 1997;17:599-607.
15. Lois M, Brown LAS, Moss M, Roman J, Guidot DM. Ethanol ingestion increases activation of matrix metalloproteinases in rat lungs during acute endotoxemia. Am J Respir Crit Care Med 1999;160:1354-1360.
16. Perez RL, Roman J, Roser S, Little C, Hunter R, Actor J. Cytokine message and protein expression during lung granuloma formation and resolution induced by the mycobacterial cord factor trehalose-6, 6′-dimycolate. J Interferon Cytokine Res 2000;9:795-804.
17. Dobbs LG, Gonzalez R, Williams MC. An improved method for isolating Type II cells in high yield and purity. Am Rev Respir Dis 1986;134:141-145.
18. Moss M, Guidot DM, Wong-Lambertina M, Ten Hoor T, Perez RL, Brown LAS. The effects of chronic alcohol abuse on pulmonary glutathione homeostasis. Am J Respir Crit Care Med 2000;161:414-419.
19. Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med 2000;342:1350-1358.
20. Munger JS, Harpel JG, Gleizes P-E, Mazzieri R, Nunes I, Rifkin DB. Latent transforming growth factor-beta: structural features and mechanism of activation. Kidney Int 1997;51:1376-1382.
21. Oklu R, Hesketh R. The latent transforming growth B binding protein (LTBP) family. Biochem J 2000;352:601-610.
22. Barcellos-Hoff MH, Dix TA. Redox-mediated activation of latent transforming growth factor-beta 1. Mol Endocrinol 1996;10:1077-1083.
23. Bellocq A, Azoulay E, Marullo S, Flahault A, Fouqueray B, Philippe C, Cadranel J, Baud L. Reactive oxygen and nitrogen intermediates increase transforming growth factor-betal release from human epithelial alveolar cells through two different mechanisms. Am J Respir Cell Mol Biol 1999;21:128-136.
24. Vodovotz Y, Chesler L, Chong H, Kim S-J, Simpson JT, DeGraff W, Cox GW, Roberts AB, Wink DA, Barcellos-Hoff MH. Regulation of transforming growth factor beta 1 by nitric oxide. Cancer Res 1999;59: 2142-2149.
25. Kolb M, Margetts PJ, Sime PJ, Gauldie J. Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung. Am J Physiol Lung Cell Mol Physiol 2001;280:L1327-L1334.
26. Noble NA, Harper J, Border WA. In vivo interactions of TGF-beta and extracellular matrix. Prog Growth Factor Res 1992;4:369-382.
27. Brenchley PE, Williams S, Coupes B, Short CD. Strategies for meaningful measurement of circulating levels of transforming growth factor beta 1 in clinical samples. Transplantation 2001;71:1355-1356.
28. Abe M, Harpel JG, Metz CN, Nines I, Loskutoff DJ, Rifkin DB. An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem 1994;216:276-284.