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Volumn 86, Issue 6, 2014, Pages 441-452

Idiopathic pulmonary fibrosis: From epithelial injury to biomarkers-insights from the bench side

Author keywords

Biomarkers; Epithelial injury; Fibrosis; Idiopathic pulmonary fibrosis; KL 6; Parenchymal lung disease; Surfactant proteins

Indexed keywords

ANTIGEN; BIOLOGICAL MARKER; INTERSTITIAL COLLAGENASE; KREBS VON DEN LUNGEN 6 ANTIGEN; LIPOPROTEIN; LIPOPROTEIN SP A; LIPOPROTEIN SP D; MATRILYSIN; OSTEOPONTIN; UNCLASSIFIED DRUG; VASCULOTROPIN; SP A LIPOPROTEIN COMPLEX; SP D LIPOPROTEIN COMPLEX;

EID: 84893681263     PISSN: 00257931     EISSN: 14230356     Source Type: Journal    
DOI: 10.1159/000357598     Document Type: Review
Times cited : (108)

References (108)
  • 1
    • 82755161052 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis
    • King TE Jr, Pardo A, Selman M: Idiopathic pulmonary fibrosis. Lancet 2011; 378: 1949-1961.
    • (2011) Lancet , vol.378 , pp. 1949-1961
    • King Jr., T.E.1    Pardo, A.2    Selman, M.3
  • 2
    • 80052613002 scopus 로고    scopus 로고
    • Pirfenidone: In idiopathic pulmonary fibrosis
    • Carter NJ: Pirfenidone: in idiopathic pulmonary fibrosis. Drugs 2011; 71:1721-1732.
    • (2011) Drugs , vol.71 , pp. 1721-1732
    • Carter, N.J.1
  • 4
    • 0034011982 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS)
    • American Thoracic Society.
    • American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS). Am J Respir Crit Care Med 2000; 161:646-664.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 646-664
  • 6
    • 85008987259 scopus 로고    scopus 로고
    • This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS Board of Directors June, 2001 and by the ERS Executive Committee, June 2001
    • American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias
    • American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS Board of Directors June, 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 2002; 165: 277-304.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 277-304
  • 9
    • 79951844263 scopus 로고    scopus 로고
    • Clinical course and prediction of survival in idiopathic pulmonary fibrosis
    • Ley B, Collard HR, King TE Jr: Clinical course and prediction of survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2011; 183:431-440.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 431-440
    • Ley, B.1    Collard, H.R.2    King Jr., T.E.3
  • 12
    • 0035895243 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Prevailing and evolving hypotheses about its pathogenesis and implications for therapy
    • Selman M, King TE, Pardo A: Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 2001; 134: 136-151. (Pubitemid 32096342)
    • (2001) Annals of Internal Medicine , vol.134 , Issue.2 , pp. 136-151
    • Selman, M.1    King Jr., T.E.2    Pardo, A.3
  • 13
    • 0029866586 scopus 로고    scopus 로고
    • Alterations in the alveolar epithelium after injury leading to pulmonary fibrosis
    • Kasper M, Haroske G: Alterations in the alveolar epithelium after injury leading to pulmonary fibrosis. Histol Histopathol 1996; 11: 463-483. (Pubitemid 26135211)
    • (1996) Histology and Histopathology , vol.11 , Issue.2 , pp. 463-483
    • Kasper, M.1    Haroske, G.2
  • 14
    • 0022135836 scopus 로고
    • Pathogenesis of 'fibrosis' in interstitial pneumonia: An electron microscopic study
    • Katzenstein AL: Pathogenesis of 'fibrosis' in interstitial pneumonia: an electron microscopic study. Hum Pathol 1985; 16:1015-1024.
    • (1985) Hum Pathol , vol.16 , pp. 1015-1024
    • Katzenstein, A.L.1
  • 15
    • 0020052468 scopus 로고
    • Structure of alveolar epithelial cells in patients with fibrotic lung disorders
    • Kawanami O, Ferrans VJ, Crystal RG: Structure of alveolar epithelial cells in patients with fibrotic lung disorders. Lab Invest 1982; 46: 39-53. (Pubitemid 12167015)
    • (1982) Laboratory Investigation , vol.46 , Issue.1 , pp. 39-53
    • Kawanami, O.1    Ferrans, V.J.2    Crystal, R.G.3
  • 16
    • 0018288704 scopus 로고
    • Bleomycin-induced injury and metaplasia of alveolar type 2 cells. Relationship of cellular responses to drug presence in the lung
    • Adamson IY, Bowden DH: Bleomycin-in-duced injury and metaplasia of alveolar type 2 cells. Relationship of cellular responses to drug presence in the lung. Am J Pathol 1979; 96:531-544. (Pubitemid 9253492)
    • (1979) American Journal of Pathology , vol.96 , Issue.2 , pp. 531-544
    • Adamson, I.Y.R.1    Bowden, D.H.2
  • 24
    • 0032793098 scopus 로고    scopus 로고
    • Hepatocyte growth factor stimulates migration of type II alveolar epithelial cells on the provisional matrix proteins fibronectin and fibrinogen
    • DOI 10.1378/chest.116.suppl-1.94S
    • Kim HJ, Sammak PJ, Ingbar DH: Hepatocyte growth factor stimulates migration of type II alveolar epithelial cells on the provisional matrix proteins fibronectin and fibrinogen. Chest 1999; 116:94S-95S. (Pubitemid 29340232)
    • (1999) Chest , vol.116 , Issue.SUPPL.
    • Kim, H.J.1    Sammak, P.J.2    Ingbar, D.H.3
  • 26
    • 79960612606 scopus 로고    scopus 로고
    • Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis
    • Plantier L, Crestani B, Wert SE, Dehoux M, Zweytick B, Guenther A, Whitsett JA: Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis. Thorax 2011; 66:651-657.
    • (2011) Thorax , vol.66 , pp. 651-657
    • Plantier, L.1    Crestani, B.2    Wert, S.E.3    Dehoux, M.4    Zweytick, B.5    Guenther, A.6    Whitsett, J.A.7
  • 27
    • 79957922264 scopus 로고    scopus 로고
    • The three R's of lung health and disease: Repair, remodeling, and regeneration
    • Beers MF, Morrisey EE: The three R's of lung health and disease: repair, remodeling, and regeneration. J Clin Invest 2011; 121:2065-2073.
    • (2011) J Clin Invest , vol.121 , pp. 2065-2073
    • Beers, M.F.1    Morrisey, E.E.2
  • 28
    • 84873625826 scopus 로고    scopus 로고
    • Regulation and repair of the alveolar-capillary barrier in acute lung injury
    • Bhattacharya J, Matthay MA: Regulation and repair of the alveolar-capillary barrier in acute lung injury. Annu Rev Physiol 2013; 75:593-615.
    • (2013) Annu Rev Physiol , vol.75 , pp. 593-615
    • Bhattacharya, J.1    Matthay, M.A.2
  • 29
    • 0035721766 scopus 로고    scopus 로고
    • Alveolar epithelial type II cell: Defender of the alveolus revisited
    • DOI 10.1186/rr36
    • Fehrenbach H: Alveolar epithelial type II cell: defender of the alveolus revisited. Respir Res 2001; 2:33-46. (Pubitemid 34187905)
    • (2001) Respiratory Research , vol.2 , Issue.1 , pp. 33-46
    • Fehrenbach, H.1
  • 30
    • 0028281523 scopus 로고
    • Function of the alveolar epithelial barrier under pathologic conditions
    • Matthay MA: Function of the alveolar epithelial barrier under pathologic conditions. Chest 1994; 105:67S-74S.
    • (1994) Chest , vol.105
    • Matthay, M.A.1
  • 32
    • 0016742681 scopus 로고
    • Derivation of type 1 epithelium from type 2 cells in the developing rat lung
    • Adamson IY, Bowden DH: Derivation of type 1 epithelium from type 2 cells in the developing rat lung. Lab Invest 1975; 32:736-745.
    • (1975) Lab Invest , vol.32 , pp. 736-745
    • Adamson, I.Y.1    Bowden, D.H.2
  • 37
    • 84855844345 scopus 로고    scopus 로고
    • Pathogenesis of idiopathic pulmonary fibrosis: From initial apoptosis of epithelial cells to lung remodeling?
    • Jin HL, Dong JC: Pathogenesis of idiopathic pulmonary fibrosis: from initial apoptosis of epithelial cells to lung remodeling? Chin Med J (Engl) 2011; 124:4330-4338.
    • (2011) Chin Med J (Engl) , vol.124 , pp. 4330-4338
    • Jin, H.L.1    Dong, J.C.2
  • 44
    • 80052518623 scopus 로고    scopus 로고
    • Prostaglandin E2 and the pathogenesis of pulmonary fibrosis
    • Bozyk PD, Moore BB: Prostaglandin E2 and the pathogenesis of pulmonary fibrosis. Am J Respir Cell Mol Biol 2011; 45:445-452.
    • (2011) Am J Respir Cell Mol Biol , vol.45 , pp. 445-452
    • Bozyk, P.D.1    Moore, B.B.2
  • 52
    • 0037006639 scopus 로고    scopus 로고
    • The architecture of diagnostic research
    • Sackett DL, Haynes RB: The architecture of diagnostic research. BMJ 2002; 324:539-541.
    • (2002) BMJ , vol.324 , pp. 539-541
    • Sackett, D.L.1    Haynes, R.B.2
  • 53
    • 0035100888 scopus 로고    scopus 로고
    • Bio-markers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group
    • Biomarkers Definitions Working Group: Bio-markers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001; 69:89-95.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
  • 54
    • 84867123261 scopus 로고    scopus 로고
    • The expanding role of biomarkers in the assessment of smoking-related paren-chymal lung diseases
    • Doyle TJ, Pinto-Plata V, Morse D, Celli BR, Rosas IO: The expanding role of biomarkers in the assessment of smoking-related paren-chymal lung diseases. Chest 2012; 142:1027-1034.
    • (2012) Chest , vol.142 , pp. 1027-1034
    • Doyle, T.J.1    Pinto-Plata, V.2    Morse, D.3    Celli, B.R.4    Rosas, I.O.5
  • 55
    • 84858427847 scopus 로고    scopus 로고
    • Peripheral blood biomarkers in idiopathic pulmonary fibrosis
    • Vij R, Noth I: Peripheral blood biomarkers in idiopathic pulmonary fibrosis. Transl Res 2012; 159:218-227.
    • (2012) Transl Res , vol.159 , pp. 218-227
    • Vij, R.1    Noth, I.2
  • 57
    • 0037260159 scopus 로고    scopus 로고
    • High serum concentrations of surfactant protein A in usual interstitial pneumonia compared with non-specific interstitial pneumonia
    • DOI 10.1136/thorax.58.1.52
    • Ishii H, Mukae H, Kadota J, Kaida H, Nagata T, Abe K, Matsukura S, Kohno S: High serum concentrations of surfactant protein A in usual interstitial pneumonia compared with nonspecific interstitial pneumonia. Thorax 2003; 58:52-57. (Pubitemid 36135359)
    • (2003) Thorax , vol.58 , Issue.1 , pp. 52-57
    • Ishii, H.1    Mukae, H.2    Kadota, J.3    Kaida, H.4    Nagata, T.5    Abe, K.6    Matsukura, S.7    Kohno, S.8
  • 59
  • 60
    • 84857355923 scopus 로고    scopus 로고
    • Pneu-mocyte biomarkers KL-6 and surfactant protein D reflect the distinct findings of high-resolution computed tomography in nonspecific interstitial pneumonia
    • Ichiyasu H, Ichikado K, Yamashita A, Iyona-ga K, Sakamoto O, Suga M, Kohrogi H: Pneu-mocyte biomarkers KL-6 and surfactant protein D reflect the distinct findings of high-resolution computed tomography in nonspecific interstitial pneumonia. Respiration 2012; 83: 190-197.
    • (2012) Respiration , vol.83 , pp. 190-197
    • Ichiyasu, H.1    Ichikado, K.2    Yamashita, A.3    Iyona-Ga, K.4    Sakamoto, O.5    Suga, M.6    Kohrogi, H.7
  • 62
    • 0031813126 scopus 로고    scopus 로고
    • Immunoreactive MUC1 expression at the deepest invasive portion correlates with prognosis of colorectal cancer
    • DOI 10.1159/000011868
    • Hiraga Y, Tanaka S, Haruma K, Yoshihara M, Sumii K, Kajiyama G, Shimamoto F, Kohno N: Immunoreactive MUC1 expression at the deepest invasive portion correlates with prognosis of colorectal cancer. Oncology 1998; 55: 307-319. (Pubitemid 28279672)
    • (1998) Oncology , vol.55 , Issue.4 , pp. 307-319
    • Hiraga, Y.1    Tanaka, S.2    Haruma, K.3    Yoshihara, M.4    Sumii, K.5    Kajiyama, G.6    Shimamoto, F.7    Kohno, N.8
  • 66
    • 33750018921 scopus 로고    scopus 로고
    • Increased levels of KL-6 and subsequent mortality in patients with interstitial lung diseases
    • DOI 10.1111/j.1365-2796.2006.01704.x
    • Satoh H, Kurishima K, Ishikawa H, Ohtsuka M: Increased levels of KL-6 and subsequent mortality in patients with interstitial lung diseases. J Intern Med 2006; 260:429-434. (Pubitemid 44571130)
    • (2006) Journal of Internal Medicine , vol.260 , Issue.5 , pp. 429-434
    • Satoh, H.1    Kurishima, K.2    Ishikawa, H.3    Ohtsuka, M.4
  • 67
    • 0031740674 scopus 로고    scopus 로고
    • Pulmonary surfactant: Functions and molecular composition
    • DOI 10.1016/S0925-4439(98)00060-X, PII S092544399800060X
    • Goerke J: Pulmonary surfactant: functions and molecular composition. Biochim Bio-phys Acta 1998; 1408:79-89. (Pubitemid 28517859)
    • (1998) Biochimica et Biophysica Acta - Molecular Basis of Disease , vol.1408 , Issue.2-3 , pp. 79-89
    • Goerke, J.1
  • 68
    • 0037251554 scopus 로고    scopus 로고
    • Prognostic value of surfactant proteins A and D in patients with acute lung injury
    • DOI 10.1097/00003246-200301000-00003
    • Cheng IW, Ware LB, Greene KE, Nuckton TJ, Eisner MD, Matthay MA: Prognostic value of surfactant proteins A and D in patients with acute lung injury. Crit Care Med 2003; 31:20-27. (Pubitemid 36151144)
    • (2003) Critical Care Medicine , vol.31 , Issue.1 , pp. 20-27
    • Cheng, I.W.1    Ware, L.B.2    Greene, K.E.3    Nuckton, T.J.4    Eisner, M.D.5    Matthay, M.A.6
  • 71
    • 84872099747 scopus 로고    scopus 로고
    • Genetic characterization of a Chinese family with familial idiopathic pulmonary fibrosis
    • Zhang X, Jiang J, Chen WJ, Su LX, Xie LX: Genetic characterization of a Chinese family with familial idiopathic pulmonary fibrosis. Chin Med J (Engl) 2012; 125:1945-1951.
    • (2012) Chin Med J (Engl) , vol.125 , pp. 1945-1951
    • Zhang, X.1    Jiang, J.2    Chen, W.J.3    Su, L.X.4    Xie, L.X.5
  • 74
  • 75
    • 84863798325 scopus 로고    scopus 로고
    • Angio-genesis in pulmonary fibrosis: Too much or not enough?
    • Hanumegowda C, Farkas L, Kolb M: Angio-genesis in pulmonary fibrosis: too much or not enough? Chest 2012; 142:200-207.
    • (2012) Chest , vol.142 , pp. 200-207
    • Hanumegowda, C.1    Farkas, L.2    Kolb, M.3
  • 77
    • 66449098872 scopus 로고    scopus 로고
    • VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats
    • Farkas L, Farkas D, Ask K, Moller A, Gauldie J, Margetts P, Inman M, Kolb M: VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats. J Clin Invest 2009; 119:1298-1311.
    • (2009) J Clin Invest , vol.119 , pp. 1298-1311
    • Farkas, L.1    Farkas, D.2    Ask, K.3    Moller, A.4    Gauldie, J.5    Margetts, P.6    Inman, M.7    Kolb, M.8
  • 84
    • 34547900666 scopus 로고    scopus 로고
    • Elevated matrilysin levels in bronchoalveolar lavage fluid do not distinguish idiopathic pulmonary fibrosis from other interstitial lung diseases
    • DOI 10.1111/j.1600-0463.2007.apm-697.x
    • Vuorinen K, Myllarniemi M, Lammi L, Piirila P, Rytila P, Salmenkivi K, Kinnula VL: Elevated matrilysin levels in bronchoalveolar lavage fluid do not distinguish idiopathic pulmonary fibrosis from other interstitial lung diseases. APMIS 2007; 115:969-975. (Pubitemid 47256289)
    • (2007) APMIS , vol.115 , Issue.8 , pp. 969-975
    • Vuorinen, K.1    Myllarniemi, M.2    Lammi, L.3    Piirila, P.4    Rytila, P.5    Salmenkivi, K.6    Kinnula, V.L.7
  • 87
    • 0142118162 scopus 로고    scopus 로고
    • The Role of osteopontin in lung disease
    • DOI 10.1016/S1359-6101(03)00055-8
    • O'Regan A: The role of osteopontin in lung disease. Cytokine Growth Factor Rev 2003; 14: 479-488. (Pubitemid 37296021)
    • (2003) Cytokine and Growth Factor Reviews , vol.14 , Issue.6 , pp. 479-488
    • O'Regan, A.1
  • 93
    • 67349261972 scopus 로고    scopus 로고
    • Fibro-cyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis
    • Mehrad B, Burdick MD, Strieter RM: Fibro-cyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis. Int J Biochem Cell Biol 2009; 41:1708-1718.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 1708-1718
    • Mehrad, B.1    Burdick, M.D.2    Strieter, R.M.3
  • 96
    • 33646481327 scopus 로고    scopus 로고
    • Cutting edge: Nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis
    • Marchal-Somme J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, Crestani B, Soler P: Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis. J Immunol 2006; 176:5735-5739.
    • (2006) J Immunol , vol.176 , pp. 5735-5739
    • Marchal-Somme, J.1    Uzunhan, Y.2    Marchand-Adam, S.3    Valeyre, D.4    Soumelis, V.5    Crestani, B.6    Soler, P.7
  • 104
    • 70349109207 scopus 로고    scopus 로고
    • Biomarkers in chronic obstructive pulmonary disease
    • Sin DD, Vestbo J: Biomarkers in chronic obstructive pulmonary disease. Proc Am Tho-rac Soc 2009; 6:543-545.
    • (2009) Proc Am Tho-rac Soc , vol.6 , pp. 543-545
    • Sin, D.D.1    Vestbo, J.2
  • 105
    • 24744443703 scopus 로고    scopus 로고
    • Does interstitial lung disease predispose to lung cancer?
    • Daniels CE, Jett JR: Does interstitial lung disease predispose to lung cancer? Curr Opin Pulm Med 2005; 11:431-437. (Pubitemid 41291088)
    • (2005) Current Opinion in Pulmonary Medicine , vol.11 , Issue.5 , pp. 431-437
    • Daniels, C.E.1    Jett, J.R.2
  • 106
    • 84883416033 scopus 로고    scopus 로고
    • Common pathways in idiopath-ic pulmonary fibrosis and cancer
    • Vancheri C: Common pathways in idiopath-ic pulmonary fibrosis and cancer. Eur Respir Rev 2013; 22:265-272.
    • (2013) Eur Respir Rev , vol.22 , pp. 265-272
    • Vancheri, C.1
  • 107
    • 84886311290 scopus 로고    scopus 로고
    • Advances in the study of biomarkers of idiopathic pulmonary fibrosis in Japan
    • Huang HB, Peng XN, Nakajima J: Advances in the study of biomarkers of idiopathic pulmonary fibrosis in Japan. Biosci Trends 2013; 7:172-177.
    • (2013) Biosci Trends , vol.7 , pp. 172-177
    • Huang, H.B.1    Peng, X.N.2    Nakajima, J.3
  • 108
    • 84878454973 scopus 로고    scopus 로고
    • PROFILEing idiopathic pulmonary fibrosis: Rethinking biomarker discovery
    • Maher TM: PROFILEing idiopathic pulmonary fibrosis: rethinking biomarker discovery. Eur Respir Rev 2013; 22:148-152.
    • (2013) Eur Respir Rev , vol.22 , pp. 148-152
    • Maher, T.M.1


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