Ethanol (EtOH)-Induced TGF-β1 and Reactive Oxygen Species Production Are Necessary for EtOH-Induced Alveolar Macrophage Dysfunction and Induction of Alternative Activation

Alcoholism: Clinical and Experimental Research

Volumn 36, Issue 11, 2012, Pages 1952-1962

  Brown, Sheena D ^a,b   Brown, Lou Ann S ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Graduate Division of Biological and Biomedical Sciences   (United States)

Author keywords

Alternative Activation; Glutathione; Macrophage; Oxidative Stress; TGF 1

Indexed keywords

ALCOHOL; COMPLEMENTARY DNA; GLUTATHIONE; HYDROGEN PEROXIDE; INTERLEUKIN 13; NEUTRALIZING ANTIBODY; REACTIVE OXYGEN METABOLITE; RNA; TRANSFORMING GROWTH FACTOR BETA1;

ALCOHOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLAST; INFECTION RISK; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE FUNCTION; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY TRACT INFECTION; STAPHYLOCOCCUS AUREUS; WESTERN BLOTTING;

ANIMALS; CELL LINE; ETHANOL; MACROPHAGE ACTIVATION; MACROPHAGES, ALVEOLAR; MALE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TRANSFORMING GROWTH FACTOR BETA1;

RATTUS;

EID: 84868210040     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2012.01825.x     Document Type: Article

References (47)

1. Abramson SL, Gallin JI (1990) IL-4 inhibits superoxide production by human mononuclear phagocytes. J Immunol 144:625-630.
2. Aytacoglu BN, Calikoglu M, Tamer L, Coşkun B, Sucu N, Köse N, Aktas S, Dikmengil M (2006) Alcohol-induced lung damage and increased oxidative stress. Respiration 73:100-104.
3. Bechara RI, Brown LAS, Roman J, Joshi PC, Guidot DM (2004) Transforming growth factor beta1 expression and activation is increased in the alcoholic rat lung. Am J Respir Crit Care Med 170:188-194.
4. Boé DM, Vandivier RW, Burnham EL, Moss M (2009) Alcohol abuse and pulmonary disease. J Leukoc Biol 86:1097-1104.
5. Boutard V, Havouis R, Fouqueray B, Philippe C, Moulinoux J, Baud L (1995) Transforming growth factor-beta stimulates arginase activity in macrophages. Implications for the regulation of macrophage cytotoxicity. J Immunol 155:2077-2084.
6. Brown LAS, Harris FL, Ping X-D, Gauthier TW (2004) Chronic ethanol ingestion and the risk of acute lung injury: a role for glutathione availability? Alcohol 33:191-197.
7. Brown LAS, Ping X-D, Harris FL, Gauthier TW (2007) Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat. Am J Physiol Lung Cell Mol Physiol 292:L824-L832.
8. Cubero FJ, Urtasun R, Nieto N (2009) Alcohol and liver fibrosis. Semin Liver Dis 29:211-221.
9. Downing JF, Kachel DL, Pasula R, Martin WJ II (1999) Gamma interferon stimulates rat alveolar macrophages to kill Pneumocystis carinii by l-arginine- and tumor necrosis factor-dependent mechanisms. Infect Immun 67:1347-1352.
10. Durante W, Liao L, Reyna SV, Peyton KJ, Schafer AI (2001) Transforming growth factor-beta(1) stimulates l-arginine transport and metabolism in vascular smooth muscle cells: role in polyamine and collagen synthesis. Circulation 103:1121-1127.
11. Esper A, Burnham EL, Moss M (2006) The effect of alcohol abuse on ARDS and multiple organ dysfunction. Anesthesiology 72:375-381.
12. Fichtner-Feigl S, Strober W, Kawakami K, Puri RK, Kitani A (2006) IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat Med 12:99-106.
13. Gordon S (2002) Pattern recognition receptors: doubling up for the innate immune response. Cell 111:927-930.
14. Gordon S (2003) Alternative activation of macrophages. Nat Rev Immunol 3:23-35.
15. Gordon S, Martinez FO (2010) Alternative activation of macrophages: mechanism and functions. Immunity 32:593-604.
16. Gordon S, Taylor PR (2005) Monocyte and macrophage heterogeneity. Nat Rev Immunol 5:953-964.
17. Harper C (2009) The neuropathology of alcohol-related brain damage. Alcohol Alcohol 44:136-140.
18. Isono M, Chen S, Hong SW, Iglesias-de la Cruz MC, Ziyadeh FN (2002) Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells. Biochem Biophys Res Commun 296:1356-1365.
19. Joshi PC, Guidot DM (2007) The alcoholic lung: epidemiology, pathophysiology, and potential therapies. Am J Physiol Lung Cell Mol Physiol 292:L813-L823.
20. Jurkovich GJ, Rivara FP, Gurney JG, Fligner C, Ries R, Mueller BA, Copass M (1993) The effect of acute alcohol intoxication and chronic alcohol abuse on outcome from trauma. JAMA 270:51-56.
21. Kane C, Galanes S (2004) Adult respiratory distress syndrome. Crit Care Nurs Q 27:325-335.
22. Koli K, Myllärniemi M, Keski-Oja J, Kinnula VL (2008) Transforming growth factor-β activation in the lung: focus on fibrosis and reactive oxygen species. Antioxid Redox Signal 10:333-342.
23. Lands WEM (1998) A review of alcohol clearance in humans. Alcohol 15:147-160.
24. Leask A, Abraham DJ (2004) TGF-beta signaling and the fibrotic response. FASEB J 18:816-827.
25. Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley JM, Gotwals P, Noble P, Chen Q, Senior RM, Elias JA (2001) Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor β1. J Exp Med 194:809-822.
26. MacKinnon AC, Farnworth SL, Hodkinson PS, Henderson NC, Atkinson KM, Leffler H, Nilsson UJ, Haslett C, Forbes SJ, Sethi T (2008) Regulation of alternative macrophage activation by galectin-3. J Immunol 180:2650-2658.
27. Martinez FO, Helming L, Gordon S (2009) Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 27:451-483.
28. McKenzie GJ, Bancroft A, Grencis RK, McKenzie ANJ (1998) A distinct role for interleukin-13 in Th2-cell-mediated immune responses. Curr Biol 8:339-342.
29. Mitchell PO, Jensen JS, Ritzenthaler JD, Roman J, Pelaez A, Guidot DM (2009) Alcohol primes the airway for increased interleukin-13 signaling. Alcohol Clin Exp Res 33:505-513.
30. Moss M, Bucher B, Moore FA, Moore EE, Parsons PE (1996) The role of chronic alcohol abuse in the development of acute respiratory distress syndrome in adults. JAMA 275:50-54.
31. Moss M, Burnham EL (2003) Chronic alcohol abuse, acute respiratory distress syndrome, and multiple organ dysfunction. Crit Care Med 31:S207-S212.
32. Moss M, Guidot DM, Wong-Lambertina M, Ten Hoor T, Perez RL, Brown LAS (2000) The effects of chronic alcohol abuse on pulmonary glutathione homeostasis. Am J Respir Crit Care Med 161:414-419.
33. Muller U, Stenzel W, Kohler G, Werner C, Polte T, Hansen G, Schutze N, Straubinger RK, Blessing M, McKenzie ANJ, Brombacher F, Alber G (2007) IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans. J Immunol 179:5367-5377.
34. Munder M, Eichmann K, Modolell M (1998) Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4 + T Cells correlates with Th1/Th2 phenotype. J Immunol 160:5347-5354.
35. Nair MG, Cochrane DW, Allen JE (2003) Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro. Immunol Lett 85:173-180.
36. Nathan CF, Hibbs JB (1991) Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol 3:65-70.
37. Noda T, Amano F (1997) Differences in nitric oxide synthase activity in a macrophage-like cell line, RAW264.7 cells, treated with lipopolysaccharide (LPS) in the presence or absence of interferon-γ (IFN-γ): possible heterogeneity of iNOS activity. J Biochem 121:38-46.
38. O'Brien JM Jr, Lu B, Ali NA, Martin GS, Aberegg SK, Marsh CB, Lemeshow S, Douglas IS (2007) Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients. Crit Care Med 35:345-350.
39. Oscar-Berman M, Marinkovic K (2003) Alcoholism and the brain. Alcohol Res Health 27:125-133.
40. Rehm J, Room R, Graham K, Monteiro M, Gmel G, Sempos CT (2003) The relationship of average volume of alcohol consumption and patterns of drinking to burden of disease: an overview. Addiction 98:1209-1228.
41. Room R, Babor T, Rehm J (2005) Alcohol and public health. Lancet 365:519-530.
42. Ruiz-Ortega M, Rodríguez-Vita J, Sanchez-Lopez E, Carvajal G, Egido J (2007) TGF-β signaling in vascular fibrosis. Cardiovasc Res 74:196-206.
43. Song E, Ouyang N, Hörbelt M, Antus B, Wang M, Exton MS (2000) Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts. Cell Immunol 204:19-28.
44. Stein M, Keshav S, Harris N, Gordon S (1992) Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med 176:287-292.
45. Taylor PR, Martinez-Pomares L, Stacey M, Lin HH, Brown GD, Gordon S (2005) Macrophage receptors and immune recognition. Annu Rev Immunol 23:901-944.
46. Vodovotz Y, Bogdan C, Paik J, Xie QW, Nathan C (1993) Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta. J Exp Med 178:605-613.
47. Wang W, Huang XR, Canlas E, Oka K, Truong LD, Deng C, Bhowmick NA, Ju W, Bottinger EP, Lan HY (2006) Essential role of Smad3 in angiotensin II-induced vascular fibrosis. Circ Res 98:1032-1039.